Patents by Inventor Lihua Zhang

Lihua Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150231592
    Abstract: The present invention relates to a biphasic microreactor for membrane proteins pretreatment comprising cation exchange and anion exchange materials packed in sequence in a container as stationary phase, where membrane proteins capture, pH adjustment, reduction, alkylation and tryptic digestion processed in situ. Thus the microreactor has advantages of high recovery, ease of operation, high efficiency and high throughput.
    Type: Application
    Filed: June 7, 2013
    Publication date: August 20, 2015
    Inventors: Lihua Zhang, Qun Zhao, Kaiguang Yang, Yu Liang, Zhen Liang, Yukui Zhang
  • Publication number: 20150182577
    Abstract: The present invention provides a composition for improving macular pigment optical density and preventing or treating age-related macular optical degeneration. The composition comprises lutein, zeaxanthin and tea extracts, wherein the weight ratio of zeaxanthin to lutein is more than or equal to 1. The composition may prevent formation of choroidal neovascularization to achieve effects on comprehensively preventing or treating age-related macular optical degeneration (AMD).
    Type: Application
    Filed: August 8, 2013
    Publication date: July 2, 2015
    Inventors: Xinde Xu, Lihua Zhang, Xiaoxia Sun
  • Publication number: 20150175510
    Abstract: The invention discloses a method for preparing high-content zeaxanthin. In the conventional preparation methods, some methods adopt certain toxic organic solvents; some methods require the multi-step crystallization process; and some methods are featured by long reaction time, high temperature and lower product yield, thus being not suitable for industrial production. The invention adopts lutein crystal or its fatty acid ester as the raw material and utilizes isomerization reaction to produce zeaxanthin, and is characterized in that a mixed catalyst consisting of an organic base catalyst and a cocatalyst is used in the isomerization reaction, wherein the cocatalyst is palladium carbon. The invention has the advantages of simple process route, low reaction temperature, short reaction time, good product purity and high yield, thus being suitable for industrial production, and no poisonous and harmful organic solvent residues in the product, thus being suitable for the use as a food additive or drug.
    Type: Application
    Filed: July 9, 2013
    Publication date: June 25, 2015
    Applicant: Zhejiang Medicine Co., Ltd., Xinchang Pharmaceutical Factory
    Inventors: Bin Shao, Lihua Zhang, Xinde Xu, Xiaoxia Sun
  • Patent number: 7937359
    Abstract: A method of operating a Linear Complementarity Problem (LCP) solver is disclosed, where the LCP solver is characterized by multiple execution units operating in parallel to implement a competent computational method adapted to resolve physics-based LCPs in real-time.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: May 3, 2011
    Assignee: NVIDIA Corporation
    Inventors: Lihua Zhang, Richard Tonge, Dilip Sequeira, Monier Maher
  • Patent number: 7633298
    Abstract: A continuity tester for a lamp, coaxial, plug connector has a receptacle connector with first and second coaxial, annular receptacle contacts at a same axial spacing apart as power and ground contacts of the lamp connector for electrical engagement when plugged therein and, a probe contact engageable with only the power contact. First and second LEDs connect to a battery via first and second parallel circuits. A biasing resistor in the second circuit ensures that battery power is provided to only the first LED when a battery circuit is completed only by electrical engagement of the first contact and the probe contact with the power contact of the male coaxial connector to signal absence of a short circuit and to only the second LED when a circuit is completed also by engagement of the second tester contact with the ground contact of the lamp connector to signal a short circuit.
    Type: Grant
    Filed: July 30, 2007
    Date of Patent: December 15, 2009
    Assignee: W.A.C. Lighting Co
    Inventors: Meng-Chiao Kan, Meng-Feng Tsai, Congjun Gou, Quingjun Li, Lihua Zhang
  • Publication number: 20090297618
    Abstract: The present invention provides a formula food comprising lutien, zeaxanthin, zinc, and selenium beneficial for eye health and its application. The formula food is not only applied for dietary supplement tablets and capsules, but also applied for various formula milk powders, various functional beverages, various baked food. The formula food is conducive to the human eye health, especially beneficial for the improvement of visuognosis persistence of human eyes, helpful for asthenopia remission and the improvement of eye consciousness symptoms.
    Type: Application
    Filed: May 28, 2009
    Publication date: December 3, 2009
    Inventors: Xinde Xu, Di Zhou, Lihua Zhang, Bin Shao
  • Patent number: 7526456
    Abstract: A method of operating a Linear Complementarity Problem (LCP) solver is disclosed, where the LCP solver is characterized by multiple execution units operating in parallel to implement a competent computational method adapted to resolve physics-based LCPs in real-time.
