Patents by Inventor Ling Zhang

Ling Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12215103
    Abstract: Disclosed are fused imidazole derivatives, preparation methods therefor and medical uses thereof. Specifically, the present disclosure relates to a fused imidazole derivative as shown in general formula (IM), a preparation method therefor, a pharmaceutical composition containing the derivative, and the use of same as a therapeutic agent, in particular the use thereof as a GLP-1 receptor agonist, and the use thereof in the preparation of drugs for the treatment and/or prevention of diabetes.
    Type: Grant
    Filed: March 21, 2024
    Date of Patent: February 4, 2025
    Assignee: Jiangsu Hengrui Pharmaceuticals Co., Ltd.
    Inventors: Fanglong Yang, Ling Zhang, Liangliang Zheng, Feng He, Weikang Tao
  • Patent number: 12208365
    Abstract: A gene chip includes a chip carrier, a plurality of DNA nanoballs assembled on the chip carrier, and a polymer film formed on the chip carrier and wrapping the DNA nanoballs. The polymer film includes at least one of a film of a positively charged polymer, a film of a positively charged polymer which is modified, a film of a zwitterionic polymer, and a composite polymer film. The composite polymer film is formed by a layer-by-layer self-assembly process of a positively charged polymer and a negatively charged polymer. The gene chip has good sequencing quality and different functions can be achieved by coating with different polymers, such as the chip surface rapidly drying out and surface non-specific adsorption. A method of preparing a gene chip is further disclosed.
    Type: Grant
    Filed: August 15, 2018
    Date of Patent: January 28, 2025
    Assignee: BGI SHENZHEN
    Inventors: Zhao-Hui Wang, Hui Wang, Cheng-Mei Xing, Han-Dong Li, Wen-Wei Zhang, Jay Willis Shafto, Mei-Hua Gong, Jin Yang, Yin-Ling Luo, Zhen-Hua Zhang, Yuan Li, Xue-Qin Jiang
  • Publication number: 20250026815
    Abstract: Provided are an antibody having effective neutralizing activity against RSV or an antigen-binding fragment thereof. The provided anti-RSV antibody or antigen-binding fragment thereof can be used as a drug for treating or preventing RSV infection or symptoms related to RSV infection. The provided RSV antibody, after humanization, can bind RSV-F protein with high affinity. In addition, experiments show that it is significantly better than palivizumab at providing protection against RSV challenge.
    Type: Application
    Filed: August 25, 2022
    Publication date: January 23, 2025
    Inventors: Jiao JIAO, Jing QIAO, Ruowei LI, Yaohui LIU, Jiaxing WANG, Zhen WANG, Han QIN, Ziyue MA, Jiao WANG, Ling ZHANG, Liming CHE, Shumiao TIAN, Ruixue WANG, Weihuan YAN, Yating JIANG
  • Publication number: 20250019707
    Abstract: An antisense oligonucleotide for regulating BCL2L12 expression, and a method and drug for treating BCL2L12-related diseases.
    Type: Application
    Filed: December 2, 2022
    Publication date: January 16, 2025
    Inventors: Zhaojian LIU, Zixiang WANG, Junchao QING, Ling ZHAO, Xiyu ZHANG
  • Patent number: 12195754
    Abstract: The present invention relates to a cell differentiation medium composition, a high secretion insulin-producing cells and a preparation method thereof. The high secretion insulin-producing cells obtained by using the cell differentiation medium composition to induce stem cell differentiated under specific conditions can secrete a large amount of insulin in a short time, and when the high-secreting insulin-producing cells are transplanted into the human body, they are not easy to be swallowed by macrophages, which can improve the survival rate of the insulin-producing cells and prolong the time of insulin secretion thereby.
    Type: Grant
    Filed: April 20, 2021
    Date of Patent: January 14, 2025
    Assignee: Gwo Xi Stem Cell Applied Technology Co., Ltd.
    Inventors: Ruei-Yue Liang, Kai-Ling Zhang, Ming-Hsi Chuang, Po-Cheng Lin, Chun-Hung Chen, Pei-Syuan Chao
  • Patent number: 12195659
    Abstract: The present disclosure provides a greenhouse gas emission reduction method for a heavy metal contaminated soil, falling within the technical field of emission reduction of greenhouse gas nitrous oxide. Specifically, hydroxyapatite (HAP) is added to a soil to effectively reduce the emission of nitrous oxide in the soil, and at the same time, the treatment of heavy metal contamination is realized, which is very suitable for the promotion and use of nitrous oxide emission reduction in the contaminated soil.
