Abstract: The present disclosure includes methods and systems for providing virtual reality content based on user biometric data. In particular, the disclosed systems and methods can modify virtual reality content to elicit target user responses and/or target user actions. Specifically, the disclosed systems and methods generate biometric response thresholds and determine user responses by comparing biometric data with the biometric response thresholds. The disclosed systems and methods select virtual reality content based on the user response to drive the user toward a particular target user response and/or target user action. The disclosed systems and methods also tailor virtual reality content to individual characteristics of the user. For example, the disclosed systems and methods select virtual reality content based on baseline biometric characteristics and corresponding response categories of a user.

Abstract: The present invention provides a transdermal delivery system comprising (R)-dihydroetorphine, or a salt, hydrate or derivative thereof, wherein said system has a rapid onset of (R)-dihydroetorphine plasma concentration characterised by the mean in vivo plasma concentration of (R)-dihydroetorphine achieving at least 50% of its Cmax in less than 20 hours, preferably in less than 18 hours and more preferably in less than 12 hours, after application of the system to the skin of a human subject, e.g. when based on the mean plasma concentration versus time curve.

Abstract: The present invention provides a transdermal patch comprising: a drug-containing layer comprising (R)-dihydroetorphine, or a salt or a hydrate thereof, and a poly(meth)acrylate; and a backing layer.

Abstract: The disclosure describes systems and methods of analyzing interactions with a user interface for an application, where the user interface is implemented at least partly within a virtual reality environment. Certain embodiments provide for receiving interactions that include gestures, spatial contexts, and applications contexts, and receiving results from the application, such as application behavior or error conditions. The user interface interactions and the application results are analyzed. Events, metrics, and relationships are determined based on the analysis. In some cases, additional data (such as historical interactions and results, system environment data, or system configuration data) are received and analyzed, and the determined relationships are further based on the additional data.

Abstract: Techniques disclosed herein provide a user experience with virtual reality content and user-selected, real world objects. An exemplary technique involves receiving input selecting a subset of the real world objects in a selection view. The subset of the real world objects is selected for inclusion in the user experience. The technique further involves identifying virtual reality content for inclusion in the user experience. The technique provides the user experience by combining a live view of the user's real world environment with the virtual reality content. The real world objects in the live view that are in the subset selected by the user are visible in the user experience. The real world objects in the live view that are not in the subset selected by the user are replaced with virtual reality content.

Abstract: Visual representations of recurring revenue management system data and predictions are disclosed. A user interface is generated for an electronic display, the user interface including a graphical representation of one or more recurring revenue assets, the graphical representation representing each of the one or more recurring revenue assets according to one or more metrics that define each of the one or more recurring revenue assets. A predicted outcome for at least one of the one or more recurring revenue assets is predicted, the calculating being from a predictive model that is based on aggregate historical information collected from one or more data sources. A graphical representation of the predicted outcome is generated according to one or more parameters related to the one or more metrics, for concurrent display in the user interface with the graphical representation of one or more recurring revenue assets.

Abstract: A parking assist system for a vehicle is provided that includes a proximity sensor configured to sense a distance to an obstacle, a parking controller configured to output a distance to target signal and a scheduler configured to process the distance to target signal and output a distance error signal to a control module configured to longitudinally control the vehicle. The scheduler is configured to process both a static and a dynamic distance to target signal.

Abstract: The present invention concerns a dosage form comprising oxycodone and naloxone which is characterized by specific in vivo parameters such as tmax, Cmax, AUCt value, mean bowel function score and/or duration of analgesic efficacy.

Abstract: A method is described of mixing fluid materials, including solids and gases. The materials to be mixed are introduced between two cylindrical rotors mounted in parallel on a motorized shaft. The rotors have arrays of cavities on their cylindrical surfaces and rotate within close proximity to the interior of a cylindrical shell. Passage of the fluid between the rotating rotors and the interior surface of the cylindrical shell causes cavitation, which mixes the materials. The mixture is passed to outlets on the far sides of the rotors from the inlet. Apparatus is described for extending the flow path of the materials and thus increasing exposure to the cavitation process.

Abstract: A laser is configured to emit light along a substrate-parallel plane along a first surface of the laser. An etched facet is on an emitting end of a lasing cavity and an etched mirror is on another end of the lasing cavity. An etched shaping mirror redirects light received from the etched facet in a direction normal to the substrate-parallel plane. A slider comprises an optical input coupler configured to couple the light from the laser into a waveguide of the slider. At least one protrusion is disposed on the laser and at least one recession is disposed on the slider, the at least one protrusion and the at least one recession configured to align the laser with the slider to allow the light to be coupled into the optical input coupler.

Abstract: A method is described of mixing fluid materials, including solids and gases. The materials to be mixed are introduced between two cylindrical rotors mounted in parallel on a motorized shaft. The rotors have arrays of cavities on their cylindrical surfaces and rotate within close proximity to the interior of a cylindrical shell. Passage of the fluid between the rotating rotors and the interior surface of the cylindrical shell causes cavitation, which mixes the materials. The mixture is passed to outlets on the far sides of the rotors from the inlet. Apparatus is described for extending the flow path of the materials and thus increasing exposure to the cavitation process.

