Abstract: The present disclosure provides a composition. In an embodiment an adhesive composition is provided and includes (A) a propylene-based interpolymer having a density from 0.850 g/cc to 0.900 g/cc; (B) an ethylene-based polymer composition having a melt viscosity at 140° C. from 10 mPa*s to 1,000 mPa*s; and (C) a tackifier. The composition has a molecular weight distribution ratio from 1.00 to 1.40, wherein the molecular weight distribution ratio is the molecular weight distribution of the propylene-based interpolymer of component (A) compared to the molecular weight distribution of the ethylene-based polymer composition of component (B). The composition has a density ratio from 0.93 to 1.30, wherein the density ratio is the density of the propylene-based interpolymer of component (A) compared to the density of the ethylene-based polymer composition of component (B).

Abstract: Apparatuses, systems, and techniques to generate synthesized images including digital representations of groups of cells blended realistically with appropriate background images. In at least one embodiment, background image data and gene expression data are fused together to generate such a synthesized image using one or more neural networks.

Abstract: Hybrid materials are disclosed including molecular/protein crystals integrated with synthetic polymers. The disclosed materials combine the structural order and periodicity of crystals, the adaptiveness and tunable mechanical properties of polymeric networks, and the chemical versatility of protein building blocks. Some of the properties of the disclosed materials include the following: 1) allows crystals—which are typically rigid and brittle—to expand and contract reversibly; 2) incorporates polymers to increase the mechanical toughness of the crystals and allow self-healing; 3) reversibly expand/contract crystal lattices and mobilize the protein components therein may provide a new means to improve X-ray diffraction quality and explore otherwise inaccessible protein structural states using 3D protein crystallography; 4) creation of chemically and mechanically differentiated domains within single crystals.

Abstract: The present disclosure provides a composition. In an embodiment a composition is provided and includes: (A) a propylene-based interpolymer having the following: (i) a density from 0.850 g/cc to 0.900 g/cc; and (ii) a melt viscosity, at 177° C., less than, or equal to, 10, 000 mPa·s.; and (B) a rosin ester containing the following: (i) greater than, or equal to, 75 mol % aliphatic carbon, based on total moles of carbon in the rosin ester; and (ii) less than, or equal to, 3.0 mol % ester group carbon, based on total moles of carbon in the rosin ester.

Abstract: The present invention provides rechargeable dental materials that can be widely applied in a variety of dental applications. The rechargeable dental materials of the invention may be included in dental primers, dental adhesives, dental resins, dental composites, dental bonding systems and the like, as well as dental cements, dental sealants, dental bases and dental liners, each of which is rechargeable with calcium and phosphate ions. The present invention also provides for a method of recharging the rechargeable dental material with calcium and phosphate ions.

Abstract: The present disclosure provides a composition. In an embodiment an adhesive composition is provided and includes (A) a propylene-based interpolymer having a density from 0.850 g/cc to 0.900 g/cc; (B) an ethylene-based polymer composition having a melt viscosity at 140° C. from 10 mPa*s to 1,000 mPa*s; and (C) a tackifier. The composition has a molecular weight distribution ratio from 1.00 to 1.40, wherein the molecular weight distribution ratio is the molecular weight distribution of the propylene-based interpolymer of component (A) compared to the molecular weight distribution of the ethylene-based polymer composition of component (B). The composition has a density ratio from 0.93 to 1.30, wherein the density ratio is the density of the propylene-based interpolymer of component (A) compared to the density of the ethylene-based polymer composition of component (B).

Abstract: Apparatuses, systems, and techniques to perform training of neural networks using stacked transformed images. In at least one embodiment, a neural network is trained on stacked transformed images and trained neural network is provided to be used for processing images from an unseen domain distinct from a source domain, wherein stacked transformed images are transformed according to transformation aspects related to domain variations.

Abstract: A testing device for testing adhesion force includes a thermal insulated glove box, an atomic force microscope, a cryogenic sample stage, a high pressure gas source and a circulating chiller. The atomic force microscope includes a probe for adhering mineral particles. The cryogenic sample stage is configured for preparing gas hydrate sample. The cryogenic sample stage is arranged below the probe. The atomic force microscope and the cryogenic sample stage are placed in the thermal insulated glove box. The high pressure gas source provides pressure required for synthesis of gas hydrates, the high pressure gas source comprises a high pressure chamber covered on the cryogenic sample stage and a high pressure gas cylinder connected with the high pressure chamber. The circulating chiller, an outlet of the circulating chiller is connected with the thermal insulated glove box to control humidity and temperature inside the thermal insulated glove box.

