Patents by Inventor Lan Zhang

Lan Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11175804
    Abstract: The present disclosure relates to a method and system for deploying user interface elements on a screen which has broken-faulty regions on the screen. One or more broken-faulty regions are detected on the screen. At least a part of the normal regions on the screen is determined to be a region for displaying at least a part of one or more user interface elements which are related to the one or more broken-faulty regions. The at least a part of the one or more user interface elements are deployed on the screen based on the result of the determining.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: November 16, 2021
    Assignee: International Business Machines Corporation
    Inventors: Xue Lan Zhang, Dong Jun Zong, Jin Zhang, Zhun Huang, Yuan Jie Zhang, Yan Xiu Wu
  • Patent number: 11160860
    Abstract: HSV glycoprotein B-VSV-G1 fusion proteins and variants thereof, HSV glycoprotein C antigenic peptide constructs and variants thereof, HSV immunogenic compositions and protein vaccines including the peptide constructs, and HSV DNA vaccines encoding the amino acid sequence of the peptide constructs, as well as methods of using the vaccines and compositions comprising the vaccines.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: November 2, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Dai Wang, Lan Zhang
  • Publication number: 20210300971
    Abstract: The disclosure relates to stable RSV F proteins and immunogenic compositions containing the same, as well as methods of using the immunogenic compositions and compositions comprising the RSV F proteins.
    Type: Application
    Filed: January 24, 2019
    Publication date: September 30, 2021
    Inventors: Lan Zhang, Arthur Fridman, Eberhard Durr, Andrew Bett
  • Patent number: 11112528
    Abstract: The present disclosure discloses a method of substance identification of an item to be inspected using a multi-energy-spectrum X-ray imaging system, the method comprising: acquiring a transparency related vector consisting of transparency values of the item to be inspected in N energy regions, wherein N is greater than 2; calculating distances between the transparency related vector and transparency related vectors stored in the system consisting of N transparency mean values of multiple kinds of items with multiple thicknesses in the N energy regions; and identifying the item to be inspected as the item corresponding to the minimum distance. The present disclosure is based on a multi-energy-spectrum X-ray imaging system, and proposes a method of substance identification by analyzing the multi-energy-spectrum substance identification issue.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: September 7, 2021
    Assignee: NUCTECH COMPANY LIMITED
    Inventors: Guangming Xu, Bicheng Liu, Ziran Zhao, Jianping Gu, Qiang Li, Lan Zhang
  • Publication number: 20210273124
    Abstract: Dual-depth through-wafer-via semiconductor devices and methods for fabricating dual-depth through-wafer-via semiconductor devices are disclosed. In particular, back-contact-only multijunction photovoltaic cells and the process flows for making such cells are disclosed. The dual-depth through-wafer-via multijunction photovoltaic cells include through-wafer-vias for interconnecting the front surface epitaxial layer to a contact pad on the back surface. Before etching the through-wafer-vias the substrate is thinned to less than 150 pm. The dual-depth through-wafer-vias are formed using a two-step wet etch process that removes semiconductor materials non-selectively without major differences in etch rates between heteroepitaxial III-V semiconductor layers. Low-stress passivation layers are used to reduce the thermo-mechanical stress of the semiconductor devices. A bypass diode is integrated in the recess on the backside formed by the dual-depth through-wafer structure.
    Type: Application
    Filed: July 11, 2019
    Publication date: September 2, 2021
    Inventor: Lan ZHANG
  • Publication number: 20210188951
    Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
    Type: Application
    Filed: December 8, 2020
    Publication date: June 24, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Kalpit A. Vora, Kara S. Cox, Aimin Tang, Zhifeng Chen, Daniel DiStefano, Lan Zhang, Hua-Poo Su
  • Publication number: 20210187097
    Abstract: The disclosure relates to broad spectrum influenza virus ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccine. In a preferred embodiment, the vaccine is formulated as a lipid nanoparticle comprising at least one cationic lipid.
    Type: Application
    Filed: March 15, 2018
    Publication date: June 24, 2021
    Applicant: ModernaTX, Inc.
