Abstract: An attacker is prevented from obtaining information about the configuration of a computer system. Each of one or more revealing content elements that may be found in outgoing data transmitted by the computer system and that are capable of being used by the attacker to obtain the information about the configuration of the computer system is associated with one or more respective replacement content elements. Outgoing data to be transmitted by the computer system are then scanned for these one or more revealing content elements. A revealing content element found in the outgoing data is replaced by a replacement content element from the one or more replacement content elements associated with that revealing content element. This is done before the outgoing data is transmitted.

Abstract: The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(?CH2)CH3 or CH(CH3)2; R2 together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; R3 or R4 are hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or R3 and R4 are combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and R1 is zero when Y is O, and R1 is hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells.

Abstract: The present invention relates to a process for the preparation of carbapenem compound of Formula (I), wherein P1 is hydrogen or a carboxyl protecting group, P3 is hydrogen or a hydroxyl protecting group, R1 is C1-3 alkyl, and A is selected from a group consisting of a) Formula (II), b) Formula (III), c) Formula (IV), d) Formula (V), e) Formula (VI), f) Formula (VII), wherein P2 is hydrogen or an amino protecting group, R2 and R3 may be same or different and are hydrogen, C1-5 alkyl, optionally substituted aryl, or optionally substituted heteroaryl, and X1 is O or S, or its stereoisomers, or salts thereof.

Abstract: A novel automatic standardization and verification process for system design requirements in a product development project is disclosed. In one embodiment, a method for automatic standardization and verification of system design requirements in a product development project using a standardization and verification tool embedded in a computer aided design (CAD) application includes obtaining a desired standardized requirement from a requirements database, retrieving compliance criteria from the standardized requirement, obtaining one or more components associated with the standardized requirement from one or more data sources, and obtaining relevant extracted and derived attributes from the one or more components, associated with the standardized requirement.

Abstract: A script including a plurality of actions to process in a session associated with a system is generated via a user interface, where the script includes both actions and metaactions. The actions correspond to commands associated with the session to be executed on the system, and the metaactions correspond to a selected plurality of the commands. The script is generated by receiving the actions and the metaactions to process on the system via the user interface associated with the session for interfacing with the system, capturing the actions and the metaactions, and saving the captured actions and metaactions to generate the script.

Abstract: A composition of biodegradable gear oil that mainly contains modified nontauedible vegetable oils. Mono-esters are hydrogenated, epoxidized or aryl alkylated or mixture thereof, and C7 to C12 primary alcohol. In addition to chemically modified non-edible vegetable oils, the composition also contains an additive pack, which comprises at least one: antioxidant, an extreme pressure additive, an anti foaming agent, a pour point depressant, a corrosion inhibitor and a detergent-dispersant additive. The product of this invention has utility as industrial and automotive gear oil GL 4 grade. The compositions are significantly biodegradable, eco-friendly, reduce use of petroleum, have lower cost than synthetic oil, are miscible in mineral & synthetic fluids and safe to use due to higher flash point.

Abstract: The present invention relates to compositions and methods useful in studying or modulating melanin pigmentation in the skin. Particularly, the invention relates to compositions comprising a substance capable of modulating the activity or expression of ALK6 (SEQ ID 2) or Cdc42 which in turn are capable of modulation of the transfer of melanin from melanocytes to keratinocytes and potentially from keratinocytes to keratinocytes. The invention also relates to assays for identifying such compositions, and methods of modulating skin pigmentation.

Abstract: The present invention relates to novel spiro derivatives of parthenin prepared by the dipolar cycloaddition of various dipoles viz, benzonitrile oxides, nitrones, azides, nitrile ylide diazoalkane, nitrile imide, ozone, azomethine imides, azomethine ylides etc. with exocyclic double bond of C ring (?-methylene-?-butyrolactone). Representative compounds have been screened for their anticancer activity against different cancer cell lines. ICs0 value of these analogues varies between 4.3 ?M to 93 ?M. A mechanistic correlation of their anticancer activity has been described. The results of the cytotoxicity test of the compounds studies indicated that the ?,?-unsaturated ketonic moiety in parthenin plays an important role in the maintenance of the high level of cytotoxicity.

Abstract: Novel intermediates, process for their preparation and their use in the preparation of therapeutically effective antineoplastic agents, in particular Temsirolimus of formula (I).

Abstract: In a data visualization system, a method of creating a visual representation of data, the method including the steps of providing instructions to an end user on a display device to assist the end user in: constructing multiple graphical representations of data retrieved from a data storage module in communication with the data visualization system, where each graphical representation is one of a predefined type and includes multiple layers of elements that contribute to the end user's understanding of the data; arranging multiple graphical representations of different types within the visual representation in a manner that enables the end user to understand and focus on the data being represented; and a display module displaying the visual representation on the display device; the method further including the steps of a determination module determining one or more data elements within the graphical representations that are based on variable data, the display module displaying the determined data element on th

Abstract: In a data visualization system, a method of creating a visual representation of data points from metric data and determining the positioning of data groups associated with the metric data in the visual representation, the method including the steps of: a data retrieval module retrieving the metric data from a data storage module in communication with the data visualization system, a data grouping module arranging the metric data into a plurality of data groups, a statistical distance determination module determining a minimal statistical distance between data groups positioned next to each other in the visual representation using a hierarchical force based algorithm, and a data visualization module visually arranging the data groups in a hierarchical manner based on the determined statistical distance to create the visual representation.

