Abstract: This invention comprises the innovative synthesis of N-amino tetrahydrothiazine free bases and their salts. This invention further comprises the use of the derivatives and their therapeutic application as anticancer agents. Further this invention comprises their manufacture and use.

Abstract: A method and an apparatus are provided for controllably illuminating automotive brake lights. In one embodiment, an automotive brake lighting system comprises a brake light including first and second light sources, a sensor to sense a level of an operating condition associated with at least one of a brake assembly or a brake pedal of a motor vehicle for illuminating the brake light, and a controller configured to monitor information provided by the sensor. The controller, in response to the level of the operating condition, selectively powers the at least one of the first or second light sources of the brake light based at least in part on the monitored information to generate a variable visual indication relating to braking of the motor vehicle from the brake light over a range of at least two different visual indications that indicate a variable braking rate of the motor vehicle over a corresponding range of at least two different braking rates.

Abstract: The invention provides two crystalline forms A and B of the skeletal muscle relaxant and anxiolytic agent, Metaxalone of formula (I), and a process for preparation thereof. The two crystalline forms A and B are bioavailable. The invention further provides pharmaceutical compositions comprising the two bioavailable crystalline forms, useful for the relief of discomforts associated with acute, painful musculoskeletal conditions.

Abstract: The invention discloses an improved process for producing an intermediate to produce large quantity of 2-(Phenyl methyl thio)-3-pyridine carboxylic acid. The process comprises reacting 2-chloro-3-cyanopyridine with benzyl mercaptan in presence of a base and an aprotic solvent. The resulting intermediate 2-(phenyl methyl thio)-3-cyanopyridine is hydrolyzed in presence of a base in an autoclave and isolated under acidic condition to get the desired product.

Abstract: Disclosed is a perpendicular magnetic recording medium on a substrate. The perpendicular magnetic recording medium has a recording layer. The recording layer includes a first granular recording layer and a second granular recording layer. There may be an exchange layer between the first granular recording layer and the second granular recording layer. Additionally or alternatively, the ratio of saturation magnetization of the first granular recording layer and the second granular recording layer may be greater than 1 and/or the first granular recording layer may have a relatively high magnetic anisotropy compared to the second granular recording layer magnetic anisotropy. A forming method is also disclosed.

Abstract: Implementations of power management in a device are described. The device includes a power driver configured to manage power supply to one or more components in system-on-chip (SOC) hardware. The device further includes power subsystems configured as drivers for controlling the components of the SOC hardware and a user interface configured to receive a selected power mode as an input and identify profiles of one or more applications being executed in the device. Based on the selected power mode, the power driver directs the power subsystems to change a mode of operation of at least one component determined from the profiles of the one or more applications being executed.

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract: Nodes in an Internet Protocol (IP) network receive probe packets configured to travel over particular IP media paths. The probe packets cause the network nodes to send media path reports to a logging system. The media path reports contain information identifying the different nodes in the media path. The logging system can reconstruct the network topology of a particular media path from the media path reports which can then be used for debugging purposes. In one embodiment the probe packets are Resource Reservation Setup Protocol (RSVP) packets configured for media path probing.

Abstract: A method and system for handling assertion libraries in verification of a design are disclosed. The method and system include structuring and implementing at least one verification component in at least one of the assertion libraries with at least one standard assertion language supported by at least one verification tool, creating an assertion library element for a specific requirement for verification of the design without dependence on the at least one verification tool for the assertion library element, and resolving assertion status. With the disclosed method and system, visualization of assertion status at various levels of design hierarchy and at verification component level may be achieved, and implementing verification techniques may include optimization techniques during and/or after verification.

Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.

Abstract: The present invention relates to processes for the preparation of Form I and Form II of Ritonavir, wherein no seed crystals are used.

