Abstract: Embodiments of the present invention disclose a method and system for updating a certificate issuer public key, and a related device. The method includes: receiving, by an embedded universal integrated circuit card eUICC, first information sent by a local profile assistant LPA, where the first information includes a first certificate issuer CI public key identifier, and the first CI public key identifier is a CI public key identifier that the eUICC does not have; sending, by the eUICC, second information to an OPS by using the LPA, where the second information includes the first CI public key identifier; receiving, by the eUICC, a patch package sent by the OPS by using the LPA, where the patch package includes at least a first CI public key corresponding to the first CI public key identifier; and updating, by the eUICC, a CI public key of the eUICC by using the first CI public key.

Abstract: A profile processing method, a profile processing apparatus, a user terminal (UE), and an embedded universal integrated circuit card (eUICC) conducive to profile processing efficiency enhancement of the eUICC and user experience improvement, where the method includes generating, by a local profile assistant (LPA) of a first UE (UE1), a profile request according to information about an eUICC of a second UE (UE2), sending the profile request, receiving, by the LPA, a profile request response, where the profile request response includes at least a profile of the eUICC, and forwarding, by the LPA, the profile to the eUICC.

Abstract: In a subscription profile downloading method when an application in a device triggers subscription profile downloading, an operator server sends, to a subscription management server, authentication information of an application allowed to initiate subscription profile downloading; and when receiving an authentication request sent by the device, the subscription management server uses the authentication information to attempt to authenticate the application initiating subscription profile downloading in the device, and provides subscription profile downloading for the device after the authentication succeeds. The subscription management server may add the authentication information to a subscription profile downloaded last time and send the subscription profile to the device, and when the device downloads a different subscription profile next time, the device may use the authentication information in the subscription profile downloaded last time to attempt to authenticate the application.

Abstract: Disclosed and claimed are mutation(s) or modification(s) of the CRISPR enzyme, for example a Cas enzyme such as a Cas9, which obtain an improvement, for instance a reduction, as to off-target effects of a CRISPR-Cas or CRISPR-enzyme or CRISPR-Cas9 system or complex containing or including such a mutated or modified Cas or CRISPR enzyme or Cas9. Methods for making and using and uses of such mutated or modified Cas or CRISPR enzyme or Cas9 and systems or complexes containing the same and products from such methods and uses are also disclosed and claimed.

Abstract: Embodiments include a method for installing a subscription profile, a terminal, and a server. The method includes obtaining, by a local profile assistant (LPA) in the terminal, metadata of a subscription profile, determining, based on an authorization file, whether use of each policy rule included in the metadata is allowed. The method further includes obtaining, by the LPA, the subscription profile when the use of each policy rule included in the metadata is allowed. The method further includes sending the subscription profile to an embedded universal integrated circuit card (eUICC) in the terminal. The method further includes determining, by the eUICC based on the authorization file, whether use of the subscription profile is allowed. The method further includes installing, by the eUICC, the subscription profile when the use of the subscription profile is allowed.

Abstract: An embedded universal integrated circuit card (eUICC) management method, an eUICC, an SM platform, and a system are provided. The method includes: acquiring, by an eUICC, capability information of a terminal in which the eUICC is embedded; and sending, by the eUICC, the capability information of the terminal to an SM platform, so that the SM platform manages a profile on the eUICC or generates a profile or manages the eUICC according to the capability information of the terminal. Capability information of a terminal in which the eUICC is embedded is reported to an SM platform, so that processing such as generation or management of a configuration file can match the capability information of the terminal, which improves processing accuracy.

Abstract: A profile download method and system, and a related device, where the method includes obtaining, by a user terminal, local profile assistant (LPA) indication information, obtaining download information required for downloading a target profile, and sending, by the user terminal, the download information to an embedded universal integrated circuit card (eUICC) when the LPA indication information instructs to download the profile using an LPA in the eUICC such that the eUICC downloads, using the LPA in the eUICC, the target profile from a download server indicated by the download information. Hence, the profile can be downloaded when an LPA is deployed in both the user terminal and the eUICC.

Abstract: A method for downloading a profile of an operator includes sending, by a terminal to a subscription manager-data preparer (SMDP) using a subscription manager-secure router (SM-SR), a request for downloading a profile of an operator, where the download request carries the download certificate, an identifier (ID) of an embedded universal integrated circuit card (eUICC) of the terminal, and addressing information of the SM-DP; and receiving, by the terminal, the profile of the operator that is sent by the SM-DP using the SM-SR and that corresponds to the download request, and transmitting the profile of the operator to the eUICC, where the profile of the operator is obtained by the SM-DP according to an identity of the profile of the operator after the SM-DP verifies that the certificate that is for downloading the profile of the operator and is carried in the download request is valid.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: A communication event processing method includes obtaining, by a first terminal, a use status of the first terminal and a use status of a second terminal. The method includes determining either the first terminal or the second terminal as a communication event receiving terminal according to at least one of the use status of the first terminal or the use status of the second terminal. The method includes sending, by the first terminal, a communication event transfer start instruction message to a server when the communication event receiving terminal is the second terminal and a communication event receiving terminal determined last time is the first terminal, where the communication event transfer start instruction message is used to instruct the server to forward, to the second terminal, a received communication event to be sent to the first terminal.

