Patents by Inventor Ling Zhang

Ling Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10039998
    Abstract: An anti-thermosensitization rectification tower comprising a rectification tower, a T-shaped condenser, a baffle plate, a tower bottom, a falling-film reboiler and a recirculation system, wherein the T-shaped condenser is secured exactly on the top of the rectification tower without any pipeline in between, and the circular baffle plate is installed in the T-shaped condenser; an annular sump located between the rectification tower and the T-shaped condenser for collecting the liquid condensed in the T-shaped condenser and channeling it out of the rectification tower into a liquid-collecting tank, and a centrifugal pump utilized to connect together the tower bottom and the falling-film reboiler to form a high-speed circulation system, wherein the tower bottom is an elongated conduit and the falling-film reboiler is in the form of a stout shell-and-tube heat exchanger is provided.
    Type: Grant
    Filed: March 14, 2011
    Date of Patent: August 7, 2018
    Assignee: NANJING UNIVERSITY
    Inventors: Zhibing Zhang, Zheng Zhou, Gaodong Yang, Defang Sun, Ling Zhang
  • Patent number: 10036102
    Abstract: A bismuth and magnesium co-doped lithium niobate crystal includes Li2CO3, Nb2O5, Bi2O3 and MgO, wherein the molar ratio of [Li] and [Nb] is 0.90-1.00, the molar percentage of Bi2O3 in the mixture is 0.25-0.80%, and the molar percentage of MgO in the mixture is 3.0-7.0%. The bismuth and magnesium co-doped lithium niobate crystal has enhanced photorefraction, improved photorefractive sensitivity, shortened holographic grating saturation writing time, and the photorefractive diffraction efficiency can reach up to 17%. The response time is only 170 ms, when the holographic storage experiment is carried out using 488 nm continuous laser. Therefore, this crystal can be used in the field of holographic imaging.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: July 31, 2018
    Assignees: NANKAI UNIVERSITY, TAISHAN SPORTS INDUSTRY GROUP CO., LTD.
    Inventors: Yongfa Kong, Dahuai Zheng, Shiguo Liu, Jingjun Xu, Peiming Xu, Zhiyong Bian, Shaolin Chen, Ling Zhang, Hongde Liu
  • Patent number: 10031028
    Abstract: An optical wavelength detecting device, the device including: a polarizer configured to transform an incident light into a polarized light; a detecting element configured to receive the polarized light and form a temperature difference or a potential difference between two points of the detecting element, wherein the detecting element comprises a carbon nanotube structure including a plurality of carbon nanotubes oriented along the same direction, and angles between a polarizing direction of the polarized light and an oriented direction of the plurality of carbon nanotubes is adjustable; a measuring device electrically connected to the detecting element and configured to measure the temperature difference or the potential difference; a data processor electrically connected to the measuring device and configured to obtain the optical wavelength by calculating and analyzing the temperature difference or the potential difference.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: July 24, 2018
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Ling Zhang, Yang Wu, Kai-Li Jiang, Chang-Hong Liu, Jia-Ping Wang, Shou-Shan Fan
  • Publication number: 20180200223
    Abstract: The present invention provides applications of a small molecular flavonoid compound in preparing a medication for sensitizing/synergizing tumor radiation therapy as well as reducing radioactive damage. The small molecular flavonoid compound can be naringenin, hesperetin, luteolin and apigenin, etc. The medication contains a small molecular flavonoid compound and a plurality of conventional pharmaceutical additives; wherein the small molecular flavonoid compound is an active ingredient.
    Type: Application
    Filed: August 25, 2016
    Publication date: July 19, 2018
    Applicant: INSTITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
    Inventors: Wei LIANG, Chun Ling ZHANG, Wen Feng ZENG, Chao ZHANG, Luo Yang WANG
  • Patent number: 9995633
    Abstract: An optical wavelength detecting device, the device including: a polarizer configured to transform an incident light into a polarized light; a detecting element configured to receive the polarized light and form a temperature difference or a potential difference between two points of the detecting element, wherein the detecting element includes a carbon nanotube structure including a plurality of carbon nanotubes oriented along the same direction, and angles between a polarizing direction of the polarized light and an oriented direction of the plurality of carbon nanotubes is adjustable; a measuring device electrically connected to the detecting element and configured to measure the temperature difference or the potential difference; a data processor electrically connected to the measuring device and configured to obtain the optical wavelength by calculating and analyzing the temperature difference or the potential difference.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: June 12, 2018
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Ling Zhang, Yang Wu, Kai-Li Jiang, Chang-Hong Liu, Jia-Ping Wang, Shou-Shan Fan
  • Publication number: 20180155760
    Abstract: The invention relates to a compound of Formula I: F1—X1-L1-X2—P1—X3-G1 ??(Formula I).
