Patents by Inventor Keith Brown

Keith Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Destruction of PFAS Via an Oxidation Process and Apparatus Suitable for Transportation to Contaminated Sites
    Publication number: 20250083978
    Abstract: Per-and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water can be concentrated and prepared for destruction in a pretreatment phase. Following annihilation of the PFAS in supercritical conditions to levels below 5 parts per trillion (ppt), the water effluent can be used to recover heat, returned to sub-critical conditions, and then released back into the environment.
    Type: Application
    Filed: September 2, 2024
    Publication date: March 13, 2025
    Inventors: Lindy E. Dejarme, Kavitha Dasu, Russell R. Sirabian, Christopher F. Buurma, Jeffrey Ellis, Michael M. Miller, Dan Garbark, Nathan Bryant, John Tallarico, Joseph Casciano, Slawomir Winecki, David Holley, Joshua James, Keith Brown, Doug Hendry, Darwin Argumedo, Aaron Frank, Christopher Gordon Scheitlin
  • METHODS AND COMPOSITIONS FOR TRANSCRIPTOME ANALYSIS
    Publication number: 20250084484
    Abstract: Provided herein are methods and compositions for analysis of a transcriptome, for example detection of a RNA isoform, of a cell, tissue, organ, or subject.
    Type: Application
    Filed: January 10, 2023
    Publication date: March 13, 2025
    Inventor: Keith BROWN
  • Compositions and methods for molecular labeling
    Patent number: 12140590
    Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.
    Type: Grant
    Filed: November 17, 2021
    Date of Patent: November 12, 2024
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Michael L. Samuels, Jeffrey Charles Olson, Andrew Watson, Keith Brown, Darren R. Link
  • Compositions and methods for molecular labeling
    Patent number: 12140591
    Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: November 12, 2024
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Michael L. Samuels, Jeffrey Charles Olson, Andrew Watson, Keith Brown, Darren R. Link
  • Destruction of PFAS via an oxidation process and apparatus suitable for transportation to contaminated sites
    Patent number: 12091331
    Abstract: Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water can be concentrated and prepared for destruction in a pretreatment phase. Following annihilation of the PFAS in supercritical conditions to levels below 5 parts per trillion (ppt), the water effluent can be used to recover heat, returned to sub-critical conditions, and then released back into the environment.
    Type: Grant
    Filed: November 21, 2022
    Date of Patent: September 17, 2024
    Assignee: Revive Environmental Technology, LLC
    Inventors: Lindy E. Dejarme, Kavitha Dasu, Russell R. Sirabian, Christopher F. Buurma, Jeffrey Ellis, Michael M. Miller, Dan Garbark, Nathan Bryant, John Tallarico, Joseph Casciano, Slawomir Winecki, David Holley, Joshua James, Keith Brown, Doug Hendry, Darwin Argumedo, Aaron Frank, Christopher Gordon Scheitlin
  • Salt Separation and Destruction of PFAS Utilizing Reverse Osmosis and Salt Separation
    Publication number: 20240182341
    Abstract: Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water is concentrated in a reverse osmosis step and salt from the resulting solution is removed in supercritical conditions prior to destruction of PFAS in supercritical conditions.
    Type: Application
    Filed: January 9, 2024
    Publication date: June 6, 2024
    Inventors: Stephen H. Rosansky, Michael Miller, Patrick Norris, Darwin Argumedo, Douglas Hendry, Ian Haggerty, Keith Brown, Joshua James, Joseph Casciano, Slawomir Winecki, Vivek Lal, Tom McGuinness
  • METHODS FOR TARGETED NUCLEIC ACID SEQUENCING
    Publication number: 20240182951
    Abstract: Disclosed herein are compositions and methods related to the detection and/or elimination of a first nucleic acid and enrichment of a second nucleic acid in a sample, for example to exclude the first nucleic acid from downstream analysis or sequencing, or to exclude such sequences from a downstream data set.
