Patents by Inventor Leilei Zhang

Leilei Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250127817
    Abstract: An application of Bone Marrow Mesenchyml Stem Cell Exosomes (BMSC-Exos) in treating Parkinson's disease (PD) is provided, wherein the BMSC-Exos are generated by stimulating BMSCs with a culture solution and extracted from the culture solution after passage; and the culture solution of the BMSCs is an ?-MEM culture solution containing FBS and PS. The BMSC-Exos can greatly improve a motor function of a model mouse with PD, protect dopaminergic neurons of the model mouse with PD, improve an olfactory function of the model mouse with PD, and also inhibit the activation of olfactory astrocytes of the model mouse with PD.
    Type: Application
    Filed: October 19, 2022
    Publication date: April 24, 2025
    Applicant: NANTONG UNIVERSITY
    Inventors: Xiaosong GU, Cheng SUN, Fei DING, Leilei GONG, Meng CONG, Xiaomin WANG, Hualin SUN, Yu ZHANG, Lili ZHAO, Tianmei QIAN
  • Patent number: 12280079
    Abstract: The disclosure discloses a strain of Lactobacillus crispatus capable of preventing and/or treating Helicobacter pylori infection, and belongs to the technical fields of microorganisms and medicine. The disclosure provides a strain of Lactobacillus crispatus CCFM1118. The Lactobacillus crispatus CCFM1118 can inhibit Helicobacter pylori, specifically embodied in that: (1) the diameter of an inhibition zone of supernatant of the Lactobacillus crispatus CCFM1118 on Helicobacter pylori can reach 13.14 mm; and (2) the Lactobacillus crispatus CCFM1118 can significantly reduce the adhesion of Helicobacter pylori to AGS cells. Therefore, the Lactobacillus crispatus CCFM1118 has great application prospects in inhibiting Helicobacter pylori (not for the purposes of disease diagnosis and treatment) and preparing Helicobacter pylori inhibitors.
    Type: Grant
    Filed: March 31, 2022
    Date of Patent: April 22, 2025
    Assignee: Jiangnan University
    Inventors: Qixiao Zhai, Wei Chen, Meiyi Zhang, Leilei Yu, Fengwei Tian, Shunhe Wang, Jianxin Zhao, Hao Zhang
  • Publication number: 20250121236
    Abstract: The present invention is directed to firefighting foam compositions (e.g., concentrates, foam forming compositions, and solutions) including a combination of surfactants (e.g., anionic surfactants and amphoteric surfactants) and one or more additional components (e.g., polyethylene glycol (PEG), glycerin, and/or a sugar component).
    Type: Application
    Filed: September 19, 2024
    Publication date: April 17, 2025
    Inventors: Monica AMANDI, Pamela HAVELKA-RIVARD, Covadonga PEREZ, Carlson SUGIARTO, Leilei ZHANG
  • Publication number: 20250122099
    Abstract: The present application relates to a positive electrode active material and a preparation method thereof, a positive electrode sheet and a secondary battery. The positive electrode active material has a composition chemical formula of LixNa1-xAyB1-yO2-nDn, where A is selected from a combination of Ni and Mn, B is selected from at least one non-alkali metal positive-valent element other than Ni, Mn, Co, and S, D is selected from F and/or S, 0.8?x?0.92, 0.90?y<1.0, 0<n?0.2, and a peak position difference between the Ni—O bond and the Mn—O bond of the positive electrode active material in a Raman spectrum is greater than 80 cm?1 and less than 110 cm?1. The positive electrode active material has high specific capacity and high cycle stability at a high voltage window, and low cost, causing the prepared secondary battery to have high cost performance.
