Abstract: Provided is an anti-PD-L1 antigen binding protein, capable of binding to primate-derived PD-L1 with a KD value of 1×10?8 M or less. The antigen binding protein can block the binding of PD-1 and CD80 to PD-L1, stimulate the secretion of cytokines in immune cells, and can inhibit tumor growth and/or tumor cell proliferation. Also provided is a fusion protein, comprising human TGFBRII or a fragment thereof and the antigen binding protein. Also provided is an application of the antigen binding protein and/or the fusion protein in the prevention and treatment of tumors or cancers.

Abstract: The present application relates to the technical field of engineering construction and provides a rebar, a device and a construction method for 3D-printing a concrete interlayer structure. The rebar at least comprises: a body in the form of a chain structure, comprising a plurality of sub-parts mutually spliced, wherein the body is adapted for being sandwiched between two adjacent upper and lower cement-based slurry layers; a rotatable joint arranged between two adjacent sub-parts in such a way that the two adjacent sub-parts are rotatably connected to each other; insertion members, wherein both sides of each of the sub-parts are provided with the insertion members extending away from the center of each of the sub-parts, wherein the insertion member on one side of each of the sub-parts is adapted for being inserted in an upper cement-based slurry layer, and the insertion member on an opposite side of each of the sub-parts is adapted for being inserted in a lower cement-based slurry layer.

Abstract: The present disclosure relates to the technical field of electric power transmission systems, and relates to an SLCC commutation system for a novel electric power system, and a method for controlling the SLCC commutation system. The SLCC commutation system for a novel electric power system comprises: a converter transformer for providing an alternating-current voltage and a converter unit for alternating-current and direct-current conversion. The converter transformer is connected in series to each phase in the converter unit by means of an inductor, each phase comprises an upper bridge arm and a lower bridge arm, each bridge arm comprises a VSC valve, an SVG branch is connected between the converter transformer and the converter unit, and the SVG branch is connected in parallel to an LCC converter valve; the SVG branch comprises a converter transformer and a reactor that are connected in series, and the output end of the reactor is connected to the converter transformer and the converter unit.

Abstract: The disclosure relates to the technical field of medicines, and relates to keratin CF1, a preparation method therefor, a pharmaceutical composition comprising same, and a use thereof, and in particular to keratin CF1, a nucleic acid molecule encoding keratin CF1, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or a genome into which the nucleic acid molecule is integrated, a preparation method for keratin CF1, a pharmaceutical composition containing keratin CF1, and a use of keratin CF1, the nucleic acid molecule, the expression vector, the host cell or the pharmaceutical composition in preparation of medications for relieving fever, easing pain, relieving cough, eliminating phlegm, resisting convulsion, resisting epilepsy, reducing blood pressure, resisting inflammation, and resisting viruses.

Abstract: A recycled material based on in-situ compatibilization and chain extension is mainly prepared from the following raw materials in parts by mass: 30-70 parts of waste HIPS, 30-70 parts of waste PP, 2-6 parts of POE, 0.1-0.4 part of an alkylation reaction catalyst, 0.1-0.3 part of a co-catalyst, and 2-8 parts of a macromolecular chain extender. Further, a preparation method for the recycled material based on in-situ compatibilization and chain extension is provided.

Abstract: Provided is an anti-PD-L1 antigen binding protein, capable of binding to primate-derived PD-L1 with a KD value of 1×10?8 M or less. The antigen binding protein can block the binding of PD-1 and CD80 to PD-L1, stimulate the secretion of cytokines in immune cells, and can inhibit tumor growth and/or tumor cell proliferation. Also provided is a fusion protein, comprising human TGFBRII or a fragment thereof and the antigen binding protein. Also provided is an application of the antigen binding protein and/or the fusion protein in the prevention and treatment of tumors or cancers.

Abstract: Methods for preferentially and/or selectively detecting and/or quantitating target RNA, over DNA, in a biological or non-biological sample are described. The methods include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, the reaction mixture includes dNTPs, that include dITP. Also described are kits, reaction mixtures, and oligonucleotides (e.g., primer and probe) for the preferential and/or selective amplification and detection and/or quantitation of target RNA (over DNA), in the presence of dITP. The methods, kits, and reaction mixtures are for the preferential and/or selective detection and/or quantitation of RNA, over DNA, and are particularly useful with samples that comprise a number of different types of nucleic acids (e.g., DNA and RNA).

Abstract: A compound represented by general formula (I) or a pharmaceutically acceptable salt or a stereoisomer thereof, and a use thereof in treating diseases such as tumors, immunological diseases, and inflammatory diseases, as well as a pharmaceutical preparation and a pharmaceutical composition of the compound, and a use thereof.

Abstract: A method for indoor operation monitoring of a cleaning device is provided, which is executed by a server of a system for indoor operation monitoring of a cleaning device. The method includes generating a work region map; forming a monitoring map based on location fingerprints taken from a work region in the work region map; determining working trajectory points of the cleaning device based on a set of positioning data; obtaining a monitoring task region through a monitoring terminal; determining, based on the monitoring map, a monitoring region map corresponding to the monitoring task region, matching the working trajectory points with the monitoring region map, and determining cumulative trajectory points within the monitoring task region; and in response to determining that a count of the cumulative trajectory points and distribution situation of the cumulative trajectory points satisfy a preset update condition, sending a display update instruction to the monitoring terminal.

