Abstract: The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.

Abstract: The invention provides a method for preparing an expanded cell or tissue sample suitable for microscopic analysis. Expanding the sample can be achieved by binding, e.g., anchoring, key biomolecules to a DMAA-TF polymer network and swelling, or expanding, the polymer network, thereby moving the biomolecules apart as further described herein. As the biomolecules are anchored to the polymer network isotropic expansion of the polymer network retains the spatial orientation of the biomolecules resulting in an expanded, or enlarged, sample.

Abstract: Disclosed and claimed are mutation(s) or modification(s) of the CRISPR enzyme, for example a Cas enzyme such as a Cas9, which obtain an improvement, for instance a reduction, as to off-target effects of a CRISPR-Cas or CRISPR-enzyme or CRISPR-Cas9 system or complex containing or including such a mutated or modified Cas or CRISPR enzyme or Cas9. Methods for making and using and uses of such mutated or modified Cas or CRISPR enzyme or Cas9 and systems or complexes containing the same and products from such methods and uses are also disclosed and claimed.

Abstract: Novel programmable targeting sequences and applications thereof. The targeting sequences can be engineered for binding to proteins, polypeptides, and other macromolecules.

Abstract: A method includes receiving, by an embedded universal integrated circuit card (eUICC), first information from a local profile assistant (LPA), where the first information includes a first certificate issuer (CI) public key identifier, and the first CI public key identifier is a CI public key identifier that the eUICC does not have. The method further includes sending, by the eUICC, second information to an OPS, where the second information includes the first CI public key identifier. The method further includes receiving, by the eUICC, a patch package from the OPS, where the patch package includes at least a first CI public key corresponding to the first CI public key identifier. The method further includes updating, by the eUICC, a CI public key of the eUICC by using the first CI public key.

Abstract: An information verification method and a related device are disclosed. The method includes: receiving, by a first profile server, a remote profile management request sent by a remote profile management server, where the remote profile management request includes a first profile owner identifier; obtaining a second profile owner identifier in profile information; determining whether the first profile owner identifier is the same as the second profile owner identifier; and sending a remote profile management command to user equipment when the first profile owner identifier is the same as the second profile owner identifier. In this way, a loss caused to an operator or a profile owner due to a user's access to an invalid network or random profile unlocking is avoided, network security is improved, and a waste of network resources is reduced.

Abstract: The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.

Abstract: A method for updating network access application authentication information applicable to a terminal having an embedded universal integrated circuit card (eUICC) that has at least one profile. The method includes receiving, by the terminal, a first message from a remote server, where the first message includes network access application (NAA) authentication parameter update information and a first identifier, updating, by the terminal, authentication information of a profile corresponding to the first identifier based on the NAA authentication parameter update information, and detaching, by the terminal, from a network and re-attaching to the network based on updated authentication information of the profile.

Abstract: A method includes receiving, by an embedded universal integrated circuit card (eUICC), first information from a local profile assistant (LPA), where the first information includes a first certificate issuer (CI) public key identifier, and the first CI public key identifier is a CI public key identifier that the eUICC does not have. The method further includes sending, by the eUICC, second information to an OPS, where the second information includes the first CI public key identifier. The method further includes receiving, by the eUICC, a patch package from the OPS, where the patch package includes at least a first CI public key corresponding to the first CI public key identifier. The method further includes updating, by the eUICC, a CI public key of the eUICC by using the first CI public key.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.

Abstract: In a subscription profile downloading method when an application in a device triggers subscription profile downloading, an operator server sends, to a subscription management server, authentication information of an application allowed to initiate subscription profile downloading; and when receiving an authentication request sent by the device, the subscription management server uses the authentication information to attempt to authenticate the application initiating subscription profile downloading in the device, and provides subscription profile downloading for the device after the authentication succeeds. The subscription management server may add the authentication information to a subscription profile downloaded last time and send the subscription profile to the device, and when the device downloads a different subscription profile next time, the device may use the authentication information in the subscription profile downloaded last time to attempt to authenticate the application.

