Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds, as well as methods and uses of these compounds in the treatment of diseases.

Abstract: The present application discloses a focal length adjustment method, device, apparatus and computer readable storage medium for AR glasses, the method includes: receiving a focal length adjustment command, and displaying a preset circle with a preset reference radius through a display module; capturing a first image of the preset circle in an eye of a wearer of the AR glasses through the camera to obtain a first captured image, and determining a first imaging radius of the preset circle in the first image according to the first captured image; determining target diopter of the eye of the wearer according to the preset reference radius and the first imaging radius; and determining a target deflecting angle of the display module according to the target diopter, and adjusting the display module according to the target deflecting angle.

Abstract: A low-cost and high-strength Bi-based superconducting wire/tape and a preparation method thereof, the preparation method includes: 1. subjecting a first Bi-based superconducting wire/tape to electrochemical silver reduction to remove a Ag alloy layer to obtain a second Bi-based superconducting wire/tape; and 2. subjecting the second Bi-based superconducting wire/tape to surface enhancement, such that a Cu layer is formed to obtain the low-cost and high-strength Bi-based superconducting wire/tape. An electrochemical silver reduction technology combines with an electrochemical additive method to remove a Ag alloy layer on a surface of a Bi-based superconducting wire/tape and coat a high-strength Cu layer, such that a low-cost and high-strength Bi-based superconducting wire/tape can be prepared, which reduces a preparation cost and improves a strength of a Bi-based superconducting wire/tape to meet the application requirements of large super-strong magnets.

Abstract: Provided are certain BCL-2 inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: The present disclosure discloses a method for preparing a tensile specimen and a vibration curing device. The method includes obtaining a colloid mixture and putting it into a beaker and using a stirring device to stir the colloid mixture mixed evenly. The method further includes putting the colloid mixture into a vacuum dryer, and spraying a release agent on cleaned tensile specimen mold, and using a needle to inject the colloid mixture into a molding groove of the tensile specimen mold and filling the molding groove, fixing the pressing plate and the tensile specimen mold together to form a whole mold, fixing it on a vibration platform of a vibration device, turning on the vibration device to vibrate the whole mold and to heat the whole mold to a predetermined temperature, cooling the whole mold, and demolding the whole mold to obtain the tensile specimen of the structural adhesive.

Abstract: A production method for a bispecific antibody, comprising constructing cells for producing a bispecific antibody, screening the cells, culturing the cells obtained in step one to obtain a culture solution, and performing separation and purification to obtain the bispecific antibody. The cells comprise CHO cells. The culture mode comprises fed-batch culture or perfusion culture. Various influence factors in fermentation culture and separation and purification are comprehensively analyzed, and by effective control, all factors can effectively cooperate, so that a high-purity bispecific antibody is efficiently produced, the daily output can reach 3 g/L or above, and the purity of the purified bispecific antibody can reach 90% or above. Moreover, the production process is amplified and verified, the process is stable and reliable, the cost is low, a great breakthrough is achieved compared with an existing production method.

Abstract: Provided are a display panel and a display device. The display panel includes a pixel driver circuit. The pixel driver circuit includes a light-emitting module, a drive transistor and at least one light-emitting control transistor. The drive transistor, the light-emitting control transistor and the light-emitting module are connected in series between a first power supply signal terminal and a second power supply signal terminal, and at least one of the drive transistor or the light-emitting control transistor is a first double-gate transistor. The first double-gate transistor includes a first gate, a second gate and a first source, and the second gate is electrically connected to the first source.

Abstract: A cholinesterase inhibitor polymorph, wherein specifically disclosed are a octahydroaminoacridine succinate polymorph, a corresponding crystal composition and pharmaceutical composition, and applications thereof. The compound octahydroaminoacridine succinate is used for screening and studying polymorphs, and the discovered polymorphs are appraised and evaluated; crystal forms having better physical and chemical properties are determined for subsequent development and study, and crystal forms having good stability and an excellent therapeutic effect are obtained.

Abstract: The present application relates to a supercritical fluid injection foaming polylactide foam material and a preparation method therefor. The method includes: first obtaining a surface-modified cellulose nanofiber aqueous solution; then melting and blending the cellulose nanofiber aqueous solution and a polylactide twice; passing same through extrusion, cooling under water, and granulation so as to obtain a polylactide/cellulose nanofiber composite material; then plasticizing and melting the polylactide/cellulose nanofiber composite material in a microporous foaming injection molding machine; uniformly mixing same with a supercritical fluid foaming agent in the injection molding machine; injecting same into a mold cavity; and subjecting the resultant to post-treatment so as to obtain a polylactide foam material.