    Inventors: Giuseppe Ciaramella, Eric Yi-Chun Huang, Kerim Babaoglu, Jessica Anne Flynn, Lan Zhang, David Nickle
  • Patent number: 11011656
    Abstract: A photodiode device and a photodiode detector are provided. According to an embodiment, the photodiode device may include a first type lightly doped semiconductor base including a first surface and a second surfaces opposite to each other, a first electrode region being first type heavily doped and disposed on the first surface of the semiconductor base, a second electrode region being second type heavily doped and disposed on the second surface of the semiconductor base, wherein the first surface is a light incident surface.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: May 18, 2021
    Assignee: NUCTECH COMPANY LIMITED
    Inventors: Lan Zhang, Haifan Hu, Xuepeng Cao, Jun Li
  • Patent number: 11008380
    Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: May 18, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kalpit A. Vora, Kara S. Cox, Aimin Tang, Zhifeng Chen, Daniel DiStefano, Lan Zhang, Hua-Poo Su
  • Publication number: 20210132756
    Abstract: The present disclosure relates to a method and system for deploying user interface elements on a screen which has broken-faulty regions on the screen. One or more broken-faulty regions are detected on the screen. At least a part of the normal regions on the screen is determined to be a region for displaying at least a part of one or more user interface elements which are related to the one or more broken-faulty regions.
    Type: Application
    Filed: October 30, 2019
    Publication date: May 6, 2021
    Inventors: Xue Lan Zhang, Dong Jun Zong, Jin Zhang, Zhun Huang, Yuan Jie Zhang, Yan Xiu Wu
  • Publication number: 20210126140
    Abstract: Surface mount semiconductor devices and methods for fabricating surface mount semiconductor devices are disclosed. In particular, back-contact-only multijunction photovoltaic cells and the process flows for making such cells are disclosed. The surface mount multijunction photovoltaic cells include through-wafer-vias for interconnecting the front surface epitaxial layer to a contact pad on the back surface. Before etching the through-wafer-vias the substrate is thinned to less than 150 ?m. The through-wafer-vias are formed using a wet etch process that removes semiconductor materials non-selectively without major differences in etch rates between heteroepitaxial III-V semiconductor layers. Low stress passivation layers are used to reduce the thermo-mechanical stress of the semiconductor devices.
    Type: Application
    Filed: January 17, 2019
    Publication date: April 29, 2021
    Applicants: Array Photonics, Inc., Array Photonics, Inc.
    Inventors: Lan ZHANG, Ewelina LUCOW, Ligang GAO
  • Publication number: 20210093703
    Abstract: The present invention relates to methods for the recombinant expression of chlamydia major outer membrane protein (MOMP) comprising transforming a population of E. coli host cells with an expression vector comprising a nucleic acid molecule that encodes chlamydia MOMP and encodes a leader sequence for targeting the MOMP to the outer membrane of the cell, wherein the nucleic acid molecule is operatively linked to a promoter. The method of the invention allows expression of MOMP in the outer membrane of the cell, which leads to protein folding that is more like native MOMP relative to a MOMP protein that is expressed intracellularly. Also provided by the invention are uses of the recombinant MOMP in pharmaceutical compositions and methods for the treatment and/or prophylaxis of chlamydia infection and/or the effects thereof.
    Type: Application
    Filed: June 8, 2020
    Publication date: April 1, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Lan Zhang, Zhiyun Wen, Craig T. Przysiecki, Puneet Khandelwal, Ping Qiu
  • Publication number: 20210046173
    Abstract: The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines. The vaccine can be formulated in a lipid nanoparticle.
    Type: Application
    Filed: January 28, 2019
    Publication date: February 18, 2021
    Applicant: ModernaTX, Inc.
    Inventors: Giuseppe Ciaramella, Kapil Bahl, Amy Espeseth, Andrew J. Bett, Pedro Cejas, Lan Zhang, Christine Shaw
  • Publication number: 20200309987
    Abstract: The present disclosure discloses a method of substance identification of an item to be inspected using a multi-energy-spectrum X-ray imaging system, the method comprising: acquiring a transparency related vector consisting of transparency values of the item to be inspected in N energy regions, wherein N is greater than 2; calculating distances between the transparency related vector and transparency related vectors stored in the system consisting of N transparency mean values of multiple kinds of items with multiple thicknesses in the N energy regions; and identifying the item to be inspected as the item corresponding to the minimum distance. The present disclosure is based on a multi-energy-spectrum X-ray imaging system, and proposes a method of substance identification by analyzing the multi-energy-spectrum substance identification issue.
    Type: Application
    Filed: September 12, 2017
    Publication date: October 1, 2020
    Inventors: Guangming XU, Bicheng LIU, Ziran ZHAO, Jianping GU, Qiang LI, Lan ZHANG
  • Publication number: 20200250582
    Abstract: In one example, the present disclosure describes a device, computer-readable medium, and method for automatically learning and facilitating interaction routines involving at least one human participant. In one example, a method includes learning an interaction routine conducted between a human user and a second party, wherein the interaction routine comprises a series of prompts and responses designed to identify and deliver desired information, storing a template of the interaction routine based on the learning, wherein the template includes at least a portion of the series of prompts and responses, detecting, in the course of a new instance of the interaction routine, at least one prompt from the second party that requests a response from the human user, and using the template to provide a response to the prompt so that involvement of the human user in the new instance of the interaction routine is minimized.
