Abstract: Provided are fusion molecule having a PD-L1 inhibitor fused to a human IL-7 protein or fragment thereof through a peptide linker. The disclosed fusion molecules exhibited synergistic anti-tumor effects.

Abstract: A method and apparatus for locating a collar of a casing of a wellbore is disclosed. A sensor for measuring a magnetic field is conveyed through the casing on a tool string. A physical model is formed of a process of obtaining a magnetic measurement of the casing with the sensor. A simulation of the physical model is run through a processor to select a design parameter of the tool that allows for using the sensor at a determined value of an operational parameter for obtaining the measurement at a selected signal-to-noise ratio. The tool is conveyed into the wellbore and the sensor set to the determined value of the operational parameter. The magnetic measurement of the casing is obtained using the sensor, and the collar is located using the obtained magnetic measurement.

Abstract: A Lateral Diffusion Metal Oxide Semiconductor (LDMOS) device and its manufacturing method are presented. The LDMOS device comprises a first region that has a first conductivity type; a drift region that has a second conductivity type in the first region, wherein the second conductivity type is opposite to the first conductivity type; and a plurality of second regions that have the first conductivity type in the drift region, wherein the second regions are separated from each other and extend to the first region along a depth direction of the drift region. This LDMOS device has an higher Breakdown Voltage and thus better performance than conventional LDMOS devices.

Abstract: A method for accessing a non-volatile memory comprises that an NVM controller receive a first access request from a processor and determines whether the first access request is used to access a page table. If the first access request is used to access the page table, the NVM controller obtains an AIT entry by reading a page table entry indicated by the first address information and caches the AIT entry to an AIT cache. The NVM controller monitors access of the processor to the page table, prefetches the to-be-accessed AIT entry.

Abstract: Provided are a vehicle positioning method, an apparatus and a device. The method includes: sending an auxiliary positioning request to an auxiliary positioning device within a preset distance range; receiving an auxiliary positioning message returned by the auxiliary positioning device with respect to the auxiliary positioning request, where the auxiliary positioning message carries location information of the auxiliary positioning device; and determining a current location of a current vehicle according to the location information of the auxiliary positioning device and distance information between the current vehicle and the auxiliary positioning device. The method of the present disclosure can implement vehicle positioning without a satellite positioning signal. The vehicle positioning can be performed when the vehicle is blocked by an obstacle such as a tunnel, a building and the satellite positioning signal cannot be received, improving the accuracy of the vehicle positioning.

Abstract: A computer system and a memory access technology are provided. In the computer system, when load/store instructions having a dependency relationship is processed, dependency information between a producer load/store instruction and a consumer load/store instruction can be obtained from a processor. A consumer load/store request is sent to a memory controller in the computer system based on the obtained dependency information, so that the memory controller can terminate a dependency relationship between load/store requests in the memory controller locally based on the dependency information in the received consumer load/store request, and execute the consumer load/store request.

Abstract: A method and a structure for determining a global clock among systems are disclosed. When a standardized time reference is required among systems, a reference clock source may transmit a calibration signal, and a transmitting time Td (0) may be recorded. Each system may respectively record an arrival time Ta (n), transmit a return signal to a signal recording unit of the reference clock source, and record a transmitting time Tb (n), after receiving the calibration signal. Similarly, because of different distances, the signal recording unit may record arrival times Td (n) of the return signals subsequently, and determine time delays Delay (n) between systems and the reference clock source respectively. When all the systems are required to have a completely standardized time reference, a corresponding Delay (n) may be acquired and transmitted to each system.

Abstract: The present disclosure provides a method for forming a semiconductor device, including: forming a mask layer over a substrate, the mask layer containing an opening, exposing a surface portion of the substrate to form an exposed surface portion of the substrate; forming an insulation structure between the mask layer and the substrate, and in the opening; performing a thinning process on the insulation structure exposed by the opening to form a recess region on a top of the insulation structure; and forming a gate electrode over the insulation structure and covering a portion of the recess region.

Abstract: A Lateral Diffusion Metal Oxide Semiconductor (LDMOS) device and its manufacturing method are presented. The LDMOS device comprises a first region that has a first conductivity type; a drift region that has a second conductivity type in the first region, wherein the second conductivity type is opposite to the first conductivity type; and a plurality of second regions that have the first conductivity type in the drift region, wherein the second regions are separated from each other and extend to the first region along a depth direction of the drift region. This LDMOS device has an higher Breakdown Voltage and thus better performance than conventional LDMOS devices.

Abstract: Provided are anti-CD73 antibodies or fragments thereof. The antibodies or fragments therefore include a VH CDR1 of SEQ ID NO: 1, a VH CDR2 of SEQ ID NO: 2, a VH CDR3 of SEQ ID NO: 3, a VL CDR1 of SEQ ID NO: 4, a VL CDR2 of SEQ ID NO: 5, and a VL CDR3 of SEQ ID NO: 6, or variants of each thereof. More generally, antibodies or fragments thereof are described which have specificity to one or more amino acid residues selected from the C-terminal half of a human CD73 protein, such as those in the C-terminal domains. Specific epitope amino acids in these domains include Y345, D399, E400, R401 and R480. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer are also provided.