Abstract: A method and an apparatus are provided for enabling a safe and secure environment for a pet traveling in a vehicle during a collision or sudden breaking of the vehicle by using a seat belt system to flexibly restrain the pet with a safety restrainer or a detachable safety belt. In one embodiment, a safety restrainer may secure a pet in a vehicle having a seat belt with a first seat belt prong that latches into a first seat belt buckle. The safety restrainer may comprise a restraint assembly including a restraint strap removably couplable to a body portion of the pet. The restraint assembly may be positionable about the body of the pet and the restrain strap positionable between a pair of fore legs and a pair of hind legs of the pet. The restraint strap may include a first strap end and a second strap end being releasably couplable to each other such that the restraint strap forms a loop having a hole when the first and second strap ends are releasably coupled together.

Abstract: System and method for synchronizing one or more secondary decoded media streams to a primary decoded media stream. The system includes a media stream processor and a mixer. The media stream processor receives a primary decoded media stream and secondary decoded media streams. The media stream processor synchronizes the secondary decoded media streams with the primary decoded media stream. The output of the media stream processor is coupled to the mixer. The mixer receives its second input from the primary decoded media stream. The mixer mixes the received streams and generates a PTS value for its output media stream by extrapolating the PTS of the primary decoded media stream.

Abstract: A method, apparatus, and article of manufacture is configured to define a structured view of data in a computer system. A relational database management system (RDBMS) stores information in the computer system. As part of a process and framework, a series of business rules and process workflows that manage data (that is hierarchical in nature) that resides in one or more RDBMS tables are maintained. User input is accepted that defines a hierarchical structure that is projected onto the data. The hierarchical structure is stored as metadata in the RDBMS. The hierarchical structure is utilized to graphically visualize, manage, and manipulate the data.

Abstract: Systems, methods, apparatus and software can implement a multipathing driver using dynamically loadable device policy modules that provide device specific functionality for providing at least one of input/output (I/O) operation scheduling, path selection, and I/O operation error analysis. Because the device policy modules include device specific functionality, various different devices from different manufacturers can be more efficiently and robustly supported.

Abstract: The invention provides a novel herbal formulation useful as local anesthetic in topical surgical operations, nerve block conduction, extradural and infiltration anesthesia. Formulation(s) comprises of extract(s) of Spilanthus calva and Spilanthus oleraceae with Gymnema sylvestre, Urtica dioica and Piper longum. The formulation can be used as topical application as ointment or spray or cream.

Abstract: The present disclosure provides a method for fabricating an integrated circuit. The method includes forming an energy removable film (ERF) on a substrate; forming a first dielectric layer on the ERF; patterning the ERF and first dielectric layer to form a trench in the ERF and the first dielectric layer; filling a conductive material in the trench; forming a ceiling layer on the first dielectric layer and conductive material filled in the trench; and applying energy to the ERF to form air gaps in the ERF after the forming of the ceiling layer.

Abstract: A method of processing multiple workload using virtualized operating system environments. The creation of a new user in a global operating system may automatically cause the creation of a working partition (WPAR) instance. The user will be associated with the WPAR instance and a virtualized operating system environment will be created from the global operating system within the WPAR instance. Within the WPAR instance, the user may be assigned a root identification which enables the user to have root access privileges to perform operations or processes that may only be performed by a root user. The removal of a user from the system also results in the deletion of the associated WPAR.

Abstract: The topology of a digital subscriber line loop can play an important role in provisioning service. For example, knowledge of certain topological features in a loop can enable telecommunications companies to make better decisions about the kinds of services that can be provisioned on that loop. Additionally, knowledge of those topological features can also assist field engineers in troubleshooting problems in the field. A topology recognition engine can provide key topological features such as the loop length, presence of single and multiple bridge taps and the length of single bridge taps on a loop.

Abstract: A storage stable pharmaceutical composition comprising a solution of Oxaliplatin in water and a catalytic amount of a carbohydrate. A process for forming such pharmaceutical composition comprising dissolving a known amount of Oxaliplatin in water; adding an amount of carbohydrate in the range of 0.0010% to 0.05% w/v with respect to such solution; agitating the mixture to get clear solution; filtering it through a filter membrane under aseptic conditions; and filling the solution resulting into glass vials sealed with elastomeric stoppers and aluminium flip-off seals.