Abstract: The present inventors devised a protein expression system with coexisting MiniSeV and SeV particles, and assessed the system for the ability to transfer a gene(s) of interest into target cells, and to express the gene(s) in the target cells. It was shown that the expression system of the present invention had a high ability to transfer a gene(s) of interest into target cells, and a high ability to express the gene(s) in the target cells.

Abstract: A detection section that detects a key-tapping speed and key-tapping intensity is provided to detect a user's impatience level. An input device detects the key-tapping intensity and key-tapping speed. The input device compares the detection value of the key-tapping speed and an average key-tapping speed. When the detection value exceeds a stored normal key-tapping speed, the input device then compares the detection value of the key-tapping intensity and a reference pressure value. When the detection value exceeds a stored normal key-tapping intensity, information to be output for a user is changed over. In this case, displayed characters are enlarged and emphasized to a maximum extent. On the other hand, in the case where a detection value does not exceed the normal key-tapping speed and the detection value exceeds the normal key-tapping intensity, displayed characters are only slightly enlarged.

Abstract: In an image display system that displays the condition of a person under measurement in a visible form, the person carries a PDA (10). The PDA (10) includes a bio-sensor (11) to detect bio-information on the person and an environmental information sensor (12) to acquire information on the environment around the person. The PDA (10) sends the acquired information to an image display device (20) which is connected to the PDA (10) via a network (100). The image display device (20) includes a CPU (29) that judges the condition of the person on the basis of bio-information and environmental information, generates an image representing the condition of the person and displays the image on a display unit (23).

Abstract: A playback device includes a storing unit storing a contents database in which contents including at least music and tempo information indicating the tempo of the music are correlated with each other; a playback unit for performing playback of the contents; a tempo measuring unit for measuring an exercise tempo obtained along with the body movements of a user; a searching unit for searching contents from the contents database based on the information of the measured exercise tempo by the tempo measuring unit; and a contents selecting unit for selecting the contents searched by the searching unit as contents to be played by the playback unit.

Abstract: The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein of paramyxovirus is modified to be cleaved by different proteases, were produced. In cells transfected with these vectors, the genomic RNA present in the vectors is replicated, and cell fusogenic infection spreads to neighboring cells depending on the presence of other proteases; however, no viral particles are released. The vectors of this invention, encoding the F proteins which are cleaved by proteases whose activity is enhanced in cancer, show cancer growth suppressive effect in vivo.

Abstract: An apparatus of playing back an audio signal includes storage means for dividing exercise tempos of a user into a plurality of groups and storing digital audio data concerning music pieces, the digital audio data being associated with the plurality of groups; a playback circuit that plays back the digital audio data; detecting means for detecting an exercise tempo of the user; and a control circuit that reads out the digital audio data from the storage means to supply the readout digital audio data to the playback circuit. The control circuit determines which group, among the plurality of groups, the exercise tempo detected by the detecting means belongs to, and reads out the digital audio data concerning a music piece associated with the determined group from the storage means to supply the readout digital audio data to the playback circuit.

Abstract: A portable electronic apparatus includes an acceleration detection unit, an evaluation-signal generation unit, and a control unit. The acceleration detection unit is configured to detect an acceleration generated in the portable electronic apparatus. The evaluation-signal generation unit is configured to carry out a predetermined process based on the acceleration detected by the acceleration detection unit in order to generate an evaluation signal representing the amplitude and positive or negative polarity of the acceleration. The control unit is configured to produce a result of determination as to whether or not the portable electronic apparatus has been driven to make a predetermined movement on the basis of the evaluation signal and carrying out a predetermined operation on the basis of the result of determination.

Abstract: There is disclosed an overlaminating adhesive film comprising a transparent film, an adhesive layer and a release material successively laminated in this order, wherein said release material has a surface contacting with the adhesive layer, said surface having a centerline average surface roughness of 0.5 ?m or lower; an adhesive forming said adhesive layer has a pH of 7.2 to 8.5 in a solution state before applied, and is an acrylic emulsion-type adhesive having an average particle size of 200 nm or smaller; and a monomer component used for production of said adhesive includes an alkoxysilane group-containing unsaturated monomer in which each alkoxy group has 1 to 4 carbon atoms, but includes no hydroxy-containing unsaturated monomer. The overlaminating adhesive film of the present invention exhibits a good water resistance and is free from deterioration in its transparency due to lifting or bubbles when laminated on an adherend.

Abstract: A portable electronic apparatus includes an acceleration detection unit, an evaluation-signal generation unit, and a control unit. The acceleration detection unit is configured to detect an acceleration generated in the portable electronic apparatus. The evaluation-signal generation unit is configured to carry out a predetermined process based on the acceleration detected by the acceleration detection unit in order to generate an evaluation signal representing the amplitude and positive or negative polarity of the acceleration. The control unit is configured to produce a result of determination as to whether or not the portable electronic apparatus has been driven to make a predetermined movement on the basis of the evaluation signal and carrying out a predetermined operation on the basis of the result of determination.

Abstract: An organic layer capable of forming surface areas having an adsorption property different from that of a periphery due to the chemical change of a surface functional group is formed on a board. The surface of the organic layer is patterned and oxidized by a scanning probe microscope to form an array pattern in which small sections for adsorbing nanoparticles are arranged. Then, nanoparticle dispersed solution is applied to the organic layer having the array pattern or the organic layer is dipped in the nanoparticle dispersed solution to form a particle layer on the organic layer. At this time, the nanoparticles in the nanoparticle dispersed solution are respectively fixed only onto the small sections. Therefore, a nanoparticle array on which groups of nanoparticles are arranged in an array can be obtained. Thus, the nanoparticle array on which the groups of the nanoscale particles are arranged on the board is efficiently formed.

