Abstract: The present invention provides a vehicle traction device which may be conveniently attached and applied to roadways that are subject to accumulations of ice, snow, and other wintry precipitation. The vehicle traction device provides a center strip which deters unintended horizontal motion of vehicles as well as skidding, sliding, spinning, and the general loss of traction. The center strip can include a collapsible support system which will allow the center strip to collapse to low height to permit the passage of road clearing equipment or other low clearance vehicles. In addition, the vehicle traction device provides angled strips which deter unintended sliding motion forward or reverse relative to the normal flow of traffic, especially when vehicles are ascending or descending along steeply sloping roadways. Finally, the vehicle traction device further provides bristle strips which help to dislodge ice and other accumulations on vehicle tires which may interfere with vehicle traction.

Abstract: Embodiments of apparatuses and methods for processing virtualization events in a layered virtualization architecture are disclosed. In one embodiment, an apparatus includes a hardware processor including event circuit to recognize a virtualization event, and evaluation circuit to determine whether to transfer control of the apparatus from a child guest to a parent guest in response to the virtualization event, wherein the child guest and the parent guest each include a bit per virtualization event to indicate whether the parent guest is to gain control when the virtualization event occurs.

Abstract: The invention relates to polypeptides, antibodies, and antigen-binding fragments thereof, that comprise a substituted cysteine for site-specific conjugation.

Abstract: A steering wheel cover has an inner core and an outer casing. The inner core has a series of alternating ribs and openings that together form a spring-like structure that more easily fits over a steering wheel while retaining its initial shape once installed.

Abstract: Methods are described herein for isolating clonal populations of T cells having a defined genetic modification. The methods are performed, at least in part, in a microfluidic device comprising one or more sequestration pens. The methods include the steps of: maintaining individual T cells (or precursors thereof) that have undergone a genomic editing process in corresponding sequestration pens of a microfluidic device; expanding the T cells into respective clonal populations of T cells; detecting, in one or more T cells of each clonal population, the absence of a cell surface marker that was present in the individual T cells (or precursors thereof); and detecting, in one or more T cells of each clonal population, the presence of a first nucleic acid sequence that is indicative of the presence of an on-target genome edit in the clonal population of T cells. Also described are compositions comprising one or more clonal populations of T cells isolated according to the methods disclosed herein.

Abstract: A steering wheel cover has an inner core and an outer casing. The inner core has a series of alternating ribs and openings that together form a spring-like structure that more easily fits over a steering wheel while retaining its initial shape once installed. The inner core requires significantly less material than conventional steering wheel cover cores.

Abstract: An ice scraper comprising a handle and a scraper head connected to the handle. The scraper head includes a proximal end, a distal end having a scraping edge, a scraping side, a chipping side, and at least three chipping teeth for chipping ice, hard snow, or frost from a curved surface. The chipping teeth extend outwardly from the chipping side. Each chipping tooth has a contact edge. At least one of the contact edges is offset forward or rearward of contact edges of two of the other chipping teeth so that at least one point of each contact edge can simultaneously contact the curved surface regardless of the scraper's position relative to the curved surface and regardless of a direction of the scraper.

Abstract: A boat including one or more seats, which may be aft-facing. The seat includes a seat bottom, which may be movable between a first position and a second position. The second position is a position in which the seat bottom is pivoted upwardly relative to the position of the seat bottom in the first position to allow access to a hidden compartment. The seat may also include a leg rest. The leg rest may extend aft of the transom, and may extend in a direction that is at a downward angle relative to the seat bottom. The leg rest may also have a length such that a gap is present between the leg rest and a surface beneath the leg rest.

Abstract: Apparatuses, compositions and processes for DNA barcode deconvolution are described herein. A DNA barcode may be used to provide a bead specific identifier, which may be detected in situ using hybridization strategies. The DNA barcode provides identification by sequencing analysis. The dual mode of detection may be used in a wide variety of applications to link positional information with assay information including but not limited to genetic analysis. Methods are described for generation of barcoded single cell sequencing libraries. Isolation of nucleic acids from a single cell within a microfluidic environment can provide the foundation for cell specific sequencing library preparation.

