Abstract: Clustering methods are disclosed including a hidden Markov model (HMM) based clustering algorithm having particular applicability for identifying tumor subtypes using array comparative genomic hybridization (aCGH) DNA copy number data. In one embodiment, clusters of tumor samples are modeled with a mixture of HMMs where each HMM fits a cluster of samples. With respect to this embodiment, a computationally efficient and fast clustering algorithm takes only a computational time of O(n), has less than half the error rate of non-negative matrix factorization (NMF) clustering, and can locate the optimal number of groups automatically (e.g., as applied to a data set including glioma aCGH data).

Abstract: Disclosed is a circuit breaker, including a housing; a trip rod and locking device being disposed in the housing. The locking device includes a lock head, a mounting portion, a sliding member and at least one elastic element. The mounting portion includes a base plate and a first side plate. At least one protruding portion is provided on the base plate and a through-hole is formed in the first side plate. The lock head includes a first driving member. The sliding member includes a body and a push rod. A second driving member and at least one mounting slot are formed on the body. The second driving member is mated with the first driving member and the protruding portion is located in the mounting slot. The push rod is formed on the body and can pass through the through-hole to trigger the trip rod.

Abstract: Disclosed is a handle locking device, including a first frame, a first snap hook and a second frame. A second snap hook is provided on the first frame; the first snap hook is rotatably mounted on the first frame; the second frame is rotatably mounted on the first frame; a protruding portion is formed on the second frame; and the protruding portion can push the first snap hook towards the first frame. By having the first snap hook and second snap hook disposed asymmetrically on the first frame, accidental mounting of the “OFF” position of the handle locking device in the “ON” position of the circuit breaker during installation by an operator can be avoided. Moreover, since the protruding portion can push the first snap hook towards the first frame, forced deformation of the snap claw and second snap hook can be prevented.

Abstract: Video coding systems and methods are provided that protect against various artifacts (e.g., banding artifacts) in decoded frame content. The embodiments to protect against introducing artifacts include pre-processing the input video frame, controlling the encoding parameters and/or post-processing the decoded video frame. A method for encoding a frame may include calculating a dark-scene score for the frame based on measured statistics of the frame. The dark-scene score may be compared to a threshold to determine if the banding artifacts may be present in the frame. Based on the comparison, filtering parameters for the frame may be altered to reduce the amount of noise filtered from the frame. The frame may be filtered based on the altered filtering parameters and encoded.

Abstract: A video coding/decoding system builds implied reference frames from a plurality of reference frames developed during coding. Coded data of reference pictures are decoded and stored in a reference picture cache. An implied reference frame may be derived from a plurality of reference frames and may be stored in the reference picture cache. Thereafter, coding of new input data may proceed using the implied reference frame as a source of prediction. The method may be used to identify visual elements such as background elements that may persist in video over a longer period that can be captured by the system under conventional reference frames assembly and eviction. Implied reference frames may be built at both an encoder and a decoder to serve as sources of prediction.

Abstract: The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

Abstract: The present disclosure relates to telecommunication, and in particular, to a base station Radio Frequency (RF) duplexer, an RF module, and an RF system. A base station RF apparatus provided herein includes: an enclosure, an intermediate RF processing unit, and a duplexer. The enclosure is located on the duplexer; the intermediate RF processing unit is located inside a cavity enclosed by the enclosure and the duplexer, or on the duplexer; a duplexer cavity and a heat dissipation part exist on the surface of the duplexer; the opening of the duplexer cavity is opposite to or against the enclosure; the heat dissipation part is designed to dissipate heat of the intermediate RF processing unit; and the duplexer is integrally molded. The foregoing technical solution requires no external fasteners, reduces the time of production and assembly. In addition, waterproof design and shielding design are not required, and thus improves the reliability.

Abstract: Disclosed is a handle locking device including a first frame, a first hook and a second frame, wherein a second hook is provided on the first frame. The first and second hooks are rotatably installed on the first frame, and the second frame capable of fixing the first hook and the first frame. Since the handle locking device is only be installable on a circuit breaker by mating between the first hook and a first installation part of the circuit breaker and mating between the second hook and a second installation part of the circuit breaker, an operator is prevented from unintentionally setting an “OFF” position of the handle locking device in an “ON” position of the circuit breaker during installation. The first hook is rotatably installed on the first frame, so that the handle locking device can be conveniently and rapidly installed on or demounted from the circuit breaker.