    Type: Application
    Filed: April 20, 2020
    Publication date: August 6, 2020
    Inventors: Harry Blanchard, Lan Zhang, Gregory Pulz
  • Patent number: 10675339
    Abstract: The present invention relates to methods for the recombinant expression of Chlamydia major outer membrane protein (MOMP) comprising transforming a population of E. coli host cells with an expression vector comprising a nucleic acid molecule that encodes Chlamydia MOMP and encodes a leader sequence for targeting the MOMP to the outer membrane of the cell, wherein the nucleic acid molecule is operatively linked to a promoter. The method of the invention allows expression of MOMP in the outer membrane of the cell, which leads to protein folding that is more like native MOMP relative to a MOMP protein that is expressed intracellularly. Also provided by the invention are uses of the recombinant MOMP in pharmaceutical compositions and methods for the treatment and/or prophylaxis of Chlamydia infection and/or the effects thereof.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: June 9, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Lan Zhang, Zhiyun Wen, Craig T. Przysiecki, Puneet Khandelwal
  • Patent number: 10670743
    Abstract: A semiconductor detector and a packaging method thereof. The semiconductor detector includes: a cathode circuit board including a read out chip, a high voltage side top layer of the cathode circuit board, a bottom connection layer of the cathode circuit board and a dielectric filled between the high voltage side top layer and the bottom connection layer, wherein the high voltage side top layer is connected to the bottom connection layer through a via hole; and a detector crystal including a crystal body, an anode and a cathode, the anode is connected to the read out chip of the cathode circuit board, the high voltage side top layer is connected to an input terminal of the semiconductor detector and the bottom connection layer directly contacts the cathode of the detector crystal to connect the cathode to the cathode circuit board.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: June 2, 2020
    Assignee: NUCTECH COMPANY LIMITED
    Inventors: Lan Zhang, Yingshuai Du, Bo Li, Zonggui Wu, Jun Li, Xuepeng Cao, Haifan Hu, Jianping Gu, Guangming Xu, Bicheng Liu
  • Patent number: 10663607
    Abstract: The present disclosure provides an apparatus for processing signals for a plurality of energy regions, and a system and method for detecting radiation of a plurality of energy regions. The apparatus for processing signals for a plurality of energy regions may comprise: a first processor, configured to receive a signal from a detector and process the received signal to generate a gated signal, wherein a turn-on period of the gated signal represents magnitude of the received signal; and a second processor, configured to receive the gated signal from the first processor, and determine one of the plurality of energy regions to which the received signal belongs according to the turn-on period of the gated signal, so as to count signals within the determined energy region.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: May 26, 2020
    Assignee: Nuctech Company Limited
    Inventors: Lan Zhang, Yingshuai Du, Bo Li, Zonggui Wu, Jun Li, Xuepeng Cao, Haifan Hu, Jianping Gu, Guangming Xu, Bicheng Liu
  • Patent number: 10649104
    Abstract: A method and apparatus for reconstructing an incident energy spectrum for a detector are disclosed. In this method, an object to be inspected is illuminated with rays, and then rays transmitted through the object to be inspected are received by the detector to convert the received rays into data of a detected energy spectrum. The incident energy spectrum for the detector is reconstructed based on the data of the energy spectrum using a statistical iterative algorithm with a pre-established detector response function. With the above solution of the embodiments, the incident energy spectrum for the detector can be more accurately acquired, thereby reducing a distortion of the incident energy spectrum caused by the detector.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: May 12, 2020
    Assignees: Tsinghua University, Nuctech Company Limited
    Inventors: Liang Li, Zhiqiang Chen, Li Zhang, Ziran Zhao, Yuxiang Xing, Kejun Kang, Lan Zhang, Ruizhe Li
  • Patent number: 10646179
    Abstract: The present disclosure provides a method for recognizing an article using a multi-energy spectrum X-ray imaging system and a multi-energy spectrum X-ray imaging system. The method comprises: recognizing an application scenario and/or priori information of the article; selecting a parameter mode suitable for the article from a plurality of parameter modes stored in the multi-energy spectrum X-ray imaging system based on the recognized application scenario and/or priori information; and recognizing the article using the selected parameter mode, wherein the plurality of parameter modes are obtained by optimizing system parameters of the multi-energy spectrum X-ray imaging system under a specific condition using a training sample library for various articles.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: May 12, 2020
    Assignee: NUCTECH COMPANY LIMITED
    Inventors: Guangming Xu, Bicheng Liu, Ziran Zhao, Lan Zhang, Jianping Gu