Patents by Inventor Manfred Keller

Manfred Keller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Beta-hairpin peptidomimetic with elastase inhibitory activity and aerosol dosage forms thereof
    Patent number: 11844823
    Abstract: The present invention relates to pharmaceutical aerosols comprising a ?-hairpin peptidomimetic of formula cyclo(-OctG-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-DPro-Pro-), or a pharmaceutically acceptable salt thereof, having inhibitory activity against human neutrophil elastase. It further relates to solid or liquid pharmaceutical compositions and kits for preparing and administering such aerosols. The invention can be used for the prevention, management or treatment of pulmonary diseases, such as alpha-1 antitrypsin deficiency (AATD), cystic fibrosis (CF), non-cystic fibrosis bronchiactasis (NCFB), or chronic obstructive pulmonary disease (COPD), or infections, or diseases, or conditions of the lungs, being mediated by or resulting from human neutrophil elastase activity.
    Type: Grant
    Filed: October 6, 2021
    Date of Patent: December 19, 2023
    Assignee: POLYPHOR AG
    Inventors: Christian Ludin, Manfred Keller, Piet Bruijnzeel, Johann Zimmermann, Philip Barth, Eric Chevalier
  • Beta-hairpin peptidomimetic with elastase inhibitory activity and aerosol dosage forms thereof
    Patent number: 11235024
    Abstract: The present invention relates to pharmaceutical aerosols comprising a ?-hairpin peptidomimetic of formula cyclo(-OctG-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-DPro-Pro-), or a pharmaceutically acceptable salt thereof, having inhibitory activity against human neutrophil elastase. It further relates to solid or liquid pharmaceutical compositions and kits for preparing and administering such aerosols. The invention can be used for the prevention, management or treatment of pulmonary diseases, such as alpha-1 antitrypsin deficiency (AATD), cystic fibrosis (CF), non-cystic fibrosis bronchiactasis (NCFB), or chronic obstructive pulmonary disease (COPD), or infections, or diseases, or conditions of the lungs, being mediated by or resulting from human neutrophil elastase activity.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: February 1, 2022
    Assignee: POLYPHOR AG
    Inventors: Christian Ludin, Manfred Keller, Piet Bruijnzeel, Johann Zimmermann, Philip Barth, Eric Chevalier
  • Beta-hairpin peptidomimetic with elastase inhibitory activity and aerosol dosage forms thereof
    Patent number: 11235023
    Abstract: The present invention relates to pharmaceutical aerosols comprising a ?-hairpin peptidomimetic of formula cyclo(-OctG-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-DPro-Pro-), or a pharmaceutically acceptable salt thereof, having inhibitory activity against human neutrophil elastase. It further relates to solid or liquid pharmaceutical compositions and kits for preparing and administering such aerosols. The invention can be used for the prevention, management or treatment of pulmonary diseases, such as alpha-1 antitrypsin deficiency (AATD), cystic fibrosis (CF), non-cystic fibrosis bronchiactasis (NCFB), or chronic obstructive pulmonary disease (COPD), or infections, or diseases, or conditions of the lungs, being mediated by or resulting from human neutrophil elastase activity.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: February 1, 2022
    Assignee: POLYPHOR AG
    Inventors: Christian Ludin, Manfred Keller
  • BETA-HAIRPIN PEPTIDOMIMETIC WITH ELASTASE INHIBITORY ACTIVITY AND AEROSOL DOSAGE FORMS THEREOF
    Publication number: 20220023379
    Abstract: The present invention relates to pharmaceutical aerosols comprising a ?-hairpin peptidomimetic of formula cyclo(-OctG-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-DPro-Pro-), or a pharmaceutically acceptable salt thereof, having inhibitory activity against human neutrophil elastase. It further relates to solid or liquid pharmaceutical compositions and kits for preparing and administering such aerosols. The invention can be used for the prevention, management or treatment of pulmonary diseases, such as alpha-1 antitrypsin deficiency (AATD), cystic fibrosis (CF), non-cystic fibrosis bronchiactasis (NCFB), or chronic obstructive pulmonary disease (COPD), or infections, or diseases, or conditions of the lungs, being mediated by or resulting from human neutrophil elastase activity.
    Type: Application
    Filed: October 6, 2021
    Publication date: January 27, 2022
    Applicant: POLYPHOR AG
    Inventors: Christian LUDIN, Manfred KELLER, Piet BRUIJNZEEL, Johann ZIMMERMANN, Philip BARTH, Eric CHEVALIER
  • Methods of treating respiratory syncytial virus infections
    Patent number: 10835512
    Abstract: Compositions and methods for the treatment of respiratory syncytial virus infections are provided.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: November 17, 2020
    Assignee: Respivant Sciences GmbH
    Inventors: Pravin Soni, William Gerhart, Manfred Keller, Ahmet Tutuncu
  • BETA-HAIRPIN PEPTIDOMIMETIC WITH ELASTASE INHIBITORY ACTIVITY AND AEROSOL DOSAGE FORMS THEREOF
    Publication number: 20200230203
    Abstract: The present invention relates to pharmaceutical aerosols comprising a ?-hairpin peptidomimetic of formula cyclo(-OctG-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-DPro-Pro-), or a pharmaceutically acceptable salt thereof, having inhibitory activity against human neutrophil elastase. It further relates to solid or liquid pharmaceutical compositions and kits for preparing and administering such aerosols. The invention can be used for the prevention, management or treatment of pulmonary diseases, such as alpha-1 antitrypsin deficiency (AATD), cystic fibrosis (CF), non-cystic fibrosis bronchiactasis (NCFB), or chronic obstructive pulmonary disease (COPD), or infections, or diseases, or conditions of the lungs, being mediated by or resulting from human neutrophil elastase activity.
    Type: Application
    Filed: May 31, 2017
    Publication date: July 23, 2020
    Applicant: POLYPHOR AG
    Inventors: Christian LUDIN, Manfred KELLER, Piet BRUIJNZEEL, Johann ZIMMERMANN, Philip BARTH, Eric CHEVALIER
  • BETA-HAIRPIN PEPTIDOMIMETIC WITH ELASTASE INHIBITORY ACTIVITY AND AEROSOL DOSAGE FORMS THEREOF
    Publication number: 20200230202
    Abstract: The present invention relates to pharmaceutical aerosols comprising a ?-hairpin peptidomimetic of formula cyclo(-OctG-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Tyr-DPro-Pro-), or a pharmaceutically acceptable salt thereof, having inhibitory activity against human neutrophil elastase. It further relates to solid or liquid pharmaceutical compositions and kits for preparing and administering such aerosols. The invention can be used for the prevention, management or treatment of pulmonary diseases, such as alpha-1 antitrypsin deficiency (AATD), cystic fibrosis (CF), non-cystic fibrosis bronchiactasis (NCFB), or chronic obstructive pulmonary disease (COPD), or infections, or diseases, or conditions of the lungs, being mediated by or resulting from human neutrophil elastase activity.
    Type: Application
    Filed: May 31, 2017
    Publication date: July 23, 2020
    Applicant: POLYPHOR AG
    Inventors: Christian LUDIN, Manfred KELLER
  • MAST CELL STABILIZERS TREATMENT FOR SYSTEMIC DISORDERS
    Publication number: 20190388386
    Abstract: Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders, are provided.
    Type: Application
    Filed: July 10, 2019
    Publication date: December 26, 2019
    Inventors: William Gerhart, Manfred Keller, Ahmet Tutuncu, Pravin Soni
  • METHODS OF TREATING RESPIRATORY SYNCYTIAL VIRUS INFECTIONS
    Publication number: 20190328700
    Abstract: Compositions and methods for the treatment of respiratory syncytial virus infections are provided.
    Type: Application
    Filed: July 10, 2019
    Publication date: October 31, 2019
    Inventors: William Gerhart, Manfred Keller, Ahmet Tutuncu, Pravin Soni
  • MAST CELL STABILIZERS TREATMENT FOR SYSTEMIC DISORDERS
    Publication number: 20190307721
    Abstract: Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders, are provided.
    Type: Application
    Filed: May 7, 2019
    Publication date: October 10, 2019
    Inventors: William Gerhart, Manfred Keller, Ahmet Tutuncu, Pravin Soni
  • Mast cell stabilizers treatment for systemic disorders
    Patent number: 10398673
    Abstract: Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders, are provided.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: September 3, 2019
    Assignee: Respivant Services GmbH
    Inventors: William Gerhart, Manfred Keller, Ahmet Tutuncu, Pravin Soni
  • Method for producing 1,5-pentanediisocyanate in the gas phase
    Patent number: 10329248
    Abstract: The invention relates to a method for producing 1,5-pentanediisocyanate (PDI) by reacting 1,5-pentanediamine (PDA) with phosgene in the gas phase.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: June 25, 2019
    Assignee: Covestro Deutschland AG
    Inventors: Josef Sanders, Martin Ehrig, Reinhard Halpaap, Manfred Keller-Killewald, Armin Schymura, Dietmar Wastian
  • MAST CELL STABILIZERS TREATMENT FOR SYSTEMIC DISORDERS
    Publication number: 20190175546
    Abstract: Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders, are provided.
    Type: Application
    Filed: February 12, 2019
    Publication date: June 13, 2019
    Inventors: William Gerhart, Manfred Keller, Ahmet Tutuncu, Pravin Soni
  • METHOD FOR PRODUCING 1,5-PENTANEDIISOCYANATE IN THE GAS PHASE
    Publication number: 20190112259
    Abstract: The invention relates to a method for producing 1,5-pentanediisocyanate (PDI) by reacting 1,5-pentanediamine (PDA) with phosgene in the gas phase.
    Type: Application
    Filed: December 7, 2018
    Publication date: April 18, 2019
    Inventors: Josef Sanders, Martin Ehrig, Reinhard Halpaap, Manfred Keller-Killewald, Armin Schymura, Dietmar Wastian
  • Mast cell stabilizers treatment for systemic disorders
    Patent number: 10238628
    Abstract: Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders, are provided.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: March 26, 2019
    Assignee: RESPIVANT SCIENCES GMBH
    Inventors: William Gerhart, Manfred Keller, Ahmet Tutuncu, Pravin Soni
  • DRY POWDER FOR INHALATION
    Publication number: 20190022106
    Abstract: The present invention provides dry powder formulations for inhalation having improved moisture resistance such that the powders maintain a high fine particle dosage or fine particle fraction following storage under relatively extreme temperature and humidity conditions.
    Type: Application
    Filed: September 21, 2018
    Publication date: January 24, 2019
    Inventors: Manfred Keller, Rudi Mueller-Walz
  • Method for producing 1,5-pentanediisocyanate in the gas phase
    Patent number: 10173970
    Abstract: The invention relates to a method for producing 1,5-pentanediisocyanate (PDI) by reacting 1,5-pentanediamine (PDA) with phosgene in the gas phase.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: January 8, 2019
    Assignee: Covestro Deutschland AG
    Inventors: Josef Sanders, Martin Ehrig, Reinhard Halpaap, Manfred Keller-Killewald, Armin Schymura, Dietmar Wastian
  • Process for preparing polyisocyanates
    Patent number: 10112892
    Abstract: The present invention relates to a continuous process for preparing a polyisocyanate, in which a polyamine and phosgene are first converted predominantly to carbamoyl chloride and amine hydrochloride and only in minor proportions to polyisocyanate, and a portion of the carbamoyl chloride- and amine hydrochloride-containing reaction mixture thus obtained is recycled into the reaction with phosgene, wherein polyamine, phosgene and the carbamoyl chloride- and amine hydrochloride-containing reaction mixture are mixed intimately in a mixing unit. The portion of the carbamoyl chloride- and amine hydrochloride-containing reaction mixture which is not recycled into the phosgenation is worked up to give the polyisocyanate.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: October 30, 2018
    Assignee: Covestro Deutschland AG
    Inventors: Jürgen Arras, Jan Busch, Christian Steffens, Dietmar Wastian, Manfred Keller-Killewald, Holger Conzelmann
  • MAST CELL STABILIZERS TREATMENT FOR SYSTEMIC DISORDERS
    Publication number: 20180280341
    Abstract: Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders, are provided.
    Type: Application
    Filed: April 19, 2018
    Publication date: October 4, 2018
    Applicant: Patara Pharma, LLC
    Inventors: William Gerhart, Manfred Keller, Ahmet Tutuncu, Pravin Soni
  • MAST CELL STABILIZERS TREATMENT FOR SYSTEMIC DISORDERS
    Publication number: 20180271828
    Abstract: Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders, are provided.
    Type: Application
    Filed: April 19, 2018
    Publication date: September 27, 2018
    Applicant: Patara Pharma, LLC
    Inventors: William Gerhart, Manfred Keller, Ahmet Tutuncu, Pravin Soni