Abstract: There are provided new heterobifunctional agents designed to mediated formation of protein-protein dimers and promote ubiquitination of a protein of the dimer. Also provided are methods of synthesizing the agents, pharmaceutical formulations including the agents, and methods of using the agents to treat, ameliorate or cure diseases characterized by protein over-expression or malfunction.

Abstract: Provided is an anti-PD-L1 antigen binding protein, capable of binding to primate-derived PD-L1 with a KD value of 1×10?8 M or less. The antigen binding protein can block the binding of PD-1 and CD80 to PD-L1, stimulate the secretion of cytokines in immune cells, and can inhibit tumor growth and/or tumor cell proliferation. Also provided is a fusion protein, comprising human TGFBRII or a fragment thereof and the antigen binding protein. Also provided is an application of the antigen binding protein and/or the fusion protein in the prevention and treatment of tumors or cancers.

Abstract: Disclosed are a power grid-friendly control method and system for a data center cooling system. The method includes: dividing an equipment room into a plurality of pieces of subspace in advance, with a plurality of servers and a cooling device comprised in each piece of subspace; obtaining total power consumption of the servers in each piece of subspace; performing priority sorting on the total power consumption of the servers in each piece of subspace; obtaining a real-time power supply energy consumption value of a power grid; determining, whether an energy supply is sufficient; and if the energy supply is sufficient, skipping turning off the cooling device in the subspace; or if the energy supply is not sufficient, turning off a cooling device, till it is determined that the energy supply is sufficient, thus minimizing impact of turning off the cooling system on stability.

Abstract: A display apparatus includes a cover plate and a display substrate. The cover plate includes a first base substrate, a black matrix and a support layer stacked on a side of the first base substrate, and a quantum dot layer disposed on the side of the first base substrate. The black matrix and the support layer each have a plurality of openings to form a plurality of opening regions. The quantum dot layer includes a plurality of quantum dot units. Each quantum dot unit is located in an opening region in the plurality of opening regions. The display substrate includes a second base substrate, driving circuit structures disposed on a side of the second base substrate, and light-emitting devices disposed on a side of the driving circuit structures. Each light-emitting device is coupled to a driving circuit structure in the driving circuit structures to emit light.

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: Provided are keratin BD-4, an encoding nucleic acid molecule thereof, an expression vector, a host cell, and a pharmaceutical composition containing the keratin. The keratin BD-4 can be used for preparing drugs having antipyretic and analgesic, antitussive and expectorant, and antiepileptic effects.

Abstract: This invention involves immunizing mice with human ecto-5?-nucleotidase (CD73) to obtain multiple monoclonal antibodies whose heavy-chain and light-chain sequences are both novel amino acid sequences and which can be used to prepare CD73 enzyme activity inhibitors and anti-tumor drugs.

Abstract: Provided is a display substrate, including: a substrate, and multiple light-emitting units and multiple light-detecting units located on a substrate. At least one light-emitting unit includes a light-emitting element and a pixel driving circuit coupled with the light-emitting element, and at least one light-detecting unit includes an optical sensing element and a light-emitting detection circuit coupled with an optical sensing element; an optical sensing element is located on one side of a light-emitting detection circuit and a pixel driving circuit away from a substrate and between a light-emitting element and a substrate; the light-emitting element emits light from a side away from the substrate, and a light transmittance region is provided on one side of the light-emitting element facing the optical sensing element.

Abstract: A refrigerator has a refrigeration compartment, a drawer located inside the refrigeration compartment, and a lid adapted to open or close the drawer. The refrigeration compartment includes: a support module, mounted on an inner side wall of the refrigeration compartment, where the support module includes an elastic member; and a motor module, including a motor, a cam, and a connection portion connected to the lid and the cam. The motor drives the cam to generate a first rotation to push the connection portion to move upward, to cause the lid to compress upward the elastic member, so that the lid ascends to a first position. The motor further drives the cam to generate a second rotation to push the connection portion to move downward, to cause the connection portion and the elastic member to push downward the lid, so that the lid descends to a second position.

Abstract: A support base includes a connector hub having a top end, a bottom end spaced apart from the top end, and a chamber wall extending between the top and bottom ends. The chamber wall defines a chamber within the connector hub. An interface may be positioned in the chamber. The interface is dimensioned such that a support gap is formed between the interface and the chamber wall. The support gap may be dimensioned for receiving a wall of a support structure having a hollow interior into which the interface is received.

Abstract: A method for preventing aging of a subject in need thereof includes administering to the subject a composition including a bioactive compound. The bioactive compound is a peptide, and includes at least one amino acid sequence as set forth in SEQ ID NO: 1 to SEQ ID NO: 6. Each of the amino acid sequence is a peptide of fish skin. The composition has anti-aging and cellular health maintaining capabilities. In addition, the composition can also be used for increasing collagen content, improving skin collagen density, improving skin moisture, minimizing skin pores, reducing wrinkles or achieving a combination of these effects.

Abstract: The invention relates to a variable speed limit (VSL), ramp metering (RM), and a collaborative method of variable speed limit and ramp metering (VSL-RM) on expressways based on crash risk, including the following steps: 1) calculating the crash risk index within each control step, activating the VSL-RM strategy when the crash risk index exceeds the threshold of the crash risk index, and 2) conduct a multiple-ramp metering strategy, determine the ramps to be controlled and the start-up time for RM, and calculate the integrated ramp regulation rate; 3) execute a variable speed limit strategy to obtain the displayed speed limit value for the segment downstream of the cluster and adjust the ramp regulation rate, mainline desired speed and mainline speed of the segment for the next time period accordingly.

Abstract: Disclosed are a display panel and a display device. The display panel includes: a base substrate; a detection circuit, located on the side of the base substrate, and including a transistor and a photosensitive detection component electrically connected to the transistor, and an orthographic projection of the transistor on the base substrate and an orthographic projection of the photosensitive detection component on the base substrate do not overlap with each other; a planarization layer, located on the side of the detection circuit facing away from the base substrate, and including a first surface facing away from the base substrate at the position in which the transistor is located, and a second surface facing away from the base substrate at the position in which the photosensitive detection component is located; and a light-emitting device, located on the side of the planarization layer away from the detection circuit.

Abstract: A method is implemented for a memory sub-system that detects a sequential write pattern in a write sequence for a memory device in a set of commands received from a host, detects current bandwidth utilization deviating from a write bandwidth utilization performance target, in response to detecting the sequential write pattern, and adjusts write bandwidth utilization to conform to the write bandwidth utilization target, in response to detecting the current bandwidth utilization deviating from the write bandwidth utilization performance target.

Abstract: This application discloses a display method when an application is exited and a terminal. The method includes: receiving, by a terminal, a keyword entered by a user into a search bar; displaying, by the terminal, a search result associated with the keyword; receiving, by the terminal, a first operation of the user for opening a first application from the search result; opening, by the terminal, the first application in response to the first operation; receiving, by the terminal, a second operation of the user for exiting the first application; and exiting, by the terminal, the first application in response to the second operation, and displaying a display screen on which an icon of the first application is located, where a size of the icon of the first application on the display screen is a first size.

Abstract: A lower support type rehabilitation device for fingers includes a cover plate having a hand covering portion and a plurality of through holes. A plurality of finger supports are disposed on the hand covering portion, each having a first finger base, a second finger base pivotally connected to the first finger base, two side arms and a beam disposed on the first finger base. A traction device is disposed on the hand covering portion and has a first processing module, a plurality of driving modules electrically connected to the first processing module, a plurality of pulling ropes connected to the plurality of driving modules and a plurality of pressure sensors electrically connected to the first processing module. Each of the plurality of pulling ropes passes through one of the plurality of through holes for fixing to the beam of the first finger base.

Abstract: Provided is an apparatus for preparing a building structure with 3D printing, comprising: a 3D printing device (1), having a storage chamber (11) and a printing head (12) connected to the storage chamber (11) and being movable relative to a base frame; and a reinforcing device, movably disposed relative to the base frame, and having a driving mechanism (3) for driving short rebars or short ribs to perform an insertion movement in a direction intersected with a stacking direction of a cement-based slurry layer; the driving mechanism inserts the short rebars or the short ribs into an interlayer interface spanning at least two adjacent cement-based slurry layers printed by the 3D printing device (1). Also provided a method for preparing a building structure with 3D printing.

Abstract: Various methods, apparatuses/systems, and media for integrating data are provided. A processor implements a data processing framework configured to run native on a big data platform and abstracts data processing constructs to a user friendly template, thereby eliminating necessity of user initiated tasks of instantiating language level objects. The processor also implements a core set of data pipeline configurations on the template configured to initiate a chain of user defined data transformations. A receiver operatively connected with the processor via a communication network receives input of the chain of the user defined data transformations. The processor tests each transformation independently of each other and outputs data integration solutions on the big data platform based on a positive test result.

Abstract: The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein.