Abstract: The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.

Abstract: A mechanical structure for installing cover plates of a pasta machine includes at least two brackets arranged symmetrically; a plurality of cover plates arranged between the two brackets, two ends of each cover plate are respectively and detachably connected to the two brackets. The cover plates are integrally formed by sheet metal technology. The cover plates are connected/mounted to brackets respectively through a snap-on and/or a slide-on connection.

Abstract: Disclosed are fused imidazole derivatives, preparation methods therefor and medical uses thereof. Specifically, the present disclosure relates to a fused imidazole derivative as shown in general formula (IM), a preparation method therefor, a pharmaceutical composition containing the derivative, and the use of same as a therapeutic agent, in particular the use thereof as a GLP-1 receptor agonist, and the use thereof in the preparation of drugs for the treatment and/or prevention of diabetes.

Abstract: Embodiments of the present disclosure provide methods and apparatus for antenna calibration. A method implemented at a network function comprises calibrating an antenna of the network function based on available time-frequency resources. The method further comprises communicating with at least one terminal device via the calibrated antenna.

Abstract: An automatic berthing system for an unmanned ship includes a plurality of roof plates fixedly arranged at a side edge of a shore, and a position adjusting mechanism is fixedly arranged in the roof plate. The position adjusting mechanism includes an X-direction adjusting assembly, a Y-direction adjusting assembly, and a Z-direction adjusting assembly. The X-direction adjusting assembly is fixedly connected to an inner sidewall of a fixing bracket. The fixing bracket is fixedly connected to an inner sidewall of the roof plate. A fixing plate is connected to the inner side of the X-direction adjusting assembly. The Y-direction adjusting assembly is connected to the bottom of the fixing plate. The automatic berthing system can realize accurate berthing of an unmanned ship, achieve an excellent berthing effect, and provide protection for the unmanned ship, achieving high safety.

Abstract: An automatic berthing system for an unmanned ship includes a plurality of roof plates fixedly arranged at a side edge of a shore, and a position adjusting mechanism is fixedly arranged in the roof plate. The position adjusting mechanism includes an X-direction adjusting assembly, a Y-direction adjusting assembly, and a Z-direction adjusting assembly. The X-direction adjusting assembly is fixedly connected to an inner sidewall of a fixing bracket. The fixing bracket is fixedly connected to an inner sidewall of the roof plate. A fixing plate is connected to the inner side of the X-direction adjusting assembly. The Y-direction adjusting assembly is connected to the bottom of the fixing plate. The automatic berthing system can realize accurate berthing of an unmanned ship, achieve an excellent berthing effect, and provide protection for the unmanned ship, achieving high safety.

Abstract: The present invention provides a pharmaceutical composition for treating chronic stroke, involving injection via brain into the cranium of a patient having chronic stroke for six months or more; the pharmaceutical composition is a suspension at least comprising TS stem cells, an active synergistic component and a growth factor, wherein the expression level of CD34 and CD45 of the TS stem cells is 10% or less, and the expression level of CD90 and CD105 is 90% or more; the active synergistic component is an extracellular vesicle; the growth factor is at least one selected from the group consisting of HGF, G-CSF, Fractalkine, IP-10, EGF, IL-1?, IL-1?, IL-4, IL-5, IL-13, IFN?, TGF? and sCD40L. The present invention overcomes the limitations of previous cell therapy and provides a cell-based preparation that is clinically safe and therapeutically effective for chronic cerebral stroke.

Abstract: The present disclosure provides a method for treating arthritis by using a stem cell preparation. The stem cell preparation of the present disclosure can effectively delay cartilage degeneration caused by arthritis, and it is confirmed by whole blood analysis and blood biochemical analysis that the stem cell preparation in the form of three-dimensional stem cell spheres provides a safe treatment for arthritis. The present disclosure also provides a method for preparing the stem cell preparation.

Abstract: Embodiments of the present disclosure provide methods and apparatus for antenna calibration. A method implemented at a network function comprises calibrating an antenna of the network function based on available time-frequency resources. The method further comprises communicating with at least one terminal device via the calibrated antenna.

Abstract: The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopaminergic activity.

Abstract: The present disclosure relates to a new polypeptide complex. Specifically, the present disclosure relates to a domain engineered antibody. At least one of the constant region domains CH1 and/or CL of the antibody is replaced, and the domain CH1/CL is replaced by a Titin T chain/Obscurin-O chain or by a Titin T chain/Obscurin-like-O chain.

Abstract: Embodiments include monoclonal antibodies (mAbs) that recognize SARS-Cov-2 spike protein. The mAbs are capable of distinguishing among variants of the virus. The present disclosure also provides a composition and methods of making and using such a composition for treating, preventing, and/or detecting SARS-CoV-2 infection.

Abstract: The present invention generally relates to computer security, and more specifically, related to registration and authorization cross multiple domains. In an aspect, a computer-implemented method, computer-implemented system, and computer program product for cross domain registration by a source domain is provided. A request is sent by a source domain to register the source domain as a trusted domain of a target domain. An approval of the request is received by the source domain. The source domain issues a key to an application of the source domain for accessing the target domain.

Abstract: A composition comprising an acid and/or anhydride grafted ethylene/alpha-olefin interpolymer that comprises the following properties: A) number of grafts per polymer chain?1.80, and B) melt viscosity (at 177° C.)?50,000 mPa·s.

Abstract: Described are methods and systems for cationizing and dyeing a natural fiber-containing textile. The method includes a step of steam treating a textile padded with a base and cationizing agent in a defined temperature range (greater than 100° C. to less than 110° C.) and for a defined time period (1 min to 10 min). The cationizing agent in the presence of the base is capable of generating two epoxide groups. The cationization step in the presence of steam using the halogenated catonization agent of the invention facilitates improved dyeing.

Abstract: A computer-implemented method includes receiving, by a processing unit, from a first tenant, a query to retrieve data from a nonrelational database system. The method further includes determining, by the processing unit, that an index associated with the query is cached in a shared index cache, wherein the shared index cache stores indexes for a plurality of tenants. The method further includes retrieving, by the processing unit, a result of the query based on the index in the shared index cache. The method further includes outputting, by the processing unit, the result of the query.

Abstract: Described are methods and systems for cationizing and dyeing a natural fiber-containing textile, which uses a mono- or di-quaternized cationizing agent. The method includes a step of heating the textile to a temperature in the range of 90° C. to less than 110° C. for a period of time in the range of 1 min to 10 min to react the cationizing agent with the textile. The cationization step in the presence of heat using the halogenated cationization agent of the invention facilitates improved dyeing.

Abstract: The present invention relates to a method of preparing a black phosphorus nanosheet and application, belonging to the technical field of functional material production. In the method, the black phosphorus sheet is used as the electrolytic anode, and an electrochemical reaction system is constructed together with an inert electrode and an alkaline aqueous electrolyte, wherein the alkaline aqueous electrolyte comprises an N-N dimethylformamide solution dissolved with epoxy resin. In alkaline aqueous electrolyte, the prepared black phosphorus nanosheet structure tends to be more stable, not easy to be damaged and the oxidation degree is reduced. Under alkaline conditions, it is conducive to improve the intercalation and stripping effect of black phosphorus material of anode and make the black phosphorus exfoliation more complete.