Abstract: The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula: wherein X, Y, a, R1, and R2 are as defined herein.

Abstract: An apparatus and method are described for mapping a plurality of multimedia streams (e.g., received from a set of satellite transponders) across a lesser plurality of decoders. In one embodiment, arbitration logic allocates the multimedia streams to divide the decoding load equally among the group of decoders (or at least as equally as possible). Allocation may occur statically, when the system is initialized, or dynamically, as the streams are being processed. In addition, in one embodiment, the arbitration logic monitors the amount of multimedia data for each stream stored in a buffer and causes streams to be serviced by the decoders which have relatively more stored multimedia data.

Abstract: The present invention provides Stearoyl CoA Desaturase (SCD) inhibitors. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by Stearoyl CoA Desaturase 1 (SCD1) inhibitors. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by Stearoyl CoA Desaturase (SCD) inhibitors.

Abstract: In one embodiment, a processor comprises a plurality of instruction buffers, an instruction cache coupled to supply instructions to the plurality of instruction buffers, and a cache miss unit coupled to the instruction cache. Each of the plurality of instruction buffers is configured to store instructions fetched from a respective thread of a plurality of threads. The cache miss unit is configured to monitor cache misses in the instruction cache. Particularly, the cache miss unit is configured to detect which of the plurality of threads experience a cache miss to a cache line. Responsive to a return of the cache line for storage in the instruction cache, the cache miss unit is configured to concurrently cause at least one instruction from the cache line to be stored in each of the plurality of instruction buffers that corresponds to one of the plurality of threads which experienced the cache miss to the cache line.

Abstract: A reputability analysis system receives a domain assessment request associated with a domain and accesses a database to find a match for the domain. A reputability score is derived according to a hierarchical analysis of a matching domain in the database. Traceability, accountability, and association information associated with the domain assessment request may also be used to adjust the reputability score.

Abstract: An apparatus and method for mapping memory addresses to reduce or avoid conflicting memory accesses in memory systems such as cache memories is described in connection with a multithreaded multiprocessor chip. A CMT processor reduces the probability of hot-spots in cache operations by hashing certain bits of a physical cache address to form a hashed cache address. By using exclusive OR functionality to hash the index bits, an efficient address transformation is achieved for indexing into an L2 cache memory.

Abstract: The present invention relates to novel dipeptidyl peptidase IV (DPP-IV) inhibitors their analogs, isomers, pharmaceutical compositions, therapeutic uses and methods of making the same.

Abstract: The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula: wherein X, Y, a, R1, and R2 are as defined herein.

Abstract: Methods and compositions for producing a solid support having a ligand immobilized on a surface thereof, e.g. a ligand array, are provided. Aspects of the methods include: providing a solid support having a bounded feature location on a surface thereof, where the bounded feature location includes a region of the surface at least partially bounded by an electromagnetic radiation modified boundary; and producing a ligand in the feature location. Also provided are systems for practicing the subject methods, as well as devices produced by the methods and methods of using such devices.

Abstract: In one embodiment, a processor comprising at least one translation lookaside buffer (TLB) and a control unit coupled to the TLB. The control unit is configured to track whether or not at least one update to the TLB is pending for at least one of a plurality of strands. Each strand comprises hardware to support a different thread of a plurality of concurrently activateable threads in the processor. The strands share the TLB, and the control unit is configured to delay a demap operation issued from one of the estrands responsive to the pending update, if any.

Abstract: In one embodiment, a processor comprises a plurality of processor cores and an interconnect to which the plurality of processor cores are coupled. Each of the plurality of processor cores comprises at least one translation lookaside buffer (TLB). A first processor core is configured to broadcast a demap command on the interconnect responsive to executing a demap operation. The demap command identifies one or more translations to be invalidated in the TLBs, and remaining processor cores are configured to invalidate the translations in the respective TLBs. The remaining processor cores transmit a response to the first processor core, and the first processor core is configured to delay continued processing subsequent to the demap operation until the responses are received from each of the remaining processor cores.

Abstract: A system and method are described in which a decoder decodes data from a plurality of data streams. In one embodiment, the decoder is restored to the state it was in the last time it processed data from each data stream by re-decoding data stored in a replay buffer before decoding new data from each respective data stream. In one embodiment, multiple decoders are grouped together to process data from a plurality of satellite transponders.

