Patents by Inventor Koji Eto

Koji Eto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11115684
    Abstract: A video distribution server according to an embodiment provides a live video distribution service for distributing and viewing live video to a user via a user terminal. This server determines the ranking of distributors on the basis of live video distribution performance, sets a base reward quantity for distributors on the basis of the determined ranking, and gives distributors rewards in a quantity based on the distribution duration of the live video and the base reward quantity, so even if a distributor is a novice, he can obtain a reward in a quantity based on the distribution duration and the base reward quantity by continuing to distribute live video.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: September 7, 2021
    Assignee: DeNA CO., LTD.
    Inventors: Kazuto Shibata, Yasunori Beppu, Seiichiro Sumiyoshi, Yujiro Eto, Koji Murata
  • Publication number: 20210239682
    Abstract: The present invention provides a method for screening for platelet production promoters, the method including a step for selecting a candidate substance that significantly increases expression of TUBB1 as a platelet production promoter.
    Type: Application
    Filed: March 30, 2021
    Publication date: August 5, 2021
    Inventors: Koji Eto, Hideya Seo, Akira Ota, Yukitaka Ito, Yasuko Hazama
  • Publication number: 20210222124
    Abstract: The present invention provides a method for producing megakaryocytes that have an increased capacity to produce platelets, the method comprising a step of culturing, under conditions that cause the death of cells that do not express a gene that is specifically expressed by megakaryocytes, cells that have the capacity to differentiate into megakaryocytes.
    Type: Application
    Filed: March 22, 2021
    Publication date: July 22, 2021
    Inventors: Takeaki Dohda, Sachiko Kobayashi, Koji Eto, Hiroshi Endo, Sou Nakamura
  • Patent number: 11016083
    Abstract: The present invention provides a method for screening for platelet production promoters, the method including a step for selecting a candidate substance that significantly increases expression of TUBB1 as a platelet production promoter.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: May 25, 2021
    Assignees: Kyoto University, Megakaryon Corporation
    Inventors: Koji Eto, Hideya Seo, Akira Ota, Yukitaka Ito, Yasuko Hazama
  • Publication number: 20210130781
    Abstract: Methods of production and apparatuses for production for stably producing healthy and functional platelets, and methods for determining operating conditions of an apparatus for producing platelets are provided. The present invention relates to methods of production comprising a step of culturing megakaryocytes in a platelet production medium C, wherein the step of culturing comprises a step of stirring a medium C in containers 1, 4 using stirring mechanisms 2, 5. In one method of production, the step of stirring comprises reciprocating stirring blades 21, 24 in the stirring mechanisms 2, 24 such that any of predetermined turbulent energy, shearing stresses, or Kolmogorov scale is produced, in the medium C. In another method of production, the step of stirring comprises pivoting a stirring blade 51 in the stirring mechanism 5 wherein a plurality of stationary members 53 is placed therearound in a bottom region 4e of the container 4 such that the step of stirring produces turbulence in the medium C.
    Type: Application
    Filed: July 5, 2018
    Publication date: May 6, 2021
    Inventors: Koji ETO, Sou NAKAMURA, Yukitaka ITO, Tomohiro SHIGEMORI, Yoshikazu KATO
  • Patent number: 10947504
    Abstract: The present invention provides a highly functional platelet production promoting agent which comprises one or a plurality of aryl hydrocarbon receptor (AhR) antagonists and one or a plurality of Rho-associated coiled-coil forming kinase (ROCK) inhibitors.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: March 16, 2021
    Assignees: Kyoto University, Megakaryon Corporation
    Inventors: Koji Eto, Sou Nakamura, Yukitaka Ito, Tomohiro Shigemori, Takeaki Dohda
  • Patent number: 10941382
    Abstract: The present invention provides: a platelet production promoter that contains one or more substances selected from the group consisting of Wnt inhibitors and FMS-like tyrosine kinase (FLT) inhibitors; and a platelet production method that uses this platelet production promoter.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: March 9, 2021
    Assignees: Kyoto University, Megakaryon Corporation
    Inventors: Koji Eto, Hideya Seo, Akira Ota, Yukitaka Ito, Yasuko Hazama
  • Publication number: 20210062158
    Abstract: Provided is a method for producing a stem cell clone, which comprises the steps of: (i) introducing into stem cells an exogenous gene associated with induction of differentiation into somatic cells; (ii) inducing differentiation of the stem cells, introduced with an exogenous gene, into the somatic cells; (iii) dedifferentiating the differentiation-induced somatic cells; and (iv) isolating stem cells having the exogenous gene incorporated into a chromosome thereof from a colony of the stem cells formed in step (iii).
