Abstract: A system and method for adjusting or controlling at least one milling operating feature of a cutting mill assembly within a wellbore includes sensing at least one milling operating parameter with a sensor that is operably associated with the cutting mill assembly that is run into the wellbore. At least one milling operating feature of the cutting mill assembly is adjusted or controlled in response to the at least one milling operating parameter that is sensed.

Abstract: A system and method for orienting a tool in a near vertical wellbore. The system includes a tool string having a whipstock at an end thereof, at least two magnetometers oriented transverse to a longitudinal axis of the tool string, and a processor. A first set of magnetic measurements of the earths' magnetic field is obtained during rotation of the tool using a first of the at least two magnetometers and a second set of magnetic measurements of the earth's magnetic field is obtained during rotation using a second of the at least two magnetometers. The processor fits a curve to the first and second sets of magnetic measurements to determine a peak value, determines magnetic north from the determined peak value, determines a toolface orientation of the drill string with respect to the determined magnetic north, and anchors the whipstock at the selected depth and toolface orientation.

Abstract: A multiple chip multiprocessor cache coherence operation method and a multiple chip multiprocessor are disclosed. The method includes: receiving a write request for a first data block; finding, in an on-chip directory of the first processor chip, an on-chip directory entry corresponding to the first data block based on an identifier of the first data block, determining, from the found on-chip directory entry, a core identifier of a processor core storing the first data block, sending, to the processor core corresponding to the core identifier, an instruction message for deleting the first data block, skipping sending an inter-chip directory query request for the first data block, and instructing the first processor core to write the to-be-written data into a private cache of the first processor core.

Abstract: A method and a device for providing a global clock in a system, the terminals in the system are channel connected to each other via paths, each terminal is communicatively connected to a clock source ultimately via a signal recording unit, respectively, the clock source sends a calibration signal to the network, the signal recording unit records the current transmitting time T (0) of the calibration signal, each terminal will receive the calibration signal sequentially due to different distances from the clock source and will return the signal, the backward signals are returned to the signal recording unit along the network sequentially, and the signal recording unit records the time T (n) of each backward signal sequentially, in this way, the signal recording unit can then measure the delay between each terminal and the clock source signal, which can be used as a correction parameter to ensure that all terminals are in exactly the same time reference, in addition, in this way, there is no need to control the

Abstract: Provided are anti-GM-CSF antibodies or fragments thereof including humanized antibodies and fragments. Also provided are uses of the antibodies and fragments for therapeutic, diagnostic and prognostic purposes. Therapeutic uses of the antibodies and fragments, for example include the treatment of inflammatory and autoimmune diseases and disorders.

Abstract: Provided are anti-GM-CSF antibodies or fragments thereof including humanized antibodies and fragments. Also provided are uses of the antibodies and fragments for therapeutic, diagnostic and prognostic purposes. Therapeutic uses of the antibodies and fragments, for example include the treatment of inflammatory and autoimmune diseases and disorders.

Abstract: Provided are anti-PD-L1 antibodies or fragments thereof. The antibodies or fragments thereof specifically bind to the immunoglobulin C domain of the PD-L1 protein. In various example, the antibodies or fragments thereof include a VH CDR1 of SEQ ID NO: 1, a VH CDR2 of SEQ ID NO: 2, a VH CDR3 of SEQ ID NO: 3, a VL CDR1 of SEQ ID NO: 4, a VL CDR2 of SEQ ID NO: 5, and a VL CDR3 of SEQ ID NO: 6, or variants of each thereof. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and infectious diseases are also provided.

Abstract: Provided are anti-PD-L1 antibodies or fragments thereof. The antibodies or fragments thereof specifically bind to the immunoglobulin C domain of the PD-L1 protein. In various example, the antibodies or fragments thereof include a VH CDR1 of SEQ ID NO: 1, a VH CDR2 of SEQ ID NO: 2, a VH CDR3 of SEQ ID NO: 3, a VL CDR1 of SEQ ID NO: 4, a VL CDR2 of SEQ ID NO: 5, and a VL CDR3 of SEQ ID NO: 6, or variants of each thereof. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and infectious diseases are also provided.

Abstract: Provided are anti-PD-L1 antibodies or fragments thereof. The antibodies or fragments thereof specifically bind to the immunoglobulin C domain of the PD-L1 protein. In various example, the antibodies or fragments thereof include a VH CDR1 of SEQ ID NO: 1, a VH CDR2 of SEQ ID NO: 2, a VH CDR3 of SEQ ID NO: 3, a VL CDR1 of SEQ ID NO: 4, a VL CDR2 of SEQ ID NO: 5, and a VL CDR3 of SEQ ID NO: 6, or variants of each thereof. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and infectious diseases are also provided.

Abstract: A method and apparatus for locating a collar of a casing of a wellbore is disclosed. A sensor for measuring a magnetic field is conveyed through the casing on a tool string. A physical model is formed of a process of obtaining a magnetic measurement of the casing with the sensor. A simulation of the physical model is run through a processor to select a design parameter of the tool that allows for using the sensor at a determined value of an operational parameter for obtaining the measurement at a selected signal-to-noise ratio. The tool is conveyed into the wellbore and the sensor set to the determined value of the operational parameter. The magnetic measurement of the casing is obtained using the sensor, and the collar is located using the obtained magnetic measurement.