    Type: Grant
    Filed: March 8, 2004
    Date of Patent: April 28, 2009
    Assignee: NVIDIA Corporation
    Inventors: Lihua Zhang, Richard Tonge, Dilip Sequeira, Monier Maher
  • Patent number: 7485738
    Abstract: This invention has disclosed a method for preparation of food-grade zeaxanthin through chemical isomerizaton reaction from lutein. The technical issues to be solved in this invention are quite low product yield obtained with existing methods, need of purification treatment process, and inadaptability to industrialized production. The technical schemes of this invention are: a. Mix xanthophyll crystal or its fatty acid ester with food-grade glycol or propylene glycol, for full dissolution under 60-90° C. temperature. Add organic alkali into the mixed liquor acquired from step 1, for isomerization reaction to take place under inertial environment. c. Dilute the reaction solution gained from step b with the mixed solution of deionized water and ethanol, and separate the obtained crystal with conventional separating method. d. Vacuum dries the acquired crystal from step c, to get the zeaxanthin crystal.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: February 3, 2009
    Assignee: Zhejiang Medicine Co., Ltd., XinChang Pharmaceutical Factory
    Inventors: Xinde Xu, Lihua Zhang, Boqiu Chen, Di Zhou, Shuangming Ye, Chiyu Ding, Hongping Lv, Bin Shao
  • Patent number: 7421303
    Abstract: A Linear Complementarity Problem (LCP) solver is characterized by multiple execution units operating in parallel to implement a competent computational method adapted to resolve physics-based LCPs in real-time.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: September 2, 2008
    Assignee: NVIDIA Corporation
    Inventors: Lihua Zhang, Richard Tonge, Dilip Sequeira, Monier Maher
  • Publication number: 20080081932
    Abstract: This invention has disclosed a method for preparation of food-grade zeaxanthin through chemical isomerizaton reaction from lutein. The technical issues to be solved in this invention are quite low product yield obtained with existing methods, need of purification treatment process, and inadaptability to industrialized production. The technical schemes of this invention are: a. Mix xanthophyll crystal or its fatty acid ester with food-grade glycol or propylene glycol, for full dissolution under 60-90° C. temperature. Add organic alkali into the mixed liquor acquired from step 1, for isomerization reaction to take place under inertial environment. c. Dilute the reaction solution gained from step b with the mixed solution of deionized water and ethanol, and separate the obtained crystal with conventional separating method. d. Vacuum dries the acquired crystal from step c, to get the zeaxanthin crystal.
    Type: Application
    Filed: September 18, 2007
    Publication date: April 3, 2008
    Applicants: Zhejiang Medicine Co., Ltd., Xinchang Pharmaceutical Factory
    Inventors: Xinde Xu, Lihua Zhang, Boqiu Chen, Di Zhou, Shuangming Ye, Chiyu Ding, Hongping Lv, Bin Shao
  • Publication number: 20060182804
    Abstract: The present invention also relates to carvedilol free base, salts, anhydrous forms, or solvates thereof, corresponding pharmaceutical compositions or controlled release formulations, and methods delivery of carvedilol forms to the lower gastrointestingal tract or methods to treat cardiovascular diseases, which may include, but are not limited to hypertension, congestive heart failure, and angina. The present invention relates to control release formulations, which comprise various cavedilol forms, which may include, but are not limited to carvedilol free base and corresponding carvedilol salts, anhydrous forms or solvates thereof.
    Type: Application
    Filed: May 25, 2005
    Publication date: August 17, 2006
    Inventors: Matthew Burke, Mark Coffin, Kimberly Lamey, Luigi Martini, Choon Oh, Heather Peterson, Jeffrey Staton, Lihua Zhang
  • Patent number: 7079145
    Abstract: A projected iterative descent method is used to resolve LCPs related to rigid body dynamics, such that animation of the rigid body dynamics on a display system occur in real-time.
    Type: Grant
    Filed: March 8, 2004
    Date of Patent: July 18, 2006
    Assignee: AGEIA Technologies, Inc.
    Inventors: Richard Tonge, Lihua Zhang, Dilip Sequeira
  • Publication number: 20050169994
    Abstract: The present invention also relates to carvedilol free base, salts, anhydrous forms, or solvates thereof, corresponding pharmaceutical compositions or controlled release formulations, and methods delivery of carvedilol forms to the lower gastrointestingal tract or methods to treat cardiovascular diseases, which may include, but are not limited to hypertension, congestive heart failure, and angina. The present invention relates to control release formulations, which comprise various cavedilol forms, which may include, but are not limited to carvedilol free base and corresponding carvedilol salts, anhydrous forms or solvates thereof.
    Type: Application
    Filed: November 24, 2004
    Publication date: August 4, 2005
    Inventors: Matthew Burke, Mark Coffin, Kimberly Lamey, Luigi Martini, Choon Oh, Heather Peterson, Jeffrey Staton, Lihua Zhang
  • Publication number: 20050165874
    Abstract: A Linear Complementarity Problem (LCP) solver is characterized by multiple execution units operating in parallel to implement a competent computational method adapted to resolve physics-based LCPs in real-time.
    Type: Application
    Filed: April 2, 2004
    Publication date: July 28, 2005
    Inventors: Lihua Zhang, Richard Tonge, Dilip Sequeira, Monier Maher
  • Publication number: 20050162433
    Abstract: A projected iterative descent method is used to resolve LCPs related to rigid body dynamics, such that animation of the rigid body dynamics on a display system occur in real-time.
    Type: Application
    Filed: March 8, 2004
    Publication date: July 28, 2005
    Inventors: Richard Tonge, Lihua Zhang, Dilip Sequeira
  • Publication number: 20050165873
    Abstract: A method of operating a Linear Complementarity Problem (LCP) solver is disclosed, where the LCP solver is characterized by multiple execution units operating in parallel to implement a competent computational method adapted to resolve physics-based LCPs in real-time.
    Type: Application
    Filed: March 8, 2004
    Publication date: July 28, 2005
    Inventors: Lihua Zhang, Richard Tonge, Dilip Sequeira, Monier Maher
  • Patent number: 6858630
    Abstract: Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected substituted naphthimidazole derivative.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: February 22, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Juan I. Luengo, Kevin J. Duffy, Alan T. Price, Lihua Zhang
  • Publication number: 20030083361
    Abstract: Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected substituted naphthimidazole derivative.
    Type: Application
    Filed: September 12, 2002
    Publication date: May 1, 2003
    Inventors: Juan I Luengo, Kevin J Duffy, Alan T Price, Lihua Zhang