Patents by Inventor Lan Zhang

Lan Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210132756
    Abstract: The present disclosure relates to a method and system for deploying user interface elements on a screen which has broken-faulty regions on the screen. One or more broken-faulty regions are detected on the screen. At least a part of the normal regions on the screen is determined to be a region for displaying at least a part of one or more user interface elements which are related to the one or more broken-faulty regions.
    Type: Application
    Filed: October 30, 2019
    Publication date: May 6, 2021
    Inventors: Xue Lan Zhang, Dong Jun Zong, Jin Zhang, Zhun Huang, Yuan Jie Zhang, Yan Xiu Wu
  • Publication number: 20210126140
    Abstract: Surface mount semiconductor devices and methods for fabricating surface mount semiconductor devices are disclosed. In particular, back-contact-only multijunction photovoltaic cells and the process flows for making such cells are disclosed. The surface mount multijunction photovoltaic cells include through-wafer-vias for interconnecting the front surface epitaxial layer to a contact pad on the back surface. Before etching the through-wafer-vias the substrate is thinned to less than 150 ?m. The through-wafer-vias are formed using a wet etch process that removes semiconductor materials non-selectively without major differences in etch rates between heteroepitaxial III-V semiconductor layers. Low stress passivation layers are used to reduce the thermo-mechanical stress of the semiconductor devices.
    Type: Application
    Filed: January 17, 2019
    Publication date: April 29, 2021
    Applicants: Array Photonics, Inc., Array Photonics, Inc.
    Inventors: Lan ZHANG, Ewelina LUCOW, Ligang GAO
  • Publication number: 20210093703
    Abstract: The present invention relates to methods for the recombinant expression of chlamydia major outer membrane protein (MOMP) comprising transforming a population of E. coli host cells with an expression vector comprising a nucleic acid molecule that encodes chlamydia MOMP and encodes a leader sequence for targeting the MOMP to the outer membrane of the cell, wherein the nucleic acid molecule is operatively linked to a promoter. The method of the invention allows expression of MOMP in the outer membrane of the cell, which leads to protein folding that is more like native MOMP relative to a MOMP protein that is expressed intracellularly. Also provided by the invention are uses of the recombinant MOMP in pharmaceutical compositions and methods for the treatment and/or prophylaxis of chlamydia infection and/or the effects thereof.
    Type: Application
    Filed: June 8, 2020
    Publication date: April 1, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Lan Zhang, Zhiyun Wen, Craig T. Przysiecki, Puneet Khandelwal, Ping Qiu
  • Publication number: 20210046173
    Abstract: The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines. The vaccine can be formulated in a lipid nanoparticle.
    Type: Application
    Filed: January 28, 2019
    Publication date: February 18, 2021
    Applicant: ModernaTX, Inc.
    Inventors: Giuseppe Ciaramella, Kapil Bahl, Amy Espeseth, Andrew J. Bett, Pedro Cejas, Lan Zhang, Christine Shaw
  • Publication number: 20200309987
    Abstract: The present disclosure discloses a method of substance identification of an item to be inspected using a multi-energy-spectrum X-ray imaging system, the method comprising: acquiring a transparency related vector consisting of transparency values of the item to be inspected in N energy regions, wherein N is greater than 2; calculating distances between the transparency related vector and transparency related vectors stored in the system consisting of N transparency mean values of multiple kinds of items with multiple thicknesses in the N energy regions; and identifying the item to be inspected as the item corresponding to the minimum distance. The present disclosure is based on a multi-energy-spectrum X-ray imaging system, and proposes a method of substance identification by analyzing the multi-energy-spectrum substance identification issue.
    Type: Application
    Filed: September 12, 2017
    Publication date: October 1, 2020
    Inventors: Guangming XU, Bicheng LIU, Ziran ZHAO, Jianping GU, Qiang LI, Lan ZHANG
  • Publication number: 20200250582
    Abstract: In one example, the present disclosure describes a device, computer-readable medium, and method for automatically learning and facilitating interaction routines involving at least one human participant. In one example, a method includes learning an interaction routine conducted between a human user and a second party, wherein the interaction routine comprises a series of prompts and responses designed to identify and deliver desired information, storing a template of the interaction routine based on the learning, wherein the template includes at least a portion of the series of prompts and responses, detecting, in the course of a new instance of the interaction routine, at least one prompt from the second party that requests a response from the human user, and using the template to provide a response to the prompt so that involvement of the human user in the new instance of the interaction routine is minimized.
