Patents by Inventor Lan Zhang

Lan Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190046626
    Abstract: The present invention relates to methods for the recombinant expression of chlamydia major outer membrane protein (MOMP) comprising transforming a population of E. coli host cells with an expression vector comprising a nucleic acid molecule that encodes chlamydia MOMP and encodes a leader sequence for targeting the MOMP to the outer membrane of the cell, wherein the nucleic acid molecule is operatively linked to a promoter. The method of the invention allows expression of MOMP in the outer membrane of the cell, which leads to protein folding that is more like native MOMP relative to a MOMP protein that is expressed intracellularly. Also provided by the invention are uses of the recombinant MOMP in pharmaceutical compositions and methods for the treatment and/or prophylaxis of chlamydia infection and/or the effects thereof.
    Type: Application
    Filed: November 16, 2015
    Publication date: February 14, 2019
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Lan Zhang, Zhiyun Wen, Craig T. Przysiecki, Puneet Khandelwal, Ping Qiu
  • Publication number: 20190031644
    Abstract: The invention relates to flavanone derivatives, and preparation method and use thereof, particularly relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, a preparation method thereof, and use thereof for preventing or treating a mental disorder or a nervous system disease. The compound of the invention exerts significant activity of inhibiting microglial activation and neuroinflammation, can antagonize dopamine D2 receptor, improve the ethological change in multiple animal models for mental disorders, effectively inhibit neuroinflammation and demyelination, and can be used to prevent or treat a mental disorder and a nervous system disease.
    Type: Application
    Filed: January 11, 2017
    Publication date: January 31, 2019
    Applicant: Xuanwu Hospital of Capital Medical University
    Inventors: Lin LI, Hongshun GU, Lan ZHANG, Xi CHEN, Linlin YIN, Ruyi ZHANG, Cuicui YANG
  • Publication number: 20190015804
    Abstract: A hydrogen generator includes a container having a gas outlet that is configured to contain a soluble chemical fuel that reacts with a catalyst to generate hydrogen. A control cylinder is attached to the container and comprises a piston configured to travel axially within the control cylinder, a pole attached to the piston and extending into the container, a catalyst holder provided within the container and connected to the pole, resilient means biasing the catalyst holder towards a bottom of the container, and a gas inlet port. A gas flow line is in fluid communication with the gas outlet and has a first end in fluid communication with the gas inlet port, a second end configured to feed hydrogen to a hydrogen-consuming device, and a two-way valve provided to allow fluid communication between the first and second ends of the gas flow line to be selectably established or cut off.
    Type: Application
    Filed: March 22, 2017
    Publication date: January 17, 2019
    Inventors: Hongquan HE, Siew Hwa CHAN, Ovi Lian DING, Caizhi ZHANG, Lan ZHANG
  • Patent number: 10168867
    Abstract: Devices, systems, and methods for generating a unified menu for multiple communication channels are provided. User interaction information received via the multiple communication channels are transmitted to a central server over a network. The central server also receives notification information or directive information from a source external to the central server. The central server weighs the received information and transforms the weighted information into unified menu options in a unified menu. The unified menu is transmitted to the multiple communication channels, such that same unified menu options are provided at each of the multiple communication channels.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: January 1, 2019
    Assignee: AT&T INTELLECTUAL PROPERTY I, L.P.
    Inventors: Harry E. Blanchard, Lan Zhang, Gregory Pulz
  • Publication number: 20180366598
    Abstract: This disclosure relates to semiconductor devices and methods for fabricating semiconductor devices. Particularly, the disclosure relates to back-contact-only multijunction solar cells and the process flows for making such solar cells, including a wet etch process that removes semiconductor materials non-selectively without major differences in etch rates between heteroepitaxial III-V semiconductor layers.
    Type: Application
    Filed: August 23, 2018
    Publication date: December 20, 2018
    Inventors: Ewelina Lucow, Lan Zhang, Sathya Chary, Ferran Suarez
  • Publication number: 20180349799
    Abstract: In one example, the present disclosure describes a device, computer-readable medium, and method for automatically learning and facilitating interaction routines involving at least one human participant. In one example, a method includes learning an interaction routine conducted between a human user and a second party, wherein the interaction routine comprises a series of prompts and responses designed to identify and deliver desired information, storing a template of the interaction routine based on the learning, wherein the template includes at least a portion of the series of prompts and responses, detecting, in the course of a new instance of the interaction routine, at least one prompt from the second party that requests a response from the human user, and using the template to provide a response to the prompt so that involvement of the human user in the new instance of the interaction routine is minimized.
