Patents by Inventor Lixiao Wang

Lixiao Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MEDICAL DEVICE BALLOONS WITH IMPROVED STRENGTH PROPERTIES AND PROCESSES FOR PRODUCING SAME
    Publication number: 20140330202
    Abstract: A tubular parison for forming a medical device balloon. The parison is formed of a polymeric material, for instance a thermoplastic elastomer. The parison has an elongation at break which is not more than 80% of the elongation of the bulk polymeric material. The elongation of the parison is controlled by altering extrusion conditions. Balloons prepared from the parisons provide higher wall strength and/or higher inflation durability than balloons prepared from conventional parisons of the same material.
    Type: Application
    Filed: July 15, 2014
    Publication date: November 6, 2014
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Lixiao Wang, Jeffrey S. Lindquist, Pao Nao Lee, John Jianhua Chen, Douglas A. Devens
  • IMPLANT HAVING HIGH FATIGUE RESISTANCE, DELIVERY SYSTEM, AND METHOD OF USE
    Publication number: 20140180382
    Abstract: According to one aspect of the present invention, a fatigue resistant stent comprises a flexible tubular structure having an inside diameter, an outside diameter, and a sidewall therebetween and having apertures extending through the sidewall. According to other aspects of the invention, processes for making a fatigue resistant stent are disclosed. According to further aspects of the invention, delivery systems for a fatigue resistant stent and methods of use are provided.
    Type: Application
    Filed: October 11, 2013
    Publication date: June 26, 2014
    Applicant: Covidien LP
    Inventors: Jianlu Ma, Joe Tatalovich, Lixiao Wang, Xiaoling Zhao, Dan Ranum
  • IMPLANT DELIVERY SYSTEM WITH INTERLOCKED RX PORT ORIENTATION
    Publication number: 20140088565
    Abstract: A medical implant delivery system maintains an orientation between a guidewire lumen of an inner member of the system and a rapid-exchange port in an outer member. The medical device is disposed intermediate the inner and outer members and in friction or pressure-fit contact with the outer member. Once the guidewire lumen of the inner member and the rapid exchange port of the outer member are oriented, the friction or pressure-fit operates to maintain the orientation until deployment of the medical implant. Orientation is further maintained by a telescoping coupling of the guide wire lumen with the rapid exchange port.
    Type: Application
    Filed: December 3, 2013
    Publication date: March 27, 2014
    Applicant: Covidien LP
    Inventors: Khamla Vongphakdy, Huisun Wang, Adel Hashw, Lixiao Wang
  • Medical devices visible by magnetic resonance imaging
    Patent number: 8620406
    Abstract: Medical devices that are visible by magnetic resonance imaging (MRI), and optionally, other imaging techniques, are described. In some embodiments, a medical device adapted for insertion into the body includes an elongated shaft and an electrically conductive path extending spirally about a portion of the shaft. The conductive path is capable of being connected to a current source. The medical device can further include one or more contrast agents (such as MRI contrast agents, radiopaque materials, and/or ultrasound visible materials), which can be arranged in a predetermined manner.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: December 31, 2013
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Scott R. Smith, Steven E. Walak, Lixiao Wang, Jan Weber, Sheng-Ping Zhong
  • Implant delivery system with interlocked RX port orientation
    Patent number: 8597276
    Abstract: A medical implant delivery system maintains an orientation between a guidewire lumen of an inner member of the system and a rapid-exchange port in an outer member. The medical device is disposed intermediate the inner and outer members and in friction or pressure-fit contact with the outer member. Once the guidewire lumen of the inner member and the rapid exchange port of the outer member are oriented, the friction or pressure-fit operates to maintain the orientation until deployment of the medical implant. Orientation is further maintained by a telescoping coupling of the guide wire lumen with the rapid exchange port.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: December 3, 2013
    Assignee: Covidien LP
    Inventors: Khamla Vongphakdy, Huisun Wang, Adel Hashw, Lixiao Wang
  • Implant having high fatigue resistance, delivery system, and method of use
    Patent number: 8562668
    Abstract: According to one aspect of the present invention, a fatigue resistant stent comprises a flexible tubular structure having an inside diameter, an outside diameter, and a sidewall therebetween and having apertures extending through the sidewall. According to other aspects of the invention, processes for making a fatigue resistant stent are disclosed. According to further aspects of the invention, delivery systems for a fatigue resistant stent and methods of use are provided.
    Type: Grant
    Filed: June 18, 2007
    Date of Patent: October 22, 2013
    Assignee: Covidien LP
    Inventors: Jianlu Ma, Joe Tatalovich, Lixiao Wang, Xiaoling Zhao, Dan Ranum
  • TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH ANTI-PROLIFERATE AND ANTI-INFLAMMATORY DRUGS
    Publication number: 20130261603
    Abstract: Embodiments of the present invention provide a method for treatment of respiratory disorders such as asthma, chronic obstructive pulmonary disease, and chronic sinusitis, including cystic fibrosis, interstitial fibrosis, chronic bronchitis, emphysema, bronchopulmonary dysplasia and neoplasia. The method involves administration, preferably oral, nasal or pulmonary administration, of anti-inflammatory and anti-proliferative drugs (rapamycin or paclitaxel and their analogues) and an additive.
