Abstract: The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines. The vaccine can be formulated in a lipid nanoparticle.

Abstract: The disclosure relates to HSV glycoprotein E antigenic peptide constructs and HSV protein vaccines, as well as methods of using the vaccines and compositions comprising the vaccines. The present invention directed to immunogenic polypeptides of use for a vaccine against Herpes Simplex Virus (HSV). The polypeptides are glycoprotein E peptides that are mutated to reduce their binding to antibody Fc domain.

Abstract: A construction method and use of a Thy1-SNCA;Clu gene knockout mouse model are provided. The construction method includes: subjecting a Thy1-SNCA mouse to crossing with a Clu-KO mouse to obtain an F1 generation, and then conducting identification to obtain a Thy1-SNCA;Clu?/+ mouse; and subjecting the Thy1-SNCA;Clu?/+ mouse to backcrossing with the Clu-KO mouse to obtain an F2 generation, and then conducting identification to obtain a mouse with a target genotype, recorded as a Thy1-SNCA;Clu?/? mouse. The Thy1-SNCA;Clu?/? mouse can effectively shorten a time point for the onset of Parkinson's disease (PD)-like movement disorders, thereby shortening an experimental period. The mouse can provide more model mouse options for PD research.

Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.

Abstract: Disclosed are single-domain antibodies that can bind (e.g., separately) to at least two spike proteins from different coronaviruses. Additionally disclosed are polypeptides that have multiple coronavirus spike-protein binders and can neutralize (e.g., separately) at least two different coronaviruses. These single-domain antibodies and polypeptides can be used for treating coronavirus infections.

Abstract: The present disclosure relates to the field of cationic polymers, and in particular to highly alkali-stable poly(arylene alkylene piperidinium) cationic polymers having branched structures, and the preparation method and application thereof. The highly alkali-stable poly(arylene alkylene piperidinium) cationic polymers having branched structures include one or more of a central unit, a linear unit L1, and a linear unit L2, where the central unit includes one or more of an MA unit, a piperidinium group (m-DMP) and a CA unit, the linear unit L1 includes the piperidinium group (m-DMP) and a BA unit, and the linear unit L2 includes a BA unit and a CA unit. The disclosure employs the aforementioned steps to enhance the intermolecular interactions and increase the molecular weight of the polymer through a branching strategy.

Abstract: The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines. The vaccine can be formulated in a lipid nanoparticle.

Abstract: A needle tube structure and an endoscopic interventional instrument are disclosed that relate to the technical field of endoscopic medical instruments. The needle tube structure provided in the present disclosure includes a needle tube body and a polymer material tube body provided inside the needle tube body. The side wall of the needle tube body is provided with at least one slot, and the polymer material tube body is fixedly fitted to the slot. The needle tube structure and the endoscopic interventional instrument can ensure that the polymer material tube body is firmly joined to the needle tube body, which not only prevents a guide wire passing through the needle tube body from being scratched or damaged by the needle tube body but also enhances the stability of the polymer material tube body, thus reducing the risk of detachment of the polymer material tube body.

Abstract: A method includes placing a first wafer carrier on a first wafer carrier support base of an automated mechanism platform apparatus, the first wafer carrier accommodating a plurality of wafers; grapping the wafers from the first wafer carrier by a gripper of the automated mechanism platform apparatus; moving the wafers from the gripper to a second wafer carrier placing on a second wafer carrier support base of the automated mechanism platform apparatus; grapping the second wafer carrier with the wafers from the second wafer carrier support base by the gripper; transferring the second wafer carrier with the wafers from the gripper to a processing apparatus.

Abstract: In an embodiment, a method (100) is described. The method comprises receiving (102) data corresponding to a plurality of radiographic imaging slices of a body. The method further comprises determining (104) a position of a needle inserted in the body. The determination is based on combining information from at least one of the radiographic imaging slices comprising an indication of a first portion of the needle outside the body and at least one other of the radiographic imaging slices comprising an indication of a second portion of the needle inside the body. A combined needle region is generated by merging data corresponding to a position of the first portion of the needle outside the body with data corresponding to a position of the second portion of the needle inside the body.

Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.

Abstract: The present disclosure generally provides compounds that antagonize certain T2R taste receptors, including related uses, methods, and compositions for the reduction of bitter taste and/or the enhancement of sweet taste. In certain aspects, the disclosure provides flavored articles or flavored compositions comprising such compounds, as well as uses of such compounds to reduce the bitter taste and/or enhance the sweet taste of such flavored articles or flavored compositions.

Abstract: This application provides a screen casting method, a device, and a storage medium. In a screen casting process, when a sound output device is switched to the screen casting transmit end, whether the screen casting transmit end outputs a sound depends on a current status of an audio status switching control, thereby ensuring that whether the screen casting transmit end outputs a sound can be consistent with an expectation of a user in a screen casting scenario. In addition, in the screen casting method provided in this application, when whether the screen casting transmit end outputs a sound is set based on a click operation performed by the user on the audio status switching control, an icon corresponding to the audio status switching control is dynamically modified based on an audio status (mute or non-mute) corresponding to the audio status switching control.

Abstract: Provided is an intelligent control-based dosing and stirring device for sediment pollution control, including a support underframe, a support frame, a chemical cartridge, and a stirring assembly which works through intelligent control. A support ring positioned in a middle position is fixed into the support underframe by multiple support rods, and an anti-shaking mechanism is arranged in the support ring, and mounted in the support ring by multiple shock-absorbing assemblies. The shock-absorbing assemblies are used for shock absorption, thus preventing the chemical cartridge from shaking. The anti-shaking mechanism includes a circular support block, and an annular groove is formed in the circular support block. The intelligent control-based dosing and stirring device for sediment pollution control relates to the technical field of dosing and stirring devices.

Abstract: The disclosure relates to stable RSV F proteins and immunogenic compositions containing the same, as well as methods of using the immunogenic compositions and compositions comprising the RSV F proteins.

Abstract: The present disclosure generally provides methods for identifying compounds that attenuate the bitter taste of plant proteins. In some particular aspects, the disclosure provides methods of identifying compounds that attenuate the bitter taste of plant proteins by determining whether the compounds modulate certain T2R bitter taste receptors. In some other aspects, the disclosure provides uses of such identified compounds to attenuate the bitter taste of an ingestible composition that comprises one or more plant proteins. In some further aspects, the disclosure provides flavored products, such as food or beverage products, that incorporate such ingestible compositions. Such food products include meat and dairy analogues.

Abstract: The present invention relates to anti-human metapneumovirus (hMPV) antibodies, as well as use of such antibodies in the treatment of viral infections. The invention also includes antigenic hMPV proteins and immunogenic compositions comprising such antigenic hMPV proteins, and the use of such antigenic hMPV proteins and related compositions for preventing or treating viral infection in a subject.

Abstract: The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines. The vaccine can be formulated in a lipid nanoparticle.

Abstract: This application provides a screen casting method, a device, and a storage medium. In a screen casting process, when a sound output device is switched to the screen casting transmit end, whether the screen casting transmit end outputs a sound depends on a current status of an audio status switching control, thereby ensuring that whether the screen casting transmit end outputs a sound can be consistent with an expectation of a user in a screen casting scenario. In addition, in the screen casting method provided in this application, when whether the screen casting transmit end outputs a sound is set based on a click operation performed by the user on the audio status switching control, an icon corresponding to the audio status switching control is dynamically modified based on an audio status (mute or non-mute) corresponding to the audio status switching control.

Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.