Abstract: The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopaminergic activity.

Abstract: This disclosure relates to methods of detecting and quantifying neuronal activation. This disclosure further relates to a particular phosphorylation of calcineurin A alpha (CNA?) at serine 469 (S469) of the amino acid sequence of the protein as a marker for neuronal activation, antibodies recognizing that phosphorylated form of CNA?, and uses of such antibodies, for example, in various neuronal activity assays and related kits.

Abstract: A pasta roller with a built-in motor for manual and electric pasta roller machine includes a first shaft and a direct current motor received in a main roller. The first shaft is fixed to the main roller. The direct current motor drives the first shaft in one direction via a planetary reduction gear unit. A second shaft is co-axially located in the main roller and has a first end gear mounted thereto. A secondary roller is located beside the main roller and has a second end gear connected to one end thereof. The first and second end gears are engaged with each other. A crank is removably inserted into a hole in the first shaft. When in manual operation, the crank is rotated to rotate the main roller and the second shaft, and the secondary roller is rotated by the engagement between the first and second end gears.

Abstract: A testing device for testing adhesion force includes a thermal insulated glove box, an atomic force microscope, a cryogenic sample stage, a high pressure gas source and a circulating chiller. The atomic force microscope includes a probe for adhering mineral particles. The cryogenic sample stage is configured for preparing gas hydrate sample. The cryogenic sample stage is arranged below the probe. The atomic force microscope and the cryogenic sample stage are placed in the thermal insulated glove box. The high pressure gas source provides pressure required for synthesis of gas hydrates, the high pressure gas source comprises a high pressure chamber covered on the cryogenic sample stage and a high pressure gas cylinder connected with the high pressure chamber. The circulating chiller, an outlet of the circulating chiller is connected with the thermal insulated glove box to control humidity and temperature inside the thermal insulated glove box.

Abstract: The present disclosure provides a composition. In an embodiment a composition is provided and includes: (A) an ethylene-based interpolymer having the following: (i) a density from 0.860 g/cc to 0.900 g/cc; and (ii) a melt viscosity, at 177° C., less than, or equal to, 50,000 mP•a·s; and (B) a rosin ester containing the following: (i) greater than, or equal to, 75 mol % aliphatic carbon, based on total moles of carbon in the rosin ester; and (ii) less than, or equal to, 3.0 mol % ester group carbon, based on total moles of carbon in the rosin ester.

Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.

Abstract: A data caching method and device, and a resource request response method and device. The data caching method comprise: receiving a resource request for group content belonging to a specific user group, the resource request being sent from a user terminal to an application server by a user; checking if a mapping between the group content and a group caching ID for identifying the user group and a mapping between the user and the group caching ID have been established in the caching server; and returning the group content cached in the caching server to the user terminal in responses to the mapping between the group content and the group caching ID and the mapping between the user and the group caching ID having been established in the caching server.

Abstract: A method may be performed using a server. The method may include receiving an identity authentication request associated with a user, generating authentication information based on the identity authentication request, and generating candidate information based on the authentication information such that the authentication information is a subset of the candidate information. The candidate information may be displayed at a randomly selected location. The user may provide input through a graphic input interface to select the authentication information from among the candidate information.

Abstract: The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopaminergic activity. The present invention relates to novel compounds that modulate dopamine D2 receptors. In particular, compounds of the present invention show functional selectivity at the dopamine D2 receptors and exhibit selectivity downstream of the D2 receptors, on the 0-arrestin pathway and/or on the cAMP pathway.

Abstract: The invention relates to a compound of Formula I: F1—X1-L1-X2—P1—X3-G1??(Formula I).

Abstract: The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.

Abstract: Provided are an anti-c-Met antibody or an antigen binding fragment thereof, and an anti-c-Met antibody-cytotoxic drug conjugate, wherein the antibody or antigen binding fragment thereof is a chimeric antibody or a humanized antibody. Also provided are pharmaceutical compositions containing the humanized anti-c-Met antibody or antigen binding fragment thereof, the antibody-cytotoxic drug conjugate, or pharmaceutically acceptable salts or solvents thereof, that are used in the treatment of cancer.