    Type: Application
    Filed: April 3, 2020
    Publication date: March 4, 2021
    Inventors: Koji Eto, Hiroshi Endo, Tomohiro Shigemori
  • Publication number: 20200216807
    Abstract: Healthy functional platelets are mass produced. A method for producing platelets, comprising: (1) a culture step of culturing megakaryocytes in a platelet producing medium in the presence of mechanical stress and platelet production promoting factors including MIF, NRDc, IGFBP2, TSP-1, PAI-1, and CCL5, and (2) a harvest step of harvesting the platelets obtained by the culture step; wherein the culture step comprises: (a) a step of promoting a release of the platelet production promoting factors from megakaryocytes by mechanical stress; and/or (b) a step of externally adding platelet production promoting factors including MIF, NRDc, and IGFBP2.
    Type: Application
    Filed: March 5, 2018
    Publication date: July 9, 2020
    Inventors: KOJI ETO, SOU NAKAMURA, YUKITAKA ITO
  • Patent number: 10656597
    Abstract: To provide an authentication device and method for a security medium including a reflective volume hologram having a light source disposed on the front surface side of the reflective volume hologram so that light emitted therefrom is incident on the reflective volume hologram, a first observation device disposed in a pre-designed diffraction direction of the reflective volume hologram, and a second observation device disposed in a direction other than the pre-designed diffraction direction of the reflective volume hologram. Light including a pre-designed diffraction wavelength is emitted from the light source to be incident on the reflective volume hologram, and when the light amount observed in the first observation device is larger in the diffraction wavelength than in other wavelengths, and the light amount observed in the second observation device is smaller in the diffraction wavelength than in other wavelengths, it is determined that the reflective volume hologram is genuine.
    Type: Grant
    Filed: September 7, 2015
    Date of Patent: May 19, 2020
    Assignee: Dai Nippon Printing Co., Ltd.
    Inventors: Mitsuru Kitamura, Tsuyoshi Yamauchi, Koji Eto, Nobuko Oikawa, Tomoe Sato
  • Patent number: 10533185
    Abstract: An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: January 14, 2020
    Assignee: The University of Tokyo
    Inventors: Koji Eto, Hiromitsu Nakauchi, Naoya Takayama, Sou Nakamura
  • Patent number: 10474099
    Abstract: A main object of the present invention is to provide a method of producing a volume hologram laminate which can regenerate a hologram image in an arbitrary wavelength by a simple process. To attain the object, the present invention provides a method of producing a volume hologram laminate using a volume hologram forming substrate which comprises: a substrate, a volume hologram layer formed on the substrate and containing a photopolymerizable material, a resin layer, formed on the substrate so as to contact to the volume hologram layer, containing a resin and a polymerizable compound, characterized in that the producing method comprises processes of: a hologram recording process to record a volume hologram to the volume hologram layer, a substance transit process of transiting the polymerizable compound to the volume hologram layer, and an after-treatment process of polymerizing the polymerizable compound.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: November 12, 2019
    Assignee: Dai Nippon Printing Co., Ltd.
    Inventors: Minoru Azakami, Koji Eto, Hiroyuki Ohtaki, Yoshihito Maeno, Sakurako Hatori
  • Patent number: 10359735
    Abstract: A display article includes a plurality of display areas. Display areas adjacent to each other differ in at least one of an average hue, an average brightness and an average chroma and a first object to be displayed is formed by a combination of the plurality of display areas. At least one of the display areas includes a Fourier transform hologram configured to convert incident ray from a point light source or a laser light source into a second object to be displayed.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: July 23, 2019
    Assignee: Dai Nippon Printing Co., Ltd.
