Abstract: Described herein are novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.

Abstract: By allowing the movement of a user to affect the playback of content, the entertainment characteristic or uplifting spirits derived from content playback itself can be enhanced. The timing at which the user places his/her foot on the ground while walking or the timing at which the user shakes or changes from swinging in one direction to swinging to another direction is detected. Then, content, such as a music piece or moving pictures, is played back by allowing the timing of beats or bars of the music piece or the timing of scene changes or cut changes of the moving pictures to be synchronized with the timing of the movement of the user.

Abstract: A player device uses playlists having names of contents. Users can update the playlists via network. The player device includes a storage device for storing digital data of the contents, a reception/reception circuit for downloading playlists, a display for displaying the titles of contents included in the playlists, a pointing device for specifying displayed titles, a circuit for retrieving digital data from the storage device in the event that digital data of a content specified by the pointing device is stored within the storage device, and an output circuit for outputting the retrieved digital data.

Abstract: Described herein are novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.

Abstract: A content reproducing apparatus is disclosed which includes: a sensor; a discrimination circuit configured to discriminate whether a movement of a user is a first movement or a second movement based on a detection output from the sensor; a storage configured to store contents; a reproduction circuit configured to reproduce the contents; and a control circuit configured to supply the reproduction circuit with contents retrieved from the storage in accordance with a discrimination output from the discrimination circuit.

Abstract: The present invention provides methods for producing DCs, which comprise the step of culturing DC precursor cells in the presence of multiple cytokines, dendritic cells produced thereby, and uses thereof. The methods of the present invention enable production of large quantities of DC precursors with a high ability to differentiate into DCs. The present invention enables one to obtain large quantities of DCs from a small number of DC precursor cells, and therefore makes it easier to increase the number of DCs for administration in DC-based anti-tumor immunotherapy, treatment of infection, and such. Thus, an enhancement is expected for the effect of DC vaccines.

Abstract: A communication terminal includes a communication unit configured to carry out communications with a communication terminal of an intended counterparty; a detector configured to detect information reflecting a status of a user of the own communication terminal; a condition checker configured to check whether a predetermined condition is satisfied by comparing information reflecting a status of a user of the communication terminal of the counterparty, received via the communication unit, with the information detected by the detector; and a controller configured to exercise control so that a communication circuit is established with the communication terminal of the counterparty via the communication unit when it is determined by the condition checker that the condition is satisfied.

Abstract: A player device uses playlists having names of contents. Users can update the playlists via network. The player device includes a storage device for storing digital data of the contents, a reception/reception circuit for downloading playlists, a display for displaying the titles of contents included in the playlists, a pointing device for specifying displayed titles, a circuit for retrieving digital data from the storage device in the event that digital data of a content specified by the pointing device is stored within the storage device, and an output circuit for outputting the retrieved digital data.

Abstract: An electronic apparatus is disclosed which includes: a main body motion determination device configured to determine whether a predetermined accelerated motion is exerted on a main body of the electronic apparatus in a predetermined axial direction; and a control device configured to control the electronic apparatus to perform a predetermined action based on a pattern of the predetermined accelerated motion determined to occur by the main body motion determination device.

Abstract: Provided is a compound useful as an N-type Ca2+ channel blocker. As a result of intensive studies of compounds having an action of blocking N-type Ca2+ channels, the present inventors found that a tetrahydroisoquinoline compound of the present invention having a substituent at the 1-position has an action of blocking the N-type Ca2+ channels, an antinociceptive pain action, an antineuropathic pain action, an abdominal pain-inhibitory action and an opioid-induced constipation-improving action, and the present invention has been completed based on these findings.

Abstract: To aim to provide a lighting apparatus that is compact yet easy in lamp replacement. A lighting apparatus 1 comprises: a lamp 6 including an outer tube 13 and an arc tube 15 provided inside the outer tube 13; and an opening-type lighting fixture 3 having a mirror part 11 having a concave reflective surface 9 inside which the lamp 6 is disposed. The mirror part 11 reflects light emitted from the lamp 6 at the reflection surface 9 such that the reflected light is emitted through an opening 10 of the mirror part 11. Relational expressions 22?r?28, R?130, and 3.5?R/r are satisfied, with r denoting a maximum outer diameter [mm] of the outer tube 13, and R denoting an opening diameter [mm] of the mirror part 11.