Abstract: Provided are an antibody targeting Claudin 18.2, an antibody-drug conjugate, and use thereof in treatment of cancer. Also provided are a nucleotide encoding the Claudin 18.2 antibody, a polynucleotide combination, an expression vector, an expression vector combination, a pharmaceutical composition comprising the Caudill 18.2 antibody and the antibody-drug conjugate, and an application thereof in preparation of a medication for treatment or prevention of cancer.

Abstract: A cup lid that enables single-handed operation, including a main lid body and an auxiliary lid body. The main lid body seals an opening of a container and has a circular recess, a water passing hole, an air vent, and at least one limiting flange. The auxiliary lid body is rotatably disposed on the circular recess and has at least one limiting groove, at least one cutaway portion, a water passing port, and an air guide slot in communication with the atmosphere. Each limiting flange enters a corresponding limiting groove via a corresponding cutaway portion and is slidably received therein. The water passing port opens and closes the water passing hole as the auxiliary lid body rotates, and the air vent is slidably received in the air guide slot.

Abstract: This invention involves immunizing mice with human ecto-5?-nucleotidase (CD73) to obtain multiple monoclonal antibodies whose heavy-chain and light-chain sequences are both novel amino acid sequences and which can be used to prepare CD73 enzyme activity inhibitors and anti-tumor drugs.

Abstract: Methods for the rapid detection of the presence or absence of Epstein Barr Virus (EBV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting EBV, and kits are provided that are designed for the detection of target regions of EBV. Also described are kits, reaction mixtures, and oligonucleotides (e.g., primer and probe) for the amplification and detection of EBV. Also described are primers and probes that detect different regions of EBV, and can be employed in a dual target assay for simultaneously detecting two different and non-overlapping target regions of EBV.

Abstract: A method for preparing nickel-magnesium loaded biochar-based bifunctional material is provided. The method includes: carbonizing a waste biomass material and washing it in a sulfuric acid solution, followed by deionized water washing, suction filtration, and drying to obtain a carbonized biochar; adding Ni(NO3)2·6H2O and Mg(NO3)2·6H2O to deionized water and stirring uniformly to obtain a loading solution; weighing the carbonized biochar according to a nickel loading amount of 20%-50% and adding to the loading solution and stirring to obtain a mixed solution, transferring the mixed solution to an oil bath for drying until water is completely evaporated; transferring a solid material to a crucible and roasting in the muffle furnace at 550° C.-650° C. under the nitrogen atmosphere for 1.5 h-2.5 h to obtain the nickel-magnesium loaded biochar-based bifunctional material.

Abstract: Provided is use of low-intensity pulsed ultrasound (LIPUS) in preparation of a product for treating dry age-related macular degeneration (dAMD), which belongs to the technical field of biomedicine. The present disclosure proposes for the first time that LIPUS can be used to treat the eye disease of dAMD. LIPUS allows for treating dAMD by transmitting acoustic energy to a target tissue. The LIPUS method provided by the present disclosure has the characteristics of non-invasiveness, painlessness, and no side effects.

Abstract: Disclosed is a torque sensing bionic clamping jaw. In the torque sensing bionic clamping jaw, a left clamping jaw skeleton is movably connected to a substrate, the left clamping jaw skeleton includes a first left groove and a second left groove which are in a side facing a right jaw, a left sensor quick-release connecting piece is detachably connected to the first left groove, a left torque measuring sensor is mounted on the left sensor quick-release connecting piece, a left flexible gasket quick-release connecting piece is detachably connected to the second left groove, and a left flexible gasket is mounted on the left flexible gasket quick-release connecting piece; a right torque measuring sensor is mounted on a right sensor quick-release connecting piece and opposite to the left torque measuring sensor, and a right flexible gasket is mounted on a right flexible gasket quick-release connecting piece.

Abstract: In various examples, a guidewire for temporary pacing of tissue includes an elongate core wire and a coil disposed along at least a portion of a length of the core wire. The coil is disposed radially outwardly from and around the core wire, wherein a core axis and a coil axis are substantially aligned. At least one electrode is disposed along the guidewire and includes an uninsulated portion of the core wire disposed within an electrode section of the coil. A spacing between adjacent windings of the electrode section of the coil is configured to allow a stimulation pulse to travel from the uninsulated portion of the core wire, through the spacing between the adjacent windings of the electrode section, and to the tissue in order to stimulate the tissue.

Abstract: A thermo container structure convenient to be stored, provides good thermal insulation effect and achieves stable support after being unfolded, including an outer container and an inner container; the outer container has a first body and a first cover; both filled with thermally insulated materials; the inner container has a second body and a second cover; the first body and the second body are both compressible and foldable structures, and the first body and the second body are foldable towards two different folding directions perpendicular to each other; in an unfolded state of the thermo container structure, the first cover can close against an opening of the first body, and the second cover can close against an opening of the second body.