Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: Refiner plate segments for a conical refiner may include a rotor plate segment having inlet openings disposed at one or more inlet locations on the rotor plate segment, and a stator plate segment having outlet openings disposed at one or more outlet locations on the stator plate segment. The rotor plate segment is disposed opposite the stator plate segment such that the one or more rotor plate segment refining areas and the one or more stator plate segment refining areas oppose each other, and the one or more inlet locations and the one or more outlet locations are separated by one or more refining zones formed by the rotor plate segment refining areas and the stator plate segment refining areas.

Abstract: Refiner plate elements for a conical mechanical refiner include: a rotor plate element including at least one rotor plate segment having a feedstock inlet opening disposed at a first end of the rotor plate segment; and a rotor plate segment refining area disposed between the feedstock inlet opening and a second end of the rotor plate segment. The refiner plate elements may further include: a stator plate element including at least one stator plate segment having a stator plate segment refining area; and first and second attaching rails configured to couple to the stator plate segment to a stator support frame of the conical mechanical refiner. A separation between the first attaching rail and the second attaching rail that is not covered by the stator plate segment is configured to form a feedstock outlet opening.

Abstract: To preserve error context during a reboot of a computing device, firmware within the computing device can be configured to implement a method that includes determining where the error context is stored in volatile memory. The method can also include identifying a plurality of recorder regions in non-volatile memory that have been assigned to store the error context. The plurality of recorder regions can be disaggregated across a plurality of distinct non-volatile memory regions. The method can also include flushing the error context from a plurality of different volatile memory locations to the plurality of recorder regions in response to detecting a trigger. The flushing can occur prior to the reboot of the computing device. The method can also include restoring at least some of the error context to the volatile memory after the computing device has been rebooted.

Abstract: Network access is provided to a networking device. In one approach, a method includes: obtaining, by a gateway, access rules for a networking device; providing, by the gateway, one or more dedicated networking tunnels between the gateway and respective remote gateways to one or more respective network segments, wherein the networking device is authorized to access the one or more network segments by the access rules; and routing, by the gateway, networking packets from the networking device based on source address information in the networking packets to the one or more dedicated networking tunnels, and based on destination address information in the networking packets, routing the networking packets to a selection of the one or more dedicated networking tunnels.

Abstract: An electronic communication method and system are disclosed. Exemplary methods include rating agent soft skills using an artificial intelligence (AI) module that continuously evaluates these skills, based on artifacts available from previous interactions with customers. The artifacts can be the voice recordings, chat transcripts, as well as Key Performance Indicators (KPIs) used for reporting. Once agents are rated, targeted soft skill-based routing is implemented for high priority calls or calls that are detected by a sentiment analyzer as requiring special attention. For training purposes, the system can be configured to route calls to agents with lower soft skills ratings during off hours. Completed calls may be used as further feedback to the AI module and the soft skill ratings acquired by the AI module may be added to an existing “hard skills” dataset for contact center call routing, to assist with continuous learning of soft skills as well as agent and supervisor training.

Abstract: The invention relates to a method for recovery of hydrocarbons in a geological reservoir by injection of a low-salinity aqueous solution. A representative model of the evolution of the flow parameters as a function of the aqueous solution salinity is calibrated by use of laboratory measurements performed on a rock sample from the reservoir for at least two salinity values. Then, by use of a flow simulator including the calibrated model, the injection of aqueous solutions into the sample is simulated, with and without capillary effects, for at least the two salinity values with a microscopic residual oil saturation being determined for each salinity value. Then, from the flow simulator including the calibrated model and the microscopic residual oil saturation values, a reservoir development scheme is determined with hydrocarbons of the reservoir being exploited according to the development scheme.

Abstract: A method of determining a modified shape of a computer-aided design model of an object or a partition thereof is described. With the method, at least two reference landmarks are placed at a reference position with respect to the shape of the object or to the partition. An adjustment landmark is placed at the reference position of the corresponding reference landmark. The adjustment landmarks are displaced from the reference position to a modified position, and a displacement between the modified position and the reference position is obtained. The modified shape of the object or the partition is generated by modifying the shape of the object or the partition by applying a homogeneous function of the displacement to the computer-aided design model of the shape of the object or the partition.

Abstract: System and methods for obtaining sizing of an irregularly shaped object. The methods comprise: displaying, by a display of a handheld scanner system, a 3D optical figure of a subject; displaying a grid superimposed over the 3D optical figure of the subject, the grid comprising a plurality of marks arranged in rows and columns; generating, by a radar module of the handheld scanner system, range data specifying a sensed spacing between the radar module and at least a surface of a first portion of the irregularly shaped object which is covered by at least one item; receiving, by a processor of the handheld scanner system, the range data from the radar module as the subject is being scanned; and causing at least one first visual characteristic of a first mark of said plurality of marks to change when corresponding range data is successfully received by the processor.

