Abstract: It relates to a method of treating a subject with liver fibrosis and/or liver cirrhosis. The disclosure provides a pharmaceutical composition that includes hydronidone or a salt thereof that can be used for treating a subject with liver fibrosis and/or liver cirrhosis. Liver stiffness measurements values and/or Ishak scores may be used to identify subjects for treatment of liver fibrosis and/or liver cirrhosis.

Abstract: Embodiments described herein relate to a Radio Distribution Network Board, RDNB, for testing functionality of a plurality of radio chains, and to a method of calibrating a plurality of radio chains using said RDNB. The RDNB comprises a plurality of first ports for connecting to the plurality of radio chains; a plurality of second ports for connecting to one or more external devices, wherein each first port is coupled to a respective second port; and a plurality of coupling paths, wherein each coupling path is configured to provide coupling between two first ports, and wherein each coupling path comprises one or more non-directional power splitter/combiners.

Abstract: The present disclosure relates to anti-KLB antibodies and uses.

Abstract: The present disclosure provides a greenhouse gas emission reduction method for a heavy metal contaminated soil, falling within the technical field of emission reduction of greenhouse gas nitrous oxide. Specifically, hydroxyapatite (HAP) is added to a soil to effectively reduce the emission of nitrous oxide in the soil, and at the same time, the treatment of heavy metal contamination is realized, which is very suitable for the promotion and use of nitrous oxide emission reduction in the contaminated soil.

Abstract: Light emitting diodes with regrown semiconductor layers and methods of manufacture are described. In an embodiment, a light emitting diode includes a base structure including a first cladding layer doped with a first dopant type (e.g. n-type) and step surface. A mesa pillar including an active layer protrudes from the step surface, and a regrown second cladding layer doped with a second dopant type (e.g. p-type) is in direct contact with and spans a bottom surface and sidewalls of the mesa pillar and the step surface.

Abstract: Disclosed are fused imidazole derivatives, preparation methods therefor and medical uses thereof. Specifically, the present disclosure relates to a fused imidazole derivative as shown in general formula (IM), a preparation method therefor, a pharmaceutical composition containing the derivative, and the use of same as a therapeutic agent, in particular the use thereof as a GLP-1 receptor agonist, and the use thereof in the preparation of drugs for the treatment and/or prevention of diabetes.

Abstract: The present disclosure provides antibodies that bind to the SARS-CoV-2 spike protein, as well as compositions containing the same, and methods of making and using such a composition for treating, preventing, and/or detecting SARS-CoV-2 infection.

Abstract: Regular expression (“regex”) decomposition and evaluation is disclosed. In an aspect of the disclosure, a literal component and a pattern component in a regex are determined. A plurality of evaluation processes is determined based on the regex, including a first evaluation process configured to identify text that matches the literal component and the pattern component. The evaluation processes are executed with respect to a sample of data to determine performance characteristics including a performance characteristic respective to each evaluation process. An evaluation process of the evaluation processes is selected based on the determined performance characteristics. The selected evaluation process is executed with respect to further data to retrieve results that satisfy the selected evaluation process. In another aspect, the pattern component is decomposed into subcomponents.

Abstract: A computer-implemented method includes receiving, by a processing unit, from a first tenant, a query to retrieve data from a nonrelational database system. The method further includes determining, by the processing unit, that an index associated with the query is cached in a shared index cache, wherein the shared index cache stores indexes for a plurality of tenants. The method further includes retrieving, by the processing unit, a result of the query based on the index in the shared index cache. The method further includes outputting, by the processing unit, the result of the query.

Abstract: An electric scooter includes a deck, a power wheel unit, a power wheel steering unit, a driven wheel, a driven wheel steering unit, a power supply unit and a whole scooter controller. The power wheel unit includes a driving wheel; the power wheel steering unit is arranged between the deck and the power wheel unit; the driven wheel is spaced apart from the power wheel unit; the driven wheel steering unit is arranged between the driven wheel and the deck; the power supply unit is electrically coupled to the power wheel unit; the whole scooter controller is in communication with the power wheel unit and controls rotation of the driving wheel.

