Abstract: The specification generally relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where R1, R2A, R2B, R2C, R2D, W, X, Y, and Z have the meanings defined herein. Such compounds are useful in inhibiting NLRP3 inflammasome activity and may be useful as therapeutic agents. The specification also relates to the use of such compounds to treat or prevent diseases and conditions in which the NLRP3 inflammasome is implicated. The specification further relates to compositions comprising such compounds.

Abstract: This invention relates to combination therapies comprising a cyclin dependent kinase 4 (CDK4) inhibitor of Formula (I) or a pharmaceutically acceptable salt thereof, and an antiandrogen, optionally in further combination with an additional anti-cancer agent, and associated methods of treatment, pharmaceutical compositions, and uses thereof.

Abstract: This disclosure describes an artificial reality system that presents artificial reality content or artificial reality effects based on, or in response to, interactions with one or more physical objects within a physical environment. In one example, this disclosure describes a method that includes determining that a user has performed a trigger action on a trigger object; responsive to determining that the user has performed the trigger action, generating artificial reality content; presenting the artificial reality content on a display associated with a head-mounted display; determining that the user has performed a de-trigger action; and responsive to determining that the user has performed the de-trigger action, discontinuing presentation of the artificial reality content.

Abstract: This disclosure describes an artificial reality system that presents artificial reality content or artificial reality effects based on, or in response to, interactions with one or more physical objects within a physical environment. In one example, this disclosure describes a method that includes determining that a user has performed a trigger action on a trigger object; responsive to determining that the user has performed the trigger action, generating artificial reality content; presenting the artificial reality content on a display associated with a head-mounted display; determining that the user has performed a de-trigger action; and responsive to determining that the user has performed the de-trigger action, discontinuing presentation of the artificial reality content.

Abstract: A wearable local muscle vibratory stimulator includes a frame including a concave surface for conforming to a treatment surface of a subject. The stimulator further includes an electromagnetic oscillator located in the frame for applying vibratory stimulus to a treatment region of the subject located beneath the treatment surface. The stimulator further includes a waveform generator coupled to the oscillator for generating an electrical signal that causes the electromagnetic oscillator to oscillate. The stimulator further includes an accelerometer coupled to the oscillator for measuring frequency and acceleration of oscillation of the oscillator. The stimulator further includes a controller user interface for receiving user input regarding a desired frequency and acceleration of oscillation of the oscillator.

Abstract: The specification generally relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where R1, R2A, R2B, R2C, R2D, W, X, Y, and Z have the meanings defined herein. Such compounds are useful in inhibiting NLRP3 inflammasome activity and may be useful as therapeutic agents. The specification also relates to the use of such compounds to treat or prevent diseases and conditions in which the NLRP3 inflammasome is implicated. The specification further relates to compositions comprising such compounds.

Abstract: An active backboard that can assist with adjusting a patient on the backboard to ensure that the backboard is correctly aligned for a compression mechanism of an upper portion of a mechanical cardiopulmonary resuscitation (CPR) device to perform compressions. The active backboard can also include multiple layers that can slide or move relative to each other to move the patient relative to the backboard. The active backboard can include roller bars, a wheel, and/or projections to assist with moving a patient relative to the backboard.

Abstract: Techniques and devices for extending a piston and/or compression unit, for example connected to a medical device such as a mechanical CPR device, to accommodate different sized patients, are described herein. In some cases, a piston of a mechanical CPR device may include an inner piston at least partially slidable into an external piston sleeve. In one aspect, some aspects, the piston includes sleeves which can move relative to each other to extend the piston. In additional aspects, the compression mechanism may also extend downward toward the patient. In all aspects, the change in length of the piston may be detected and used to modify movement of the piston, for example to more safely perform mechanical CPR.

Abstract: A virtual reality (VR) system is described that enables users to create, model, and visualize augmented reality experiences at physical, real-world locations, without needing to physically be at the location for which the augmented experience is being modeled. In one example, the VR system includes a head-mounted device (HMD), an augmented reality content development system, and a rendering engine. The HMD is configured to output VR content representing a physical environment for an augmented reality experience. The augmented reality content development system is configured to identify, based on an input, augmented reality content with which to augment the physical environment for the augmented reality experience. The rendering engine is configured to render, via the HMD, the VR content representing the physical environment, augmented with the augmented reality content.

Abstract: An apparatus for repairing a metal sheet and method of operating the same are provided. The apparatus includes: a base unit including: a frame and an attachment feature on the frame, a cutting unit removably attachable to the base unit to cut out a damaged portion of the metal sheet, and a welding unit removably attachable to the base unit. The cutting unit includes: a cutting arm including a cutting blade, and a motor for operating the cutting arm. The welding unit includes: a fixed platform, a weld movement motor for moving a moveable platform on the fixed platform, and a welding assembly, attached to the moveable platform, to automatically weld a replacement piece to the metal sheet. In operation, the frame is continuously attached to the metal sheet during cutting of the damaged portion and welding of the replacement piece, providing a stable and repeatable frame of reference.

