Patents by Inventor Lihua Zhang

Lihua Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190202692
    Abstract: A hydrogen gas production method includes a light irradiation step of applying light to a surface of a metal material immersed in water to produce gas containing hydrogen. In this hydrogen gas production method, the metal material contains iron, in the spectrum of the light, a wavelength at which the intensity is maximum is not less than 360 nm and less than 620 nm, and as the gas is produced, at least one of iron oxide and iron hydroxide is formed on the surface.
    Type: Application
    Filed: August 25, 2017
    Publication date: July 4, 2019
    Inventors: Shuichiro ADACHI, Masaki KITAGAWA, Seiichi WATANABE, Lihua ZHANG, Noriyuki OKINAKA
  • Publication number: 20190193042
    Abstract: The present invention provides a method for drying high-stability microcapsule particles containing multiple double bonds fat soluble nutrients comprises: a) preparing a microcapsule emulsion containing multiple double bonds fat soluble nutrients, performing spray granulation on the microcapsule emulsion in a spray system (1), and meanwhile blasting air into the spray system (1), the blasted air wrapping adsorption materials, and the microcapsule emulsion being immediately solidified and sized after coming into contact with the air, so as to obtain liquid droplets having surfaces to which adsorption materials are adsorbed; b) performing fluidized drying on the liquid droplets having surfaces to which the adsorption materials are adsorbed in the step a) in a multi-stage fluidized bed system (5); c) collecting non-adsorbed adsorption materials by means of an adsorption material dust removal, recovery and circulation system; and d) collecting microcapsule particle products.
    Type: Application
    Filed: October 12, 2015
    Publication date: June 27, 2019
    Inventors: Xinde Xu, Bin Shao, Di Zhou, Lihua Zhang
  • Publication number: 20190153475
    Abstract: There is provided a gene cassette for disruption of at least one target gene in a yeast cell, wherein the gene cassette comprises: (d) a URA3 gene capable of being used as a marker gene; (e) at least one gene disruption auxiliary (gda) sequence; and (f) an upstream and a downstream sequences of the target gene, wherein the gda sequence is at least 300 to 600 bp in length and selected from within the nucleotide sequence of SEQ ID NO:39.
    Type: Application
    Filed: December 17, 2015
    Publication date: May 23, 2019
    Applicant: Evonik Degussa (China) Co., Ltd.
    Inventors: Xianzhong Chen, Lihua Zhang, Zheng Xiang, Wei Shen, Li Li, Markus Pötter
  • Publication number: 20190033221
    Abstract: The present invention discloses a coagulation analyzer and a coagulation analysis method which relate to the technical field of medical instruments. The coagulation analyzer includes an optical coagulation analysis module, a sample interference analysis module, a magnetic coagulation analysis module, and a test transfer module. The coagulation analyzer uses the sample interference analysis module to determine whether an interferent in the sample has effect on the coagulation test result of the optical coagulation analysis module. If the interferent in the sample has no effect on the coagulation test result, the optical coagulation analysis module is used to perform the coagulation analysis and report the test result. If the interferent in the sample has effect on the coagulation test result, the test transfer module is used to transfer the test to the magnetic coagulation analysis module to perform the coagulation analysis and report the test result.
    Type: Application
    Filed: May 30, 2018
    Publication date: January 31, 2019
    Applicant: SHENZHEN THISTORY BIO-MEDICAL CO.,LTD
    Inventor: Lihua ZHANG
  • Publication number: 20180303761
    Abstract: The present invention provides a method of preparing highly stable microcapsule powders or microparticles containing a fat-soluble nutrient having multiple double bonds.
    Type: Application
    Filed: October 12, 2015
    Publication date: October 25, 2018
    Inventors: Xinde Xu, Di Zhou, Lihua Zhang, Bin Shao
  • Publication number: 20180258147
    Abstract: A pearl protein preparation method is provided comprising the following steps: (1) grinding pearls into pearl powder; (2) performing ultra-high pressure homogenization to the nanoscale pearl powder using deionized water bath, proceeding with centrifugation at low temperature to obtain a water-soluble pearl extract a and sediments, and rinsing the sediments with ethanol solution; (3) dissolving the sediments in weak acid at certain temperature, and stirring at a low speed for reaction; performing centrifugation at low temperature, and obtaining a supernatant being an acid-soluble pearl extract b; (4) performing desalination to water-soluble pearl extract a and acid-soluble pearl extract b respectively; (5) freeze-drying the water-soluble pearl extract a and acid-soluble pearl extract b after desalination, and obtaining a water-soluble pearl protein and an acid-soluble pearl protein respectively.