Abstract: The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.

Abstract: Hybrid materials are disclosed including molecular/protein crystals integrated with synthetic polymers. The disclosed materials combine the structural order and periodicity of crystals, the adaptiveness and tunable mechanical properties of polymeric networks, and the chemical versatility of protein building blocks. Some of the properties of the disclosed materials include the following: 1) allows crystals—which are typically rigid and brittle—to expand and contract reversibly; 2) incorporates polymers to increase the mechanical toughness of the crystals and allow self-healing; 3) reversibly expand/contract crystal lattices and mobilize the protein components therein may provide a new means to improve X-ray diffraction quality and explore otherwise inaccessible protein structural states using 3D protein crystallography; 4) creation of chemically and mechanically differentiated domains within single crystals.

Abstract: A Pancreatic Ductal Adenocarcinoma (PDAC) image segmentation method, an electronic device, and a storage medium are provided. In the PDAC image segmentation method, a first model is trained using a first data set; and a second model is trained using a second data set. A third data set is obtained by annotating a to-be-annotated data set using the first model and the second model and a third model is trained using a fourth data set. A training set is obtained by modifying the first data set and the third data set using the third model and a segmentation model is obtained by training an nnUNet using the training set. A to-be-segmented PDAC image is input into the segmentation model, and a segmentation result is obtained. By utilizing the PDAC image segmentation method, a more accurate PDAC image segmentation is achieved.

Abstract: The present disclosure provides a method for preparing a composition including mesenchymal stem cells, extracellular vesicles produced by the mesenchymal stem cells, and growth factors, the composition prepared by the method, and use of the composition for treating arthritis. The composition of the present disclosure achieves the effect of treating arthritis through various efficacy experiments.

Abstract: The present invention relates to a method for preparing a modified stem cell, including the following steps: a cell culture step: culturing stem cells in a first culture medium of a culture dish at a predetermined cell density, and removing the first culture medium after a first culture time to obtain a first cell intermediate; an activity stimulation step: preserving the first cell intermediate in a freezing container having a cell cryopreservation solution, and performing a constant temperature stimulation treatment or a variable temperature stimulation treatment for at least more than 1 day; and a product collection step: after completing the activity stimulation step, placing the freezing container in an environment at a thawing temperature for thawing, and then removing the cell cryopreservation solution to obtain the modified stem cell. The modified stem cell can release at least one or more of IL-4, IL-5, IL-13, G-CSF, Fractalkine, and EGF.

Abstract: The present disclosure provides a method for treating liver cirrhosis by using a composition including mesenchymal stem cells, extracellular vesicles produced by the mesenchymal stem cells, and growth factors. The composition of the present disclosure achieves the effect of treating liver cirrhosis through various efficacy experiments.

Abstract: A method and a sensor for detecting L-cystine are disclosed. The method is implemented by assembling a sodium 3,3?-dithiodipropane sulfonate (SPS) membrane on a surface of Au membrane layer of an Au electrode and using an extended gate of field effect transistor (FET) and in-situ signal amplification of the FET to detect L-cystine sensitively. The polyanion of the SPS membrane adsorbs and binds a positively charged target L-cystine through electrostatic interaction, thus forming an electric double layer structure to generate a membrane potential identifying a monovalent organic ammonium ion. The sensor includes the FET, wherein a gate-extended gold electrode is arranged on the FET, and the SPS membrane is assembled on the surface of the Au membrane layer of the gate-extended gold electrode. The sensor has an excellent Nernst response to L-cystine.

Abstract: Disclosed in the present invention is an optimized cell transplant. The optimized cell transplant is formed by performing gene induction and modification on a mesenchymal stem cell in the form of a small molecule and protein composition. The expression levels of CD200 gene, Galectin-9 gene and VISTA gene can be increased synchronously after cell culture. Vector virus infection and plasmid transfection are not required in the cell preparation process, so that high biological safety and great clinical application value of cells are achieved.