    Type: Application
    Filed: December 23, 2024
    Publication date: April 17, 2025
    Inventors: Liangchen DONG, Wenxu ZHANG, Chong YIN, Leilei LIU, Yu CHEN, Daoyan FENG, Xufeng YAN, Rui LIU, Jonghee LEE, Hui SUN, Sangyul YOU
  • Patent number: 12275934
    Abstract: The disclosure discloses a strain of Lactobacillus rhamnosus and application thereof in inhibiting Helicobacter pylori, and belongs to the technical fields of microorganisms and medicine. The disclosure provides a strain of Lactobacillus rhamnosus CCFM1119. The Lactobacillus rhamnosus CCFM1119 can prevent and/or treat Helicobacter pylori infection, specifically embodied in that: (1) the Lactobacillus rhamnosus CCFM1119 can significantly relieve the gastrointestinal symptoms of patients with Helicobacter pylori infection; (2) the Lactobacillus rhamnosus CCFM1119 can significantly reduce the amount of colonization of Helicobacter pylori in patients with Helicobacter pylori infection; and (3) the Lactobacillus rhamnosus CCFM1119 can significantly increase the clearance rate of Helicobacter pylori in patients with Helicobacter pylori infection.
    Type: Grant
    Filed: April 1, 2022
    Date of Patent: April 15, 2025
    Assignee: Jiangnan University
    Inventors: Qixiao Zhai, Wei Chen, Jianxin Zhao, Meiyi Zhang, Shumao Cui, Wenwei Lu, Fengwei Tian, Leilei Yu, Gang Wang, Hao Zhang
  • Publication number: 20250101868
    Abstract: Disclosed are a visualization grouting device for coal and rock fissures and a test method, a test device including a visualization fissure grouting box body, a box body bracket, a grouting device and a monitoring device. A bottom plate is divided into four identical areas, rubber cushion blocks with different specifications are arranged to simulate different fissure widths and tortuosity, artificial protolith thin film is pasted inside, and a grouting hole and a plurality of pressure measuring holes are arranged in the center of the upper top plate. In the present disclosure, the grouting process of fissures under different grouting conditions, such as different fissure widths, roughness, grouting resistance and tortuosity of pore channels can be simulated, the grouting under different fissure conditions can be simultaneously simulated, and the differences of different grouting diffusion forms can be clearly and intuitively analyzed and compared through the visualization box body.
    Type: Application
    Filed: October 24, 2024
    Publication date: March 27, 2025
    Inventors: Dengke Wang, Haohang Feng, Jianping Wei, Lei Wang, Hongtu Zhang, Chuanqi Zhu, Le Wei, Banghua Yao, Bo Li, Leilei Si, Zhihui Wen, Xiangyu Xu, Yong Liu, Jian Zhang, Baobao Chen, Shaobo Li, Hewu Liu, Shuaibing Song, Hao Fan, Kun Zhang
  • Patent number: 12248651
    Abstract: A touch substrate and a display device are disclosed. The touch substrate has a folding line, the touch substrate including a touch region and a non-touch region. The non-touch region includes a first non-touch region, a second non-touch region, and a third non-touch region between the first non-touch region and the second non-touch region. The touch substrate includes: multiple first electrode groups; multiple second electrode groups; a touch integrated circuit in the third non-touch region; multiple first sub-electrode group connecting lines in the first non-touch region; and a shielded line.
    Type: Grant
    Filed: November 8, 2023
    Date of Patent: March 11, 2025
    Assignee: Wuhan China Star Optoelectronics Semiconductor Display Technology Co., Ltd.
    Inventors: Chenghao Zhang, Leilei Luo
  • Publication number: 20250053281
    Abstract: A control method includes: in case that a first operation is received, determining an operation object and an operation type of the first operation, a first window information of a first window currently displayed on a display interface and a current display mode of an electronic apparatus; in case that the current display mode is a first mode, determining a second window to be displayed on the display interface after the first operation and a second window information based on at least one of the first window information, the operation object and the operation type; and displaying the second window based on the second window information.
    Type: Application
    Filed: January 19, 2024
    Publication date: February 13, 2025
    Inventors: Huiying YANG, Jiayan LI, Siqi LI, Leilei ZHANG
  • Publication number: 20250036243
    Abstract: A touch substrate and a display device are disclosed. The touch substrate has a folding line, the touch substrate including a touch region and a non-touch region. The non-touch region includes a first non-touch region, a second non-touch region, and a third non-touch region between the first non-touch region and the second non-touch region. The touch substrate includes: multiple first electrode groups; multiple second electrode groups; a touch integrated circuit in the third non-touch region; multiple first sub-electrode group connecting lines in the first non-touch region; and a shielded line.
