Abstract: Systems and methods generate a first security node hash identifier by performing a first hash operation, such as a one-way hash, on a first data resource identifier associated with a first data resource, such as a data set, produced by a data resource platform. The systems and methods generate a dependent second security node hash identifier by performing a second hash operation on a second data resource identifier associated with a dependent second data resource produced by the data resource platform and on the first security node hash identifier, receive an access request for access to the dependent second data resource; and in response to the access request, grant permission to access the dependent second data resource to a user associated with the access request based on the dependent second security node hash identifier.

Abstract: We have discovered MAO-A induction in mouse and human TAMs. Moreover, we determined that MAO-A-deficient mice exhibited decreased TAM immunosuppressive functions corresponding with enhanced antitumour immunity. Building upon these discoveries, we then determined that MAOI treatment induced TAM reprogramming and suppressed tumour growth in preclinical mouse syngeneic and human xenograft tumour models. Surprisingly, combining MAOI and anti-PD-1 treatments resulted in synergistic tumour suppression. Together, these data identify MAO-A as a critical regulator of TAMs, and that show that repurposing MAOIs for TAM reprogramming can be used to improve cancer immunotherapies.

Abstract: Monoamine oxidase A (MAO-A) is an enzyme best known for its function in the brain, where it breaks down neurotransmitters and thereby influences mood and behavior. While small molecule MAO inhibitors (MAOIs) have been developed used for treating depression and other neurological disorder, the involvement of MAO-A in antitumor immunity has not been known. The disclosure provided herein identifies MAO-A as an immune checkpoint and the use of MAOI antidepressants for cancer immunotherapy. Here we report induction of the Maoa gene in tumor-infiltrating immune cells. MAOI treatment significantly suppressed tumor growth in preclinical mouse syngeneic and human xenograft tumor models in a T cell-dependent manner. Combining MAOI and anti-PD-1 treatments generated synergistic tumor suppression effects. Clinical data correlation studies associated intratumoral MAOA expression with T cell dysfunction and impaired patient survival in a broad range of cancers.

Abstract: Systems and methods generate a first security node hash identifier by performing a first hash operation, such as a one-way hash, on a first data resource identifier associated with a first data resource, such as a data set, produced by a data resource platform. The systems and methods generate a dependent second security node hash identifier by performing a second hash operation on a second data resource identifier associated with a dependent second data resource produced by the data resource platform and on the first security node hash identifier, receive an access request for access to the dependent second data resource; and in response to the access request, grant permission to access the dependent second data resource to a user associated with the access request based on the dependent second security node hash identifier.

Abstract: The present invention relates to the field of petroleum industry phase oilfield chemistry, and specifically relates to a bionic and dual-phobic drilling fluid. The drilling fluid contains a bionic wall-fixing agent, a bionic lubricant, a super dual-phobic agent, a scrap-carrying agent and a bionic shale inhibitor. The present invention uses the theory of bionics and the theory of a downhole rock surface being double phobic as a basis. By means of using the bionic wall-fixing agent, the bionic lubricant, the super dual-phobic agent, the scrap-carrying agent and the bionic shale inhibitor, which have special properties of imitating animals and plants in nature, and using a series of bionic treatment agents, a set of bionic and dual-phobic drilling fluid systems, which corresponds to an unconventional, complex oil and gas well, is formed.

Abstract: Aspects of the present disclosure relate to methods and compositions related to the preparation of immune cells, including engineered invariant natural killer T (iNKT) cells for off-the-shelf use for COVID-19 clinical therapy. The iNKT cells may be produced from hematopoietic stem progenitor cells and are suitable for allogeneic cellular therapy.

Abstract: A 4D quantitative and intelligent diagnosis method for spatio-temporal evolution of oil-gas reservoir damage types and extent includes: determining a characteristic parameter characterizing reservoir damage by each of a plurality of factors based on a spatio-temporal evolution simulation equation of reservoir damage by each of the plurality of factors; and determining an effective characteristic parameter characterizing the damage extent of the reservoir based on the characteristic parameter characterizing reservoir damage by each of the plurality of factors. The method quantitatively simulate the characteristic parameters of reservoir damage caused by the various factors and a total characteristic parameter of the reservoir damage.

Abstract: The present invention relates to the field of petroleum industry phase oilfield chemistry, and specifically relates to a bionic and dual-phobic drilling fluid. The drilling fluid contains a bionic wall-fixing agent, a bionic lubricant, a super dual-phobic agent, a scrap-carrying agent and a bionic shale inhibitor. The present invention uses the theory of bionics and the theory of a downhole rock surface being double phobic as a basis. By means of using the bionic wall-fixing agent, the bionic lubricant, the super dual-phobic agent, the scrap-carrying agent and the bionic shale inhibitor, which have special properties of imitating animals and plants in nature, and using a series of bionic treatment agents, a set of bionic and dual-phobic drilling fluid systems, which corresponds to an unconventional, complex oil and gas well, is formed.

Abstract: The invention relates to the technical field of oil and gas drilling, and discloses an amphiphilic block polymer ultralow-permeability agent and an intelligent temporary plugging type water-based drilling fluid. The ultralow-permeability agent contains a structural unit provided by styryl hydrophobic monomer, maleic anhydride and acrylamide; the drilling fluid contains two or more of water, sodium bentonite, Pac-Lv, the ultralow-permeability agent, calcium carbonate, one-way plugging agent, white asphalt and barite which are stored in a mixed manner or independently stored.