Abstract: A method of identifying and characterizing novel Cas protein and guide RNAs with desired activity and specificity. The disclosure further comprises compositions and systems comprising engineered Cas protein and guide RNAs with desired activity and specificity.

Abstract: A method includes receiving, by an embedded universal integrated circuit card (eUICC), first information from a local profile assistant (LPA), where the first information includes a first certificate issuer (CI) public key identifier, and the first CI public key identifier is a CI public key identifier that the eUICC does not have. The method further includes sending, by the eUICC, second information to an OPS, where the second information includes the first CI public key identifier. The method further includes receiving, by the eUICC, a patch package from the OPS, where the patch package includes at least a first CI public key corresponding to the first CI public key identifier. The method further includes updating, by the eUICC, a CI public key of the eUICC by using the first CI public key.

Abstract: A method includes receiving, by an embedded universal integrated circuit card (eUICC), first information from a local profile assistant (LPA), where the first information includes a first certificate issuer (CI) public key identifier, and the first CI public key identifier is a CI public key identifier that the eUICC does not have. The method further includes sending, by the eUICC, second information to an OPS, where the second information includes the first CI public key identifier. The method further includes receiving, by the eUICC, a patch package from the OPS, where the patch package includes at least a first CI public key corresponding to the first CI public key identifier. The method further includes updating, by the eUICC, a CI public key of the eUICC by using the first CI public key.

Abstract: An information verification method and a related device are disclosed. The method includes: receiving, by a first profile server, a remote profile management request sent by a remote profile management server, where the remote profile management request includes a first profile owner identifier; obtaining a second profile owner identifier in profile information; determining whether the first profile owner identifier is the same as the second profile owner identifier; and sending a remote profile management command to user equipment when the first profile owner identifier is the same as the second profile owner identifier. In this way, a loss caused to an operator or a profile owner due to a user's access to an invalid network or random profile unlocking is avoided, network security is improved, and a waste of network resources is reduced.

Abstract: A method includes: receiving, by an embedded universal integrated circuit card eUICC, first information sent by a local profile assistant LPA, where the first information includes a first certificate issuer CI public key identifier, and the first CI public key identifier is a CI public key identifier that the eUICC does not have; sending, by the eUICC, second information to an OPS by using the LPA, where the second information includes the first CI public key identifier; receiving, by the eUICC, a patch package sent by the OPS by using the LPA, where the patch package includes at least a first CI public key corresponding to the first CI public key identifier; and updating, by the eUICC, a CI public key of the eUICC by using the first CI public key.

Abstract: An information verification method and a related device. The method includes: receiving, by a first profile server, a remote profile management request sent by a remote profile management server, where the remote profile management request includes a first profile owner identifier; obtaining a second profile owner identifier in profile information; determining whether the first profile owner identifier is the same as the second profile owner identifier; and sending a remote profile management command to user equipment when the first profile owner identifier is the same as the second profile owner identifier. In this way, a loss caused to an operator or a profile owner due to a user's access to an invalid network or random profile unlocking is avoided, network security is improved, and waste of network resources is reduced.

Abstract: A method for updating a certificate issuer public key includes receiving, by an eUICC, first information sent by a LPA, where the first information includes a first CI public key identifier, and the first CI public key identifier is a CI public key identifier that the eUICC does not have. The method further includes sending, by the eUICC, second information to an OPS by using the LPA, where the second information includes the first CI public key identifier. The method further includes receiving, by the eUICC, a patch package sent by the OPS by using the LPA, where the patch package includes at least a first CI public key corresponding to the first CI public key identifier. The method further includes updating, by the eUICC, a CI public key of the eUICC by using the first CI public key.

Abstract: A remote management method and a device, where the method includes receiving, by a subscription manager-data preparation (SM-DP+) server, a first identifier from a local profile assistant (LPA), searching for, by the SM-DP+ server, a remote profile management command corresponding to the first identifier, generating, by the SM-DP+ server, a first digital signature according to the first identifier and the remote profile management command, and sending the first digital signature and the remote profile management command to an embedded universal integrated circuit card (eUICC) using the LPA.