    Type: Application
    Filed: November 8, 2023
    Publication date: January 30, 2025
    Inventors: Chenghao ZHANG, Leilei LUO
  • Patent number: 12041728
    Abstract: Electronic assembly methods and structures are described. In an embodiment, an electronic assembly method includes bringing together an electronic component and a routing substrate, and directing a large area photonic soldering light pulse toward the electronic component to bond the electronic component to the routing substrate.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: July 16, 2024
    Assignee: Apple Inc.
    Inventors: Maryam Rahimi, Meng Chi Lee, Wyeman Chen, Leilei Zhang, Jason P. Marsh, Lan Hoang, Yashar Abdollahian
  • Patent number: 12040262
    Abstract: Flexible modules and methods of manufacture are described. In an embodiment, a flexible module includes a flex board formed in which a passivation layer is applied in liquid form in a panel level process, followed by exposure and development. An electronic component is then mounted onto the flex board and encapsulated in a molding compound that is directly on a top surface of the passivation layer.
    Type: Grant
    Filed: July 21, 2021
    Date of Patent: July 16, 2024
    Assignee: Apple Inc.
    Inventors: Dennis R. Pyper, Leilei Zhang, Lan H. Hoang
  • Publication number: 20240075331
    Abstract: The present invention is generally directed to nanoparticle stabilized firefighting foam concentrates, firefighting foam solutions, and firefighting foams prepared from a concentrate or solution of the present invention containing one or more silica nanoparticles (e.g., surface modified silica nanoparticles) and any or all of one or more components selected from one or more organic solvents, one or more surfactants, one or more biopolymers, and one or more alcohols. The present invention is also directed to methods for increasing the resistance of a firefighting foam to a polar solvent. The present invention is further directed to methods for preparing firefighting foam concentrates including silica nanoparticles (e.g., surface modified silica nanoparticles).
    Type: Application
    Filed: September 1, 2023
    Publication date: March 7, 2024
    Inventors: Leilei ZHANG, Pamela HAVELKA-RIVARD, Monica AMANDI, Covadonga PEREZ, Melissa KIM
  • Publication number: 20240080970
    Abstract: Various embodiments of a flexible circuit package with a high-modulus molding compound layer are disclosed. A flexible circuit package includes a substrate with first and second regions. The first region is configured to bend. The flexible circuit package further includes a conductive line disposed on the second region, an electronic component disposed on the conductive line, and a molding compound layer disposed on the second region and surrounding the electronic component. A modulus of the molding compound layer is greater than a modulus of the substrate and the molding compound layer is configured to prevent the second region from bending.
    Type: Application
    Filed: March 16, 2023
    Publication date: March 7, 2024
    Applicant: Apple Inc.
    Inventors: Leilei ZHANG, Abhay Maheshwari, Ali N. Ergun, Arun Chawan
  • Publication number: 20230310918
    Abstract: The present invention is directed to fluorine-free firefighting foam concentrates containing one or more solvents, one or more surfactants, one or more alcohols, and one or more biopolymers. The present invention is also directed to firefighting foam solutions and firefighting foams prepared from such concentrates and methods for their use. The present invention is also directed to methods for controlling the viscosity of firefighting foam concentrates, including lowering of the concentrate viscosity as temperature decreases.
    Type: Application
    Filed: April 4, 2023
    Publication date: October 5, 2023
    Inventors: LeiLei Zhang, Pamela Havelka-Rivard, Aaron Donovan, Covadonga Perez
  • Publication number: 20230271046
    Abstract: The present invention is generally directed to fluorine-free firefighting foam concentrates containing a surfactant component comprising one or more surfactants, optionally one or more solvents, optionally one or more inorganic salts, and optionally one or more organic salts. The present invention is also directed to firefighting foam solutions and firefighting foams prepared from such concentrates and methods for their use. The fluorine-free firefighting foam concentrates exhibit Newtonian behavior. The fluorine-free firefighting foam solution exhibits dilution thickening properties.