Abstract: Various examples described herein are directed to systems and methods for interfacing an analytics computing system with a remote resource. An analytics computing system may access data describing a multi-resource operation. The analytics computing system may execute a multi-resource application programming interface (API) service. The multi-resource API service may send a first trigger message to a public API of the first remote resource. The analytics computing system may send first data to the remote resource and may receive, from the remote resource, first result data describing a result of the first action performed at the first remote resource using the first data.

Abstract: The present disclosure provides an ecological governance method based on erosion prevention and control for a gentle slope farmland and relates to the technical field of ecological governance of farmlands. The ecological governance method based on erosion prevention and control for a gentle slope farmland includes the following steps: sampling a gentle slope farmland to investigate erosion thereof; and determining erosion of a gentle slope cultivated land and selecting a corresponding recovery strategy based on a detection result of a sample, a soil quality index (SQI), and a comprehensive vegetation quality index (VQI), where the recovery strategy includes a natural recovery method and a biological-farming comprehensive recovery method; enclosing the gentle slope cultivated land, fallowing the gentle slope cultivated land and reducing tillage; exterminating insect pests and poisonous weeds in the enclosed area; and turning over straws under soil by a cultivator. The growth of poisonous weeds is inhibited.

Abstract: Provided herein are methods of treating a skeletal dysplasia such as hypochondroplasia or achondroplasia in a pediatric patient by administering to the patient infigratinib or a pharmaceutically acceptable salt thereof. Also provided are minitablets including infigratinib monophosphate and a pharmaceutically acceptable excipient for use in treating a skeletal dysplasia such as hypochondroplasia or achondroplasia in pediatric patients.

Abstract: A circuit board, a preparation method thereof, and an electronic device are provided. The circuit board includes: a substrate, defining a first through-hole; a metal block, embedded in the first through-hole and fixedly connected to the substrate; a conductive line layer, arranged on at least one side surface of the substrate; wherein the conductive line layer partially covers an opening of the first through-hole on a corresponding side surface of the substrate; and a conductive channel, penetrating the conductive line layer and the metal block in turn. The conductive channel comprises a second through-hole and a conductive medium plated on a wall of the second through-hole; an end of the conductive medium is connected to the conductive line layer, and another end of the conductive medium is connected to the metal block.

Abstract: The present invention belongs to the technical field of biological pharmacy, and particularly relates to a long-acting HM-3 fusion protein molecule and an application thereof. In the present invention, on the basis of the sequence of HM-3 molecule, an active polypeptide HM-3 and derivatives thereof are linked to a human Fc (IgG) fragment or a fragment of an Fc (IgG) mutant directly or by a linker peptide (Linker), thus forming a novel molecular entity. The general formula of the molecular entity is (HM-3)n-Linker-Fc(IgG), Fc(IgG)-Linker-(HM-3)n, or (HM-3)n-Linker-Fc(IgG)-Linker-(HM-3)n. The fusion protein effectively prolongs the half-life of HM-3, is low in cost and overcomes the major problem of druggability of small peptides. Therefore, the fusion protein of the present invention may serve as a potential drug for the treatment of autoimmune diseases, neovascular diseases, osteoarthritis and the like.

Abstract: The present application relates to a supercritical fluid injection foaming polylactide foam material and a preparation method therefor. The method includes: first obtaining a surface-modified cellulose nanofiber aqueous solution; then melting and blending the cellulose nanofiber aqueous solution and a polylactide twice; passing same through extrusion, cooling under water, and granulation so as to obtain a polylactide/cellulose nanofiber composite material; then plasticizing and melting the polylactide/cellulose nanofiber composite material in a microporous foaming injection molding machine; uniformly mixing same with a supercritical fluid foaming agent in the injection molding machine; injecting same into a mold cavity; and subjecting the resultant to post-treatment so as to obtain a polylactide foam material.

Abstract: A spiral impact drilling machine applicable to rock and soil and a construction method are provided. The drilling machine includes a rock chiseling part, a soil drilling part, a gear, a drill rod, and a drill bit. The rock chiseling part includes an air cylinder. A piston is arranged in the air cylinder. The top of the piston is fixedly connected with to a turbine fan blade. The bottom of the piston is fixedly connected to a force transferring component. The soil drilling part includes a motor. The motor is arranged in the force transferring component. The inner part of the gear is in nested connection with the drill rod. The outer part of the gear is in engaged connection with each of the bottom of the force transferring component and the motor. The bottom of the gear is fixedly connected to the drill rod through a stress component.