Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: Systems and methods are disclosed to implement an indexing engine that maintains an index in an index store for a storage object in a data store. In embodiments, the index store may be implemented using an in-memory storage cluster separate from the data store. The storage object may have multiple indexes, which may have different filtering or sorting criteria for the data. In embodiments, updates to the storage object are received as an update stream by the indexing engine. Based on configurable indexing rules, the indexing engine applies the updates to the appropriate indexes. To service a query to the data store, a query engine first retrieves a set of keys satisfying the query from the index store, and then data corresponding to the keys from the data store or another index. In embodiments, the index may be refreshed via touch updates of selected data in the storage object.

Abstract: An unmanned aerial vehicle comprises a central body; at least one rotor motor configured to drive at least one propeller to rotate, rotation of the at least one propeller generating thrust and causing the unmanned aerial vehicle to fly; and an integrated micro hybrid generator system configured to provide power to the at least one rotor motor. The integrated micro hybrid generator system includes an engine configured to generate mechanical energy, and a generator motor directly coupled to the engine and configured to generate AC power using the mechanical energy generated by the engine.

Abstract: Network access is provided to a networking device. In one approach, a method includes: obtaining, by a gateway, access rules for a networking device; providing, by the gateway, one or more dedicated networking tunnels between the gateway and respective remote gateways to one or more respective network segments, wherein the networking device is authorized to access the one or more network segments by the access rules; and routing, by the gateway, networking packets from the networking device based on source address information in the networking packets to the one or more dedicated networking tunnels, and based on destination address information in the networking packets, routing the networking packets to a selection of the one or more dedicated networking tunnels.

Abstract: A medical scope device such as an endoscope is produced using a cast aluminum process including a molten casting aluminum alloy including a maximum of 0.2-0.3% Si and at least 5% Zn. The process includes providing an investment casting mold, casting the aluminum alloy in the mold to create a component and removing the mold from the component, post-machining the component to meet a desired specification, and after post-machining the component, performing surface finishing, such as centrifugal barrel finishing (CBF) sufficient to remove impurities on casting surfaces by 2-3 mils, then coating the component with a micro-crystalline aluminum anodic coating of at least 0.5 mil thickness. A medical scope and product-by-process is also provided employing such techniques.

Abstract: The invention provides a method for automatically analyzing and filtering redundant alarms in radio transceiver systems consisting of the following steps: step 1: the operator shall define the relationship between the alarms, defining rules to filter redundant alarms at the FRDU block; step 2: the FSU block will detect the alarm and send it to the FAFU block; step 3: FAFU block will receive alarms from FSU, based on the rules defined in FRDU block will analyze and filter out redundant alarms; Step 4: The FSMU block will receive the alarms after being filtered, stored in the database and also send these alarms to the EMS system.

Abstract: This disclosure relates to refiner plate segments having feeding grooves having a first width at a first end of the feeding groove, wherein the first end of the feeding groove is disposed closer to an inner diameter of the refiner plate segment, and a second end of the feeding groove having a second width, wherein the second end of the feeding groove is disposed closer to the outer diameter than the first end and wherein the second width is less than the first width. It is believed that the increased width of the feeding groove at the inner diameter, coupled with the change in angle or curve of the feed groove from a feeding angle to a holding angle such that the centrifugal force applied to the lignocellulosic material surpasses the plugging force, allows for improved hydraulic capacity over the refiner plate segment without reducing refining efficiency.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: A method for targeted repair of a hardware component in a computing device that is part of a cloud computing system includes monitoring a plurality of hardware components in the computing device. At some point, a defective sub-component within the hardware component of the computing device is identified. In addition to the defective sub-component, the hardware component also includes at least one sub-component that is functioning properly and a spare component that can be used in place of the defective sub-component. The method also includes initiating a targeted repair action while the computing device is connected to the cloud computing system. The targeted repair action prevents the defective sub-component from being used by the computing device without preventing sub-components that are functioning properly from being used by the computing device. The targeted repair action causes the spare component to be used in place of the defective sub-component.