    Type: Application
    Filed: December 5, 2017
    Publication date: June 7, 2018
    Inventors: Yan-Ling Zhang, Edward Holson, Florence F. Wagner
  • Publication number: 20180155283
    Abstract: The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopammode inergic activity. The present invention relates to novel compounds that modulate dopamine D2 receptors. In particular, compounds of the present invention show functional selectivity at the dopamine D2 receptors and exhibit selectivity downstream of the D2 receptors, on the 0-arrestin pathway and/or on the cAMP pathway.
    Type: Application
    Filed: December 18, 2015
    Publication date: June 7, 2018
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventors: Edward Holson, Florence Fevrier Wagner, Michel Weiwer, Edward Scolnick, Michelle Palmer, Luka Dordevic, Michael C. Lewis, Jennifer Q. Pan, Yan-Ling Zhang, Qihong Xu
  • Publication number: 20180110875
    Abstract: Provided are an anti-c-Met antibody or an antigen binding fragment thereof, and an anti-c-Met antibody-cytotoxic drug conjugate, wherein the antibody or antigen binding fragment thereof is a chimeric antibody or a humanized antibody. Also provided are pharmaceutical compositions containing the humanized anti-c-Met antibody or antigen binding fragment thereof, the antibody-cytotoxic drug conjugate, or pharmaceutically acceptable salts or solvents thereof, that are used in the treatment of cancer.
    Type: Application
    Filed: April 7, 2016
    Publication date: April 26, 2018
    Inventors: Jiajian LIU, Lianshan ZHANG, Weikang TAO, Yayuan FU, Ling ZHANG, Dong MA, Dongbing CUI, Yali WANG, Jianyan XU, Jindong LIANG, Ying ZHANG, Guiyang JIANG, Junzhuan QIU, Ziyong SUN, Jiping ZHA, Jingping WEI
  • Publication number: 20180099046
    Abstract: Provided is a humanized antibody and chimeric antibody that specifically binds human sclerostin. The antibodies can be used for treating human bone metabolism related diseases such as osteoporosis (OP).
    Type: Application
    Filed: February 16, 2016
    Publication date: April 12, 2018
    Applicants: Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
    Inventors: Jiajian LIU, Yayuan FU, Haoying ZHANG, Yifang WANG, Zhen ZHANG, Ling ZHANG, Dongbing CUI, Lianshan ZHANG, Weikang TAO
  • Publication number: 20180099977
    Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.
    Type: Application
    Filed: October 17, 2017
    Publication date: April 12, 2018
    Applicants: The Broad Institute, Inc., The General Hospital Corporation d/b/a Massachusetts General Hospital, Massachusetts Institute of Technology
    Inventors: Edward Holson, Florence Fevrier Wagner, Michel Weiwer, Li-Huei Tsai, Stephen J. Haggarty, Yan-Ling Zhang
  • Publication number: 20180090179
    Abstract: A hard disk drive mounting assembly that includes a disk drive assembly having a base structure that includes a screw hole and a damping insert at least partially surrounding the screw hole. The disk drive assembly further includes a threaded insert positioned in the screw hole of the damping insert.
    Type: Application
    Filed: September 27, 2016
    Publication date: March 29, 2018
    Inventors: Hao Sun, Aravind Pitty, Xiong Liu, Ling Ling Zhang
  • Publication number: 20180072671
    Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein X1, X2, X3, X4, X5, W1, W2, W3, and W4 are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. In one aspect, the invention relates to selective HDAC3 inhibitors useful for protecting ?-cells and improving insulin resistence. The selective HDAC3 inhibitors are also useful for promoting cognitive function and enhancing learning and memory formation.
    Type: Application
    Filed: August 16, 2017
    Publication date: March 15, 2018
    Applicants: The Broad Institute, Inc., The General Hospital Corporation d/b/a Massachusetts General Hospital
    Inventors: Edward Holson, Florence Fevrier Wagner, Stephen J. Haggarty, Yan-Ling Zhang, Morten Lundh, Bridget Wagner, Michael C. Lewis, Tracey Lynn Petryshen
  • Patent number: 9892213
    Abstract: A cable-membrane tensegrity structure which is asymmetric, and construction method and design method thereof are provided. The cable-membrane tensegrity structure comprises a central opening and is formed by a ring cable (4) and three layers of radial cables comprising a suspension cable (1), a ridge cable (2) and a valley cable (3), wherein the suspension cable (1) is located above the ridge cable (2), the ridge cable (2) is located above the valley cable (3), wherein one end of each of the suspension cable (1), the ridge cable (2) and the valley cable (3) is connected to the ring cable (4), and the other end of each of the suspension cable (1), the ridge cable (2) and the valley cable (3) is connected to a peripheral supporting structure (7), wherein a coating membrane (5) is tensioned between the ridge cable (2) and the valley cable (3) that are adjacent to each other and function as a skeleton to tension the coating membrane (5).