    Type: Application
    Filed: March 30, 2022
    Publication date: June 6, 2024
    Inventors: Keith BROWN, Jon ARMSTRONG, Azeem SIDDIQUE
  • Destruction of PFAS via an oxidation process and apparatus suitable for transportation to contaminated sites
    Patent number: 11970409
    Abstract: Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water can be concentrated and prepared for destruction in a pretreatment phase. Following annihilation of the PFAS in supercritical conditions to levels below 5 parts per trillion (ppt), the water effluent can be used to recover heat, returned to sub-critical conditions, and then released back into the environment.
    Type: Grant
    Filed: November 21, 2022
    Date of Patent: April 30, 2024
    Assignee: Revive Environmental Technology, LLC
    Inventors: Lindy E. Dejarme, Kavitha Dasu, Russell R. Sirabian, Jeffrey Ellis, Dan Garbark, Nathan Bryant, John Tallarico, Joseph Casciano, Slawomir Winecki, David Holley, Joshua James, Keith Brown, Doug Hendry, Darwin Argumedo, Aaron Frank, Christopher Gordon Scheitlin, Michael M. Miller
  • Compositions and methods for molecular labeling
    Patent number: 11965877
    Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: April 23, 2024
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Michael Samuels, Jeffrey Charles Olson, Andrew Watson, Keith Brown, Darren R. Link
  • Salt separation and destruction of PFAS utilizing reverse osmosis and salt separation
    Patent number: 11891323
    Abstract: Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water is concentrated in a reverse osmosis step and salt from the resulting solution is removed in supercritical conditions prior to destruction of PFAS in supercritical conditions.
    Type: Grant
    Filed: August 9, 2022
    Date of Patent: February 6, 2024
    Assignee: Revive Environmental Technology, LLC
    Inventors: Stephen H. Rosansky, Michael Miller, Patrick Norris, Darwin Argumedo, Douglas Hendry, Ian Haggerty, Keith Brown, Joshua James, Joseph Casciano, Slawomir Winecki, Vivek Lal, Tom McGuinness
  • GENOME FRACTIONING
    Publication number: 20240035086
    Abstract: Disclosed herein are compositions and methods related to the elimination of molecules of a selected sequence from a nucleic acid sample or from an sequence dataset resulting from the sequencing of a sample, for example to exclude such molecules from downstream analysis or sequencing, or to exclude such sequences from a downstream data set.
    Type: Application
    Filed: August 8, 2023
    Publication date: February 1, 2024
    Inventors: Keith Brown, Peter Dansky
  • COMPOSITIONS AND METHODS FOR MOLECULAR LABELING
    Publication number: 20240011974
    Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.
    Type: Application
    Filed: July 26, 2023
    Publication date: January 11, 2024
    Inventors: Michael Samuels, Jeffrey Charles Olson, Andrew Watson, Keith Brown, Darren R. Link
  • Destruction of PFAS via an oxidation process and apparatus suitable for transportation to contaminated sites
    Patent number: 11780753
    Abstract: Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water can be concentrated and prepared for destruction in a pretreatment phase. Following annihilation of the PFAS in supercritical conditions to levels below 5 parts per trillion (ppt), the water effluent can be used to recover heat, returned to sub-critical conditions, and then released back into the environment.
    Type: Grant
    Filed: July 23, 2022
    Date of Patent: October 10, 2023
    Assignee: REVIVE ENVIRONMENTAL TECHNOLOGY, LLC
    Inventors: Lindy E. Dejarme, Kavitha Dasu, Russel R. Sirabian, Jeffrey Ellis, Dan Garbark, Nathan Bryant, John Tallarico, Joseph Casciano, Slawomir Winecki, David Holley, Joshua James, Keith Brown, Doug Hendry, Darwin Argumedo, Aaron Frank, Christopher Gordon Scheitlin, Michael M. Miller, Matthew Vaughan
  • Compositions and methods for molecular labeling
    Patent number: 11768198
    Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: September 26, 2023
    Assignee: BIO-RAD LABORATORIES, INC.
