Abstract: Selection of training utterances may be carried out in a sample-efficient manner, and the selected training utterances may be annotated to provide improved training information to an ASR system. A computing device may receive, from an ASR system, one or more transcript-score pairs, wherein a transcript-score pair comprises a transcription associated with a voice query and at least one score associated with the transcription. The computing device may determine a likelihood of a word error associated with each transcription of the one or more transcript-score pairs. The computing device may determine, based on the likelihood of the word error, an effect on a word-error rate of the ASR system. The computing device may send at least one of the one or more transcript-score pairs with a threshold effect on the word-error rate of the ASR system to be annotated.

Abstract: Methods of forming a coating system on a surface of a cobalt-based superalloy component are provided. The method includes forming a nickel-based primer layer on the surface of the cobalt-based superalloy component; forming an intermediate nickel-containing layer on the nickel-based primer layer; and heat treating the cobalt-based superalloy component to form a diffusion coating on the surface of the cobalt-based superalloy component. The intermediate nickel-containing layer includes nickel, chromium, and aluminum. Coated cobalt-based superalloy components formed from such a method are also provided.

Abstract: Broadly applicable and stereoselective formation of glycosidic linkage remains challenging yet of critical importance in giycoscience. By developing an SN2 glycosylation, this work advances a general solution to this challenge via stereoinversion at the anomeric position of glycosyl ester donors. This SN2 process is enabled by a basic directing-group in the leaving-group, which is activated by a cationic gold catalyst or any other electrophilic reagent. Unlike all the reported directing group approaches, this strategy is applicable to any glycosyl donors—a long sought-after yet unmet goal in carbohydrate chemistry; moreover, the basic directing-group upon glycosylation is lost as part of the leaving-group and hence traceless in the glycoside products, therefore avoiding potential complications in downstream transformations. Highly selective construction of glycosidic bonds including challenging 1,2-cis glycosidic bonds is achieved in excellent yields.

Abstract: A light-emitting diode (LED) includes a semiconductor structure, a transparent conducting layer, a first electrode, and a second electrode. The semiconductor structure has a lower surface and an upper surface, and includes a first semiconductor layer, an active layer, and a second semiconductor layer that are sequentially stacked in a laminating direction from the lower surface to the upper surface. The transparent conducting layer is located on the second semiconductor layer. The first electrode is located on the first semiconductor layer. The second electrode is located on the transparent conducting layer. When viewing the semiconductor structure and the transparent conducting layer from above the LED. The semiconductor structure has a shortest side with a length of X ?m.

Abstract: A method includes receiving time trace sensor data associated with a substrate processing procedure. The substrate processing procedure includes two or more sets of processing conditions. At least a first set of processing conditions and a second set of processing conditions each include one or more operations performed repeatedly. The method further includes separating a first and second portion of the time trace sensor data corresponding to the first and second sets of processing conditions into a first and second plurality of cycle data. The method further includes processing the first plurality of cycle data and the second plurality of cycle data to generate summary data. The method further includes providing an alert to a user. The alert is based on the summary data.

Abstract: A project disaster warning method and system based on collaborative fusion of multi-physical field monitoring data is provided.

Abstract: A computer-implemented method and system for performing online and offline financial transactions universally between any two users through a third party’s authentication mechanism to verify users’ identities, provided that they have at least a social media account. One user can make any payment to anyone. The SMUP system accesses the third-party’s website for credentials authentication. SMUP can be used for a purchase or money transfers with a live internet connection. The user needs to remember only one account credentials instead of many. One user can be a merchant or organization; wherein one of the users may not previously be a SMUP user, the user may passively become a SMUP user during the transaction. The above financial transactions may also happen online or offline at a physical store where a POS machine is used; the store is a SMUP user or partner, and the POS is connected with the SMUP transaction server.

Abstract: The present invention relates to the use of an acetamide derivative in the prevention and treatment of Alzheimer's disease (AD).

Abstract: First audio data associated with a first portion of a voice query (e.g., an incomplete voice query) may be received (e.g., by a device or a server). A first transcript may be determined by a speech recognition engine and based on the first audio data. A plurality of predicted queries may be determined by applying a prediction process to the first transcript. A response for each of the plurality of predicted queries may be determined by processing the plurality of the predicted queries. Second audio data associated with a second portion of the voice query (e.g., a complete voice query) may be received. A second transcript may be determined by the speech recognition engine and based on the second audio data. Based on comparing the second transcript to one of the plurality of predicted queries, a response for the voice query may be returned.

Abstract: Provided are a compound as a PD-L1 inhibitor, a preparation method therefor, and use thereof. Further provided is use of the compound or a pharmaceutical composition thereof in the preparation of a medicine, wherein the medicine is used for preventing and treating a PD-L1-related disease.