    Type: Application
    Filed: October 28, 2015
    Publication date: September 13, 2018
    Applicant: Osmun Biological co., LTD
    Inventors: Anquan YANG, Jing WANG, Lihua ZHANG
  • Publication number: 20180246117
    Abstract: A multiplex proteome quantification method based on isobaric dimethyl labeling, which implements dimethyl labeling of peptide N-terminal in an acidic condition and C-terminal in an alkaline condition one after another by means of a property that a dimethylation reaction has different rates on an amino group at the peptide N-terminal and an amino group on a Lysine side chain at the peptide C-terminal in the acidic condition. Multiplex labeling of peptide samples is implemented by means of the organic combination of various isotope forms of a dimethyl labeling reagents. The mass-to-charge ratios in MS1 of peptides after multiplex labeling are completely the same, the mass-to-charge ratios of the fragment ions in MS2 are different, and multiplex quantitative analyses are carried out by extracting the intensity values of corresponding fragment ions in the MS2.
    Type: Application
    Filed: November 20, 2015
    Publication date: August 30, 2018
    Inventors: Lihua ZHANG, Jianhui LIU, Yuan ZHOU, Kaiguang YANG, Yukui ZHANG
  • Patent number: 10028914
    Abstract: The present invention describes a reduction type coenzyme Q10 powder, a composition thereof, and a preparation method thereof. The reduction type coenzyme Q10 powder is obtained by reacting an oxidation type coenzyme Q10 with the presence of a reducing agent, removing an organic solvent and other purities from a reaction solution after the reaction is finished to obtain an oil-soluble reduction type coenzyme Q10 liquid, and then directly performing prill formation with cold wind on an obtained reduction type coenzyme Q10 greasy substance. The obtained reduction type coenzyme Q10 powder has a lower crystallinity, and in a Cu-K[alpha] X-ray diffraction spectrum, has a strong peak at a diffraction angle 2[theta] being 18.9 DEG, and has a very strong absorption peak at a diffraction angle 2[theta] being 22.8 DEG.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: July 24, 2018
    Assignee: ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICA FACTORY
    Inventors: Xinde Xu, Gang Chen, Xuejun Lao, Lihua Zhang, Xiaoxia Sun, Xiaoyue Jiang
  • Patent number: 10011550
    Abstract: A method for preparing high-content conjugated linoleic acid (CLA) through purification of vegetable oil includes alcoholysis, purification and isomerization of vegetable oil. Alcoholysis is for preparing corresponding methyl ester or ethyl ester with glyceride; purification of methyl ester or ethyl ester is for obtaining methyl linoleate or ethyl linoleate of content over 85% through silver-based silica gel column chromatography; high-content CLA is obtained after alkali-catalyzed conjugation of methyl linoleate or ethyl linoleate, and CLA products are prepared as needed. This invention changes the status quo of preparing high-content CLA with safflower oil alone, expands sources of CLA, and develops an efficient technology for separation and purification of linoleic acid. The CLA obtained is of high purity and meets applications in pharmaceutical, health care products and other industries.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: July 3, 2018
    Assignee: ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY
    Inventors: Yongjian Peng, Xinde Xu, Bin Shao, Lihua Zhang
  • Publication number: 20180148169
    Abstract: An unmanned aerial vehicle (UAV) with omnidirectional thrust vectoring includes a central unit, a connective structure, and a plurality of propulsion units with omnidirectional thrust vectoring allowing a full six degrees of freedom. A vectored propulsion unit comprises thruster vectored by an omnidirectional mechanism and may include an autonomous sub-vehicle housed within a rotational frame, or an actuator-thruster assembly with directional control. A UAV with omnidirectional thrust vectoring includes a control system with a ground station unit, a central flight control unit, and a propulsion control unit. A plurality of vectored propulsion units working in coordination allows an unmanned aerial vehicle to maneuver with any stance or body orientation.