Abstract: Specific binding agents that interact with hepatocyte growth factor (HGF) are described. Methods of treating cancer by administering a pharmaceutically effective amount of a specific binding agent to HGF are described. Methods of detecting the amount of HGF in a sample using a specific binding agent to HGF are described.

Abstract: The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.

Abstract: A housing for an electronic device includes a ceramic patterned light transmitting portion and a ceramic light resistant portion surrounding the light transmitting portion. A thickness of the light transmitting portion is in a range from 0.2 mm to 1 mm. A thickness of the light resistant portion is at least 0.3 mm thicker than that of the light transmitting portion.

Abstract: A system for, and a method of, configuring an electro-optical reader as a keyboard device having a selected keyboard layout containing keyboard layout data, encode each of a plurality of configuration symbols with a symbol sequence number, a total number of the configuration symbols, and a fractional amount of the keyboard layout data. During a configuration procedure, all the configuration symbols are electro-optically scanned and decoded, and the symbol sequence number, the total number of the configuration symbols, and the fractional amount of the keyboard layout data are extracted for each configuration symbol. The keyboard layout data for all the configuration symbols are linked in a sequence determined by each symbol sequence number and the total number of the configuration symbols. All the keyboard layout data is processed to configure the reader during the configuration procedure.

Abstract: A method and system for cross domain interaction of a Web application are proposed, wherein a Web application belonging to a first domain needs to interact with a service belonging to a second domain. The method comprises: by the Web application, creating an iFrame in a webpage, wherein the iFrame is belonging to the first domain; creating a form in the iFrame; submitting the form to a Web server providing a service belonging to the second domain; and refreshing the iFrame by receiving a response from the Web server, changing the domain, to which the iFrame is belonging, to the second domain, and performing cross domain interaction with the service belonging to the second domain with the information contained in the form.

Abstract: The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.

Abstract: Specific binding agents that interact with hepatocyte growth factor (HGF) are described. Methods of treating cancer by administering a pharmaceutically effective amount of a specific binding agent to HGF are described. Methods of detecting the amount of HGF in a sample using a specific binding agent to HGF are described.

Abstract: A vide coding server may code a common video sequence into a plurality of coded data streams, each coded data stream representing the video sequence coded using coding parameters tailored for a respective transmission bit rate. The coding may cause a set of transmission units from among the coded data streams to include coded video data from a common point of the video sequence, and a first coded frame of each transmission unit of the set to be a synchronization frame. A manifest file may be built representing an index of transmission units of the respective coded data streams. The coded data streams and manifest file may be stored by the server for delivery to a client device. During download and decode, the chunks may be decoded efficiently even when switching among streams because the first frame in each chunk is a synchronization frame.

Abstract: The present invention provides a grounding structure for a printed circuit board which is fixed onto a chassis by a force applied at a first side of the printed circuit board towards the chassis.

Abstract: A separation device and a method for transmitting voice signal are disclosed. The separation device includes a line interface adapted to provide an interface for connecting to a telecommunication access system which provides public switched telephone network (PSTN) and data services; a data interface adapted to provide an interface connected with customer premises equipment (CPE) and connected with the line interface; a first communication interface adapted to provide an interface connected with a PSTN communication terminal; a second communication interface adapted to provide an interface connected with a foreign exchange station (FXS) interface of the CPE; and a connection switching unit adapted to connect the first communication interface with the line interface or connect the first communication interface with the second communication interface, and to perform switching between the two connections to implement PSTN communication or VoIP communication respectively.

Abstract: Video coding systems and methods protect against banding artifacts in decoded image content. According to the method, a video coder may identify, from content of pixel blocks of a frame of video data, which pixel blocks are likely to exhibit banding artifacts from the video coding/decoding processes. The video coder may assemble regions of the frame that are likely to exhibit banding artifacts based on the identified pixel blocks' locations with respect to each other. The video coder may apply anti-banding processing to pixel blocks within one or more of the identified regions and, thereafter, may code the processed frame by a compression operation.

Abstract: The disclosure provides a method and a system for network handover. The method includes: during a process that equipment hands over from a current network to another network, a driver receiving a network-disconnected message, and judging whether the network-disconnected message is sent from a Connection Manager (CM); if the network-disconnected message is sent from the CM, the driver reporting, to an operating system, a first signalling which identifies that the current network is disconnected; and if the network-disconnected message is not sent from the CM, the driver reporting, to the operating system, a second signalling which identifies that the current network is connected. By the adoption of the method and the system, power consumption of the equipment can be reduced.