Abstract: Described herein are compositions and methods for use in targeted drug delivery using cell-surface receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations.

Abstract: Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations, such as inflammatory cells.

Abstract: A substrate-guided holographic diffuser has a light-guide section configured to in-couple light and transmit the light within itself via total internal reflection. It can also have a brightness enhancement section that recycles non-diffracted light within the light-guide section. A hologram section that receives light from the light-guide section has a holographic structure defining acceptance conditions and is positioned relative to the internally reflected light such that the internally reflected light meets the acceptance conditions of the holographic structure. The internally reflected light is out-coupled by the holographic structure as a projected image of light scattered from a diffuser.

Abstract: The present disclosure relates to pyrrolobenzodiazepine (PBD) prodrugs and conjugates thereof. The present disclosure also relates to pharmaceutical compositions of the conjugates described herein, methods of making and methods of using the same.

Abstract: Methods are provided for treating cancers using a conjugate herein described as Conjugate 5, or a pharmaceutically acceptable salt thereof. Methods for treating cancers using Conjugate 5, or a pharmaceutically acceptable salt thereof, to target tumor associated macrophages are also described.

Abstract: A method for design and fabrication of holographic optical elements for a compact holographic sight is proposed. The method includes use of ray-trace software to design holographic elements having optical power using an intermediate hologram with parameters obtained through minimization of the merit function defining image quality.

Abstract: A substrate-guided holographic diffuser has a light-guide section configured to in-couple light and transmit the light within itself via total internal reflection. It can also have a brightness enhancement section that recycles non-diffracted light within the light-guide section. A hologram section that receives light from the light-guide section has a holographic structure defining acceptance conditions and is positioned relative to the internally reflected light such that the internally reflected light meets the acceptance conditions of the holographic structure. The internally reflected light is out-coupled by the holographic structure as a projected image of light scattered from a diffuser.

Abstract: Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations, such as inflammatory cells.

Abstract: A method for design and fabrication of holographic optical elements for a compact holographic sight is proposed. The method includes use of ray-trace software to design holographic elements having optical power using an intermediate hologram with parameters obtained through minimization of the merit function defining image quality.

Abstract: A holographic substrate-guided wave-based see-through display can has a microdisplay, capable of emitting light in the form of an image. The microdisplay directs its output to a holographic optical element, capable of accepting the light in the form of an image. The microdisplay directs its output to a holographic optical element, capable of accepting the image from the microdisplay, and capable of transmitting the light. The holographic optical element couples its output to an elongate substrate, capable of accepting the light from the holographic lens at a first location, and transmitting the light along a length of the substrate by total internal reflection to a second location, the elongate substrate being capable of transmitting the accepted light from the second location.

Abstract: An illustrative embodiment of a computer-implemented process for dynamic management of integration protocols connects a set of applications to a communication fabric to form a set of connections, which are monitored to collect a set of performance metrics. In response to a determination the predetermined performance metric is not within the predetermined tolerance associated with the particular application in the set of applications an integration path in the set of connections for the particular application in the set of applications is adjusted by programmatically using a set of rules wherein each rule in the set of rules is a performance driven rule.

Abstract: A holographic substrate-guided wave-based see-through display has a microdisplay, capable of emitting light in the form of an image. The microdisplay directs its output to a holographic optical element, capable of accepting the image from the microdisplay, and capable of transmitting the light. The holographic optical element couples its output to an elongate substrate, capable of accepting the light from the holographic optical element at a first location, and transmitting the light along a length of the substrate by internal reflection to a second location, the elongate substrate being capable of transmitting the accepted light from the second location. The substrate couples out what it receives to a transparent holographic optical element, capable of accepting the light transmitted from the substrate and transmitting it to a location outside of the holographic optical element as a viewable image.

Abstract: A method for design and fabrication of holographic optical elements for a compact holographic sight is proposed. The method includes use of ray-trace software to design holographic elements having optical power using an intermediate hologram with parameters obtained through minimization of the merit function defining image quality.

Abstract: A method for design and fabrication of holographic optical elements for a compact holographic sight is proposed. The method includes use of ray-trace software to design holographic elements having optical power using an intermediate hologram with parameters obtained through minimization of the merit function defining image quality.

Abstract: The present disclosure relates to pyrrolobenzodiazepine (PBD) prodrugs and conjugates thereof. The present disclosure also relates to pharmaceutical compositions of the conjugates described herein, methods of making and methods of using the same.

Abstract: Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations, such as inflammatory cells.

Abstract: Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations, such as inflammatory cells.

Abstract: Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations. The compounds described herein include conjugates of tubulysins and vitamin receptor binding ligands. The conjugates also include a releasable bivalent linker.

Abstract: Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations, such as inflammatory cells.

Abstract: Methods and apparatus for supporting a data center relocation with regard to an access point are described. A primary gateway connection is established between the access point and a primary gateway in a first data center, and a secondary gateway connection is established between the access point and a secondary gateway in a second data center. A path switch request is sent via the secondary gateway connection. A DNS server sends an IP address corresponding to the second data center. The data center for the access point is switched from the first data center to the second data center. In some embodiments, the transition from the first data center to the second data center is in response to a detected communications failure. In other embodiments, the transition from the first data center to the second data center is due to scheduled maintenance.