Abstract: This disclosure describes an artificial reality system that presents artificial reality content or artificial reality effects based on, or in response to, interactions with one or more physical objects within a physical environment. In one example, this disclosure describes a method that includes determining that a user has performed a trigger action on a trigger object; responsive to determining that the user has performed the trigger action, generating artificial reality content; presenting the artificial reality content on a display associated with a head-mounted display; determining that the user has performed a de-trigger action; and responsive to determining that the user has performed the de-trigger action, discontinuing presentation of the artificial reality content.

Abstract: Disclosed herein includes a system, a method, and a device for interacting with displayed items. A contact point can be established with a surface of a contact panel and the contact panel can be operated in a navigation mode during which a selection element, for selecting one or more items of a user interface (UI) in a display of a second device, is maintained at a determined location in the display. The UI can be moved in the display relative to the selection element as the selection element is maintained at the determined location, by moving the contact point on the surface of the contact panel in the navigation mode. At least one item of the UI that is moved within a selection threshold of the selection element can be selected by removing the contact point with the contact panel.

Abstract: This disclosure describes an artificial reality system that presents artificial reality content or artificial reality effects based on, or in response to, interactions with one or more physical objects within a physical environment. In one example, this disclosure describes a method that includes determining that a user has performed a trigger action on a trigger object; responsive to determining that the user has performed the trigger action, generating artificial reality content; presenting the artificial reality content on a display associated with a head-mounted display; determining that the user has performed a de-trigger action; and responsive to determining that the user has performed the de-trigger action, discontinuing presentation of the artificial reality content.

Abstract: This disclosure describes an artificial reality system that presents artificial reality content or artificial reality effects based on, or in response to, interactions with one or more physical objects within a physical environment. In one example, this disclosure describes a method that includes determining that a user has performed a trigger action on a trigger object; responsive to determining that the user has performed the trigger action, generating artificial reality content; presenting the artificial reality content on a display associated with a head-mounted display; determining that the user has performed a de-trigger action; and responsive to determining that the user has performed the de-trigger action, discontinuing presentation of the artificial reality content.

Abstract: This invention relates to combination therapies comprising a cyclin dependent kinase (CDK) inhibitor that inhibits CDK4 and/or CDK6, and a bromodomain and extra-terminal domain (BET) family inhibitor, and associated pharmaceutical compositions, methods of treatment, and pharmaceutical uses.

Abstract: A mechanism attached to a mechanical CPR device can be automatically attached to the patient's torso. The mechanical CPR device can extend the mechanism to a first position at which the mechanism comes into contact with the patient's torso. The mechanism can be further extended until a first threshold is reached. The mechanism can be retracted to the first position. The mechanism can be further retracted from the first position until a second threshold is exceeded. The mechanism can then be extended to a second point at which the second threshold is no longer exceeded. The mechanism may comprise a suction cup or sticker plate, and may be attached to an end of a piston of the mechanical CPR device.

Abstract: An apparatus for repairing a metal sheet and method of operating the same are provided. The apparatus includes: a base unit including: a frame and an attachment feature on the frame, a cutting unit removably attachable to the base unit to cut out a damaged portion of the metal sheet, and a welding unit removably attachable to the base unit. The cutting unit includes: a cutting arm including a cutting blade, and a motor for operating the cutting arm. The welding unit includes: a fixed platform, a weld movement motor for moving a moveable platform on the fixed platform, and a welding assembly, attached to the moveable platform, to automatically weld a replacement piece to the metal sheet. In operation, the frame is continuously attached to the metal sheet during cutting of the damaged portion and welding of the replacement piece, providing a stable and repeatable frame of reference.

Abstract: A method for displaying a screen on an electronic device is provided. The method includes displaying, on a display of the electronic device, a first screen configured with a plurality of areas in which a plurality of contents are respectively displayed in a plurality of rows, and displaying, if an area is selected from among the plurality of areas, a second screen configured with one or more recommended item areas in which information related to content corresponding to the selected area is arranged.

Abstract: The disclosed method may include (1) sensing, via a depth-sensing subsystem, a plurality of locations in three-dimensional space corresponding to physical surfaces in a real-world environment, (2) determining a dominant plane within the real-world environment, (3) defining a three-dimensional grid that is aligned with the dominant plane, (4) identifying, based on the plurality of locations relative to the dominant plane, a set of grid coordinates within the three-dimensional grid that are indicative of the physical surfaces, and (5) determining, based on the set of grid coordinates, a safety boundary to be employed by a head-mounted display system to notify a user of the head-mounted display system of the user's proximity to the physical surfaces. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A back plate for use with a CPR compression device can include first and second static attachment elements configured on first and second sides, respectively, to releasably connect to first and second legs, respectively. In addition, a bottom surface of the back plate can include a plurality of ribs that run from the first side to the second side in parallel to the third and fourth sides. The back plate also includes a hollow portion between the upper and bottom surfaces and the first, second, third, and fourth sides, and the ribs and third and fourth sides provide structural rigidity to the back plate. A plurality of openings along the third and fourth sides may be configured for strapping the back plate to a patient. Grooves may be configured on the top surface to hide sink marks on the top surface caused by the ribs on the bottom surface.