Abstract: A computing system that enables data stored in a persistent memory region to be preserved when a processor fails can include volatile memory comprising the persistent memory region, non-volatile memory, and a system on a chip (SoC). The SoC can include a main processor that is communicatively coupled to both the volatile memory and the non-volatile memory. The SoC can also include an auxiliary processor that is communicatively coupled to both the volatile memory and the non-volatile memory. The SoC can also include instructions that are executable by the auxiliary processor to cause the data in the persistent memory region of the volatile memory to be transferred to the non-volatile memory in response to a failure of the main processor.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: Refiner plate elements for a conical mechanical refiner include: a rotor plate element including at least one rotor plate segment having a feedstock inlet opening disposed at a first end of the rotor plate segment; and a rotor plate segment refining area disposed between the feedstock inlet opening and a second end of the rotor plate segment. The refiner plate elements may further include: a stator plate element including at least one stator plate segment having a stator plate segment refining area; and first and second attaching rails configured to couple to the stator plate segment to a stator support frame of the conical mechanical refiner. A separation between the first attaching rail and the second attaching rail that is not covered by the stator plate segment is configured to form a feedstock outlet opening.

Abstract: The purpose of the invention is to provide a novel hematopoiesis-promoting agent and a medicament comprising the hematopoiesis-promoting agent as an active ingredient for preventing or treating anemia, in particular refractory anemia. The present invention provides a hematopoiesis-promoting agent comprising an S-adenosylmethionine synthase inhibitor.

Abstract: A medical scope device such as an endoscope is produced using a cast aluminum process including a molten casting aluminum alloy including a maximum of 0.2 - 0.3% Si and at least 5% Zn. The process includes providing an investment casting mold, casting the aluminum alloy in the mold to create a component and removing the mold from the component, post-machining the component to meet a desired specification, and after post-machining the component, performing surface finishing, such as centrifugal barrel finishing (CBF) sufficient to remove impurities on casting surfaces by 2 - 3 mils, then coating the component with a micro-crystalline aluminum anodic coating of at least 0.5 mil thickness. A medical scope and product-by-process is also provided employing such techniques.

Abstract: The invention provides a method for automatically analyzing and filtering redundant alarms in radio transceiver systems consisting of the following steps: step 1: the operator shall define the relationship between the alarms, defining rules to filter redundant alarms at the FRDU block; step 2: the FSU block will detect the alarm and send it to the FAFU block; step 3: FAFU block will receive alarms from FSU, based on the rules defined in FRDU block will analyze and filter out redundant alarms; Step 4: The FSMU block will receive the alarms after being filtered, stored in the database and also send these alarms to the EMS system.

Abstract: To preserve error context during a reboot of a computing device, firmware within the computing device can be configured to implement a method that includes determining where the error context is stored in volatile memory. The method can also include identifying a plurality of recorder regions in non-volatile memory that have been assigned to store the error context. The plurality of recorder regions can be disaggregated across a plurality of distinct non-volatile memory regions. The method can also include flushing the error context from a plurality of different volatile memory locations to the plurality of recorder regions in response to detecting a trigger. The flushing can occur prior to the reboot of the computing device. The method can also include restoring at least some of the error context to the volatile memory after the computing device has been rebooted.

Abstract: The invention relates to a method for processing a sequence of top view image frames ({ItLR}t=0T) of low resolution of a same terrestrial location, each top view image frame ({ItLR}t=0T) having pixels and pixel values, comprising the following steps: choosing (S0) one top view image frame (I0LR), called reference frame (I0LR), among the top view image frames ({ItLR}t=0T), estimating (S1) motion fields (Ft?0, ME) between each top view image frame ({ItLR}t=1T) and the reference frame (I0LR) by using a first neural network (NN1), encoding (S1?) the top view image frames ({ItLR}t=1T) to produce convolutional features ({JtLR}t=1T) extracted respectively from the top view image frames ({ItLR}t=1T) by using a second neural network (NN2), aggregating (S2, S3, Shift-and-add, SPMC) pixels of the convolutional features ({JtLR}t=1T) to positions ({JtHR}t=1T) in a high resolution grid (HRG) using the motion fields (Ft?0, ME) to obtain aggregated features (JHR), decoding (S4) by a decoder network (DN) the aggregated fea

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.