Abstract: Provided are a preparation method for amide compounds and use thereof in medical field. Specifically, provided are small molecule amide compounds. Such compounds are inhibitors of enhancer homolog 2 (EZH2) of Zeste gene, and can be used for preventing and/or treating related diseases mediated by EZH2, including tumors, myeloproliferative diseases or autoimmune diseases.

Abstract: An interactive method and device for an e-commerce application program are provided, which belong to the technical field of mobile terminal. The method includes: receiving an interactive virtual item sent from a seller account in an interactive channel of the e-commerce application program, wherein the interactive channel is a collection of groups configured to realize instant communications between the seller account and at least one user account, and the interactive channel corresponds to a product category in the e-commerce application program; determining the at least one user account in the interactive channel; and sending the interactive virtual item to the at least one user account in the interactive channel.

Abstract: The present disclosure relates to a parallel proxy model based machine learning method for oil reservoir production. With the proposed method, multiple optimized candidate solutions can be obtained within an iteration, and then a matrix laboratory (e.g., MATLAB) is used to call numerical simulation software Eclipse in parallel to conduct actual evaluation on the candidate solutions simultaneously, so that optimization time of complex problems can be greatly reduced. With the method of the present disclosure, the efficiency of solving an oilfield production optimization problem can be speeded up to a greater extent than in the art, and the final optimization effect can be improved. Moreover, the method of the present disclosure may further be used for well pattern optimization, history matching, and so on, apart from adjusting schedules of the producers and injectors in the oilfield.

Abstract: A method includes masking at least one hole of an article with a paste, wherein the hole opens onto a surface of the article, applying a coating to the surface of the article, and removing the paste including contacting the paste with water, leaving at least one open hole in the surface of the coated article. The paste includes about 40-80 wt % of a filler material, about 0.5-20 wt % of an inorganic binder, about 0.5-15 wt % of a polyhydroxy compound and about 5-25 wt % of water. The filler material includes a first material which includes alkali metal doped alumina, zirconium oxide, titanium oxide, silicon dioxide, or a combination thereof and a second material which includes a silicate. A weight ratio between the first and second materials is in a range of about 1-10.

Abstract: A method of recondensing boil off gas includes receiving liquefied natural gas from a storage tank and increasing the pressure of the received liquefied natural gas to produce increased pressure liquefied natural gas. The method further includes receiving boil off gas from the storage tank at a gas inlet of an ejector, and receiving the increased pressure liquefied natural gas at a liquefied gas inlet of the ejector. The pressure of the increased pressure liquefied gas is used as a motive force to eject combined liquefied natural gas and boil off gas at a pressure greater than that of the boil off gas received at the gas inlet of the ejector. The method additionally includes increasing the pressure of the fluid ejected from the ejector to produce increased pressure ejected fluid.

Abstract: Disclosed are a class of ?-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The ?-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.

Abstract: A method for removing oxide materials from a crack of a metallic workpiece comprises: infiltrating an alkali solution into the crack in a pressurized atmosphere or an ultrasonic environment; applying an energy to the crack to react the oxide materials with the alkali solution and form a resultant material; and rinsing the resultant material with an acid solution to remove the resultant material from the crack. The method is easier to penetrate into the inside of the cracks, in particular suitable for cleaning narrow and deep cracks.

Abstract: Embodiments of the present disclosure provide a terminal verification method, a terminal device and a computer readable storage medium. The method includes: reading machine verification parameters of a target terminal, determining that the target terminal is a fake in response to determining that the machine verification parameters of the target terminal satisfy a first condition, a second condition and a third condition, and displaying on a user interface of the target terminal that the target terminal is a fake.

Abstract: Embodiments of the present disclosure provide a terminal verification method, a terminal device and a computer readable storage medium. The method includes: reading machine verification parameters of a target terminal, determining that a system of the target terminal is modified in response to determining that the machine verification parameters of the target terminal satisfy a first condition, a second condition and a third condition, and displaying on a user interface of the target terminal that, the system of the target terminal is modified.

Abstract: Embodiments of the present disclosure provide a terminal verification method, a terminal device and a computer readable storage medium. The method includes: reading machine verification parameters of a target terminal, determining that the target terminal is incompletely configured in response to determining that the machine verification parameters of the target terminal satisfy a first condition and a second condition, and displaying on a user interface of the target terminal that, the target terminal is incompletely configured. The machine verification parameters of the target terminal include N terminal configuration parameters. The first condition includes abnormally reading the GPU manufacturer parameter and the GPU renderer parameter. The second condition includes normally reading a first group of terminal configuration parameters of the machine verification parameters of the target terminal. The first group of terminal configuration parameters includes (N?2) terminal configuration parameters.