    Type: Application
    Filed: April 20, 2020
    Publication date: August 6, 2020
    Inventors: Harry Blanchard, Lan Zhang, Gregory Pulz
  • Patent number: 10675339
    Abstract: The present invention relates to methods for the recombinant expression of Chlamydia major outer membrane protein (MOMP) comprising transforming a population of E. coli host cells with an expression vector comprising a nucleic acid molecule that encodes Chlamydia MOMP and encodes a leader sequence for targeting the MOMP to the outer membrane of the cell, wherein the nucleic acid molecule is operatively linked to a promoter. The method of the invention allows expression of MOMP in the outer membrane of the cell, which leads to protein folding that is more like native MOMP relative to a MOMP protein that is expressed intracellularly. Also provided by the invention are uses of the recombinant MOMP in pharmaceutical compositions and methods for the treatment and/or prophylaxis of Chlamydia infection and/or the effects thereof.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: June 9, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Lan Zhang, Zhiyun Wen, Craig T. Przysiecki, Puneet Khandelwal
  • Patent number: 10670743
    Abstract: A semiconductor detector and a packaging method thereof. The semiconductor detector includes: a cathode circuit board including a read out chip, a high voltage side top layer of the cathode circuit board, a bottom connection layer of the cathode circuit board and a dielectric filled between the high voltage side top layer and the bottom connection layer, wherein the high voltage side top layer is connected to the bottom connection layer through a via hole; and a detector crystal including a crystal body, an anode and a cathode, the anode is connected to the read out chip of the cathode circuit board, the high voltage side top layer is connected to an input terminal of the semiconductor detector and the bottom connection layer directly contacts the cathode of the detector crystal to connect the cathode to the cathode circuit board.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: June 2, 2020
    Assignee: NUCTECH COMPANY LIMITED
    Inventors: Lan Zhang, Yingshuai Du, Bo Li, Zonggui Wu, Jun Li, Xuepeng Cao, Haifan Hu, Jianping Gu, Guangming Xu, Bicheng Liu
  • Patent number: 10663607
    Abstract: The present disclosure provides an apparatus for processing signals for a plurality of energy regions, and a system and method for detecting radiation of a plurality of energy regions. The apparatus for processing signals for a plurality of energy regions may comprise: a first processor, configured to receive a signal from a detector and process the received signal to generate a gated signal, wherein a turn-on period of the gated signal represents magnitude of the received signal; and a second processor, configured to receive the gated signal from the first processor, and determine one of the plurality of energy regions to which the received signal belongs according to the turn-on period of the gated signal, so as to count signals within the determined energy region.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: May 26, 2020
    Assignee: Nuctech Company Limited
    Inventors: Lan Zhang, Yingshuai Du, Bo Li, Zonggui Wu, Jun Li, Xuepeng Cao, Haifan Hu, Jianping Gu, Guangming Xu, Bicheng Liu
  • Patent number: 10646179
    Abstract: The present disclosure provides a method for recognizing an article using a multi-energy spectrum X-ray imaging system and a multi-energy spectrum X-ray imaging system. The method comprises: recognizing an application scenario and/or priori information of the article; selecting a parameter mode suitable for the article from a plurality of parameter modes stored in the multi-energy spectrum X-ray imaging system based on the recognized application scenario and/or priori information; and recognizing the article using the selected parameter mode, wherein the plurality of parameter modes are obtained by optimizing system parameters of the multi-energy spectrum X-ray imaging system under a specific condition using a training sample library for various articles.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: May 12, 2020
    Assignee: NUCTECH COMPANY LIMITED
    Inventors: Guangming Xu, Bicheng Liu, Ziran Zhao, Lan Zhang, Jianping Gu
  • Patent number: 10649104
    Abstract: A method and apparatus for reconstructing an incident energy spectrum for a detector are disclosed. In this method, an object to be inspected is illuminated with rays, and then rays transmitted through the object to be inspected are received by the detector to convert the received rays into data of a detected energy spectrum. The incident energy spectrum for the detector is reconstructed based on the data of the energy spectrum using a statistical iterative algorithm with a pre-established detector response function. With the above solution of the embodiments, the incident energy spectrum for the detector can be more accurately acquired, thereby reducing a distortion of the incident energy spectrum caused by the detector.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: May 12, 2020
    Assignees: Tsinghua University, Nuctech Company Limited
    Inventors: Liang Li, Zhiqiang Chen, Li Zhang, Ziran Zhao, Yuxiang Xing, Kejun Kang, Lan Zhang, Ruizhe Li
  • Publication number: 20200129615
    Abstract: The disclosure relates to herpes simplex virus (HSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines. In a preferred embodiment, the vaccine is formulated as a lipid nanoparticle comprising at least one cationic lipid.
    Type: Application
    Filed: March 15, 2018
    Publication date: April 30, 2020
    Applicant: ModernaTX, Inc.