Abstract: Technologies are described which permit kernel updates or firmware fixes, and include re-initialization of kernel data structures, without losing user context information that has been created by services, virtual machines, or user applications. Tailored code in a server or other computing system sets a kernel soft reset (KSR) indicator and saves the user context to non-volatile storage. When a KSR is underway, boot code skips the power on self-test and similar initializations (thereby reducing downtime), loads a kernel image, initializes kernel data structures, restores the user context, and passes control to the initialized kernel to continue computing system operation with the same user context. Device drivers may also be re-initialized. The loaded kernel may use newly fixed firmware, or may have a security patch installed, for instance. The non-volatile storage may operate at RAM speed, e.g., it may include NVDIMM memory. The kernel may be validated before receiving control.

Abstract: Network access is provided to a networking device. In one approach, a method includes: obtaining, by a gateway, access rules for a networking device; providing, by the gateway, one or more dedicated networking tunnels between the gateway and respective remote gateways to one or more respective network segments, wherein the networking device is authorized to access the one or more network segments by the access rules; and routing, by the gateway, networking packets from the networking device based on source address information in the networking packets to the one or more dedicated networking tunnels, and based on destination address information in the networking packets, routing the networking packets to a selection of the one or more dedicated networking tunnels.

Abstract: Network access is provided to a networking device. In one approach, a method includes: obtaining, by a gateway, access rules for a networking device; providing, by the gateway, one or more dedicated networking tunnels between the gateway and respective remote gateways to one or more respective network segments, wherein the networking device is authorized to access the one or more network segments by the access rules; and routing, by the gateway, networking packets from the networking device based on source address information in the networking packets to the one or more dedicated networking tunnels, and based on destination address information in the networking packets, routing the networking packets to a selection of the one or more dedicated networking tunnels.

Abstract: A method for targeted repair of a hardware component in a computing device that is part of a cloud computing system includes monitoring a plurality of hardware components in the computing device. At some point, a defective sub-component within the hardware component of the computing device is identified. In addition to the defective sub-component, the hardware component also includes at least one sub-component that is functioning properly and a spare component that can be used in place of the defective sub-component. The method also includes initiating a targeted repair action while the computing device is connected to the cloud computing system. The targeted repair action prevents the defective sub-component from being used by the computing device without preventing sub-components that are functioning properly from being used by the computing device. The targeted repair action causes the spare component to be used in place of the defective sub-component.

Abstract: A method for making a polishing pad includes rotating a cylinder about a central axis. The cylinder encloses in an interior space a polymer mixture. The method also includes forming the polishing pad from at least some of a polymer formed after the polymer mixture has gelled. The rotating of the cylinder may be continued until the polymer has cured. The method may include forming at least two distinct layers in the polishing pad by casting and gelling sequentially at least two different polymer mixtures. A system for manufacturing a polishing pad includes a centrifugal caster adapted to rotate. A polishing pad made by a method is provided.

Abstract: Disclosed are a user terminal device for providing a call control and a control method therefor. A user terminal device according to the present invention comprises: a display; a first communication unit for communication with a first external device; a second communication unit for communication with a second external device; and a processor for: transmitting a call request received from the first external device to the second external device through the second communication unit; transmitting a response to the call request, which has been received from the second external device, to the first external device through the first communication unit; controlling the display to display a call user interface (UI), on the basis of the response to the call request; and when call data is received from the first external device, converting the call data into Internet protocol (IP) data and transmitting the converted IP data to the second external device through the second communication unit.

Abstract: Methods, systems, and computer-readable media for lottery-based resource allocation with capacity guarantees are disclosed. A job request is received from a first client. The job request is submitted to a capacity management system that schedules jobs in a pool of compute resources. The pool comprises a first quantity of one or more slots and a second quantity of one or more slots. The second quantity is associated with a capacity guarantee for a second client. It is determined that the first quantity of one or more slots are in use by one or more jobs initiated prior to receiving the job request. It is determined that the second quantity of one or more slots comprises an available slot. The available slot is allocated to the job request.

Abstract: A computing device including a memory module. The computing device may further include a processor configured to, by executing instructions of an operating system, divide a non-volatile region of the memory module into a first non-volatile storage partition allocated to the operating system and a second non-volatile storage partition allocated to system firmware. The processor may write a globally unique identifier (GUID) to the non-volatile region. The GUID may indicate a location of a boundary between the first non-volatile storage partition and the second non-volatile storage partition. The processor may access the first non-volatile storage partition. By executing instructions of the system firmware, the processor may determine the location of the boundary. The processor may access the second non-volatile storage partition.

Abstract: An apparatus controls a high-power drive device external to a package of a gate driver circuit. A first circuit charges the control node over a first length of time in response to a first signal through the first node indicating an absence of a fault condition and a first level of a control signal. A second circuit discharges the control node over a second length of time in response to a second signal through the second node indicating the absence of the fault condition and a second level of a control signal. A third circuit includes a current amplifier and is configured as a soft shutdown path to discharge the control node over a third length of time in response to the first signal through the first node indicating a presence of the fault condition. The third length of time is different from the second length of time.

Abstract: The purpose of the invention is to provide a novel hematopoiesis-promoting agent and a medicament comprising the hematopoiesis-promoting agent as an active ingredient for preventing or treating anemia, in particular refractory anemia. The present invention provides a hematopoiesis-promoting agent comprising an S-adenosylmethionine synthase inhibitor.