Abstract: A torque-transmitting, variably-flexible, locking insertion device includes a hollow body having a proximal end with an entrance for receiving an instrument, a distal end with a tip for protrusion of the instrument, and a handle to be gripped by an operator. A device locks the handle to and unlocks the handle from the instrument, which is at least partly disposed within the hollow body. A device transitions the hollow body between a relatively flexible condition and a relatively stiff condition. A method for operating a torque-transmitting, locking insertion device includes placing the instrument at least partly within the hollow body and locking the handle to and unlocking the handle from the instrument. The hollow body is transitioned between a relatively flexible condition and a relatively stiff condition.

Abstract: The present invention relates to an intranasal pharmaceutical dosage form comprising a dosing unit comprising naloxone or a pharmaceutically acceptable salt thereof in an amount of equivalent to ?0.5 mg naloxone HCl dissolved in an application fluid of a volume of ?250 ?l. Furthermore, the present invention relates to such an intranasal pharmaceutical dosage form for use in the treatment of opioid overdosing and/or at least one symptom thereof.

Abstract: A method is described of mixing fluid materials, including solids and gases. The materials to be mixed are introduced between two cylindrical rotors mounted in parallel on a motorized shaft. The rotors have arrays of cavities on their cylindrical surfaces and rotate within close proximity to the interior of a cylindrical shell. Passage of the fluid between the rotating rotors and the interior surface of the cylindrical shell causes cavitation, which mixes the materials. The mixture is passed to outlets on the far sides of the rotors from the inlet. Apparatus is described for extending the flow path of the materials and thus increasing exposure to the cavitation process.

Abstract: A method for making a device for causing thrombosis of an aneurysm, wherein said device comprises a single elastic filament configurable between (i) an elongated, substantially linear configuration, and (ii) a longitudinally-contracted, substantially three-dimensional configuration, said method comprising: providing a sheet of shape memory material; producing a single filament, two-dimensional interim structure from said sheet of shape memory material; mounting said single filament, two-dimensional interim structure to a fixture so that said single filament, two-dimensional interim structure is transformed into said longitudinally-contracted, substantially three-dimensional configuration; and heat treating said single filament, two-dimensional interim structure while it is mounted to said fixture so as to produce said device in its longitudinally-contracted, substantially three-dimensional configuration.

Abstract: Computer-implemented systems and methods disclosed herein disclose features for determining the frequency of exposure to real-world products embedded with Internet-Of-Things (IoT) hardware and determining a comprehensive targeting profile identifying the interests of users based on their exposure to real-world products. A computing device carried by a user wirelessly receives product exposure data from a nearby IoT-enabled device upon entering within a certain proximity of the IoT-enabled device. The computing device further compiles the product exposure data with previous product exposure data for IoT-enabled devices to which the computing device was previously exposed. Based on the compiled product exposure data, a server device determines a frequency of exposure to a product corresponding to the IoT-enabled device over a period of time.

Abstract: Visual representations of recurring revenue management system data and predictions are disclosed. A user interface is generated for an electronic display, the user interface including a graphical representation of one or more recurring revenue assets, the graphical representation representing each of the one or more recurring revenue assets according to one or more metrics that define each of the one or more recurring revenue assets. A predicted outcome for at least one of the one or more recurring revenue assets is predicted, the calculating being from a predictive model that is based on aggregate historical information collected from one or more data sources. A graphical representation of the predicted outcome is generated according to one or more parameters related to the one or more metrics, for concurrent display in the user interface with the graphical representation of one or more recurring revenue assets.

Abstract: The present invention relates to an intranasal pharmaceutical dosage form comprising a dosing unit comprising naloxone or a pharmaceutically acceptable salt thereof in an amount of equivalent to ?0.5 mg naloxone HCl dissolved in an application fluid of a volume of ?250 ?l. Furthermore, the present invention relates to such an intranasal pharmaceutical dosage form for use in the treatment of opioid overdosing and/or at least one symptom thereof.

Abstract: A mobile telecommunications network includes a plurality of nodes for wireless communication with a mobile telecommunications device and a respective server associated with each of said nodes, each server having processing functions, wherein a processing function of a first one of the servers associated with a first one of the nodes is operable to support a communication session with the mobile telecommunications device to provide a service thereto. The processing function of the first one of the servers is operable to send data relating to the communication session to a second one of the servers associated with a second one of the nodes for use by a processing function of the second one of the servers to enable the processing function of the second one of the servers to support the communication session and provide continuity of the communication session if the mobile telecommunications device moves from registration with the first one of the nodes to the second one of the nodes.

Abstract: Implementations disclosed herein provide a method comprising emitting light at a plurality of locations across a surface of a recording head, detecting light output from a diffraction grating axis with a detector, and determining a target position for mounting a light source on the surface of the recording head by analyzing the detected light output corresponding to one or more of the plurality of locations.