Abstract: An apparatus is described comprising: a decoder which decodes a plurality of data streams, the decoder having a state associated with each of the data streams; and state restoration logic to restore the decoder's state upon switching from decoding one data stream to another data stream.

Abstract: Systems, methods and computer readable media for automatically inspecting a chemical array. At least one processor is adapted to receive a digitized image of the chemical array, and at least one of hardware, software and firmware are adapted to quantify at least one visual characteristic of a feature on the chemical array that contributes to uniformity of the visualization of the feature. Systems, methods and computer readable media are provided for automatically quantifying a visual characteristic of a chemical array. A digitized image of a chemical array having at least one feature is received, and at least one visual characteristic of a feature on the chemical array that contributes to uniformity of the visualization of the feature automatically quantified. A result based on the automatically quantification processing may be outputted to quantify at least one visual characteristic of a feature.

Abstract: An apparatus and method are described for mapping a plurality of multimedia streams (e.g., received from a set of satellite transponders) across a lesser plurality of decoders. In one embodiment, arbitration logic allocates the multimedia streams to divide the decoding load equally among the group of decoders (or at least as equally as possible). Allocation may occur statically, when the system is initialized, or dynamically, as the streams are being processed. In addition, in one embodiment, the arbitration logic monitors the amount of multimedia data for each stream stored in a buffer and causes streams to be serviced by the decoders which have relatively more stored multimedia data.

Abstract: An apparatus and method are described for normalizing a plurality of state metric values stored in a plurality of accumulators. In one embodiment, normalization logic monitors the each of the state metric values. When all of the values are above a predetermined threshold, the normalization logic subtracts a normalization amount from each of the state metric values. In one embodiment, the normalization amount is incorporated into branch metric calculations at one or more branch metric units. In addition, in one embodiment, different normalization amounts are employed based on the state metric values.

Abstract: A method and apparatus are provided for providing improved radio frequency (RF) receiver signal correction. For RF receiver circuitry (106) having receive path and a warmup period associated therewith and including at least one analog baseband gain control stage (218) having a gain associated therewith, the method includes the step of performing a DC correction calculation operation during the warmup period to derive a DC correction value having a first component and a second component for each of the at least one gain control stage (218). The DC correction calculation step includes the steps of performing a first closed loop correction (460) of a baseband path to derive the first component of the DC correction value and performing a second closed loop correction (462) of the receive path as a function of the (218) gain during the warmup period to derive the second component of the DC correction value.

Abstract: In one embodiment of the invention, during add-compare-select computations, the output of the adders is guaranteed to be a positive value because the only time normalization logic subtracts a normalization amount is when all accumulators are greater than the normalization amount. As such, the detection of overflow is greatly simplified. Overflow in the add-compare-select unit may be indicated simply by the value of the most significant bit (“MSB”) (i.e., the sign bit) of the result. If the MSB of the result of the adder is set then, in one embodiment, the output of the adder gets forced the maximum possible value given the number of bits. For example, this value will be forced to 7h7f if the value is represented by 7-bits. That is to say, if an overflow is detected, then the accumulator is saturated to the maximum value.

Abstract: An apparatus and method are described for mapping a plurality of multimedia streams (e.g., received from a set of satellite transponders) across a lesser plurality of decoders. In one embodiment, arbitration logic allocates the multimedia streams to divide the decoding load equally among the group of decoders (or at least as equally as possible). Allocation may occur statically, when the system is initialized, or dynamically, as the streams are being processed. In addition, in one embodiment, the arbitration logic monitors the amount of multimedia data for each stream stored in a buffer and causes streams to be serviced by the decoders which have relatively more stored multimedia data.

Abstract: Extended release formulations for the delivery of opioid agonists, including oxycodone, are provided which exhibit low peak to trough plasma concentration fluctuations and sufficiently high plasma concentrations over an extended period of time to provide a once a day dosage administration, wherein the formulations provide pain relief for up to 24 hours The extended release formulations may be customized to achieve the desired plasma concentration profile, e.g. two or more different extended release drug-loaded pellets or granules may be combined in a formulation. Additional formulations include combinations of drug loaded and extended release opioid agonists-loaded pellets or granules. Other formulations include a combination of an opioid agonist and an opioid antagonist, as well as a combination of an opioid agonist and a NSAID.