    Type: Grant
    Filed: April 11, 2024
    Date of Patent: January 14, 2025
    Assignee: JIANGXI AGRICULTURAL UNIVERSITY
    Inventors: Ling Zhang, Yu Gao, Baihui Wang, Jian Bai, Aixin Li, Laicong Luo, Xiaoqin Lai
  • Patent number: 12195620
    Abstract: Disclosed are reversibly-expandable polymer-integrated crystals (PIX) materials, devices, and methods for controllably encapsulating and releasing molecular cargo. The disclosed PIX materials are engineered crystalline materials with large pores that can entrap macromolecules, such as proteins and nanoparticles. The material expands and contracts reversibly, allowing controlled encapsulation and release of guest/cargo molecules.
    Type: Grant
    Filed: November 19, 2021
    Date of Patent: January 14, 2025
    Assignee: The Regents of the University of California
    Inventors: Faik Akif Tezcan, Ling Zhang, Youjeong Na, Kenneth Han
  • Publication number: 20240392020
    Abstract: Provided is an antigen-binding molecule, particularly a domain-engineered antibody, wherein at least one constant region domain CH1/CL of the antibody is replaced by a Titin T-chain/Obscurin-O chain.
    Type: Application
    Filed: May 12, 2022
    Publication date: November 28, 2024
    Inventors: Hua Ying, Qiyue Hu, Xinsheng Jin, Jinping Shi, Ling Zhang, Langyong Mao, Xin Ye, Weikang Tao
  • Publication number: 20240368147
    Abstract: The disclosure provides a compound of formula (I) and pharmaceutical compositions thereof. The compound of formula (I) of the present disclosure can be used as a degradation agent of cyclin K (CyclinK protein), and can be used to prevent or treat diseases related to CyclinK protein.
    Type: Application
    Filed: August 25, 2022
    Publication date: November 7, 2024
    Applicant: ADLAI NORTYE BIOPHARMA CO., LTD.
    Inventors: Beidi XU, Qingchong QIU, Zhiyong YU, Nanhai HE, Bin JI, Ling ZHANG, Xiaohan WANG, Xiangyu XIA, Zhao SUN
  • Patent number: 12101259
    Abstract: Provided are a data transmission control method and device and a non-transitory computer-readable medium. The data transmission control method includes: determining a multiple and a remainder according to a total data size of to-be-transmitted data and a set byte size, where the multiple is equal to a quotient obtained by dividing the total data size by the set byte size, and the remainder is equal to a remainder obtained by dividing the total data size by the set byte size; sequentially transmitting data whose size is the set byte size multiplied by the multiple in the to-be-transmitted data by transmitting data of the set byte size each time; and in response to the remainder being not zero, transmitting remaining data whose size is the remainder in the to-be-transmitted data.
    Type: Grant
    Filed: August 31, 2021
    Date of Patent: September 24, 2024
    Assignee: LANTO ELECTRONIC LIMITED
    Inventors: Lin Wu, Yuss Mu, Ling Zhang, Peng Sun
  • Publication number: 20240286113
    Abstract: Hybrid materials are disclosed including molecular/protein crystals integrated with synthetic polymers. The disclosed materials combine the structural order and periodicity of crystals, the adaptiveness and tunable mechanical properties of polymeric networks, and the chemical versatility of protein building blocks. Some of the properties of the disclosed materials include the following: 1) allows crystals-which are typically rigid and brittle—to expand and contract reversibly; 2) incorporates polymers to increase the mechanical toughness of the crystals and allow self-healing; 3) reversibly expand/contract crystal lattices and mobilize the protein components therein may provide a new means to improve X-ray diffraction quality and explore otherwise inaccessible protein structural states using 3D protein crystallography; 4) creation of chemically and mechanically differentiated domains within single crystals.
    Type: Application
    Filed: May 3, 2024
    Publication date: August 29, 2024
    Inventors: Faik Tezcan, Jake Bailey, Ling Zhang
  • Publication number: 20240277682
    Abstract: It relates to a method of treating a subject with liver fibrosis and/or liver cirrhosis. The disclosure provides a pharmaceutical composition that includes hydronidone or a salt thereof that can be used for treating a subject with liver fibrosis and/or liver cirrhosis. Liver stiffness measurements values and/or Ishak scores may be used to identify subjects for treatment of liver fibrosis and/or liver cirrhosis.