    Type: Application
    Filed: February 24, 2023
    Publication date: August 31, 2023
    Inventors: Mark Siem, Pamela Havelka-Rivard, LeiLei Zhang, Robert Paulick, Monica Fernandez, Covadonga Perez
  • Publication number: 20230099638
    Abstract: Robust estimation of temperatures inside and outside a device can be achieved using one or more absolute temperature sensors optionally in conjunction with thermopile heat flux sensors. Thermopile temperature sensing systems can measure a temperature gradient across two locations within the device, to estimate absolute temperature at locations that are impractical to measure using absolute temperature sensors. Using heat flux models associated with the device, the thermopile temperature sensing system can be used to estimate temperature associated with objects that contact an outer surface of the device, such as a user's skin temperature. Additionally, the thermopile temperature sensing system can be used to estimate ambient air temperature. Within a device, temperature measurements from the thermopile temperature sensors can be used to compensate sensor measurements, such as when the accuracy or reliability of a sensor varies with temperature.
    Type: Application
    Filed: September 6, 2022
    Publication date: March 30, 2023
    Inventors: James C. CLEMENTS, Lan Hoang HOANG, Leilei ZHANG, Jacky G. KO, Jafir A. HAIDRI, Xinsheng CHU, Saahil MEHRA
  • Publication number: 20230026254
    Abstract: Flexible modules and methods of manufacture are described. In an embodiment, a flexible module includes a flex board formed in which a passivation layer is applied in liquid form in a panel level process, followed by exposure and development. An electronic component is then mounted onto the flex board and encapsulated in a molding compound that is directly on a top surface of the passivation layer.
    Type: Application
    Filed: July 21, 2021
    Publication date: January 26, 2023
    Inventors: Dennis R. Pyper, Leilei Zhang, Lan H. Hoang
  • Patent number: 11550975
    Abstract: Methods and systems are provided for characterizing interfacial tension (IFT) of reservoir fluids, which involves obtaining fluid property data that represents fluid properties of a reservoir fluid sample measured downhole at reservoir conditions, and inputting the fluid property data to a computational model that determines a value of oil-water IFT of the reservoir fluid sample based on the fluid property data. In embodiments, the fluid property data represents single-phase fluid properties of the reservoir fluid sample, such as fluid density and viscosity of an oil phase of the reservoir fluid sample and fluid density of a water phase of the reservoir fluid sample. In embodiments, the computation model can be based on machine learning or analytics combined with a thermodynamics-based physics model.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: January 10, 2023
    Assignees: SCHLUMBERGER TECHNOLOGY CORPORATION, SAUDI ARABIAN OIL COMPANY
    Inventors: Sharath Chandra Mahavadi, Robin Singh, Wael Abdallah, Mohammed Al-Hamad, Bastian Sauerer, Shouxiang Ma, Leilei Zhang
  • Patent number: 11462461
    Abstract: Electronic package structures and assembly methods are described. In an embodiment, an electronic package includes a die mounted face up on a bottom side of a package substrate, and a plurality of components on a top side of the package substrate. The plurality of components may be unmolded, and available for rework. Additional structures are included within the package substrate to provide mechanical rigidity and robustness to the package for warpage control.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: October 4, 2022
    Assignee: Apple Inc.
    Inventors: Leilei Zhang, Lan H. Hoang
  • Publication number: 20220035971
    Abstract: Methods and systems are provided for characterizing interfacial tension (IFT) of reservoir fluids, which involves obtaining fluid property data that represents fluid properties of a reservoir fluid sample measured downhole at reservoir conditions, and inputting the fluid property data to a computational model that determines a value of oil-water IFT of the reservoir fluid sample based on the fluid property data. In embodiments, the fluid property data represents single-phase fluid properties of the reservoir fluid sample, such as fluid density and viscosity of an oil phase of the reservoir fluid sample and fluid density of a water phase of the reservoir fluid sample. In embodiments, the computation model can be based on machine learning or analytics combined with a thermodynamics-based physics model.
    Type: Application
    Filed: July 28, 2020
    Publication date: February 3, 2022
    Inventors: Sharath Chandra Mahavadi, Robin Singh, Wael Abdallah, Mohammed Al-Hamad, Bastian Sauerer, Shouxiang Ma, Leilei Zhang