    Type: Application
    Filed: May 25, 2017
    Publication date: May 31, 2018
    Inventors: Lihua Zhang, Xing Wang, Zheng Zhang
  • Patent number: 9889093
    Abstract: The present invention relates to an andrographolide enteric targeting micropellet and a method for preparation thereof; furthermore, the present invention also relates to uses of andrographolide and andrographolide enteric targeting micropellets in preparation of a pharmaceutical for treatment of inflammatory bowel disease.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: February 13, 2018
    Assignee: Tasly Pharmaceutical Group Co., Ltd.
    Inventors: Henry Sun, Xiaohui Ma, Zhixin Guo, Sen Lin, Genbei Wang, Lulu Yan, Lihua Zhang, Shuiping Zhou, Shunnan Zhang
  • Patent number: 9889173
    Abstract: The present invention provides a composition for improving macular pigment optical density and preventing or treating age-related macular optical degeneration. The composition comprises lutein, zeaxanthin and tea extracts, wherein the weight ratio of zeaxanthin to lutein is more than or equal to 1. The composition may prevent formation of choroidal neovascularization to achieve effects on comprehensively preventing or treating age-related macular optical degeneration (AMD).
    Type: Grant
    Filed: August 8, 2013
    Date of Patent: February 13, 2018
    Assignee: Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
    Inventors: Xinde Xu, Lihua Zhang, Xiaoxia Sun
  • Publication number: 20170275228
    Abstract: A method for preparing high-content conjugated linoleic acid (CLA) through Purification of vegetable oil includes alcoholysis, purification and isomerization of vegetable oil. Alcoholysis is for preparing corresponding methyl ester or ethyl ester with glyceride; purification of methyl ester or ethyl ester is for obtaining methyl linoleate or ethyl linoleate of content over 85% through silver-based silica gel column chromatography; high-content CLA is obtained after alkali-catalyzed conjugation of methyl linoleate or ethyl linoleate, and CLA products are prepared as needed. This invention changes the status quo of preparing high-content CLA with safflower oil alone, expands sources of CLA, and develops an efficient technology for separation and purification of linoleic acid. The CLA obtained is of high purity and meets applications in pharmaceutical, health care products and other industries.
    Type: Application
    Filed: September 17, 2015
    Publication date: September 28, 2017
    Applicant: ZHEJIANG MEDICINE CO., LTD., XINCHANG PHARMACEUTICAL FACTORY
    Inventors: YONGJIAN PENG, XINDE XU, BIN SHAO, LIHUA ZHANG
  • Publication number: 20170224622
    Abstract: The present invention relates to an andrographolide enteric targeting micropellet and method for preparation thereof; furthermore, the present invention also relates to uses of andrographolide and andrographolide enteric targeting micropellets in the preparation of a pharmaceutical for treatment of inflammatory bowel disease.
    Type: Application
    Filed: March 27, 2017
    Publication date: August 10, 2017
    Inventors: Henry Sun, Xiaohui Ma, Zhixin Guo, Sen Lin, Genbei Wang, Lulu Yan, Lihua Zhang, Shuiping Zhou, Shunnan Zhang
  • Publication number: 20170224623
    Abstract: The present invention relates to an andrographolide enteric targeting micropellet and method for preparation thereof; furthermore, the present invention also relates to uses of andrographolide and andrographolide enteric targeting micropellets in the preparation of a pharmaceutical for treatment of inflammatory bowel disease.
    Type: Application
    Filed: March 27, 2017
    Publication date: August 10, 2017
    Inventors: Henry Sun, Xiaohui Ma, Zhixin Guo, Sen Lin, Genbei Wang, Lulu Yan, Lihua Zhang, Shuiping Zhou, Shunnan Zhang
  • Publication number: 20170225094
    Abstract: The present disclosure discloses a microwave flash evaporation process and apparatus and uses thereof. A microwave flash evaporation process, wherein the process makes integration of those technologies for liquid spraying, liquid droplet flash evaporation, microwave enhancement, vacuum steam discharge, and simulation and optimization of multi-mode resonant cavity, wherein through the coupling effect of the microwave, by means of one stage microwave flash evaporation, the effect normally achieved by multi-effect evaporation and flash evaporation is obtained and a liquid droplet micro-system with microwave energy transfer in situ is formed so as to prevent a circulation pump and a steam heat exchange system from being corroded under high temperature and high pressure, and prevent scaling on a heat exchanger, and improve evaporation efficiency.