Abstract: A Lateral Diffusion Metal Oxide Semiconductor (LDMOS) device and its manufacturing method are presented. The LDMOS device comprises a first region that has a first conductivity type; a drift region that has a second conductivity type in the first region, wherein the second conductivity type is opposite to the first conductivity type; and a plurality of second regions that have the first conductivity type in the drift region, wherein the second regions are separated from each other and extend to the first region along a depth direction of the drift region. This LDMOS device has an higher Breakdown Voltage and thus better performance than conventional LDMOS devices.

Abstract: Provided are anti-PD-L1 antibodies or fragments thereof. The antibodies or fragments thereof specifically bind to the immunoglobulin C domain of the PD-L1 protein. In various example, the antibodies or fragments thereof include a VH CDR1 of SEQ ID NO: 1, a VH CDR2 of SEQ ID NO: 2, a VH CDR3 of SEQ ID NO: 3, a VL CDR1 of SEQ ID NO: 4, a VL CDR2 of SEQ ID NO: 5, and a VL CDR3 of SEQ ID NO: 6, or variants of each thereof. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and infectious diseases are also provided.

Abstract: The present disclosure relates to synthesis of porous polymer networks and applications of such materials.

Abstract: A bottom hole assembly (BHA) contains a motor and a section mill for milling in an uphole direction after blade extension with circulating fluid through the BHA. Below the section mill is sensing equipment to detect location of a bridge formed by the cuttings or swarf from the section mill. A secondary mill oriented for cutting in a downhole direction is located at the bottom of the BHA for use in removal of the bridge. The sensing equipment delivers in real time data as to the density of the bridge so that decisions to interrupt the section milling and to lower the secondary mill to the bridge can be made in real time. Cement is pumped and displaced by a wiper plug to plug and abandon the hole.

Abstract: A milling and scraping tool for preparing a borehole to be plugged includes a tool body including a first end, a second end, and an intermediate portion extending therebetween and a milling system arranged between the first end and the second end. The milling system includes one or more selectively deployable milling blades. The one or more selectively deployable milling blades is shiftable between a retracted position and a deployed position. A scraping system IS arranged on the tool body. The scraping system includes a plurality of selectively deployable scraping blades selectively deployable from a retracted position to a deployed position.

Abstract: Embodiments of the present disclosure disclose a method for combining entries, including: determining N to-be-combined entries, where a cache block indicated by an entry label of each entry of the N entries belongs to a combination range, and the combination range indicates 2a cache blocks; and combining the N entries into a first entry, where an entry label of the first entry indicates the 2a cache blocks, and a sharer number of the first entry includes a sharer number of each entry of the N entries. According to the method, entries in a directory can be combined effectively, thereby improving directory usage efficiency.

Abstract: A data transmission and control device in a multi-node sensor network, comprising a processing control module (110). The processing control module (110) comprises an instruction processing unit, a data processing unit, at least one group of first-type interfaces (J101-J10n), at least one group of second-type interfaces (J201-J20n), one group of fifth-type interfaces (J500) and one group of sixth-type interfaces (J600). The fifth-type interfaces (J500) have communication connections with an external control device (120). The first-type interfaces (J101-J10n) respectively have communication connections with a sensor (140) so as to cooperate with the instruction processing unit to configure and query a parameter of the sensor (140), and to upgrade firmware and report feedback information of the sensor (140) and the processing control module.

Abstract: The Bacterial cocaine esterase (CocE) mutants disclosed herein each have enhanced catalytic efficiency for (?)-cocaine, as compared to CocE mutants in the prior art, including CocE mutant E172-173. The presently-disclosed subject matter further includes a pharmaceutical composition including a mutant of bacterial cocaine hydrolase, as described herein, and a suitable pharmaceutical carrier. The presently-disclosed subject matter further includes a method of treating a cocaine-induced condition comprising administering to an individual an effective amount of a mutant of bacterial cocaine hydrolase variant, as disclosed herein, to accelerate cocaine metabolism and produce biologically inactive metabolites.

Abstract: The disclosed subject matter provides an LDMOS device and fabrication method thereof. In an LDMOS device, a drift region and a body region are formed in a substrate. A first trench is formed in the drift region and in the substrate between the drift region and the body region. The first trench is separated from the drift region by a first shallow trench isolation structure. A gate dielectric layer is formed on a side surface and a bottom surface of the first trench. A gate electrode filling up the first trench is formed on the gate dielectric layer with a top surface above a top surface of the semiconductor substrate. A source region is formed in the body region on one side of the gate electrode and a drain region is formed in the drift region on another side of the gate electrode.

Abstract: Disclosed is a pet sanitary pant, including a flaky water absorption body and a main body part that clamps and fixes the water absorption body and at least has a double-layer structure; the main body part includes an upper girdle part and lower girdle part at both ends of a length direction; adhesion parts are arranged at both ends of a width direction of the lower girdle part for adhering the upper girdle part to cylindrically cover a pet waist during wearing; a tail passing part for a pet tail to pass through is arranged at a hip position on the main body part; and a stereoscopic wrinkle part capable of erecting towards the pet skin is arranged on the inner side of the length direction of the lower girdle part. Due to the technical solution, excrement overflow from the pet waist is prevented to better guarantee cleanness.