Abstract: Described herein are novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.

Abstract: Provided are methods for optimizing treatment of an autoimmune disease in a subject, methods for identifying and/or selecting a compound as a therapeutic for an autoimmune disease, methods of identifying a patient that is responsive to IFN-? therapy, and methods for identifying an agent that inhibits NLRP3 inflammasome activity.

Abstract: A content providing method includes the steps of preparing, on a network, a bulletin board server that provides an electronic bulletin board and a content server that accommodates content; enabling, by the bulletin board server, a second user to make a post on a topic when a first user introduces the topic under a predetermined title on the electronic bulletin board; outputting, by the bulletin board server, a list indicating recommended content as a playlist to an apparatus of a user who accesses via the network when the second user posts information on the recommended content that suits the title in the topic; and outputting, by the content server, designated content to the apparatus of the user to which the playlist is output when the content included in the playlist is designated.

Abstract: A communication terminal includes a communication unit configured to carry out communications with a communication terminal of an intended counterparty; a detector configured to detect information reflecting a status of a user of the own communication terminal; a condition checker configured to check whether a predetermined condition is satisfied by comparing information reflecting a status of a user of the communication terminal of the counterparty, received via the communication unit, with the information detected by the detector; and a controller configured to exercise control so that a communication circuit is established with the communication terminal of the counterparty via the communication unit when it is determined by the condition checker that the condition is satisfied.

Abstract: Provided is a device for playing audio with improved convenience, wherein music can be played such that oneness with the actions of the user can be obtained at all times, without giving the user any unnaturalness whatsoever such as unpleasant sensations. After starting playing of music data through such as an audio signal output processing unit 31, action tempo of the user is detected by an exercise information analyzing circuit 23, based on detection output from an exercise information sensor 24, and in the event that the difference between the detected action tempo of the user and the tempo of the music data being played is not a predetermined range, music data with a tempo of which the difference as to the action tempo of the user is within the predetermined range is searched by searching means such as a music playing data generating device unit 22, and a control unit 10 changes the music data to be played so as to play this searched music data.

Abstract: To enable a lot of audio data and image data such as a still image and a moving image to be effectively and efficiently used. When audio data accumulated in a material database 21 is replayed, a controller 10 acquires the metadata added to the audio data to be replayed from the material database, refer to the metadata of image data based on the above metadata to thereby search image data intimately related to the audio data, controls a voice replay system such as an audio decoder 32 and the like and an image replay system such as an image decoder 31 and the like, and replay the audio data to be replayed and the searched image data in relation with each other.

Abstract: A contents reproduction apparatus that reproduces contents suitable for a user's environment includes a position detecting unit detecting a user's position, an operation detecting unit detecting a movement of a user's body, a contents generating unit generating contents based on the user's position and the movement of the user's body, and a contents reproducing unit reproducing the generated contents.

Abstract: A content recommendation system includes first and second communication devices which are connected to each other and in which content recommendation information is transmitted and received between both devices. The first communication device includes a storage section for storing pieces of content recommendation information to be transmitted, a selecting section for selecting a piece of content recommendation information to be transmitted from the storage section, and a transmitting section for transmitting the selected piece of content recommendation information. The second communication device includes a receiving section for receiving the piece of content recommendation information transmitted from the first communication device, and a storage section for storing the received piece of content recommendation information.

Abstract: The present invention provides methods for efficiently inducing anti-A? antibody and methods for preventing and treating Alzheimer's disease. The present inventors successfully induced anti-A? antibody in a highly efficient manner by administering an RNA viral vector that expresses a fusion protein between an AB5 toxin B subunit and an A? antigen peptide. Administration of the vector resulted in a significant increase of anti-A? antibody in plasma, and decrease in the A? level in brain tissues and decrease in the anti-A? antibody-positive area. The present invention enables more efficient vaccine gene therapy for preventing and treating Alzheimer's disease.