Abstract: In a graphical analysis computing system, a method of arranging data sets for graphical analysis, wherein at least two of the data sets have different periodicities, the method comprising the steps of: a data retrieval module retrieving data from a data storage module in communication with the graphical analysis computing system; a periodicity determination module determining a plurality of periodicities within the retrieved data to identify a plurality of data sets based on the determined periodicities; and an alignment module aligning a first identified data set of a first periodicity relative to a second identified data set of a second periodicity, wherein the second periodicity is different to the first periodicity.

Abstract: In a data visualization system, a method of creating a visual representation of data points from metric data, wherein the method includes the steps of: a data retrieval module retrieving the metric data from a data storage module in communication with the data visualization system, a determination module determining the data points based on the retrieved metric data, and a display module arranging the data points for displaying on a display device according to a predetermined visual representation, arranging the data points into a plurality of meta groups in a hierarchical manner, and arranging the meta groups into a plurality of layers, where each layer represents the data points at different levels of granularity, and a statistical distance determination module determining a statistical distance between items in the meta groups, and the display module arranging the items within the meta groups based on the determined statistical distance.

Abstract: A recombinant microorganism employing a bacterial pathway to produce a cyclic amino acid (e.g., coronamic acid or norcoronamic acid) and a plant enzyme (ACC oxidase) to oxidize the amino acid and produce an alkene (e.g., 1-butene or propene) is provided herein. Expression of these two biosynthetic modules in various microbial chassis will facilitate alkene production from diverse energy and carbon sources, including sugars, glycerol, CO2, CH4, H2, and sunlight.

Abstract: A data obfuscation system, method, and computer implementation via software or hardware allows a legitimate user to gain access via a query to data of sufficient granularity to be useful while maintaining the confidentiality of sensitive information about individual records. Output values of a data request are obfuscated in a repeatable manner, via the use of an Obfuscating Function (OF), while maintaining the amount of obfuscation within a range so that the transformed values provide to a user information of a prescribed level of granularity. The data obfuscating system and method is particularly applicable to databases. The data obfuscation engine may be implemented in hardware and/or software within a stand alone or distributed environment.

Abstract: An automated debugging method and system for over-constrained circuit verification environment are described. Useful information related to circuit evaluation and/or over-constrained event is collected and provided. The information may include: clock cycles at which an over-constrained event occurs; identification of a minimum subset of constraints that will cause an over-constrained event to occur; signal ports having an associated signal that can not switch between different signal states; whether a triggering signal event has occurred during the evaluation; indicating whether constraints in the evaluation are realizable, etc. Novel approaches for detecting and obtaining the useful information also are described.

Abstract: A method and an apparatus are provided for controllably illuminating automotive brake lights. In one embodiment, an automotive brake lighting system comprises a brake light including first and second light sources, a sensor to sense a level of an operating condition associated with at least one of a brake assembly or a brake pedal of a motor vehicle for illuminating the brake light, and a controller configured to monitor information provided by the sensor. The controller, in response to the level of the operating condition, selectively powers the at least one of the first or second light sources of the brake light based at least in part on the monitored information to generate a variable visual indication relating to braking of the motor vehicle from the brake light over a range of at least two different visual indications that indicate a variable braking rate of the motor vehicle over a corresponding range of at least two different braking rates.

Abstract: A method for analyzing, querying, and mining graph databases using subgraph and similarity querying. An index structure, known as a closure tree, is defined for topological summarization of a set of graphs. In addition, a significance model is created in which the graphs are transformed into histograms of primitive components. Finally, connected substructures or clusters, comprising paths or trees, are detected in networks found in the graph databases using a random walk technique and a repeated random walk technique.

Abstract: In a data visualization system, a method of arranging, in n dimensions, data points representing n or more variables, the method including the steps of: a data point ranking module ranking a set of data points with respect to a first axis of a visual representation using a first variable; and based on a second variable, a data point distribution module distributing the set of data points along the first axis while retaining information relating to the ranking of data points determined in step i).

Abstract: A dry low NOx (DLN) fuel nozzle of a fuel system is provided and includes one or more downstream orifices formed to define a first fluid path along which fluid is directed to flow, an upstream orifice, located upstream from the one or more downstream orifices, formed to define a second fluid path along which the fluid is directed to flow and connecting passages disposed to fluidly couple the first and second fluid paths of the downstream and upstream orifices, respectively, to one another. At least one of a radial size and an axial location of the upstream orifice is set to cooperatively detune an acoustic impedance of the fuel system.