Patents by Inventor Klaus Gebauer

Klaus Gebauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9527009
    Abstract: The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port, the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: December 27, 2016
    Assignee: GE Healthcare BioProcess R&D AB
    Inventor: Klaus Gebauer
  • Publication number: 20160320358
    Abstract: The invention relates to containers or bags for chromatographic media and methods of packing chromatography columns using such containers. The bags may be used for storing and/or transporting chromatographic media and can be inserted directly into the chamber of a chromatography column in readiness for use.
    Type: Application
    Filed: July 12, 2016
    Publication date: November 3, 2016
    Inventor: Klaus Gebauer
  • Patent number: 9421479
    Abstract: The invention relates to containers or bags for chromatographic media and methods of packing chromatography columns using such containers. The bags may be used for storing and/or transporting chromatographic media and can be inserted directly into the chamber of a chromatography column in readiness for use.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: August 23, 2016
    Assignee: GE Healthcare BioProcess R&D AB
    Inventor: Klaus Gebauer
  • Publication number: 20160235962
    Abstract: The invention discloses a connector (1) for substantially aseptic connection of tubing, comprising: a) a central tubular stem member (2) with a line connection end (3) and a coupling end (5) having an annular gasket (6) arranged to engage a similar annular gasket (26) on a similar second connector (21) in sealing abutment and; b) a tubular socket member (7), concentrically arranged outside the stem member, having a flange (8) concentrically arranged outside the coupling end and comprising a cover film (9) releasably bonded to the flange and covering the coupling end of the stem member, the annular gasket and at least a portion of the flange; wherein the socket member is rotatable around the stem member and wherein the connector further comprises an annular seal member (10) in sealing abutment between an inside (11) of the socket member and an outside (12) of the stem member.
    Type: Application
    Filed: November 5, 2014
    Publication date: August 18, 2016
    Inventor: Klaus Gebauer
  • Publication number: 20160194591
    Abstract: The invention discloses a bioreactor with a vessel defining an inner volume, agitation means and at least one addition tube, wherein a delivery orifice in the addition tube is located within the inner volume and a check valve is arranged in proximity of the delivery orifice for allowing flow of a fluid in the direction from the addition tube into the inner volume of the vessel and blocking flow in the reverse direction.
    Type: Application
    Filed: August 27, 2013
    Publication date: July 7, 2016
    Inventors: Andreas Castan, Klaus Gebauer
  • Publication number: 20160144293
    Abstract: A chromatography column distribution system includes a set of first bed support ribs extending radially from an inner, first radial position near the centre of the plate to an outer radial position nearer to the periphery of the plate and at least one set of intermediate bed support ribs starting at an intermediate radial position and extending to an outer radial position nearer to the periphery of the plate. Channels are formed between adjacent bed support ribs. The desired local effective channel height varies in accordance with a predetermined formula from the first radial position to the outer radial position. The transverse cross-sectional areas of the ribs or the channels are adapted such that the actual local effective channel height is within 15% of the desired local effective channel height over portions of the distribution system situated between the first radial position and the outer radial position.
    Type: Application
    Filed: January 29, 2016
    Publication date: May 26, 2016
    Applicant: GE Healthcare Bio-Sciences AB
    Inventor: Klaus Gebauer
  • Publication number: 20160114935
    Abstract: A disposable container comprising a side wall, top and bottom, wherein the side wall comprises a first flexible material and the bottom comprises a rigid or semi-rigid material. The side wall top and bottom are joined together to define the container with an interior compartment for keeping a fluid inside the container. The bottom comprises at least one opening that is fluid-tightly covered with an assembly comprising a second flexible material. The assembly comprises at least one port which provides access to the interior compartment of the container. The invention also relates to a mixing system comprising the disposable container.
