Abstract: The present invention provides a 19F-MR/fluorescence multi-mode molecular imaging and drug loading diagnosis-treatment integrated nanoprobe, and a preparation method and an application. The nano-probe is a nanoparticle formed by coating a mixture of a surfactant containing a molecular targeting treatment drug and a fluorescent dye with a Perfluorocarbon (PFC) carrier; and by uniformly dispersing a mixed solution into water and glycerol, processing ultrasonically, removing a component which is not effectively coated, and purifying, the drug-loading nanoparticle capable of being used for 19 F-MR imaging may be prepared.

Abstract: Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.

Abstract: A data processing method, apparatus, and a fitness robot relate to the artificial intelligent field, where the data processing method includes calculating first energy consumption of a user in a preset time interval based on exercise data of the user, obtaining a first body weight change of the user in the preset time interval, predicting, based on the first energy consumption and the first body weight change, second energy consumption and a second body weight change of the user in a future preset time interval, obtaining, based on the first energy consumption, the first body weight change, the second energy consumption, and the second body weight change, a result indicating the user capability of completing an intended fitness plan, and correcting specified energy consumption of the user and a specified body weight change of the user in the preset time interval in the intended fitness plan based on the result.

Abstract: Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.

Abstract: The invention relates to the field of petroleum drilling fluids, and discloses a super-amphiphobic strongly self-cleaning high-performance water-based drilling fluid comprising polymeric super-amphiphobic agent and a drilling method. The polymeric super-amphiphobic agent comprises structural units A derived from acrylamide, structural units B derived from methyl methacrylate, structural units C derived from butyl acrylate, structural units D derived from a compound represented by the following formula (1), structural units E derived from a silane coupler, and nano-titania; wherein the nano-titania is bonded to the polymeric super-amphiphobic agent via the structural unit E, and the silane coupler is a silane coupler having double bonds; R is a C3-C8 perfluoroalkyl group. A water-based drilling fluid additive prepared from the polymeric super-amphiphobic agent in the present invention has excellent wettability, inhibition, lubrication, reservoir protection, and rheology and fluid loss properties.

Abstract: The present invention relates to the well drilling field in petrochemical industry, in particular to use of dual-cation fluorocarbon surfactant as amphiphobic wettability reversal agent in drilling fluid. The dual-cation fluorocarbon surfactant is a dual-cation fluorocarbon surfactant of which the cation part is represented by the following formula (1). The dual-cation fluorocarbon surfactant of the present invention can serve as wettability reversal agent when it is used for oil-gas drilling to enable rock amphiphobic, and is an amphiphobic wettability reversal agent which can cause rock surface to be non-hydrophilic and non-lipophilic. Using of dual-cation fluorocarbon surfactant, especially when drilling highly hydrous mud shale, can avoid permeation of water and oil into the rock effectively and thereby a capillary phenomenon can be prevented, and an effect of stabilizing the well wall and protecting the reservoir is attained.

Abstract: A super-amphiphobic composite material and use of the same as an inhibitor, lubricant, reservoir protectant, and accelerator in water-based drilling fluids. A method for preparing the amphiphobic composite material includes: performing a first mixing of nano-titanium dioxide and nano-silicon dioxide in an alcohol-water mixed solvent under an alkaline condition, to obtain a dispersion of nano-titanium dioxide and nano-silicon dioxide; then introducing a fluorosilicone-containing coupler into the dispersion of nano-titanium dioxide and nano-silicon dioxide and performing a second mixing. The amphiphobic composite material may be applied in water-based drilling fluids. It has an effect of strongly inhibiting hydrated swelling and disintegration, low toxicity and high compatibility; can solve problems such as well wall instability, blockage of drilling tools, and reservoir damage, etc.

Abstract: The present invention relates to well drilling field in the petroleum industry, particularly to accelerator used for drilling fluids, water-based drilling fluid and usage thereof. The accelerator contains: sulfonated polyglycerol long-chain fatty acid ester, fatty alcohol polyoxyethylene ether, alcohol ether carboxylate, glycidyl ether, and polyoxyethylene alkylphenol ether; wherein, the weight ratio of the sulfonated polyglycerol long-chain fatty acid ester:the fatty alcohol polyoxyethylene ether:the alcohol ether carboxylate:the glycidyl ether:the polyoxyethylene alkylphenol ether is 100:1-10:0.5-10:1-10:1-10. The accelerator provided in the present invention can lubricate the drill bit and drilling tool, prevent accumulation of drill cuttings, reduce friction, and improve rate of penetrate.

Abstract: Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.

Abstract: The present invention relates to the well drilling field in the petroleum industry, particularly to film former used for coal-bed gas well drilling and preparation method thereof, drilling fluid and usage thereof. The preparation method of the film former includes: (1) controlling polycaprolactone diol and diisocyanate to have a first polymerization reaction in the presence of a polyurethane catalyst, to obtain a polyurethane prepolymer with two ends blocked by diisocyanate; (2) controlling the product of the first polymerization reaction to have a chain extension reaction with a polyalcohol; (3) controlling the product of the chain extension reaction and one part of hydroxyalkyl acrylate monomer to have an additive reaction, and then introducing the other part of hydroxyalkyl acrylate monomer and a styrene monomer, and emulsifying in water to obtain an emulsion; (4) mixing a radical initiator with the emulsion to have a second polymerization reaction.

