Abstract: Described herein are systems, mediums, and methods for simultaneously determining multiple types of changes in time series data. A plurality of potential change points may be selected in a signal representing the time series data. For each potential change point the signal may be a split into two segments including data points before and data points after the potential change point, respectively. Estimate of cumulative distribution function for each segment may be determined. A normalized difference of the respective estimates of cumulative distribution functions may be determined. The normalized difference may be compared to a threshold value to determine whether the potential change point qualifies as valid change point. The techniques discussed herein may determine at least two valid change points representing at least two different types of changes in the signal.

Abstract: In one embodiment, a computer-implemented method for dynamic management of integration points includes connecting a set of applications to a communication interconnect fabric to form a set of connections, wherein each application in the set of applications is interconnected and each individual connection has a set of integration paths defined including a default path. The set of connections is monitored to determine whether a performance metric for a specific application in the set of applications is within a predefined tolerance. Responsive to a determination that the performance metric for the specific application in the set of applications is not within a predefined tolerance, a change may be instructed in availability of an integration component.

Abstract: Described herein are compositions and methods for use in targeted drug delivery using cell receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in imaging, diagnosing, and/or treating diseases and disease states caused by pathogenic cell populations.

Abstract: Systems and methods are described herein for detecting an anomaly in a discrete signal, where samples in the signal correspond to amounts of data flow in a network within a time interval. The discrete signal is received, and a sequence of likelihoods corresponding to the sample values in the signal is generated. The likelihoods are based at least in part on a historical probability distribution of previously received sample values, and a likelihood is a probability of occurrence of a corresponding sample value in the signal. Likelihood change points are identified in the likelihood sequence, and the discrete signal is segmented into a plurality of segments at samples corresponding to the identified change points. A segment is identified as an anomaly based on a comparison between a statistic of the segment and a statistic of the historical probability distribution.

Abstract: Described herein are systems, mediums, and methods for detecting blockage of network traffic at a network server. A signal representative of time series data associated with network traffic is received at a processor for analysis. A data segmentation algorithm and an anomaly detection algorithm are applied in series to the received data. The segmentation algorithm detects regime shifts in the data. Data between regime shifts is considered a segment of data. The anomaly detection algorithm analyzes each segment individually to determine whether anomalies exist in the segment. If a cyclic pattern is found in the segment, the cyclic pattern is extracted from the segment leaving a residual data for analysis. A probability distribution of the residual data is determined for analysis. When an anomaly is detected in the segment o based on the probability distribution of the residual data, it is determined that blockage has occurred on the network traffic.

Abstract: Methods and apparatus for supporting a data center relocation with regard to an access point are described. A primary gateway connection is established between the access point and a primary gateway in a first data center, and a secondary gateway connection is established between the access point and a secondary gateway in a second data center. A path switch request is sent via the secondary gateway connection. A DNS server sends an IP address corresponding to the second data center. The data center for the access point is switched from the first data center to the second data center. In some embodiments, the transition from the first data center to the second data center is in response to a detected communications failure. In other embodiments, the transition from the first data center to the second data center is due to scheduled maintenance.

Abstract: Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.

Abstract: Systems and methods are disclosed herein for detecting an anomaly in a discrete signal, where a long-term trend of the discrete signal is identified. Samples in the signal correspond to a number of data packets arriving at a location in a network within a time interval. The long-term trend is subtracted from the discrete signal to obtain a detrended signal. A cyclic pattern is identified in the detrended signal and is subtracted from the detrended signal to obtain a residual signal. Anomaly detection is performed on the residual signal.

Abstract: Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.

Abstract: Described herein are systems, mediums, and methods for detecting anomalies in a signal by applying two analysis algorithms in parallel to the signal. The results of the two algorithms are combined during a post-processing step. The first analysis algorithm detects a first set of anomalies using amplitude-based anomaly detection method. The first set of anomalies includes large dips/spikes with short duration and large week-by-week variations with long duration. The second analysis algorithm detects a second set of anomalies using statistics-based anomaly detection method. The second set of anomalies includes subtle changes with sharp edges and medium duration. The first set of anomalies and the second set of anomalies are merged in a post-processing step. All spikes and all changes that satisfy a pre-determined criteria are removed from the merged data. Adjacent anomalies are concatenated. The resulting set of anomalies is used to determine service outage at a network server.

Abstract: An illustrative embodiment of a computer-implemented process for dynamic management of integration protocols connects a set of applications to a communication fabric to form a set of connections, which are monitored to collect a set of performance metrics. In response to a determination the predetermined performance metric is not within the predetermined tolerance associated with the particular application in the set of applications an integration path in the set of connections for the particular application in the set of applications is adjusted by programmatically using a set of rules wherein each rule in the set of rules is a performance driven rule.

Abstract: Processes are described for the preparation of tubulysins. The processes are useful for preparing predetermined mixtures of tubulysins, preparing single tubulysins from mixtures of tubulysins, and for converting one tubulysin into a different tubulysin. The tubulysins described herein are useful in treating diseases and disease states that include pathogenic cell populations.

Abstract: Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.

Abstract: Systems and methods for reducing the cost but increasing the performance caused in streaming data between a client and a server are described herein. Embodiments of the present invention relate to reducing the cost but increasing the performance by the traditional data streaming where two TCP connections, one for each direction of traffic is used. Further embodiments allow a server in communication with one or more clients using a RPC based communication protocol to bi-directional stream not on two TCP connections but a single TCP connection. In one embodiment, this is achieved by transmitting from the client to the server an initial handshake. If the server receives the handshake, then the client streams a request stream to the server and the server streams a response stream to the client simultaneously over the same single TCP connection establishing full-duplex streaming.

Abstract: A method for design and fabrication of holographic optical elements for a compact holographic sight is proposed. The method includes use of ray-trace software to design holographic elements having optical power using an intermediate hologram with parameters obtained through minimization of the merit function defining image quality.

Abstract: Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.

Abstract: A collimator can be made of a compound holographic optical element made of three holographic optical elements. The first reflection holographic optical element will have recorded within it continuous lens configured to receive light from a diffuse light beam and diffract the received light as a first collimated light beam. The second reflection holographic optical element will have recorded within it a regular hologram that is configured to permit the light from the diffuse light source to transmit through it to reach the first reflection holographic element, the second reflection holographic element having within it a second holographically reflective structure configured to receive the first collimated light beam and diffract the first collimated light beam as a second collimated light beam. The third transmission holographic optical element is configured to receive the second collimated light beam and diffract it as a third holographic light beam.

Abstract: The present invention provides stimulus responsive nanocomplexes comprising a masking moiety, e.g., a peptide, and a therapeutic moiety, e.g., an anti-coagulant. The invention also provides methods for treating or preventing a condition, such as a hypercoagulable state, e.g., blood clotting disorders or a cardiovascular disease, in a subject.

Abstract: Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.

Abstract: Systems and methods are provided for estimating missing samples in a signal. A plurality of samples in the signal is received, and a respective sample corresponds to a respective sample location in a plurality of sample locations. A subset of sample locations representing missing samples in the signal is identified, and a first and a second threshold are determined. Each threshold is an integer number of samples, and the second threshold is greater than the first threshold. A first set of consecutive sample locations from the identified subset of sample locations is formed, and the missing samples in the first set of consecutive sample locations are replaced based on a comparison between a number of locations in the first set of consecutive locations, the first threshold, and the second thresholds.