Abstract: A method for detecting an endpoint of a seasoning process in a process chamber includes obtaining seasoning progress data indicating a progress of the seasoning process for each substrate of a first plurality of substrates, and collecting historical parameter values from a plurality of sensors disposed in the process chamber. The historical parameter values for each substrate of the first plurality of substrates are normalized with respect to a plurality of parameter values for a particular substrate in the first plurality of substrates. An MVA model is generated by applying a set of coefficients to the normalized parameter values for each substrate of the first plurality of substrates, and the set of coefficients are regressed based on the seasoning progress data. An end point of the seasoning process is determined using the MVA model with a plurality of substantially real-time parameter values measured when performing a seasoning process over each substrate of a second plurality of substrates.

Abstract: Disclosed are a whole-cell tumor vaccine based on the principle of extracellular traps and a method of making the same, where a CpG ODN network similar to the extracellular trap in structure is formed on the tumor cell surface. The tumor cells are coated with a histone and CpG ODN to form the CpG ODN-coated tumor cells, which are inactivated to produce the whole-cell tumor vaccine. The vaccine of the invention, after injected to tumor model mice, can induce the occurrence of effective immune response to achieve the effective treatment for tumors.

Abstract: Disclosed are a bacteriologically-modified whole-cell tumor vaccine and a method of making the same. The method includes: lysing bacteria at logarithmic growth phase to obtain a bacterial lysate; mixing the bacterial lysate with an excessive amino compound solution to aminate the bacterial lysate in the presence of EDC; mixing the aminated bacterial lysate with the tumor cells for a certain period of time to produce bacteriologically-modified tumor cells; and inactivating the bacteriologically-modified tumor cells to produce the bacteriologically-modified whole-cell tumor vaccine. The bacteriologically-modified whole-cell tumor vaccine has been demonstrated to have desirable therapeutic effect in tumor model mice.

Abstract: The present application provides a vortioxetine pamoic acid salt, which includes a crystal form, a solvate or an amorphous substance of the vortioxetine pamoic acid salt. The present application provides a preparation method and use of the vortioxetine pamoic acid salt and the crystal form thereof. The vortioxetine pamoic acid salt prepared in the present application prolongs the residence time of the vortioxetine in vivo, achieving a slow release of the vortioxetine in vivo, and is suitable for preparing a long-acting dosage form.

Abstract: Disclosed are a class of ?-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The ?-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.

Abstract: A method for selective aluminide diffusion coating removal. The method includes diffusing aluminum into a substrate surface of a component to form a diffusion coating. The diffusion coating includes an aluminum-infused additive layer and an interdiffusion zone. The diffusion coating is solution heat treated at a temperature and for a time sufficient to dissolve at least a portion of the interdiffusion zone. Thereafter the aluminum-infused additive layer is selectively removed. An aluminide diffusion coated turbine component is also disclosed.

Abstract: A method includes masking at least one hole of an article with a paste, wherein the hole opens onto a surface of the article, applying a coating to the surface of the article, and removing the paste including contacting the paste with water, leaving at least one open hole in the surface of the coated article. The paste includes about 40-80 wt % of a filler material, about 0.5-20 wt % of an inorganic binder, about 0.5-15 wt % of a polyhydroxy compound and about 5-25 wt % of water. The filler material includes a first material which includes alkali metal doped alumina, zirconium oxide, titanium oxide, silicon dioxide, or a combination thereof and a second material which includes a silicate. A weight ratio between the first and second materials is in a range of about 1-10.

Abstract: Various embodiments of the disclosure include a thermal coating powder, a system for providing a thermal spray coating, and a method for coating a component. The thermal coating powder may include fused and crushed yttria-stabilized zirconia, wherein the thermal coating powder is in a form of substantially spherically-shaped, solid particles. The system may comprise: a plasma spray gun apparatus having an exit annulus for releasing a plasma jet stream; and a powder injector port coupled to the plasma spray gun apparatus for supplying the thermal coating powder to the plasma jet stream. The method may include: providing a plasma spray gun apparatus including an exit annulus for releasing a plasma jet stream; and spraying the thermal coating powder on the component with the plasma jet stream from the plasma spray gun apparatus.

Abstract: A method for detecting an endpoint of a seasoning process in a process chamber includes obtaining seasoning progress data indicating a progress of the seasoning process for each substrate of a first plurality of substrates, and collecting historical parameter values from a plurality of sensors disposed in the process chamber. The historical parameter values for each substrate of the first plurality of substrates are normalized with respect to a plurality of parameter values for a particular substrate in the first plurality of substrates. An MVA model is generated by applying a set of coefficients to the normalized parameter values for each substrate of the first plurality of substrates, and the set of coefficients are regressed based on the seasoning progress data. An end point of the seasoning process is determined using the MVA model with a plurality of substantially real-time parameter values measured when performing a seasoning process over each substrate of a second plurality of substrates.

Abstract: Embodiments of the present disclosure provide a terminal verification method, a terminal device and a computer readable storage medium. The method includes: reading machine verification parameters of a target terminal, determining that a system of the target terminal is modified in response to determining that the machine verification parameters of the target terminal satisfy a first condition, a second condition and a third condition, and displaying on a user interface of the target terminal that, the system of the target terminal is modified.