Abstract: A boat, having a transom, includes one or more aft-facing seats. Each aft-facing seat is positioned proximate to the transom and includes a seat bottom that is inclined at a downward angle in a direction extending from aft to fore, a seatback, a headrest, a seat support structure having at least one hidden compartment therein, and at least one pivot mechanism attached to the seatback and the headrest and configured to allow the seatback to move between a first position in which the seatback is capable of supporting the back of a person seated in the seat and a second position in which the seatback is pivoted upwardly to allow access to the compartment and the headrest to move between an upright position and a folded position. A plurality of handles may be provided for each aft-facing seat, with one at an outboard side and another at an inboard side.

Abstract: A steering wheel cover has an inner core and an outer casing. The inner core has a series of alternating ribs and openings that together form a spring-like structure that more easily fits over a steering wheel while retaining its initial shape once installed.

Abstract: A virtual reality device can implement varying interactive modes for document viewing and editing by displaying, at an application container level, a current mode view in a view frame of the virtual reality device; and in response to receiving an overview command trigger, determining context, including that the current mode view is at the application container level; expanding to a next level view of, e.g., a task level or an overview level; and displaying, at a next level, the next level view in the view frame of the virtual reality device. The current mode view of the application container level includes a container space of an application and an application container level rule for the container space. Conversely, the virtual reality device can adjust the next level view back to the application container level in response to a focused command trigger and identified region of interest.

Abstract: Techniques for sharing network information, such as routing table information, are described. In some examples, network nodes share information about the topology of their network. For example, nodes may share routing tables with their neighbors from time to time. To improve the performance of the network, by reducing the overhead of transmitting routing tables, the nodes share their routing tables with neighbor nodes only when those tables are updated or upon request. In other circumstances, such as when a routing table has not changed since it was last shared, each network node instead transmits an indicator, such as a routing table checksum, hash, or the like, that can be used by a neighbor node to determine the routing table is unchanged.

Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided. The present invention also relates to a humanized antibody that specifically binds human TrkB and methods for producing and using the antibody to, inter alia, treat a hearing loss disorder.

Abstract: A boat, having a transom, includes an aft-facing seat. The aft-facing seat may be positioned proximate to the transom and includes a seat bottom that is inclined at a downward angle in a direction extending from aft to fore. A plurality of handles may be provided for the aft-facing seat, with one at an outboard side and another at an inboard side. The aft-facing seat may be configured to be occupied by a person while the boat is moving through the water such that the person's legs extend aft, over the transom.

Abstract: A processor including a virtualization system of the processor with a memory virtualization support system to map a reference to guest-physical memory made by guest software executable on a virtual machine which in turn is executable on a host machine in which the processor is operable to a reference to host-physical memory of the host machine.

Abstract: A downhole tool includes a section mill, a bridge plug, and a connector releasably coupling the section mill to the bridge plug. A guide is coupled to the connector and maintains the section mill centered within a wellbore during sue of the section mill. A method for setting a bridge plug and cutting casing includes deploying a tool string downhole in a wellbore, with the tool string including a casing cutting tool releasably coupled to a bridge plug. The bridge plug is set within the wellbore and the casing cutting tool is released from the bridge plug. In the same trip during which the bride plug is set, the casing cutting tool is expanded and used to remove an axial section of casing while maintaining the casing cutting tool centered within the casing.

Abstract: A thermal distribution assembly for an electronic device is disclosed. The electronic device includes an enclosure defined by a metal band and a non-metal bottom wall formed by glass, sapphire, or plastic. In this regard, the enclosure may include a relatively low thermal conductivity. However, the thermal distribution assembly provides heat transfer capabilities that offset thermal conductivity losses by using a non-metal bottom wall, and also provides added structural support. The thermal distribution assembly may include a first layer, a second layer, and a third layer. The first and third layers provide structural support, while the second layer provides a relatively high thermally conductive layer.

Abstract: Embodiments of apparatuses and methods for processing virtualization events in a layered virtualization architecture are disclosed. In one embodiment, an apparatus includes a hardware processor including event circuit to recognize a virtualization event, and evaluation circuit to determine whether to transfer control of the apparatus from a child guest to a parent guest in response to the virtualization event, wherein the child guest and the parent guest each include a bit per virtualization event to indicate whether the parent guest is to gain control when the virtualization event occurs.

Abstract: A processor including logic to execute an instruction to synchronize a mapping from a physical address of a guest of a virtualization based system (guest physical address) to a physical address of the host of the virtualization based system (host physical address), and stored in a translation lookaside buffer (TLB), with a corresponding mapping stored in an extended paging table (EPT) of the virtualization based system.