Abstract: Provided are multivalent saccharide-containing compounds which are bonded to nucleic acids. These compounds contain a shikimic acid-derived core and are useful for delivering nucleic acids to cells or tissues, e.g. for use in therapeutic treatments. Also provided are pharmaceutical compositions comprising the aforementioned compounds and medical uses of the same, including their use in treating or preventing conditions such as liver diseases.

Abstract: This disclosure describes an artificial reality system that presents artificial reality content or artificial reality effects based on, or in response to, interactions with one or more physical objects within a physical environment. In one example, this disclosure describes a method that includes determining that a user has performed a trigger action on a trigger object; responsive to determining that the user has performed the trigger action, generating artificial reality content; presenting the artificial reality content on a display associated with a head-mounted display; determining that the user has performed a de-trigger action; and responsive to determining that the user has performed the de-trigger action, discontinuing presentation of the artificial reality content.

Abstract: Provided are multivalent saccharide-containing compounds which are bonded to nucleic acids. These compounds comprise one or more nitrogen-modified phosphate groups which link the cargo moieties (e.g., therapeutic nucleic acids) and/or the ligands (e.g., GalNAc) to the core of the complex. The compounds are useful for delivering nucleic acids to cells or tissues, e.g. for use in therapeutic treatments. Also provided are pharmaceutical compositions comprising the aforementioned compounds and medical uses of the same, including their use in treating or preventing conditions such as liver diseases.

Abstract: A process for purifying a crude methyl methacrylate (MMA) stream is described, typically from one or more depolymerised (co)polymers comprising methyl methacrylate (MMA). The stream comprises MMA at a level of at least 80 wt % and ethyl acrylate (EA). The process includes the steps of:— fractionally crystallising the said MMA stream to provide a fractionally crystallised MMA stream having a reduced EA content relative to the MMA stream immediately prior to fractional crystallisation.

Abstract: This disclosure describes an artificial reality system that presents artificial reality content or artificial reality effects based on, or in response to, interactions with one or more physical objects within a physical environment. In one example, this disclosure describes a method that includes determining that a user has performed a trigger action on a trigger object; responsive to determining that the user has performed the trigger action, generating artificial reality content; presenting the artificial reality content on a display associated with a head-mounted display; determining that the user has performed a de-trigger action; and responsive to determining that the user has performed the de-trigger action, discontinuing presentation of the artificial reality content.

Abstract: The specification generally relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where R1, R2A, R2B, R2C, R2D, W, X, Y, and Z have the meanings defined herein. Such compounds are useful in inhibiting NLRP3 inflammasome activity and may be useful as therapeutic agents. The specification also relates to the use of such compounds to treat or prevent diseases and conditions in which the NLRP3 inflammasome is implicated. The specification further relates to compositions comprising such compounds.

Abstract: A piston assembly with a transversely removable suction cup, the piston assembly having a piston rod, a flange at an end of the piston rod, and a suction cup removably secured to the end of the piston rod. The piston rod has a longitudinal axis defining a longitudinal direction and a transverse direction that is substantially perpendicular to the longitudinal direction. The flange has a width in the transverse direction that is greater than a width of the piston rod in the transverse direction. The suction cup includes a receptacle configured to accept and secure the flange within the receptacle. The receptacle has an opening allowing the flange to be accepted into the receptacle in the transverse direction and to be removed from the receptacle in the transverse direction.

Abstract: The specification generally relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where R1, R2A, R2B, R2C, R2D, W, X, Y, and Z have the meanings defined herein. Such compounds are useful in inhibiting NLRP3 inflammasome activity and may be useful as therapeutic agents. The specification also relates to the use of such compounds to treat or prevent diseases and conditions in which the NLRP3 inflammasome is implicated. The specification further relates to compositions comprising such compounds.

Abstract: This disclosure describes an artificial reality system that presents artificial reality content or artificial reality effects based on, or in response to, interactions with one or more physical objects within a physical environment. In one example, this disclosure describes a method that includes determining that a user has performed a trigger action on a trigger object; responsive to determining that the user has performed the trigger action, generating artificial reality content; presenting the artificial reality content on a display associated with a head-mounted display; determining that the user has performed a de-trigger action; and responsive to determining that the user has performed the de-trigger action, discontinuing presentation of the artificial reality content.

Abstract: This disclosure describes an artificial reality system that presents artificial reality content or artificial reality effects based on, or in response to, interactions with one or more physical objects within a physical environment. In one example, this disclosure describes a method that includes determining that a user has performed a trigger action on a trigger object; responsive to determining that the user has performed the trigger action, generating artificial reality content; presenting the artificial reality content on a display associated with a head-mounted display; determining that the user has performed a de-trigger action; and responsive to determining that the user has performed the de-trigger action, discontinuing presentation of the artificial reality content.

Abstract: A wearable local muscle vibratory stimulator includes a frame including a concave surface for conforming to a treatment surface of a subject. The stimulator further includes an electromagnetic oscillator located in the frame for applying vibratory stimulus to a treatment region of the subject located beneath the treatment surface. The stimulator further includes a waveform generator coupled to the oscillator for generating an electrical signal that causes the electromagnetic oscillator to oscillate. The stimulator further includes an accelerometer coupled to the oscillator for measuring frequency and acceleration of oscillation of the oscillator. The stimulator further includes a controller user interface for receiving user input regarding a desired frequency and acceleration of oscillation of the oscillator.

Abstract: The specification generally relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where R1, R2A, R2B, R2C, R2D, W, X, Y, and Z have the meanings defined herein. Such compounds are useful in inhibiting NLRP3 inflammasome activity and may be useful as therapeutic agents. The specification also relates to the use of such compounds to treat or prevent diseases and conditions in which the NLRP3 inflammasome is implicated. The specification further relates to compositions comprising such compounds.

Abstract: An active backboard that can assist with adjusting a patient on the backboard to ensure that the backboard is correctly aligned for a compression mechanism of an upper portion of a mechanical cardiopulmonary resuscitation (CPR) device to perform compressions. The active backboard can also include multiple layers that can slide or move relative to each other to move the patient relative to the backboard. The active backboard can include roller bars, a wheel, and/or projections to assist with moving a patient relative to the backboard.

Abstract: Techniques and devices for extending a piston and/or compression unit, for example connected to a medical device such as a mechanical CPR device, to accommodate different sized patients, are described herein. In some cases, a piston of a mechanical CPR device may include an inner piston at least partially slidable into an external piston sleeve. In one aspect, some aspects, the piston includes sleeves which can move relative to each other to extend the piston. In additional aspects, the compression mechanism may also extend downward toward the patient. In all aspects, the change in length of the piston may be detected and used to modify movement of the piston, for example to more safely perform mechanical CPR.

Abstract: An apparatus for repairing a metal sheet and method of operating the same are provided. The apparatus includes: a base unit including: a frame and an attachment feature on the frame, a cutting unit removably attachable to the base unit to cut out a damaged portion of the metal sheet, and a welding unit removably attachable to the base unit. The cutting unit includes: a cutting arm including a cutting blade, and a motor for operating the cutting arm. The welding unit includes: a fixed platform, a weld movement motor for moving a moveable platform on the fixed platform, and a welding assembly, attached to the moveable platform, to automatically weld a replacement piece to the metal sheet. In operation, the frame is continuously attached to the metal sheet during cutting of the damaged portion and welding of the replacement piece, providing a stable and repeatable frame of reference.

Abstract: A virtual reality (VR) system is described that enables users to create, model, and visualize augmented reality experiences at physical, real-world locations, without needing to physically be at the location for which the augmented experience is being modeled. In one example, the VR system includes a head-mounted device (HMD), an augmented reality content development system, and a rendering engine. The HMD is configured to output VR content representing a physical environment for an augmented reality experience. The augmented reality content development system is configured to identify, based on an input, augmented reality content with which to augment the physical environment for the augmented reality experience. The rendering engine is configured to render, via the HMD, the VR content representing the physical environment, augmented with the augmented reality content.

Abstract: This disclosure describes an artificial reality system that presents artificial reality content or artificial reality effects based on, or in response to, interactions with one or more physical objects within a physical environment. In one example, this disclosure describes a method that includes determining that a user has performed a trigger action on a trigger object; responsive to determining that the user has performed the trigger action, generating artificial reality content; presenting the artificial reality content on a display associated with a head-mounted display; determining that the user has performed a de-trigger action; and responsive to determining that the user has performed the de-trigger action, discontinuing presentation of the artificial reality content.

Abstract: Disclosed herein includes a system, a method, and a device for interacting with displayed items. A contact point can be established with a surface of a contact panel and the contact panel can be operated in a navigation mode during which a selection element, for selecting one or more items of a user interface (UI) in a display of a second device, is maintained at a determined location in the display. The UI can be moved in the display relative to the selection element as the selection element is maintained at the determined location, by moving the contact point on the surface of the contact panel in the navigation mode. At least one item of the UI that is moved within a selection threshold of the selection element can be selected by removing the contact point with the contact panel.

Abstract: This disclosure describes an artificial reality system that presents artificial reality content or artificial reality effects based on, or in response to, interactions with one or more physical objects within a physical environment. In one example, this disclosure describes a method that includes determining that a user has performed a trigger action on a trigger object; responsive to determining that the user has performed the trigger action, generating artificial reality content; presenting the artificial reality content on a display associated with a head-mounted display; determining that the user has performed a de-trigger action; and responsive to determining that the user has performed the de-trigger action, discontinuing presentation of the artificial reality content.

Abstract: This disclosure describes an artificial reality system that presents artificial reality content or artificial reality effects based on, or in response to, interactions with one or more physical objects within a physical environment. In one example, this disclosure describes a method that includes determining that a user has performed a trigger action on a trigger object; responsive to determining that the user has performed the trigger action, generating artificial reality content; presenting the artificial reality content on a display associated with a head-mounted display; determining that the user has performed a de-trigger action; and responsive to determining that the user has performed the de-trigger action, discontinuing presentation of the artificial reality content.