Abstract: An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.

Abstract: The present invention is to provide: a photosensitive composition for volume hologram recording and a photosensitive substrate for volume hologram recording, which provide increased sensitivity during hologram recording and a high refractive index modulation amount, and which do not inhibit the decolorization of the sensitizing dye; and a volume hologram recorded medium which provides high-luminance hologram images with increased productivity.

Abstract: A main object of the present invention is to provide a method of producing a volume hologram laminate which can regenerate a hologram image in an arbitrary wavelength by a simple process. To attain the object, the present invention provides a method of producing a volume hologram laminate using a volume hologram forming substrate which comprises: a substrate, a volume hologram layer formed on the substrate and containing a photopolymerizable material, a resin layer, formed on the substrate so as to contact to the volume hologram layer, containing a resin and a polymerizable compound, characterized in that the producing method comprises processes of: a hologram recording process to record a volume hologram to the volume hologram layer, a substance transit process of transiting the polymerizable compound to the volume hologram layer, and an after-treatment process of polymerizing the polymerizable compound.

Abstract: In an image forming apparatus, when a processor starts to be supplied with a voltage in a first voltage range from a voltage generator, the processor executes start-up processing with an operation clock of a first frequency, and transmits a voltage adjustment instruction to the voltage generator. On receiving the voltage adjustment instruction, the voltage generator performs voltage adjustment to make the voltage supplied to the processor a voltage in a second voltage range. On completion of the voltage adjustment, the voltage generator transmits a completion notice to the processor. When communication related to the voltage adjustment does not end normally, the processor keeps the frequency of the operation clock at the first frequency to execute processing; thereafter based on the operation clock of the first frequency.

Abstract: A main object of the present invention is to provide a method of producing a volume hologram laminate which can regenerate a hologram image in an arbitrary wavelength by a simple process. To attain the object, the present invention provides a method of producing a volume hologram laminate using a volume hologram forming substrate which comprises: a substrate, a volume hologram layer formed on the substrate and containing a photopolymerizable material, a resin layer, formed on the substrate so as to contact to the volume hologram layer, containing a resin and a polymerizable compound, characterized in that the producing method comprises processes of: a hologram recording process to record a volume hologram to the volume hologram layer, a substance transit process of transiting the polymerizable compound to the volume hologram layer, and an after-treatment process of polymerizing the polymerizable compound.

Abstract: Provided is a composition for maintaining a function of platelets, having as an active ingredient a pyridone derivative represented by the following general formula (I), or a salt thereof (in the formula, ring A, R1, R2, R3, and R4 represent the definitions given in the description).

Abstract: The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage. The present invention also provides a method for producing specific cells, wherein oncogene-induced senescence (OIS) which is induced by the oncogene expressed in the cells in the desired differentiation stage is suppressed.

Abstract: An object of the present invention is to provide a method of efficiently producing a maturated megakaryocytic cell line from hematopoietic progenitor cells. The present invention provides a method for producing megakaryocytes from hematopoietic progenitor cells, comprising (i) forcibly expressing an apoptosis suppression gene and an oncogene in hematopoietic progenitor cells and culturing the cells, and (ii) arresting forced expression of the apoptosis suppression gene and the oncogene and culturing the hematopoietic progenitor cells.

Abstract: The present invention provides a volume hologram transfer foil which has good foil cutting characteristics and is used to manufacture a volume hologram laminate by transferring a volume hologram layer to an adherend by thermocompression. The volume hologram transfer foil includes a base material, a protective layer, a volume hologram layer, and a heat seal layer, wherein the protective layer contains a hard coat component, a rupture elongation control component, and a foil cutting characteristic control component which has a thermal expansion coefficient different from those of the hard coat component and rupture elongation control component and is incompatible with the two components.

Abstract: The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage. The present invention also provides a method for producing specific cells, wherein oncogene-induced senescence (OIS) which is induced by the oncogene expressed in the cells in the desired differentiation stage is suppressed.

Abstract: A method of culturing induced pluripotent stem cells includes using a cell culture substrate including an elasticity-variable gel having an elastic modulus larger than 1 kPa and smaller than 100 MPa and a cell adhesion protein immobilized on a surface of the elasticity-variable gel.

Abstract: The present invention is to provide: a photosensitive composition for volume hologram recording and a photosensitive substrate for volume hologram recording, which provide increased sensitivity during hologram recording and a high refractive index modulation amount, and which do not inhibit the decolorization of the sensitizing dye; and a volume hologram recorded medium which provides high-luminance hologram images with increased productivity.