    Type: Application
    Filed: May 28, 2013
    Publication date: October 3, 2013
    Applicant: Lutonix, Inc.
    Inventor: Lixiao Wang
  • TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH ANTI-PROLIFERATE AND ANTI-INFLAMMATORY DRUGS
    Publication number: 20130253475
    Abstract: Embodiments of the present invention provide a method for treatment of respiratory disorders such as asthma, chronic obstructive pulmonary disease, and chronic sinusitis, including cystic fibrosis, interstitial fibrosis, chronic bronchitis, emphysema, bronchopulmonary dysplasia and neoplasia. The method involves administration, preferably oral, nasal or pulmonary administration, of anti-inflammatory and anti-proliferative drugs (rapamycin or paclitaxel and their analogues).
    Type: Application
    Filed: May 29, 2013
    Publication date: September 26, 2013
    Applicant: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Catheter having an improved balloon-to-catheter bond
    Patent number: 8449497
    Abstract: A balloon catheter assembly includes a first tubular member with a proximal portion and a distal portion and a lumen extending between the proximal portion and the distal portion. A balloon has a proximal waist length, a distal waist length and an expandable region therebetween disposed about the distal portion. A tie layer is disposed between the proximal waist length or distal waist length and the first tubular member. The tie layer comprises a polyester polymer and a polyamide polymer.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: May 28, 2013
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: John Chen, Nie Tang, Ed Parsonage, Paul Miller, Lixiao Wang
  • Methods and apparatuses for coating balloon catheters
    Patent number: 8430055
    Abstract: Embodiments of the invention relate to a method and apparatus for coating a medical device. In one embodiment, the method for preparing a substantially uniform coated medical device includes (1) preparing a coating solution comprising a solvent, a therapeutic agent, and an additive; (2) loading a metering dispenser with the coating solution; (3) rotating the medical device about the longitudinal axis of the device and/or moving the medical device along the longitudinal or transverse axis of the device; (4) dispensing the coating solution from the metering dispenser onto a surface of the medical device and flowing the coating solution on the surface of the medical device while the medical device is rotating and/or linearly moving; and (5) evaporating the solvent, forming a substantially uniform coating layer on the medical device.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: April 30, 2013
    Assignee: Lutonix, Inc.
    Inventors: Jeffrey Wang, Harrison Malinoff, Lixiao Wang, Christopher M. Barry, Dennis W. Wahr, Scott R. Naisbitt
  • Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
    Patent number: 8425459
    Abstract: The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, a contrast agent, and an additive.
    Type: Grant
    Filed: May 20, 2008
    Date of Patent: April 23, 2013
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Embolic protection systems for bifurcated conduits
    Patent number: 8419679
    Abstract: An apparatus for removing emboli from a vessel during an interventional procedure comprising a catheter. The catheter includes: an elongate member having a lumen extending from the proximal end to the distal end; a dilation element disposed on a distal portion of the elongate member, the dilation element having a contracted state and an expanded state; an occlusion element disposed on a distal portion of the elongate member, the occlusion element being disposed proximal of the dilation element, and the occlusion element having a contracted state and an expanded state; and one or more aspiration ports disposed on a distal portion of the elongate member, the one or more aspiration ports being in fluid communication with the lumen, and one or more of the aspiration ports being disposed proximal of the dilation element and distal of the occlusion element.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: April 16, 2013
    Assignee: Covidien LP
    Inventors: Lixiao Wang, Martin Chambers
  • Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
    Patent number: 8414526
    Abstract: The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, at least one of an oil, a fatty acid, and a lipid, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, a part that has an affinity to the therapeutic agent by charge, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is at least one of a surfactant and a chemical compound. In further embodiments, the chemical compound is water-soluble.
    Type: Grant
    Filed: May 20, 2008
    Date of Patent: April 9, 2013
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Drug releasing coatings for medical devices
    Patent number: 8414910
    Abstract: The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, an antioxidant, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In some embodiments, the additive is a liquid. In other embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide or ester groups.
    Type: Grant
    Filed: March 25, 2010
    Date of Patent: April 9, 2013
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Drug releasing coatings for medical devices
    Patent number: 8414909
    Abstract: The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.
    Type: Grant
    Filed: November 19, 2007
    Date of Patent: April 9, 2013
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Drug releasing coatings for medical devices
    Patent number: 8414525
    Abstract: The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: April 9, 2013
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Drug releasing coatings for medical devices
    Patent number: 8403910
    Abstract: The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: March 26, 2013
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Drug releasing coatings for medical devices
    Patent number: 8404300
    Abstract: The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: March 26, 2013
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Drug releasing coatings for medical devices
    Patent number: 8366660
    Abstract: The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: February 5, 2013
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Drug releasing coatings for medical devices
    Patent number: 8366662
    Abstract: The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: February 5, 2013
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang