Patents by Inventor Lixiao Wang

Lixiao Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
    Patent number: 9248220
    Abstract: The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, a contrast agent, and an additive.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: February 2, 2016
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Methods and apparatuses for coating balloon catheters
    Patent number: 9180485
    Abstract: Methods and apparatus for coating a medical device are provided. In one embodiment, the method for preparing a substantially uniform coated medical device includes (1) preparing a coating solution comprising a solvent, a therapeutic agent, and an additive; (2) loading a metering dispenser with the coating solution; (3) rotating the medical device about the longitudinal axis of the device and/or moving the medical device along the longitudinal or transverse axis of the device; (4) dispensing the coating solution from the metering dispenser onto a surface of the medical device and flowing the coating solution on the surface of the medical device while the medical device is rotating and/or linearly moving; and (5) evaporating the solvent, forming a substantially uniform coating layer on the medical device.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: November 10, 2015
    Assignee: Lutonix, Inc.
    Inventors: Jeffrey Wang, Harrison Malinoff, Lixiao Wang, Christopher M. Barry, Dennis W. Wahr, Scott R. Naisbitt
  • Drug Coated Balloon Catheters for Nonvascular Strictures
    Publication number: 20150273117
    Abstract: Embodiments of the present invention provide a method for treatment of nonvascular body lumen strictures such as benign prostatic hyperplasia (BPH), urethral strictures, ureteral strictures, prostate cancer, esophageal strictures, sinus strictures, biliary tract strictures, asthma and chronic obstructive pulmonary disease (COPD). The method involves delivering, preferably via drug coated balloon catheters, of anti-inflammatory and anti-proliferative drugs (rapamycin or paclitaxel and their analogues) and one or more additives.
    Type: Application
    Filed: October 14, 2013
    Publication date: October 1, 2015
    Inventor: Lixiao Wang
  • Chemical Ablation Formulations and Methods of Treatments for Various Diseases
    Publication number: 20150272666
    Abstract: Embodiments of the present invention are directed to the treatment of hypertension, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pains, asthma, pulmonary arterial hypertension, and chronic obstructive pulmonary disease by delivering of an effective amount of formulations at desired temperature to target tissue. The formulations include gases, vapors, liquids, solutions, emulsions and suspensions of one or more ingredients. The temperature may enhance safety and efficacy of the formulations for the treatments. The amounts of the formulation and/or energy are effective to injury or damage the tissues to have a benefit of symptom relive.
    Type: Application
    Filed: October 30, 2013
    Publication date: October 1, 2015
    Inventor: Lixiao WANG
  • IMPLANT AND DELIVERY SYSTEM WITH MULTIPLE MARKER INTERLOCKS
    Publication number: 20150265443
    Abstract: An implant delivery system has one or more interlock assemblies which connect the implant delivery catheter to the implant, an improved inner tubular member and an outer tubular member. The interlock assemblies, improved inner tubular member and outer tubular member cooperate to place the implant in tension during deployment, thereby reducing implant deployment force.
    Type: Application
    Filed: June 1, 2015
    Publication date: September 24, 2015
    Inventors: Lixiao Wang, Jianlu Ma, Joe Tatalovich, Peggy Waltz, Keith Smythe, Richard Kusleika
  • MEDICAL DEVICE RAPID DRUG RELEASING COATINGS COMPRISING OILS, FATTY ACIDS AND/OR LIPIDS
    Publication number: 20150224234
    Abstract: The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, at least one of an oil, a fatty acid, and a lipid, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, a part that has an affinity to the therapeutic agent by charge, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is at least one of a surfactant and a chemical compound. In further embodiments, the chemical compound is water-soluble.
    Type: Application
    Filed: April 20, 2015
    Publication date: August 13, 2015
    Inventor: Lixiao Wang
  • DRUG RELEASING COATINGS FOR MEDICAL DEVICES
    Publication number: 20150217031
    Abstract: Medical device are provided for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.
    Type: Application
    Filed: April 17, 2015
    Publication date: August 6, 2015
    Inventor: Lixiao Wang
  • DRUG RELEASING COATINGS FOR MEDICAL DEVICES
    Publication number: 20150209489
    Abstract: The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, an antioxidant, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In some embodiments, the additive is a liquid. In other embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide or ester groups.
    Type: Application
    Filed: April 10, 2015
    Publication date: July 30, 2015
    Inventor: Lixiao Wang
  • DRUG RELEASING COATINGS FOR BALLOON CATHETERS
    Publication number: 20150209554
    Abstract: Balloon catheters, methods for preparing balloon catheters, and uses of balloon catheters are disclosed. The balloon catheter includes an elongate member, an expandable balloon, and a coating layer overlying an exterior surface of the expandable balloon. The coating layer includes a total drug load of a hydrophobic therapeutic agent and a combination of additives including a first additive and a second additive. The hydrophobic therapeutic agent is paclitaxel, rapamycin, or paclitaxel and rapamycin. The first additive is a surfactant. The second additive is a chemical compound having one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide, or ester groups.
    Type: Application
    Filed: April 2, 2015
    Publication date: July 30, 2015
    Inventor: Lixiao Wang
  • DRUG RELEASING COATINGS FOR MEDICAL DEVICES
    Publication number: 20150209553
    Abstract: Medical devices are provided for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.
    Type: Application
    Filed: April 2, 2015
    Publication date: July 30, 2015
    Inventor: Lixiao Wang
  • Implant and delivery system with multiple marker interlocks
    Patent number: 9044351
    Abstract: An implant delivery system has one or more interlock assemblies which connect the implant delivery catheter to the implant, an improved inner tubular member and an outer tubular member. The interlock assemblies, improved inner tubular member and outer tubular member cooperate to place the implant in tension during deployment, thereby reducing implant deployment force.
    Type: Grant
    Filed: May 14, 2007
    Date of Patent: June 2, 2015
    Assignee: Covidien LP
    Inventors: Lixiao Wang, Jianlu Ma, Joe Tatalovich, Peggy Waltz, Keith Smythe, Rich Kusleika
  • Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
    Patent number: 9033919
    Abstract: The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, at least one of an oil, a fatty acid, and a lipid, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, a part that has an affinity to the therapeutic agent by charge, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is at least one of a surfactant and a chemical compound. In further embodiments, the chemical compound is water-soluble.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: May 19, 2015
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Drug releasing coatings for medical devices
    Patent number: 9023371
    Abstract: Medical device are provided for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: May 5, 2015
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Drug releasing coatings for medical devices
    Patent number: 9005161
    Abstract: The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, an antioxidant, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In some embodiments, the additive is a liquid. In other embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide or ester groups.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: April 14, 2015
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Drug releasing coatings for medical devices
    Patent number: 8998847
    Abstract: Medical devices are provided for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: April 7, 2015
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Drug releasing coatings for balloon catheters
    Patent number: 8998846
    Abstract: Balloon catheters, methods for preparing balloon catheters, and uses of balloon catheters are disclosed. The balloon catheter includes an elongate member, an expandable balloon, and a coating layer overlying an exterior surface of the expandable balloon. The coating layer includes a total drug load of a hydrophobic therapeutic agent and a combination of additives including a first additive and a second additive. The hydrophobic therapeutic agent is paclitaxel, rapamycin, or paclitaxel and rapamycin. The first additive is a surfactant. The second additive is a chemical compound having one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide, or ester groups.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: April 7, 2015
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • MEDICAL DEVICE RAPID DRUG RELEASING COATINGS COMPRISING A THERAPEUTIC AGENT AND A CONTRAST AGENT
    Publication number: 20150093337
    Abstract: The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, a contrast agent, and an additive.
    Type: Application
    Filed: December 4, 2014
    Publication date: April 2, 2015
    Inventor: Lixiao Wang
  • Medical device components and processes
    Patent number: 8973238
    Abstract: Medical device components and processes are disclosed. For example, tube-shaped catheter components and processes of making tube-shaped catheter components are disclosed. Devices and systems, including medical devices and systems, such as catheters, containing tube-shaped catheter components are also disclosed.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: March 10, 2015
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Victor Schoenle, Daniel James Horn, Yiqun Wang, Lixiao Wang
  • Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
    Patent number: 8932561
    Abstract: The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, a contrast agent, and an additive.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: January 13, 2015
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • MEDICAL DEVICE BALLOONS WITH IMPROVED STRENGTH PROPERTIES AND PROCESSES FOR PRODUCING SAME
    Publication number: 20140330202
    Abstract: A tubular parison for forming a medical device balloon. The parison is formed of a polymeric material, for instance a thermoplastic elastomer. The parison has an elongation at break which is not more than 80% of the elongation of the bulk polymeric material. The elongation of the parison is controlled by altering extrusion conditions. Balloons prepared from the parisons provide higher wall strength and/or higher inflation durability than balloons prepared from conventional parisons of the same material.
    Type: Application
    Filed: July 15, 2014
    Publication date: November 6, 2014
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Lixiao Wang, Jeffrey S. Lindquist, Pao Nao Lee, John Jianhua Chen, Douglas A. Devens