    Type: Application
    Filed: October 18, 2023
    Publication date: August 22, 2024
    Inventors: Ying LUO, Ling ZHANG
  • Publication number: 20240270874
    Abstract: The present disclosure relates to anti-KLB antibodies and uses.
    Type: Application
    Filed: September 23, 2022
    Publication date: August 15, 2024
    Inventors: Ling ZHANG, Hua YING, Mingxi ZHANG, Xinsheng JIN, Weikang TAO
  • Publication number: 20240275501
    Abstract: Embodiments described herein relate to a Radio Distribution Network Board, RDNB, for testing functionality of a plurality of radio chains, and to a method of calibrating a plurality of radio chains using said RDNB. The RDNB comprises a plurality of first ports for connecting to the plurality of radio chains; a plurality of second ports for connecting to one or more external devices, wherein each first port is coupled to a respective second port; and a plurality of coupling paths, wherein each coupling path is configured to provide coupling between two first ports, and wherein each coupling path comprises one or more non-directional power splitter/combiners.
    Type: Application
    Filed: May 31, 2021
    Publication date: August 15, 2024
    Inventors: Christian Braun, Hao Zhang, Ling Zhang
  • Publication number: 20240254392
    Abstract: The present disclosure provides a greenhouse gas emission reduction method for a heavy metal contaminated soil, falling within the technical field of emission reduction of greenhouse gas nitrous oxide. Specifically, hydroxyapatite (HAP) is added to a soil to effectively reduce the emission of nitrous oxide in the soil, and at the same time, the treatment of heavy metal contamination is realized, which is very suitable for the promotion and use of nitrous oxide emission reduction in the contaminated soil.
    Type: Application
    Filed: April 11, 2024
    Publication date: August 1, 2024
    Inventors: Ling Zhang, Yu Gao, Baihui Wang, Jian Bai, Aixin Li, Laicong Luo, Xiaoqin Lai
  • Publication number: 20240246958
    Abstract: Disclosed are fused imidazole derivatives, preparation methods therefor and medical uses thereof. Specifically, the present disclosure relates to a fused imidazole derivative as shown in general formula (IM), a preparation method therefor, a pharmaceutical composition containing the derivative, and the use of same as a therapeutic agent, in particular the use thereof as a GLP-1 receptor agonist, and the use thereof in the preparation of drugs for the treatment and/or prevention of diabetes.
    Type: Application
    Filed: March 21, 2024
    Publication date: July 25, 2024
    Inventors: Fanglong YANG, Ling ZHANG, Liangliang ZHENG, Feng HE, Weikang TAO
  • Publication number: 20240250211
    Abstract: Light emitting diodes with regrown semiconductor layers and methods of manufacture are described. In an embodiment, a light emitting diode includes a base structure including a first cladding layer doped with a first dopant type (e.g. n-type) and step surface. A mesa pillar including an active layer protrudes from the step surface, and a regrown second cladding layer doped with a second dopant type (e.g. p-type) is in direct contact with and spans a bottom surface and sidewalls of the mesa pillar and the step surface.
    Type: Application
    Filed: January 9, 2024
    Publication date: July 25, 2024
    Inventors: Erin C. Young, Ling Zhang, David P. Bour
  • Publication number: 20240239875
    Abstract: The present disclosure provides antibodies that bind to the SARS-CoV-2 spike protein, as well as compositions containing the same, and methods of making and using such a composition for treating, preventing, and/or detecting SARS-CoV-2 infection.
    Type: Application
    Filed: May 17, 2022
    Publication date: July 18, 2024
    Inventors: Brian A. Zabel, Xiaomei Ge, Dan Luo, Ling Zhang, Vydehi Kanneganti, Joyce Yu, Hsunhui Yang, Lequn Zhao, Hua Tu
  • Patent number: D1051551
    Type: Grant
    Filed: April 29, 2022
    Date of Patent: November 19, 2024
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Ling Zhang, Li Jiang
  • Patent number: D1059252
    Type: Grant
    Filed: December 19, 2023
    Date of Patent: January 28, 2025
    Inventors: Yongguang Zhang, Gang Chen, Ming Su, Lianbo Liu, Chunying Zhang, Jinrong Gong, Wenli Yang, Hengwu Liu, Daihao Zhang, Ling Deng, Xiumei Wang