Abstract: State information of a user is detected via a biometric information sensor (21) and so on and the state information is accumulated in a nonvolatile memory (14) by associating it with a content ID of content that is being used. A recommendation request including the state information detected at that time via the biometric information sensor (21) and so on and a predetermined extraction condition is generated and transmitted. Provided information transmitted in response to the recommendation request is received and is provided to the user. When an information provision request is received, information to be provided is extracted from the information stored in the nonvolatile memory (14) based on the state information and extraction condition included in the received information provision request and the extracted information is transmitted to a requesting source.

Abstract: Methods and apparatus for selecting and providing content data such as visual data and audio data. Pieces of content data are associated with corresponding metadata. The metadata includes information regarding a status at the time of generation of the content data. For example, at the time a picture is taken. The status may include information such as a time, location, and bio-information of a user. A recollection value, representing the significance in recollecting the user's memory, is calculated for each piece of content data using the associated metadata. Content data is selected for output based on the recollection values. Various types of content data may be selected at appropriate times so that the content data will affect the user's memory or feeling.

Abstract: The present invention provides novel therapeutic methods and agents for treating Alzheimer's disease. Specifically, the present invention relates to anti-inflammatory cytokines, anti-inflammatory cytokine genes, negative-strand RNA viral vectors carrying an anti-inflammatory cytokine gene, which are used for treating Alzheimer's disease or developing therapeutic agents for Alzheimer's disease. The present invention also provides pharmaceutical compositions for treating or preventing Alzheimer's disease, which comprise the cytokines or vectors. The present invention further provides methods for treating Alzheimer's disease, which comprise the step of administering an anti-inflammatory cytokine, or a vector such as a negative-strand RNA viral vector carrying an anti-inflammatory cytokine gene. The present invention enables novel gene therapies for Alzheimer's disease.

Abstract: A method of navigating a mobile machine dependent upon the relationship of the mobile machine to a target path includes operating a steering system to change the heading of the mobile machine in response to the mobile machine deviating from a first navigational dead band. Additionally, the method may include subsequently operating the steering system to make a heading change of the mobile machine only in response to predetermined events, which may include operating the steering system to make a heading change of the mobile machine if the mobile machine deviates from a second navigational dead band.

Abstract: Content is selected on the basis of changes of a walking tempo. The walking tempo is detected (S5). In a state determination process (S7), it is determined whether the walking tempo tends to increase, be constant, or decrease. A walking tempo corrective coefficient is calculated on the basis of the determined result and a corrective walking tempo is calculated with the walking tempo corrective coefficient (S9). It is determined whether or not music is changed on the basis of the corrective walking tempo rather than the actually detected walking tempo (S11). When music is changed, relevant music content is searched. Controls are performed in such a manner that when the walking tempo is decreasing, the foregoing state is kept for a while, when the walking tempo is increasing, music is quickly selected according to the increase of the walking tempo, and when the walking tempo is stable, music is not selected.

Abstract: A power supply system for supplying power to a plurality of loads includes a plurality of fuel cells for generating and supplying power to be supplied to the respectively corresponding loads, wherein the fuel cells are provided to correspond to the plurality of loads, a power network for receiving surplus power, which is generated ‘by the fuel cells except power to be supplied to the loads corresponding to the fuel cells, and supplying the surplus power to the loads short of power, wherein the power network is coupled to the plurality of fuel cells, and a control unit for stopping power generation of a first fuel cell among the fuel cells corresponding to a first load among the loads and controlling a second fuel cell among the fuel cells to generate power to be supplied to the first load as the surplus power if an amount of power to be supplied to the first load is less than a predetermined first threshold.

Abstract: Provided is a device for playing audio with improved convenience, wherein music can be played such that oneness with the actions of the user can be obtained at all times, without giving the user any unnaturalness whatsoever such as unpleasant sensations. After starting playing of music data through such as an audio signal output processing unit 31, action tempo of the user is detected by an exercise information analyzing circuit 23, based on detection output from an exercise information sensor 24, and in the event that the difference between the detected action tempo of the user and the tempo of the music data being played is not a predetermined range, music data with a tempo of which the difference as to the action tempo of the user is within the predetermined range is searched by searching means such as a music playing data generating device unit 22, and a control unit 10 changes the music data to be played so as to play this searched music data.

Abstract: A time-shift image distribution system includes an image server and a time-shift image requesting apparatus. The image server includes a first communication unit configured to carry out communications with the time-shift image requesting apparatus, an image database configured to store image data of captured images in association with meta information for image data of a captured image matching search-condition information, and an image providing unit configured to provide the image data of the captured image detected by the searching unit to the time-shift image requesting apparatus. The time-shift image requesting apparatus includes a second communication unit configured to carry out communications with the image server, and a unit configured to send a search request including information representing an imaging time and information for identifying a subject image as search-condition information to the image server via the second communication unit.

Abstract: An objective of the present invention is to provide a safe and effective vaccine therapy for Alzheimer's disease. A minus strand RNA viral vector carrying amyloid gene was constructed, and administered intranasally to 24- to 25-months-old APP transgenic mice. The level of serum anti-A 42 antibody was determined and showed to be markedly higher than the control. The results of histological investigation showed that the administration of a vector of the present invention markedly reduced senile plaques in all of the frontal lobe, parietal lobe, and hippocampus. The brain A level was also markedly reduced. Furthermore, the administration of a vector of the present invention did not result in lymphocyte infiltration in the central nervous system.