Abstract: Disclosed herein are azetidinyl compounds of formula I, as described herein, pharmaceutical compositions comprising an azetidinyl compound, and a method of using an azetidinyl compound in the treatment or prophylaxis of a melanin-concentrating hormone related disease or condition.

Abstract: The present invention relates to a combination comprising compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein, and an additional active agent. The present invention also relates to pharmaceutical compositions comprising these combinations, and methods of using these combinations to treat various diseases and disorders.

Abstract: The present invention relates to combination therapy using compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein and an additional pharmaceutically active agent. The invention also relates to pharmaceutical compositions comprising these combinations, and methods of using these combinations in the treatment of various diseases and disorders.

Abstract: Disclosed herein are azetidinyl compounds of formula I, as described herein, pharmaceutical compositions comprising an azetidinyl compound, and a method of using an azetidinyl compound in the treatment or prophylaxis of a melanin-concentrating hormone related disease or condition.

Abstract: The present invention provides humanized anti-human IFN-? monoclonal antibodies useful for therapeutic applications in humans. Preferred antibodies are humanized versions of murine antibodies ACO-1 and ACO-2, as well as variants thereof.

Abstract: The invention relates to 5,6-dihydropyrrolo[2,1-?]isoquinoline and pyrrolo[2,1-?]isoquinoline derivatives according to general formula (I) or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of infertility.

Abstract: The present invention provides humanized anti-human IFN-? monoclonal antibodies useful for therapeutic applications in humans. Preferred antibodies are humanized versions of murine antibodies ACO-1 and ACO-2, as well as variants thereof.

Abstract: It is disclosed a method comprising receiving, prior to a handover operation, first key indication information, creating, prior to the handover operation, key information based on the received first key indication information, retaining the created key information, sending, after the handover operation, the received first key indication information associated with the key information created prior to the handover operation, and retrieving, after the handover operation, the retained key information based on the first key indication information; and a method comprising generating, prior to the handover operation, the first key indication information associated with key information intended to be created, sending, prior to the handover operation, the generated first key indication information, and receiving, after the handover operation, second key indication information corresponding to the generated first key indication information.

Abstract: The present invention relates to a microfabricated device for metering an analyte comprising a nucleic acid sequence into a plurality of parallel reaction chambers for nucleic acid sequence amplification. The present invention further provides a method of metering an analyte into a plurality of parallel reaction units of an integrated microfabricated device.

Abstract: The present invention provides humanized anti-human IFN-? monoclonal antibodies useful for therapeutic applications in humans. Preferred antibodies are humanized versions of murine antibodies ACO-1 and ACO-2, as well as variants thereof.

Abstract: The present invention provides humanized anti-human IFN-? monoclonal antibodies useful for therapeutic applications in humans. Preferred antibodies are humanized versions of murine antibodies ACO-1 and ACO-2, as well as variants thereof.

Abstract: In a non-limiting and exemplary embodiment, a method is provided for arranging authentication of mobility related signalling messages in a mobile communications system. An authentication code is generated on the basis of a previous authentication code stored in connection with a preceding authentication code generation event. The newly generated authentication code is stored for subsequent authentication code generation event. In response to change of the mobile device to an access network of the network entity, a control message comprising the authentication code is transmitted from a mobile device to a first network entity, for verifying the authentication code by the first network entity or by a second network entity of a previous access system.

Abstract: The present invention relates to a blister pack for pharmaceutical use comprising blisters containing a solid dosage form of desmopressin, or a pharmaceutically acceptable salt thereof, and to said solid dosage form. In one embodiment it specifically relates to a blister pack for pharmaceutical use comprising blisters containing a solid dosage form of desmopressin, or a pharmaceutically acceptable salt thereof, in association with a pharmaceutically acceptable adjuvant, diluent and/or carrier, wherein said solid dosage form is adapted to prevent moisture related degradation of said desmopressin.

Abstract: Disclosed herein are compounds of formula I in which R1, R2, R3, R4, R5, A, X, Y are as described in the specification, their use in pharmaceutical compositions and in methods of treatment or prophylaxis of a melanin-concentrating hormone related disease or condition.

Abstract: Disclosed herein are azetidinyl compounds of formula I, as described herein, pharmaceutical compositions comprising an azetidinyl compound, and a method of using an azetidinyl compound in the treatment or prophylaxis of a melanin-concentrating hormone related disease or condition.

Abstract: The present invention provides humanized anti-human IFN-? monoclonal antibodies useful for therapeutic applications in humans. Preferred antibodies are humanized versions of murine antibodies ACO-1 and ACO-2, as well as variants thereof.

Abstract: It is disclosed a method comprising receiving, prior to a handover operation, first key indication information, creating, prior to the handover operation, key information based on the received first key indication information, retaining the created key information, sending, after the handover operation, the received first key indication information associated with the key information created prior to the handover operation, and retrieving, after the handover operation, the retained key information based on the first key indication information; and a method comprising generating, prior to the handover operation, the first key indication information associated with key information intended to be created, sending, prior to the handover operation, the generated first key indication information, and receiving, after the handover operation, second key indication information corresponding to the generated first key indication information.

Abstract: The present invention relates to dihydropyridine derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, phenyl, (1-5C)heteroaryl R2, R3 are independently (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (24C)alkenyloxy, (2-4C)alkynyloxy, halogen X is SO2, CH2, C(O) or X is absent R4 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (3-6C)cycloalkyl, (3-6C)cycloalkenyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl, (2-6C)heterocycloalkyl(14C)alkyl, (6-1 OC)aryl, (6-10C)aryl(1-4C)alkyl, (1-9C)heteroaryl or (1-9C)heteroaryl(14C)alkyl. The compounds are useful for the treatment of fertility disorders.

Abstract: A method, apparatus and computer program product are provided to provide cryptographical key separation for handovers. A method is provided which includes calculating a key based at least in part upon a previously stored first intermediary value. The method also includes calculating a second intermediary value based at least in part upon the calculated key. The method additionally includes sending a path switch acknowledgement including the second intermediary value to a target access point. The method may further include receiving a path switch message including an indication of a cell identification and calculating the encryption key based upon the indication of the cell identification. The method may further include storing the second intermediary value. The calculation of the key may further comprise calculating the key following a radio link handover. Corresponding apparatuses and computer program products are also provided.

Abstract: A method, apparatus and computer program product are provided to provide fresh security context during intersystem mobility. A method is provided which includes receiving an indication of handover of a remote device from a source system to a target system. The target system may implement a communications standard different from that of the source system. The method also includes determining a current sequence number value of a security context maintained in the source system. The method additionally includes deriving a fresh mapped security context for the target system based at least in part upon the determined sequence number value. The method further includes providing the derived fresh mapped security context to the target system.