    Type: Application
    Filed: June 2, 2014
    Publication date: April 28, 2016
    Inventors: David RÖNNHOLM, Klaus GEBAUER, Rolf HJORTH, Patrick JONSSON
  • Publication number: 20160082245
    Abstract: An apparatus for substantially sterile connection of flexible tubing, including at least one tubing holder, which is adapted to receive one or more lengths of flexible tubing and which is also equipped with one or more sterilant applicators. The sterilant applicator is adapted to apply a sterilant to the length of tubing when the tubing length is received in the tubing holder. At least one cutter, which is movable in relation to the tubing holder and adapted to cut the length of tubing. A connector holder, which includes a compartment housing and a substantially sterile tubing connector. The connector holder is movable in relation to the tubing holder to a position where the length of tubing and the sterile tubing connector are aligned and can be urged together.
    Type: Application
    Filed: May 19, 2014
    Publication date: March 24, 2016
    Inventors: Klaus GEBAUER, Eric FALDT, Nachiket KARMARKAR
  • Patent number: 9290372
    Abstract: A fluid distributor for uniformly distributing flow of a feed onto a chromatography column in a cost-effective way defines a distribution channel of generally conical shape between a solid back plate and a packed bed in the column, wherein the fluid distributor comprises at least two circular and/or annular fluid-permeable porous disks essentially filling the volume of the distribution channel.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: March 22, 2016
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Peter Bellqvist, Klaus Gebauer
  • Patent number: 9279789
    Abstract: A chromatography column distribution system includes a set of first bed support ribs extending radially from an inner, first radial position near the centre of the plate to an outer radial position nearer to the periphery of the plate and at least one set of intermediate bed support ribs starting at an intermediate radial position and extending to an outer radial position nearer to the periphery of the plate. Channels are formed between adjacent bed support ribs. The desired local effective channel height varies in accordance with a predetermined formula from the first radial position to the outer radial position. The transverse cross-sectional areas of the ribs or the channels are adapted such that the actual local effective channel height is within 15% of the desired local effective channel height over portions of the distribution system situated between the first radial position and the outer radial position.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: March 8, 2016
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Klaus Gebauer
  • Publication number: 20150367302
    Abstract: A magnetic agitator mixing system comprising: a first magnetic coupling part, a first driving means provided with a second magnetic coupling part, and a container which is substantially enclosing the first magnetic coupling part. The first magnetic coupling part is rotatably suspended in a stand, which is arranged to rest on an inner surface of the container and a first impeller is arranged to be driven by the first magnetic coupling part. The invention also relates to an agitator mixing stand.
    Type: Application
    Filed: January 21, 2014
    Publication date: December 24, 2015
    Inventor: Klaus GEBAUER
  • Patent number: 9134282
    Abstract: This invention provides an automated installation procedure for assembling a disposable flow path: providing a disposable flow path comprising tubing and a plurality of sensors onto a re-usable instrument; qualifying said tubing and said plurality of sensors to be on the flow path based on a standard; and determining if the tubing and the plurality of sensors comply with characteristics and performance according to limits for specifications or acceptance criteria.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: September 15, 2015
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Kine Frej, Niklas Edblad, Klaus Gebauer, Lars Kanon
  • Publication number: 20150247114
    Abstract: The invention discloses a system for perfusion culture of cells which comprises: a bioreactor; a filter unit with a retentate inlet end, a retentate outlet end and a permeate outlet port; a reciprocating pump fluidically connected to the retentate inlet end, with the retentate inlet end fluidically connected to the bioreactor via an inlet check valve arranged to allow flow in the direction from the bioreactor to the retentate inlet end and to block flow in the reverse direction, and where the retentate outlet end is fluidically connected to the bioreactor via an outlet check valve arranged to allow flow in the direction from the retentate outlet end to the bioreactor and to block flow in the reverse direction; and where the inlet and outlet check valves are each fluidically connected to a tubing branch point, which is further connected to the bioreactor via a length of tubing.
    Type: Application
    Filed: September 25, 2013
    Publication date: September 3, 2015
    Applicant: GE Healthcare Bio-Sciences AB
    Inventor: Klaus Gebauer
  • Publication number: 20150160170
    Abstract: A chromatography column distribution system includes a set of first bed support ribs extending radially from an inner, first radial position near the centre of the plate to an outer radial position nearer to the periphery of the plate and at least one set of intermediate bed support ribs starting at an intermediate radial position and extending to an outer radial position nearer to the periphery of the plate. Channels are formed between adjacent bed support ribs. The desired local effective channel height varies in accordance with a predetermined formula from the first radial position to the outer radial position. The transverse cross-sectional areas of the ribs or the channels are adapted such that the actual local effective channel height is within 15% of the desired local effective channel height over portions of the distribution system situated between the first radial position and the outer radial position.