    Inventors: Tomoe Sato, Mitsuru Kitamura, Koji Eto, Tsuyoshi Yamauchi, Nobuko Oikawa
  • Publication number: 20190211305
    Abstract: The present invention provides a method for culturing pluripotent stem cells, comprising the step of contacting pluripotent stem cells with laminin 421 or a fragment thereof, laminin 121 or a fragment thereof, or a combination thereof.
    Type: Application
    Filed: August 25, 2017
    Publication date: July 11, 2019
    Inventors: Koji Eto, Sou Nakamura, Kiyotoshi Sekiguchi, Tomohiro Shigemori
  • Publication number: 20190071636
    Abstract: Provided is a method for inducing mesoderm, comprising a step of bringing pluripotent stem cells into contact with bone morphogenetic protein 4 (BMP4) or CHIR for at least 3 days.
    Type: Application
    Filed: March 22, 2017
    Publication date: March 7, 2019
    Inventors: Koji ETO, Hiroshi ENDO, Yukitaka ITO, Junichi FUKUNAGA
  • Publication number: 20190048317
    Abstract: The present invention provides a highly functional platelet production promoting agent which comprises one or a plurality of aryl hydrocarbon receptor (AhR) antagonists and one or a plurality of Rho-associated coiled-coil forming kinase (ROCK) inhibitors.
    Type: Application
    Filed: June 16, 2016
    Publication date: February 14, 2019
    Inventors: Koji Eto, Sou Nakamura, Yukitaka Ito, Tomohiro Shigemori, Takeaki Dohda
  • Publication number: 20190032015
    Abstract: The present invention provides: a platelet production promoter that contains one or more substances selected from the group consisting of Wnt inhibitors and FMS-like tyrosine kinase (FLT) inhibitors; and a platelet production method that uses this platelet production promoter.
    Type: Application
    Filed: January 30, 2017
    Publication date: January 31, 2019
    Applicants: Kyoto University, MEGAKARYON CORPORATION
    Inventors: Koji Eto, Hideya Seo, Akira Ota, Yukitaka Ito, Yasuko Hazama
  • Publication number: 20190033296
    Abstract: The present invention provides a method for screening for platelet production promoters, the method including a step for selecting a candidate substance that significantly increases expression of TUBB1 as a platelet production promoter.
    Type: Application
    Filed: January 30, 2017
    Publication date: January 31, 2019
    Applicants: Kyoto University, Megakaryon Corporation
    Inventors: Koji Eto, Hideya Seo, Akira Ota, Yukitaka Ito, Yasuko Hazama
  • Patent number: 10087419
    Abstract: The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage. The present invention also provides a method for producing specific cells, wherein oncogene-induced senescence (OIS) which is induced by the oncogene expressed in the cells in the desired differentiation stage is suppressed.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: October 2, 2018
    Assignee: The University of Tokyo
    Inventors: Koji Eto, Naoya Takayama, Sou Nakamura, Hiromitsu Nakauchi
  • Patent number: 10084927
    Abstract: In an image forming apparatus, when a processor starts to be supplied with a voltage in a first voltage range from a voltage generator, the processor executes start-up processing with an operation clock of a first frequency, and transmits a voltage adjustment instruction to the voltage generator. On receiving the voltage adjustment instruction, the voltage generator performs voltage adjustment to make the voltage supplied to the processor a voltage in a second voltage range. On completion of the voltage adjustment, the voltage generator transmits a completion notice to the processor. When communication related to the voltage adjustment does not end normally, the processor keeps the frequency of the operation clock at the first frequency to execute processing; thereafter based on the operation clock of the first frequency.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: September 25, 2018
    Assignee: KYOCERA Document Solutions Inc.
    Inventor: Koji Eto