Abstract: The invention relates to the technical field of oilfield exploration, and discloses a 4D quantitative and intelligent diagnosis method and system for spatio-temporal evolution of oil-gas reservoir damage types and extent. The method includes: determining a characteristic parameter characterizing reservoir damage by each of a plurality of factors based on a spatio-temporal evolution simulation equation of reservoir damage by each of the plurality of factors; and determining an effective characteristic parameter characterizing the damage extent of the reservoir based on the characteristic parameter characterizing reservoir damage rby each of the plurality of factors. The invention can quantitatively simulate the characteristic parameters of reservoir damage caused by the various factors and a total characteristic parameter of the reservoir damage.

Abstract: Disclosed herein are invariant natural killer T (iNKT) cells engineered using hematopoietic stem and progenitor cells (HSPCs) and methods of making and using thereof.

Abstract: The invention relates to the field of drilling fluid, in particular to a saturated salt water drilling fluid of salt response type intelligent polymer and preparation method thereof. The drilling fluid contains two or more of the following components stored in admixture or separately: bentonite, NaOH, KCl, calcium carbonate, barite, NaCl, supramolecular fluid loss additive, supramolecular shear-enhancing agent, plugging agent, coating agent and water. The drilling fluid provided by the invention has the characteristics of salt response and self-assembly, can keep rheological properties such as rapid recovery of the sheared structure, low extreme high shear rate viscosity, good shear dilution property and the like in a high-salt environment, has good fluid loss reduction performance, reservoir protection performance and debris dispersion inhibition performance, and has good temperature resistance and pollution resistance performance.

Abstract: The invention relates to the field of oilfield chemistry, and discloses a self-repairing plugging gel polymer for drilling fluid, a preparation method and application thereof, and the drilling fluid containing the gel polymer, wherein the polymer contains a structural unit A, a structural unit B, a structural unit C and a structural unit D, and the structural unit A is a structural unit with a structure shown in the formula (1); the structural unit B is a structural unit with a structure shown in the formula (2); the structural unit C is a structural unit with a structure shown in the formula (3); the structural unit D is a structural unit having a structure represented by the formula (4).

Abstract: As disclosed herein, we have discovered that creatine is a critical molecule buffering ATP levels in cancer-targeting CD8 T cells through maintaining a readily available high-energy phosphate reservoir. Building upon this discovery, we have designed a number of methods for modulating energy metabolism in a population of tumor-infiltrating CD8 T cells, methods that can be adapted for use in therapeutic regimens for the treatment of cancer. Illustrative embodiments of the invention include methods for enhancing tumor-infiltrating CD8 T cells ability to mount and sustain a response to tumor cells comprising increasing the concentrations of creatine available for tumor-infiltrating CD8 T cells energy metabolism, thereby enhancing the ability of the tumor-infiltrating CD8 T cells to mount and sustain a response to the tumor cells.

Abstract: Aspects of the present disclosure relate to methods and compositions related to the preparation of immune cells, including engineered immune cells. Certain embodiments of the disclosure include compositions, cells, and methods related to engineered invariant natural killer T (iNKT) cells for off-the-shelf use for clinical therapy. The iNKT cells may be produced from hematopoietic stem progenitor cells and may be suitable for allogeneic cellular therapy because they are HLA negative. In some aspects, the cells have imaging and suicide targeting capabilities.

Abstract: The present invention provides a 19F-MR/fluorescence multi-mode molecular imaging and drug loading diagnosis-treatment integrated nanoprobe, and a preparation method and an application. The nano-probe is a nanoparticle formed by coating a mixture of a surfactant containing a molecular targeting treatment drug and a fluorescent dye with a Perfluorocarbon (PFC) carrier; and by uniformly dispersing a mixed solution into water and glycerol, processing ultrasonically, removing a component which is not effectively coated, and purifying, the drug-loading nanoparticle capable of being used for 19 F-MR imaging may be prepared.

Abstract: Aspects of the present disclosure relate to methods and compositions related to the preparation of immune cells, including engineered T cells comprising at least one exogenous ?? T cell receptor, for example one that is selected to target a specific disease or pathogen (e.g., cancer or COVID-19). The T cells may be produced from human hematopoietic stem/progenitor cells and are suitable for allogeneic cellular therapy because they do not induce graft-versus-host disease (GvHD) and resist host immune allorejection. Consequently, such cells are suitable for off-the-shelf use in clinical therapy.

Abstract: The invention relates to the technical field of oil and gas drilling, and discloses an amphiphilic block polymer ultralow-permeability agent and an intelligent temporary plugging type water-based drilling fluid. The ultralow-permeability agent contains a structural unit provided by styryl hydrophobic monomer, maleic anhydride and acrylamide; the drilling fluid contains two or more of water, sodium bentonite, Pac-Lv, the ultralow-permeability agent, calcium carbonate, one-way plugging agent, white asphalt and barite which are stored in a mixed manner or independently stored.

Abstract: A system and method for authenticating users of a data processing platform stores a mapping of a unique user platform identifier to multiple user identity provider identifiers associated with multiple realms for a same user. In some examples, the method includes receiving a request from a client device to establish an access session to perform one or more actions on data of the data processing platform and receiving, from at least one of the first external identity provider of the first realm or the second external identity provider of the second realm, a user identity provider identifier associated with the request. In certain examples, the method includes granting permission to perform the one or more actions on the data of the data processing platform based at least in part on the received user identity provider identifier.

Abstract: Systems and methods generate a first security node hash identifier by performing a first hash operation, such as a one-way hash, on a first data resource identifier associated with a first data resource, such as a data set, produced by a data resource platform. The systems and methods generate a dependent second security node hash identifier by performing a second hash operation on a second data resource identifier associated with a dependent second data resource produced by the data resource platform and on the first security node hash identifier, receive an access request for access to the dependent second data resource; and in response to the access request, grant permission to access the dependent second data resource to a user associated with the access request based on the dependent second security node hash identifier.