Abstract: The present invention discloses a chitin regenerative hydrogel and a preparation method and application thereof, which belong to the technical field of energy materials. The preparation method of the chitin regenerative hydrogel comprises the following steps: 1, performing heating dissolution and cooling molding on chitin and ionic liquid to obtain chitin-ionic liquid gel; and S2, soaking the chitin-ionic liquid gel into alkaline solution to obtain the chitin regenerative hydrogel. The chitin-ionic liquid gel and the chitin regenerative hydrogel that are prepared in the present invention have good restoring capacity and thixotropy capacity.

Abstract: Described herein are compositions comprising (a) methyl 3 -((methyl sulfonyl)amino)-2-(((4-phenylcyclohexyl)oxy)methyl)piperidine- 1 -carboxylate or a salt thereof; and (b) an agent for reducing metabolism of (a) and uses thereof.

Abstract: The present invention provides a method for producing a virus and a harvesting solution composition. The method includes culturing cells, wherein the cells have been inoculated with viruses or have been transfected with viral packaging elements; and contacting the cultured cells with a harvesting solution composition to harvest the viruses by one-step, wherein the harvesting solution composition comprises a trypsin, a pH buffer and optionally a nuclease, and the pH of the harvesting solution composition is greater than 7.5 and no more than 10.5. The virus production method of the present invention has advantages of simple operation, easy scale-up, stable yield and so on, and the yield is unexpectedly and significantly improved compared to the prior art, and it can ensure the integrity of the viral particles without damaging the biological activity of the viruses. Therefore, it is very suitable for large-scale production of viruses.

Abstract: Disclosed are a whole-cell tumor vaccine based on the principle of extracellular traps and a method of making the same, where a CpG ODN network similar to the extracellular trap in structure is formed on the tumor cell surface. The tumor cells are coated with a histone and CpG ODN to form the CpG ODN-coated tumor cells, which are inactivated to produce the whole-cell tumor vaccine. The vaccine of the invention, after injected to tumor model mice, can induce the occurrence of effective immune response to achieve the effective treatment for tumors.

Abstract: The present invention relates to an injection-production relationship optimization method based on heterogeneous flow field characterization. The method comprises the steps of: first, calculating a density of a flow field by adopting a method of converting a linear density into a dot density; then, calculating an intensity of the flow field by adopting an analytic hierarchy process; and performing flow field characterization by utilizing mathematical methods such as PCA dimensionality reduction and clustering and calculating a product of flow line densities and intensities of flow fields in different regions of the flow field, and performing optimization for a goal of minimizing a variance of the product in combination of an genetic algorithm to solve the optimum injection-production quantity as an optimum solution (the optimum injection-production quantity) that enables the flow field to be displaced in a balanced manner.

Abstract: Disclosed are a bacteriologically-modified whole-cell tumor vaccine and a method of making the same. The method includes: lysing bacteria at logarithmic growth phase to obtain a bacterial lysate; mixing the bacterial lysate with an excessive amino compound solution to aminate the bacterial lysate in the presence of EDC; mixing the aminated bacterial lysate with the tumor cells for a certain period of time to produce bacteriologically-modified tumor cells; and inactivating the bacteriologically-modified tumor cells to produce the bacteriologically-modified whole-cell tumor vaccine. The bacteriologically-modified whole-cell tumor vaccine has been demonstrated to have desirable therapeutic effect in tumor model mice.

Abstract: The present invention relates to a preparation method for an amide compound and an application thereof in the field of medicine. Specifically, provided by the present invention is an amide small molecule compound which is an inhibitor of Zeste gene enhancer homolog 2 (EZH2) and which may be used to prevent and/or treat EZH2-mediated related diseases, comprising tumors, myeloproliferative diseases or autoimmune diseases.

Abstract: A method for removing oxide materials from a crack of a metallic workpiece comprises: infiltrating an alkali solution into the crack in a pressurized atmosphere or an ultrasonic environment; applying an energy to the crack to react the oxide materials with the alkali solution and form a resultant material; and rinsing the resultant material with an acid solution to remove the resultant material from the crack. The method is easier to penetrate into the inside of the cracks, in particular suitable for cleaning narrow and deep cracks.

Abstract: Provided are a preparation method for amide compounds and use thereof in medical field. Specifically, provided are small molecule amide compounds. Such compounds are inhibitors of enhancer homolog 2 (EZH2) of Zeste gene, and can be used for preventing and/or treating related diseases mediated by EZH2, including tumors, myeloproliferative diseases or autoimmune diseases.

Abstract: An interactive method and device for an e-commerce application program are provided, which belong to the technical field of mobile terminal. The method includes: receiving an interactive virtual item sent from a seller account in an interactive channel of the e-commerce application program, wherein the interactive channel is a collection of groups configured to realize instant communications between the seller account and at least one user account, and the interactive channel corresponds to a product category in the e-commerce application program; determining the at least one user account in the interactive channel; and sending the interactive virtual item to the at least one user account in the interactive channel.