    Type: Application
    Filed: February 18, 2015
    Publication date: June 11, 2015
    Inventor: KLAUS GEBAUER
  • Publication number: 20150137992
    Abstract: Methods, systems, and apparatus to monitor component status in a bioprocessing environment are disclosed and described. Certain examples provide a sensor device for a disposable bioprocessing component. The example sensor device includes a first portion affixed to the component, the first portion configured to provide an identifier associated with the component. The example sensor device also includes a second portion configured to provide a status indication based on a state of the component. The example sensor device is configured to transmit the identifier and status indication to a control computer associated with a bioproces sing platform including the component.
    Type: Application
    Filed: November 21, 2013
    Publication date: May 21, 2015
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Radislav A. Potyrailo, Klaus Gebauer, Kajsa Stridsberg-Friden, Timothy A. Wortley
  • Patent number: 8986543
    Abstract: A chromatography column distribution system (101) comprises a set of first bed support ribs (107) extending radially from a inner, first radial position (R1) near the centre of the plate to a outer radial position nearer to the periphery (109) of the plate and at least one set of intermediate bed support ribs (117, 119) starting at an intermediate radial position (R2, R3) and extending to an outer radial position nearer to the periphery (109) of the plate (101), whereby channels are formed between adjacent bed support ribs (107, 117, 119).
    Type: Grant
    Filed: April 8, 2009
    Date of Patent: March 24, 2015
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventor: Klaus Gebauer
  • Publication number: 20150061282
    Abstract: The invention relates to a An aseptic connector comprising a first connection unit (102; 202; 302; 402; 502) provided with a first terminal end surface (104; 204; 304; 404; 504) and a second connection unit (106; 206; 306; 406; 506) provided with a second terminal end surface (108; 208; 308; 408; 508); said first and second terminal end surfaces are each provided with at least one first and second opening (110, 112; 210, 212; 310, 312; 410, 412; 510, 512), which openings are orientated to substantially coincide when said first and second connection units are connected to each other; said first and second openings are sealed by at least one film (114; 214; 314; 414; 514) arranged on said first and second connection units, so that the contact between the film and each connection unit is aseptic; said at least one film is adapted to be mated with a corresponding film on the other connection unit when said first and second connection units are connected to each other; and said mated films are adapted to be pulled
    Type: Application
    Filed: March 25, 2013
    Publication date: March 5, 2015
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Eric Faldt, Klaus Gebauer
  • Publication number: 20150041009
    Abstract: The present invention relates to a device (1) for delivery of fluid, said device comprising at least two fluid ducts (12-17) of flexible material, each of which in one end can be connected to a fluid source and in the opposite end is connected to a manifold (18) having an inlet end and an outlet end, each of said fluid ducts (12-17) comprising a pinch valve (19) for closing and opening the duct. According to the invention a check valve (20) is disposed in at least one of said fluid ducts (12-17) in the end thereof connected to the manifold (18).
    Type: Application
    Filed: March 28, 2013
    Publication date: February 12, 2015
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Klaus Gebauer, Ekta Mahajan, Eric Faldt
  • Publication number: 20150029815
    Abstract: The present invention relates to a mixing system comprising a vessel (1) for housing a disposable fluid mixing bag (2), which vessel (1) comprises a base (3) supporting the fluid mixing bag (2) and a sidewall (4) extending vertically upwards from the base (3). The sidewall (4) of the vessel comprises a door opening (5) which is closable by a sliding door (6). The system with the sliding door provides an easy access to the inside of the vessel (1) in a space saving manner.
    Type: Application
    Filed: March 14, 2013
    Publication date: January 29, 2015
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Klaus Gebauer, Patrick Jonsson, David Ronnholm
  • Patent number: D766948
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: September 20, 2016
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Klaus Gebauer, Hakan Lundstrom, Markus Pitkanen