    Type: Application
    Filed: June 6, 2017
    Publication date: December 6, 2018
    Inventors: HARRY BLANCHARD, Lan Zhang, Gregory Pulz
  • Patent number: 10147528
    Abstract: A non-oriented electrical steel sheet with fine magnetic performance, and a calcium treatment method therefor, including an RH (Ruhrstahl-Heraeus) refinement step. The RH refinement step sequentially comprises a decarbonization step, an aluminum deoxidation step, and a step of adding calcium alloy. In the step of adding calcium alloy, time when the calcium alloy is added satisfies the following condition: time interval between Al and Ca/total time after ?Al=0.2-0.8. In this method, production cost is reduced, the production process is simple, a normal processing cycle of RH refinement is not affected, the device is convenient in operation and is controllable, and foreign substances are controllable in both shape and quantities. The non-oriented electrical steel sheet prepared according to the present invention has fine magnetic performance, and the method can be used for mass production of the non-oriented electrical steel sheet with fine magnetic performance.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: December 4, 2018
    Assignee: Boashan Iron & Steel Co., LTD
    Inventors: Feng Zhang, Xiandong Liu, Shishu Xie, Xuejun Lu, Xiao Chen, Aihua Ma, Peili Zhang, Yanwei Wang, Lan Zhang, Hongxu Hei
  • Publication number: 20180342542
    Abstract: A coplanar electrode photodiode array and a manufacturing method thereof are disclosed. On a top side of a low resistance rate substrate, a high resistance epitaxial silicon wafer, a first conductive type heavily doped region and a second conductive type doped region are formed, which are a cathode and an anode of a photodiode respectively. The structure includes a trench structure formed between the anode and the cathode, the trench structure may be form by a gap, an insulating material, a conductive structure, a reflective material, and ion implantation, and also includes a first conductive type heavily doped region, an insulating isolation layer or a conductive structure with an insulating layer, and the like formed under the anode and the cathode.
    Type: Application
    Filed: August 31, 2016
    Publication date: November 29, 2018
    Inventors: Lan ZHANG, Yuanjing LI, Yinong LIU, Haifan HU, Jun LI
  • Publication number: 20180324029
    Abstract: An alarm information processing method, apparatus, system, and computer storage medium are provided. The method includes receiving alarm information generated by a first node at a first time. It is determined whether the alarm information is a root alarm, and in response to a determination that the alarm information is a root alarm, a plurality of first links comprising the first node are obtained, to generate a first link set. The plurality of first links of the first link set are searched for one or more nodes located before the first node, and alarm information is generated within a first time range before the first time and a second time range after the first time, to obtain a second node. Alarm root source analysis is performed on the second node, and an analysis result is notified.
    Type: Application
    Filed: January 22, 2017
    Publication date: November 8, 2018
    Applicant: TENCENT TECHNOLOGY (SHENZHEN) COMPANY LIMITED
    Inventors: Ziqing ZHAO, Xin NIE, Dingan LIANG, Bo YANG, Haoyu HUANG, Lan ZHANG
  • Publication number: 20180311336
    Abstract: The disclosure relates to influenza virus ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
    Type: Application
    Filed: October 21, 2016
    Publication date: November 1, 2018
    Applicant: Moderna TX, Inc.
    Inventors: Giuseppe Ciaramella, Eric Yi-Chun Huang, Kerim Babaoglu, Jessica Ann Flynn, Lan Zhang
  • Patent number: 10101473
    Abstract: The present disclosure provides a semiconductor detector. The semiconductor detector comprises: a detector crystal including a crystal body, an anode and a cathode; a field enhance electrode for applying a voltage to the detector crystal; an insulating material disposed between the field enhanced electrode and a surface of the detector crystal. The semiconductor detector further comprises a field enhanced electrode circuit board having a bottom connection layer in contact with the surface of the detector crystal and a top layer opposite to the bottom connection layer, wherein the top layer is connected to a high voltage input terminal of the semiconductor detector, and an insulating material is provided between the bottom connection layer and the detector surface of the detector crystal.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: October 16, 2018
    Assignee: Nuctech Company Limited
    Inventors: Lan Zhang, Yingshuai Du, Bo Li, Zonggui Wu, Jun Li, Xuepeng Cao, Haifan Hu, Jianping Gu, Guangming Xu, Bicheng Liu
  • Publication number: 20180284302
    Abstract: The present invention relates to the field of radiation detection, and provides a CdZnTe aerial inspection system and an inspection method. The inspection system comprises a CdZnTe spectrometer (10) and an aircraft (20). The aircraft (20) flies and carries the CdZnTe spectrometer (10) to realize a function of aerial inspection, thereby improving operating efficiency of nuclear radiation monitoring. The CdZnTe spectrometer (10) has high energy resolution, a small volume, a light weight, and desirable portability. By combining the CdZnTe spectrometer (10) and the aircraft (20), the present invention enables high measurement precision, a long operation duration, and an aerial access to a site of a nuclear accident to perform operations and inspect the site, thus reducing radiation exposure received by a person entering the site, and providing support for rescue operation.