Abstract: A composition for maintaining a function of platelets, the composition comprising, as an active ingredient, a compound represented by the following general formula (I) or a salt thereof, or a solvate thereof: wherein X represents a phenylene group; Y represents any one of a hydrogen atom and —(CH2)mR1; wherein m represents an integer of any one of 0 to 4; and R1 is any one of —NR5COR2, —NR5SO2R2, and —NR3R4; wherein R2 represents any one of a C1 to C6 alkyl group, an aryl group, a C1 to C6 alkoxy group, and the like; R3 and R4 represent a C1 to C6 alkyl group or the like; and R5 represents any one of a hydrogen atom, a C1 to C6 alkyl group, and the like; and Z represents any one of a hydrogen atom and a C1 to C6 alkyl group.

Abstract: The invention provides a process capable of fabricating a cholesteric liquid crystal medium having a volume hologram with efficiency yet without recourse to complicated steps such as an alignment step. This is achievable as follows. A volume hologram layer is formed on a substrate, and a cholesteric liquid crystal layer is then formed on another substrate. The volume hologram layer and the cholesteric liquid crystal layer are laminated together via a bonding layer. Further, a bonding for lamination onto an application member is formed on either the volume hologram layer side or the cholesteric liquid crystal layer side to obtain a cholesteric liquid crystal medium having a volume hologram.

Abstract: A main object of the present invention is to provide a hologram observation sheet with a transmission type hologram formed integrally with other members, to be attached with various members for the use as for example an advertising medium or a decoration member. To achieve the object, the invention provides a hologram sheet comprising: a transparent substrate, a hologram layer formed on the transparent substrate and having a transmission type Fourier transform hologram region having the function of transforming a light beam incident from a point light source to a desired optical image, and a pressure-sensitive adhesive layer.

Abstract: A major object of the present invention is to provide a volume hologram transfer foil that gives a volume hologram laminate higher in antiforgery function. The present invention achieves the object by providing a volume hologram transfer foil comprising: a substrate, a volume hologram layer carrying a recorded volume hologram that is formed on the substrate, and an image forming layer carrying a formed image and a heat seal layer containing a thermoplastic resin that are formed on the volume hologram layer, and comprising no reflective layer having a function to reflect light.

Abstract: A main object of the present invention is to provide a method of producing a volume hologram laminate which can regenerate a hologram image in an arbitrary wavelength by a simple process. To attain the object, the present invention provides a method of producing a volume hologram laminate using a volume hologram forming substrate which comprises: a substrate, a volume hologram layer formed on the substrate and containing a photopolymerizable material, a resin layer, formed on the substrate so as to contact to the volume hologram layer, containing a resin and a polymerizable compound, characterized in that the producing method comprises processes of: a hologram recording process to record a volume hologram to the volume hologram layer, a substance transit process of transiting the polymerizable compound to the volume hologram layer, and an after-treatment process of polymerizing the polymerizable compound.

Abstract: A volume hologram layer (2) is formed on a substrate (1), and a cholesteric liquid crystal layer (3) is then formed on the hologram layer (2). After the substrate (1) is peeled off the volume hologram layer (2), an adhesive layer (4) is formed on the surface of the volume hologram layer (2) with the substrate (1) peeled off, and another substrate (5) is then formed on the adhesive layer (4). Finally, a label form of cholesteric liquid crystal medium having a volume hologram is shaped out of the resulting multilayer structure; it is thus possible to fabricate cholesteric liquid crystal media having a volume hologram with efficiency yet without recourse to any complicated steps such as an alignment step.

Abstract: An agent for inducing production of megakaryocytes and/or platelets from pluripotent stem cells which is useful for treatment of disease accompanied by a decrease in platelets is provided. A method for producing megakaryocytes and/or platelets, including separating hematopoietic progenitor cells from the septal cells in sac-like structures produced by pluripotent stem cells, and culturing the hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) where R1 to R7, W, X, Y, Z, Ar1 and n are as defined in the description to differentiate them into megakaryocytes and/or platelets.

Abstract: It is an object of the present invention to provide a method for efficient differentiation into blood cells. Specifically, in the present invention, when blood cells are produced from pluripotent stem cells such as ES cells or iPS cells in vitro, the cells are cultured under a low oxygen partial pressure to increase the efficiency of differentiating the pluripotent stem cells into hematopoietic progenitor cells, erythroid progenitor cells, and the like, so as to increase the number of finally obtained, desired blood cells.