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: February 13, 2018
    Assignee: CHINA AVIATION PLANNING & CONSTRUCTION DEVELOPMENT
    Inventors: Jiaqi Ge, Guojun Zhang, Shu Wang, Mansheng Zhang, Zhizhong Guan, Ling Zhang, Botao Ma
  • Patent number: 9890172
    Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: February 13, 2018
    Assignees: The Broad Institute, Inc., The General Hospital Corporation
    Inventors: Edward Holson, Florence Fevrier Wagner, Michel Weiwer, Stephen J. Haggarty, Yan-Ling Zhang
  • Publication number: 20180016282
    Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.
    Type: Application
    Filed: August 11, 2016
    Publication date: January 18, 2018
    Inventors: Edward Holson, Florence Fevrier Wagner, Michel Weiwer, Li-Huei Tsai, Stephen J. Haggarty, Yan-Ling Zhang
  • Publication number: 20180003326
    Abstract: A system includes a body having a front end and a back end, a channel within the body that is configured to hold at least a portion of a service unit, a guiderail extending along a portion of the channel and configured to couple with a pushrod, and an adapter configured to couple with a portion of the service unit and a portion of the body. The channel also includes a front opening positioned proximate to the front end of the body, wherein the front opening is configured to allow at least a portion of the service unit, or at least a portion of a connector, to pass through the front opening, and a back opening positioned proximate to the back end of the body, wherein the back opening is configured to allow at least a portion of the pushrod to pass through the back opening.
    Type: Application
    Filed: June 29, 2016
    Publication date: January 4, 2018
    Inventors: Michael Vincent Wozniak, Ling Zhang Larson, Floyd A. Fazi, JR., Jeffrey Allen Lucas, Stephen R. Wood
  • Patent number: 9856509
    Abstract: The invention relates to a compound of Formula I: F1—X1-L1-X2—P1—X3-G1??(Formula I).
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: January 2, 2018
    Assignee: The Broad Institute, Inc.
    Inventors: Yan-Ling Zhang, Edward Holson, Florence F. Wagner
  • Patent number: 9857224
    Abstract: An optical locking system comprises a light emitter, an optical wavelength identifying system, and a locking unit. The optical wavelength identifying system comprises an optical wavelength detecting device, a memory, a modulator, a comparison module, and an instruction module. The optical wavelength detecting device comprises a polarizer, a detecting element, a measuring device, and a data processor. The detecting element configured to form a temperature difference or a potential difference between two points of the detecting element when exposed to the polarized light, wherein the detecting element comprises a carbon nanotube structure comprising a plurality of carbon nanotubes oriented along the same direction, and angles between a polarizing direction of the polarized light and an oriented direction of the plurality of carbon nanotubes is adjustable.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: January 2, 2018
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Ling Zhang, Lei Deng, Yang Wu, Chang-Hong Liu, Kai-Li Jiang, Shou-Shan Fan
  • Patent number: 9851814
    Abstract: A foldable mouse comprises a substrate, a thin-film battery, a touch module, a signal processing module, and a communication module. The substrate is a foldable structure. The thin-film battery is electrically connected to the touch module, the signal processing module, and the communication module; the signal processing module drives the touch module, receives signals from the touch module, and sends the signals to the communication module. The substrate comprises a main body structure sandwiched between a first support plate and a second support plate. The first support plate and the second support plate are symmetrically located at two opposite sides of the main body and foldable connected to the main body structure. The main body structure comprises a first surface and a second surface, and a minidisc is integrated on the second surface.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: December 26, 2017
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Lei Deng, Ying-Ri Sun, Guang-Hong Han, Ling Zhang, Shou-Shan Fan
  • Patent number: 9790184
    Abstract: The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein X1, X2, X3, X4, X5, W1, W2, W3, and W4 are as described. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. In one aspect, the invention relates to selective HDAC3 inhibitors useful for protecting ?-cells and improving insulin resistance. The selective HDAC3 inhibitors are also useful for promoting cognitive function and enhancing learning and memory formation.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: October 17, 2017
    Assignees: The Broad Institute, Inc., The General Hospital Corporation
    Inventors: Edward Holson, Florence Fevrier Wagner, Stephen J. Haggarty, Yan-Ling Zhang, Morten Lundh, Bridget Wagner, Michael C. Lewis, Tracey Lynn Petryshen