Abstract: The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.

Abstract: Embodiments of the present invention provide a method and device for downloading a profile of an operator, where one method includes: sending, by a terminal to the SM-DP by using an SM-SR, a request for downloading a profile of an operator, where the download request carries the download certificate, an ID of an eUICC of the terminal, and addressing information of the SM-DP; and receiving, by the terminal, the profile of the operator that is sent by the SM-DP by using the SM-SR and is corresponding to the download request, and transmitting the profile of the operator to the eUICC, where the profile of the operator is obtained by the SM-DP according to an identity of the profile of the operator after the SM-DP verifies that the certificate that is for downloading the profile of the operator and is carried in the download request is valid.

Abstract: A remote management method and a device, where the method includes receiving, by a subscription manager-data preparation (SM-DP+) server, a first identifier from a local profile assistant (LPA), searching for, by the SM-DP+ server, a remote profile management command corresponding to the first identifier, generating, by the SM-DP+ server, a first digital signature according to the first identifier and the remote profile management command, and sending the first digital signature and the remote profile management command to an embedded universal integrated circuit card (eUICC) using the LPA.

Abstract: A resource migration method and apparatus are provided, so that a terminal device can change, according to a specific condition, an SFE serving the terminal device. The method includes: determining, by a terminal device, that a service function entity SFE serving the terminal device needs to be changed to a first SFE; acquiring information about a location of a resource/subresource corresponding to the terminal device in a second SFE, where the second SFE saves the resource/subresource corresponding to the terminal device; and sending, to the first SFE, a first identifier and the information about the location in the second SFE, where the first identifier is used to indicate that the terminal device needs to change the SFE serving the terminal device, so that the first SFE transfers, after receiving the first identifier, the resource/subresource corresponding to the terminal device from the second SFE to the first SFE.

Abstract: An application processing method and apparatus for an embedded universal integrated circuit card (eUICC) are disclosed. The method includes: activating, by a terminal device, an embedded universal integrated circuit card (eUICC); and selecting, by the terminal device, an Issuer Security Domain Root (ISD-R) application on the eUICC during an initialization process of the eUICC, to maintain a session between the terminal device and the eUICC.

Abstract: Disclosed and claimed are mutation(s) or modification(s) of the CRISPR enzyme, for example a Cas enzyme such as a Cas9, which obtain an improvement, for instance a reduction, as to off-target effects of a CRISPR-Cas or CRISPR-enzyme or CRISPR-Cas9 system or complex containing or including such a mutated or modified Cas or CRISPR enzyme or Cas9. Methods for making and using and uses of such mutated or modified Cas or CRISPR enzyme or Cas9 and systems or complexes containing the same and products from such methods and uses are also disclosed and claimed.

Abstract: Embodiments of the present invention provide a method and device for downloading a profile of an operator, where one method includes: sending, by a terminal to the SM-DP by using an SM-SR, a request for downloading a profile of an operator, where the download request carries the download certificate, an ID of an eUICC of the terminal, and addressing information of the SM-DP; and receiving, by the terminal, the profile of the operator that is sent by the SM-DP by using the SM-SR and is corresponding to the download request, and transmitting the profile of the operator to the eUICC, where the profile of the operator is obtained by the SM-DP according to an identity of the profile of the operator after the SM-DP verifies that the certificate that is for downloading the profile of the operator and is carried in the download request is valid.

Abstract: A profile switching method and a terminal, where the method includes sending, by a terminal, an enable instruction to an embedded universal integrated circuit card (eUICC), where the eUICC includes at least a first profile and a second profile, the terminal has accessed a network using the first profile, data of the first profile is stored in a cache of the terminal, and the enable instruction instructs the eUICC to disable the first profile and enable the second profile, and send a first instruction to the terminal, where the first instruction instructs the terminal not to restart the eUICC, and after receiving the first instruction, retaining, by the terminal, the data of the first profile in the cache, storing data of the second profile in the cache, and accessing a network using the second profile.

Abstract: Disclosed and claimed are mutation(s) or modification(s) of the CRISPR enzyme, for example a Cas enzyme such as a Cas9, which obtain an improvement, for instance a reduction, as to off-target effects of a CRISPR-Cas or CRISPR-enzyme or CRISPR-Cas9 system or complex containing or including such a mutated or modified Cas or CRISPR enzyme or Cas9. Methods for making and using and uses of such mutated or modified Cas or CRISPR enzyme or Cas9 and systems or complexes containing the same and products from such methods and uses are also disclosed and claimed.

Abstract: Embodiments of the present invention provide a method and device for downloading a profile of an operator, where one method includes: sending, by a terminal to the SM-DP by using an SM-SR, a request for downloading a profile of an operator, where the download request carries the download certificate, an ID of an eUICC of the terminal, and addressing information of the SM-DP; and receiving, by the terminal, the profile of the operator that is sent by the SM-DP by using the SM-SR and is corresponding to the download request, and transmitting the profile of the operator to the eUICC, where the profile of the operator is obtained by the SM-DP according to an identity of the profile of the operator after the SM-DP verifies that the certificate that is for downloading the profile of the operator and is carried in the download request is valid.