    Inventors: Giuseppe Ciaramella, Shinu John, Andrew J. Bett, Danilo R. Casimiro, Dai Wang, Lan Zhang
  • Patent number: 10628754
    Abstract: In one example, the present disclosure describes a device, computer-readable medium, and method for automatically learning and facilitating interaction routines involving at least one human participant. In one example, a method includes learning an interaction routine conducted between a human user and a second party, wherein the interaction routine comprises a series of prompts and responses designed to identify and deliver desired information, storing a template of the interaction routine based on the learning, wherein the template includes at least a portion of the series of prompts and responses, detecting, in the course of a new instance of the interaction routine, at least one prompt from the second party that requests a response from the human user, and using the template to provide a response to the prompt so that involvement of the human user in the new instance of the interaction routine is minimized.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: April 21, 2020
    Assignee: AT&T Intellectual Property I, L.P.
    Inventors: Harry Blanchard, Lan Zhang, Gregory Pulz
  • Publication number: 20200069792
    Abstract: The disclosure relates to HSV glycoprotein B and HSV glycoprotein C antigenic peptide constructs, HSV protein vaccines, and HSV DNA vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
    Type: Application
    Filed: April 25, 2018
    Publication date: March 5, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Dai Wang, Lan Zhang
  • Publication number: 20200054737
    Abstract: The disclosure relates to herpes simplex virus (HSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
    Type: Application
    Filed: April 25, 2018
    Publication date: February 20, 2020
    Applicant: Modema TX, Inc.
    Inventors: Giuseppe Ciaramella, Shinu John, Andrew J. Bett, Danilo R. Casimiro, Dai Wang, Lan Zhang
  • Publication number: 20200037923
    Abstract: The purpose of the present invention is to enable, even in an endoscopic operation, an operation upon a specific operation site while monitoring the overall surgical site, such as an organ. An artificial magnetic field is generated such that a surgical site of a patient is positioned within a generated three-dimensional artificial magnetic field space. A plurality of magnetic sensors are respectively mounted in a plurality of predetermined locations of the surgical site of the patient. Data of a 3-D image of the surgical site and position information of the mounting locations of the magnetic sensors with respect to the surgical site are stored in a storage unit as position information of the mounting locations with respect to the 3-D image of the surgical site.
    Type: Application
    Filed: July 20, 2017
    Publication date: February 6, 2020
    Applicant: University of Tsukuba
    Inventors: Jian LU, Ryutaro MAEDA, Lan ZHANG, Hiroshi HIROSHIMA, Nobuhiro OHKOHCHI, Masanao KURATA, Youichi OKUDA
  • Publication number: 20200002407
    Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
    Type: Application
    Filed: June 7, 2019
    Publication date: January 2, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: KALPIT A. VORA, KARA S. COX, AIMIN TANG, ZHIFENG CHEN, DANIEL DISTEFANO, LAN ZHANG, HUA-POO SU
  • Patent number: 10513512
    Abstract: The invention relates to flavanone derivatives, and preparation method and use thereof, particularly relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, a preparation method thereof, and use thereof for preventing or treating a mental disorder or a nervous system disease. The compound of the invention exerts significant activity of inhibiting microglial activation and neuroinflammation, can antagonize dopamine D2 receptor, improve the ethological change in multiple animal models for mental disorders, effectively inhibit neuroinflammation and demyelination, and can be used to prevent or treat a mental disorder and a nervous system disease.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: December 24, 2019
    Assignee: Xuanwu Hospital of Capital Medical University
    Inventors: Lin Li, Hongshun Gu, Lan Zhang, Xi Chen, Linlin Yin, Ruyi Zhang, Cuicui Yang
  • Publication number: 20190371293
    Abstract: Systems, methods, and computer-readable storage media for providing for intelligent switching of languages and/or pronunciations in a text-to-speech system. As the system receives text, the text is analyzed to identify portions which should have speech constructed using a pronunciation distinct from the remaining portions of the text. The text-to-speech system uses multiple pronunciation dictionaries to generate and produce speech corresponding to the text, where the identified portions of the text are in a different language or have a different accent from the remainder of the text. Having generated speech corresponding to the text in multiple languages, accents, or dialects, the system combines the portions, then communicates the speech to the text recipient.
    Type: Application
    Filed: August 16, 2019
    Publication date: December 5, 2019
    Inventors: Gregory Pulz, Harry E. Blanchard, Lan Zhang
  • Publication number: 20190334045
    Abstract: According to an embodiment, a method of fabricating a photodiode device may include: growing an epitaxial layer on a first surface of a substrate, wherein the epitaxial layer is first type lightly doped; forming, in the substrate, a first type heavily doped region in contact with the first type lightly doped epitaxial layer; thinning the substrate from a second surface of the substrate opposite to the first surface to expose the first type heavily doped region; patterning the first type heavily doped region from the second surface side of the substrate to form a trench therein, that penetrates through the first type heavily doped region and extends into the epitaxial layer, to serve as a first electrode region of the photodiode device; and forming a second type heavily doped region at bottom of the trench, to serve as a second electrode region of the photodiode device.
    Type: Application
    Filed: September 12, 2017
    Publication date: October 31, 2019
    Inventors: Lan ZHANG, Haifan HU, Xuepeng CAO, Jun LI