Abstract: The present invention relates to the well drilling field in the petroleum industry, particularly to film former used for coal-bed gas well drilling and preparation method thereof, drilling fluid and usage thereof. The preparation method of the film former includes: (1) controlling polycaprolactone diol and diisocyanate to have a first polymerization reaction in the presence of a polyurethane catalyst, to obtain a polyurethane prepolymer with two ends blocked by diisocyanate; (2) controlling the product of the first polymerization reaction to have a chain extension reaction with a polyalcohol; (3) controlling the product of the chain extension reaction and one part of hydroxyalkyl acrylate monomer to have an additive reaction, and then introducing the other part of hydroxyalkyl acrylate monomer and a styrene monomer, and emulsifying in water to obtain an emulsion; (4) mixing a radical initiator with the emulsion to have a second polymerization reaction.

Abstract: The present invention relates to well drilling field in the petroleum industry, particularly to accelerator used for drilling fluids, water-based drilling fluid and usage thereof. The accelerator contains: sulfonated polyglycerol long-chain fatty acid ester, fatty alcohol polyoxyethylene ether, alcohol ether carboxylate, glycidyl ether, and polyoxyethylene alkylphenol ether; wherein, the weight ratio of the sulfonated polyglycerol long-chain fatty acid ester:the fatty alcohol polyoxyethylene ether:the alcohol ether carboxylate:the glycidyl ether:the polyoxyethylene alkylphenol ether is 100:1-10:0.5-10:1-10:1-10. The accelerator provided in the present invention can lubricate the drill bit and drilling tool, prevent accumulation of drill cuttings, reduce friction, and improve rate of penetrate.

Abstract: Provided herein are fluid compositions comprising at least one silane having one or more hydrophilic groups, at least one silane having one or more fluorinated moieties, and stringed silica nanoparticles. Additionally, superamphiphobic surfaces resulting from coating and curing a fluid composition on a substrate are disclosed. Also provided are methods of forming a superamphiphobic surface, comprising coating a substrate of interest with the fluid composition and curing the coated substrate.

Abstract: The present invention discloses a high-performance PPS fiber structure and production method and use thereof. The high-performance PPS fiber structure is woven fabric made from PPS fibers in 0.1 to 12 ?m cross sectional diameter, and the maximum pore size of the PPS fiber structure is 20 ?m or smaller. The PPS fiber structure disclosed in the present invention has the advantages of high gas impermeability and good hydrophilicity, also has the advantages of simple process, low energy consumption and zero environmental pollution, and can be used in diaphragms for electrolytic apparatuses, high-temperature liquid filter materials and insulating materials.

Abstract: The present invention relates to the well drilling field in petroleum industry, in particular to a nano-hybrid lubricant and method thereof, and oil-based drilling fluid. The lubricant comprises: graphite oxide and a biquaternary ammonium salt compound of which the cation part is represented by formula (1). The present invention also provides a method for preparation of the lubricant and an oil-based drilling fluid containing the lubricant. The lubricant provided in the present invention can be comprehended as a nano-hybrid material. Thus, oil-based drilling fluids that contain the lubricant provided in the present invention have lower lubrication coefficient and excellent lubricating property without or with little negative impact on rheological property of the oil fluid, and the lubricant provided in the present invention has excellent thermostability thus suitable for use in operation at a high temperature.

Abstract: The present invention relates to the well drilling field in petrochemical industry, in particular to use of dual-cation fluorocarbon surfactant as amphiphobic wettability reversal agent in drilling fluid. The dual-cation fluorocarbon surfactant is a dual-cation fluorocarbon surfactant of which the cation part is represented by the following formula (1). The dual-cation fluorocarbon surfactant of the present invention can serve as wettability reversal agent when it is used for oil-gas drilling to enable rock amphiphobic, and is an amphiphobic wettability reversal agent which can cause rock surface to be non-hydrophilic and non-lipophilic. Using of dual-cation fluorocarbon surfactant, especially when drilling highly hydrous mud shale, can avoid permeation of water and oil into the rock effectively and thereby a capillary phenomenon can be prevented, and an effect of stabilizing the well wall and protecting the reservoir is attained.

Abstract: Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.

Abstract: The present invention relates to the well drilling field in petroleum industry, in particular to a drilling fluid additive composition that contains a lubricant, an emulsifier, and a rheological modifier, wherein, the lubricant contains: graphite oxide and a biquaternary ammonium salt compound in which the cation part is represented by formula (1); the emulsifier is one or more of compounds represented by formula (I); the rheological modifier is a dimer acid-organic amine copolymer comprising structural units from dimer acid, structural units from alkylamine and structural units from arylamine. The present invention further provides an oil-based drilling fluid containing the composition and a use thereof.

Abstract: Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus. A separate fusogenic molecule is also present on the envelope and facilitates delivery of the polynucleotide across the membrane and into the cytosol of the target cell. The methods and related compositions can be used for treating patients having suffering from a wide range of conditions, including infection, such as HIV; cancers, such as non-Hodgkin's lymphoma and breast cancer; and hematological disorders, such as severe combined immunodeficiency.

Abstract: The present invention relates to the well drilling field in petroleum industry, in particular to a drilling fluid additive composition suitable for coal-bed gas wells, and a water-based drilling fluid and use of the water-based drilling fluid. The drilling fluid additive composition suitable for coal-bed gas wells, comprising a tackifying and shear improver, a capsulating agent, a filtrate reducer, and an amphiphobic wettability reversal agent, wherein, the tackifying and shear improver is a copolymer comprising structural units represented by formula (1), structural units represented by formula (2), and structural units represented by formula (3); the capsulating agent is a comb-like polysaccharide compound; the filtrate reducer is nanocrystalline cellulose, and the amphiphobic wettability reversal agent is a dual-cation fluorocarbon surfactant.