Abstract: The present disclosure provides antibodies that bind Lymphocyte Activation Gene-3 (LAG-3). Also provided are methods of stimulating an immune response, inhibiting growth of tumor cells, and treating an autoimmune, inflammatory, or viral disease.

Abstract: An apparatus for determining a location of a downhole component includes at least one transmitter device and a receiver device. One of the at least one transmitter device and the receiver device is disposed at a first component of a borehole string configured to be deployed in a borehole and retained at a stationary position, and another of the at least one transmitter device and the receiver device is disposed at a moveable component configured to be moved while the first component is at the stationary position, the at least one transmitter device configured to emit a wireless signal and the receiver device configured to detect the wireless signal when the first component is at the stationary position. The apparatus also includes a processing device configured to receive signal data and estimate a location of the moveable component relative to the first component based on the signal data.

Abstract: This invention provides a kind of fuel filler cap actuator and automotive vehicle, comprising screw shaft, rotor, housing, first reset spring, lock block and lock block driving device; Under the action of the lock block driving device, the lock block can be rotated between the locking angle and the unlocking angle; the lock block driving device adopts an electromagnetic drive method to drive the lock block. This avoids the use of a motor drive, and achieves locking/unlocking of the fuel filler cap through the mutual interaction of the first and second magnet, which significantly reduce operational costs and increase life expectancy.

Abstract: The organic semiconductor polymers relates to the synthesis of a carbazole-based ladder polymer. The synthesis of the ladder polymer includes forming a precursor conjugated polymer by Suzuki step growth polymerization of 2,7-dibromocarbazole with 1,4-dibromo-2,5-divinylbenzene, followed by end capping with 2-bromostyrene and 2-vinyl-phenylboronic acid. Then, the pendent vinyl groups are closed by ring-closing olefin metathesis to obtain the ladder polymer.

Abstract: A bottom hole assembly (BHA) contains a motor and a section mill for milling in an uphole direction after blade extension with circulating fluid through the BHA. Below the section mill is sensing equipment to detect location of a bridge formed by the cuttings or swarf from the section mill. A secondary mill oriented for cutting in a downhole direction is located at the bottom of the BHA for use in removal of the bridge. The sensing equipment delivers in real time data as to the density of the bridge so that decisions to interrupt the section milling and to lower the secondary mill to the bridge can be made in real time. Cement is pumped and displaced by a wiper plug to plug and abandon the hole.

Abstract: A method for accessing an entry in a translation lookaside buffer and a processing chip are provided. In the method, the entry includes at least one combination entry, and the combination entry includes a virtual huge page number, a bit vector field, and a physical huge page number. The physical huge page number is an identifier of N consecutive physical pages corresponding to the N consecutive virtual pages. One entry is used to represent a plurality of virtual-to-physical page mappings, so that when a page table length is fixed, a quantity of entries in the TLB can be increased exponentially, thereby increasing a TLB hit probability, and reducing TLB misses. In this way, a delay in program processing can be reduced, and processing efficiency of the processing chip can be improved.

Abstract: Systems and methods for adjusting a drilling operation, the methods and systems include obtaining, at a control system, a first drilling characteristic associated with a first drilling operation device that is part of a drilling system on a drill string; obtaining, at the control system, a second drilling characteristic associated with a second drilling operation device located apart from the first drilling operation device along the drill string; and controlling, with the control system, at least one adjustable element of the first drilling operation device in response to at least one of the obtained first drilling characteristic and the second drilling characteristic, wherein adjustment of the at least one adjustable element causes a change in at least one of the first drilling characteristic and the second drilling characteristic.

Abstract: A translation lookaside buffer (TLB) management method and a multi-core processor are provided. the method includes: receiving, by a first core, a first address translation request; querying a TLB of the first core based on the first address translation request; determining that a first target TLB entry corresponding to the first address translation request is missing in the TLB of the first core, obtaining the first target TLB entry; determining that entry storage in the TLB of the first core is full; determining a second core from cores in an idle state in the multi-core processor; replacing a first entry in the TLB of the first core with the first target TLB entry; storing the first entry in a TLB of the second core. Thereby reducing a TLB miss rate and accelerating program execution.

Abstract: A milling and scraping tool for preparing a borehole to be plugged includes a tool body including a first end, a second end, and an intermediate portion extending therebetween and a milling system arranged between the first end and the second end. The milling system includes one or more selectively deployable milling blades. The one or more selectively deployable milling blades is shiftable between a retracted position and a deployed position. A scraping system is arranged on the tool body. The scraping system includes a plurality of selectively deployable scraping blades selectively deployable from a retracted position to a deployed position.

Abstract: Provided are anti-PD-L1 antibodies or fragments thereof. The antibodies or fragments thereof specifically bind to the immunoglobulin C domain of the PD-L1 protein. In various example, the antibodies or fragments thereof include a VH CDR1 of SEQ ID NO: 1, a VH CDR2 of SEQ ID NO: 2, a VH CDR3 of SEQ ID NO: 3, a VL CDR1 of SEQ ID NO: 4, a VL CDR2 of SEQ ID NO: 5, and a VL CDR3 of SEQ ID NO: 6, or variants of each thereof. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and infectious diseases are also provided.