    Type: Application
    Filed: August 23, 2016
    Publication date: October 4, 2018
    Inventors: Lan ZHANG, Weizhi WANG, Yingshuai DU, Zonggui WU, Wei ZHANG, Xuming MA, Kun ZHAO, Jun LI
  • Patent number: 10090420
    Abstract: This disclosure relates to semiconductor devices and methods for fabricating semiconductor devices. Particularly, the disclosure relates to back-contact-only multijunction solar cells and the process flows for making such solar cells, including a wet etch process that removes semiconductor materials non-selectively without major differences in etch rates between heteroepitaxial III-V semiconductor layers.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: October 2, 2018
    Assignee: Solar Junction Corporation
    Inventors: Ewelina Lucow, Lan Zhang, Sathya Chary, Ferran Suarez
  • Patent number: 10072072
    Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: September 11, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kalpit A. Vora, Kara S. Cox, Aimin Tang, Zhifeng Chen, Daniel DiStefano, Lan Zhang, Hua-Poo Su
  • Publication number: 20180215809
    Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
    Type: Application
    Filed: March 22, 2018
    Publication date: August 2, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Kalpit A. Vora, Kara S. Cox, Aimin Tang, Zhifeng Chen, Daniel DiStefano, Lan Zhang, Hua-Poo Su
  • Publication number: 20180215808
    Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
    Type: Application
    Filed: March 22, 2018
    Publication date: August 2, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Kalpit A. Vora, Kara S. Cox, Aimin Tang, Zhifeng Chen, Daniel DiStefano, Lan Zhang, Hua-Poo Su
  • Publication number: 20180215810
    Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
    Type: Application
    Filed: March 22, 2018
    Publication date: August 2, 2018
    Applicant: Merck Sharp & Dahme Corp.
    Inventors: Kalpit A. Vora, Kara S. Cox, Aimin Tang, Zhifeng Chen, Daniel DiStefano, Lan Zhang, Hua-Poo Su
  • Patent number: 10028913
    Abstract: The present invention relates to a liposomal pharmaceutical preparation containing a multivalent ionic drug, a process for the preparation of the liposomal pharmaceutical preparation, and a use thereof in the treatment of diseases, in which the liposome has a size of about 30-80 nm, and the phospholipid bilayer has a phospholipid with a Tm higher than body temperature, so that the phase transition temperature of the liposome is higher than the body temperature.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: July 24, 2018
    Assignee: CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD
    Inventors: Chunlei Li, Jinxu Wang, Caixia Wang, Yanhui Li, Dongmin Shen, Wenmin Guo, Li Zhang, Lan Zhang
  • Publication number: 20180153493
    Abstract: The present disclosure provides a method for recognizing an article using a multi-energy spectrum X-ray imaging system and a multi-energy spectrum X-ray imaging system. The method comprises: recognizing an application scenario and/or priori information of the article; selecting a parameter mode suitable for the article from a plurality of parameter modes stored in the multi-energy spectrum X-ray imaging system based on the recognized application scenario and/or priori information; and recognizing the article using the selected parameter mode, wherein the plurality of parameter modes are obtained by optimizing system parameters of the multi-energy spectrum X-ray imaging system under a specific condition using a training sample library for various articles.
    Type: Application
    Filed: September 29, 2017
    Publication date: June 7, 2018
    Inventors: Guangming XU, Bicheng LIU, Ziran ZHAO, Lan ZHANG, Jianping GU
  • Patent number: 9963500
    Abstract: The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: May 8, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kalpit A. Vora, Kara S. Cox, Aimin Tang, Zhifeng Chen, Daniel DiStefano, Lan Zhang, Hua-Poo Su