    Inventors: Michael L. Samuels, Jeffrey Charles Olson, Andrew Watson, Keith Brown, Darren R. Link
  • Genome fractioning
    Patent number: 11761039
    Abstract: Disclosed herein are compositions and methods related to the elimination of molecules of a selected sequence from a nucleic acid sample or from an sequence dataset resulting from the sequencing of a sample, for example to exclude such molecules from downstream analysis or sequencing, or to exclude such sequences from a downstream data set.
    Type: Grant
    Filed: October 20, 2021
    Date of Patent: September 19, 2023
    Assignee: JUMPCODE GENOMICS, INC.
    Inventors: Keith Brown, Peter Dansky
  • Compositions and methods for molecular labeling
    Patent number: 11747327
    Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.
    Type: Grant
    Filed: July 14, 2020
    Date of Patent: September 5, 2023
    Assignee: BIO-RAD LABORATORIES, INC.
    Inventors: Michael L. Samuels, Jeffrey Charles Olson, Andrew Watson, Keith Brown, Darren R. Link
  • METHODS FOR TARGETED DEPLETION OF NUCLEIC ACIDS
    Publication number: 20230265528
    Abstract: Disclosed herein are compositions and methods related to the elimination of a first nucleic acid and/or enrichment of a second nucleic acid in a sample, for example to exclude the first nucleic acid from downstream analysis or sequencing, or to exclude such sequences from a downstream data set.
    Type: Application
    Filed: August 11, 2021
    Publication date: August 24, 2023
    Inventor: Keith BROWN
  • Genome fractioning
    Patent number: 11708606
    Abstract: Disclosed herein are compositions and methods related to the elimination of molecules of a selected sequence from a nucleic acid sample or from an sequence dataset resulting from the sequencing of a sample, for example to exclude such molecules from downstream analysis or sequencing, or to exclude such sequences from a downstream data set.
    Type: Grant
    Filed: February 18, 2020
    Date of Patent: July 25, 2023
    Assignee: JUMPCODE GENOMICS, INC.
    Inventors: Keith Brown, Peter Dansky
  • Destruction of PFAS Via an Oxidation Process and Apparatus Suitable for Transportation to Contaminated Sites
    Publication number: 20230227335
    Abstract: Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water can be concentrated and prepared for destruction in a pretreatment phase. Following annihilation of the PFAS in supercritical conditions to levels below 5 parts per trillion (ppt), the water effluent can be used to recover heat, returned to sub-critical conditions, and then released back into the environment.
    Type: Application
    Filed: November 21, 2022
    Publication date: July 20, 2023
    Inventors: Lindy E. Dejarme, Kavitha Dasu, Russell R. Sirabian, Jeffrey Ellis, Dan Garbark, Nathan Bryant, John Tallarico, Joseph Casciano, Slawomir Winecki, David Holley, Joshua James, Keith Brown, Doug Hendry, Darwin Argumedo, Aaron Frank, Christopher Gordon Scheitlin, Michael M. Miller
  • Destruction of PFAS Via an Oxidation Process and Apparatus Suitable for Transportation to Contaminated Sites
    Publication number: 20230227336
    Abstract: Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water can be concentrated and prepared for destruction in a pretreatment phase. Following annihilation of the PFAS in supercritical conditions to levels below 5 parts per trillion (ppt), the water effluent can be used to recover heat, returned to sub-critical conditions, and then released back into the environment.
    Type: Application
    Filed: November 21, 2022
    Publication date: July 20, 2023
    Inventors: Lindy E. Dejarme, Kavitha Dasu, Russell R. Sirabian, Christopher F. Buurma, Jeffrey Ellis, Michael M. Miller, Dan Garbark, Nathan Bryant, John Tallarico, Joseph Casciano, Slawomir Winecki, David Holley, Joshua James, Keith Brown, Doug Hendry, Darwin Argumedo, Aaron Frank, Christopher Gordon Scheitlin