Patent number: 11920472
Abstract: A reasonable millisecond time control method for excavation blasting of a tunnel is provided, and includes: acquiring physical mechanical parameters to establish a millisecond blasting model, and designing four dimensions blasting parameters of explosive quantity, hole number, inter-hole millisecond and inter-row millisecond; simulating, based on the millisecond blasting model, a blasting process of an explosive package using blasting parameters to obtain a blasting vibration curve; obtaining single-hole blasting vibration waveforms, solving a vibration synthesis curve through a vibration synthesis theory; comparing the vibration synthesis curve with the blasting vibration curve to obtain a coupling relationship of blasting parameters; determining a target group of explosive quantity and hole numbers, determining a target millisecond through the coupling relationship of blasting parameters, and relating a millisecond blasting control strategy to control, and it is used for tunneling project to reduce cut blas
Type:
Grant
Filed:
September 20, 2023
Date of Patent:
March 5, 2024
Assignees:
CHINA RAILWAY ELEVENTH BUREAU GROUP CO., LTD, CHINA RAILWAY ELEVENTH BUREAU GROUP FOURTH ENGINEERING CO., LTD., WUJIU RAILWAY PASSENGER DEDICATED LINE HUBEI CO., LTD, CHINA RAILWAY FOURTH BUREAU GROUP CO., LTD, ANHUI CHINA RAILWAY ENGINEERING TECHNOLOGY SERVICE CO., LTD, WUHAN INSTITUTE OF GEOTECHNICAL MECHANICS, CHINESE ACADEMY OF SCIENCES, CHINA RAILWAY SOUTHWEST SCIENTIFIC RESEARCH INSTITUTE CO., LTD
Inventors:
Jun Gao, Liyun Yang, Xiao Lin, Ming Zhang, kaiwen Liu, Xiaowei Zuo, Bin Zhou, Feng Wang, Yuxin Gao, Dan Xu, Ling Wang, Zhengyi Wang, Xiaokai Wen, Yongtai Wang, Huiling Xue
Publication number: 20240050430
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
Type:
Application
Filed:
June 23, 2023
Publication date:
February 15, 2024
Inventors:
John Gordon ALLEN, Jennifer Rebecca ALLEN, Ana Elena MINATTI, Qiufen XUE, Ryan Paul WURZ, Christopher M. TEGLEY, Alexander J. PICKRELL, Thomas T. NGUYEN, Vu Van MA, Patricia LOPEZ, Longbin LIU, David John KOPECKY, Michael J. FROHN, Ning CHEN, Jian Jeffrey CHEN, Aaron C. SIEGMUND, Albert AMEGADZIE, Nuria A. TAMAYO, Shon BOOKER, Clifford GOODMAN, Mary WALTON, Nobuko NISHIMURA, Youngsook SHIN, Jonathan D. LOW, Victor J. CEE, Anthony B. REED, Hui-Ling WANG, Brian Alan LANMAN