    Type: Application
    Filed: April 19, 2016
    Publication date: August 10, 2017
    Inventors: Shaohua JU, Jinhui PENG, Zhanyong GUO, Hua CHEN, Jun SUN, Shenghui GUO, Chao LIU, Lei XU, Linqing DAI, Lihua ZHANG, Shihong TIAN
  • Publication number: 20160340670
    Abstract: A method for generating a library of expression vectors comprising a plurality of donor sequences and a plurality of oligo-linker nucleic acids, termed Oligonucleotide Linker-Mediated DNA Assembly (OLMA), is described. Also described are applications of the OLMA method, including the simultaneous tuning of several factors in metabolic and biological pathways, and the combinatorial high throughput optimization of metabolic and biological pathways.
    Type: Application
    Filed: May 20, 2016
    Publication date: November 24, 2016
    Inventors: Chunbo LOU, Yong TAO, Xuejin ZHAO, Shasha ZHANG, Lihua ZHANG, Chunhua ZHAI, Zhenyu LIU
  • Patent number: 9376357
    Abstract: The invention discloses a method for preparing high-content zeaxanthin. In the conventional preparation methods, some methods adopt certain toxic organic solvents; some methods require the multi-step crystallization process; and some methods are featured by long reaction time, high temperature and lower product yield, thus being not suitable for industrial production. The invention adopts lutein crystal or its fatty acid ester as the raw material and utilizes isomerization reaction to produce zeaxanthin, and is characterized in that a mixed catalyst consisting of an organic base catalyst and a cocatalyst is used in the isomerization reaction, wherein the cocatalyst is palladium carbon. The invention has the advantages of simple process route, low reaction temperature, short reaction time, good product purity and high yield, thus being suitable for industrial production, and no poisonous and harmful organic solvent residues in the product, thus being suitable for the use as a food additive or drug.
    Type: Grant
    Filed: July 9, 2013
    Date of Patent: June 28, 2016
    Assignees: ZHEJIANG MEDICINE CO., LTD., XIECHANG PHARMACEUTICAL FACTORY
    Inventors: Bin Shao, Lihua Zhang, Xinde Xu, Xiaoxia Sun
  • Publication number: 20160175253
    Abstract: The present invention relates to an andrographolide enteric targeting micropellet and a method for preparation thereof; furthermore, the present invention also relates to uses of andrographolide and andrographolide enteric targeting micropellets in preparation of a pharmaceutical for treatment of inflammatory bowel disease.
    Type: Application
    Filed: August 6, 2014
    Publication date: June 23, 2016
    Inventors: Henry Sun, Xiaohui Ma, Zhixin Guo, Sen Lin, Genbei Wang, Lulu Yan, Lihua Zhang, Shuiping Zhou, Shunnan Zhang
  • Publication number: 20160101053
    Abstract: The present invention describes a reduction type coenzyme Q10 powder, a composition thereof, and a preparation method thereof. The reduction type coenzyme Q10 powder is obtained by reacting an oxidation type coenzyme Q10 with the presence of a reducing agent, removing an organic solvent and other purities from a reaction solution after the reaction is finished to obtain an oil-soluble reduction type coenzyme Q10 liquid, and then directly performing prill formation with cold wind on an obtained reduction type coenzyme Q10 greasy substance. The obtained reduction type coenzyme Q10 powder has a lower crystallinity, and in a Cu-K[alpha] X-ray diffraction spectrum, has a strong peak at a diffraction angle 2[theta] being 18.9 DEG, and has a very strong absorption peak at a diffraction angle 2[theta] being 22.8 DEG.
    Type: Application
    Filed: March 14, 2014
    Publication date: April 14, 2016
    Inventors: Xinde XU, Gang CHEN, Xuejun LAO, Lihua ZHANG, Xiaoxia SUN, Xiaoyue JIANG