Abstract: Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.

Abstract: Provided herein are RET kinase inhibitors according to the formula: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. A, R1, n, X1, X2, X3, X4, and R2 have the meanings given in the specification.

Abstract: Aspects of a geogrid system and method for improving substrate interactions within a geotechnical environment is disclosed. In one aspect a geotechnical environment is configured with a horizontal multilayer mechanically stabilizing geogrid. In said aspect the geogrid is extruded with a polymeric material and a compressible cellular layer, wherein the geogrid comprises a heightened aspect ratio with a patterned structure of engineered discontinuities and a plurality of strong axes. The combination of elements provides for a system and method of stabilizing soils and aggregate, by resisting lateral movement from the strong axes, and trapping particles in the patterned structure of engineered discontinuities.

Abstract: An electronic device may identify one or more search queries occurring frequently in a query log during a temporal period and maintain, for each of the one or more search queries, a frequency count of the search query occurring in the query log. The device may identify, a plurality of uniform resource locators (URLs) and match, one or more URLs of the plurality of URLs based on text of the URLs. The device may generate a news event profile for each search query and add each of the matching URLs into a respective news event profile. The device may receive a query from a user and identify, a matching news event profile. The device causes URLs of the matching news event profile and one or more related search queries from the first group of search queries to be presented to the user.

Abstract: The disclosure relates to an Electrostatic Discharge (ESD) protection semiconductor device for providing ESD protection between a first and a second terminal of another semiconductor device, the ESD protection device includes a semiconductor body having a first major surface, the semiconductor device further includes a first ESD terminal arranged to be connected to a first terminal of the other semiconductor device, a second ESD terminal arranged to be connected to a second terminal of the other semiconductor device, and a floating terminal.

Abstract: The present invention relates to a process for production of high yield of hydrogen by carrying out the dry reforming of the dry gas generated from the process itself by utilizing the same catalyst for cracking and producing high yield of light olefins such as ethylene, propylene and butylenes from residue feedstocks.

Abstract: A method and system for providing information management of data from hosted services receives information management policies for a hosted account of a hosted service, requests data associated with the hosted account from the hosted service, receives data associated with the hosted account from the hosted service, and provides a preview version of the received data to a computing device. In some examples, the system indexes the received data to associate the received data with a user of an information management system, and/or provides index information related to the received data to the computing device.

Abstract: An integral geogrid includes a plurality of interconnected, oriented strands having an array of openings therein that is produced from a coextruded multilayer polymer sheet starting material. By virtue of the construction, the coextruded multilayer sheet components provide a crystalline synergistic effect during extrusion and orientation of the integral geogrid, resulting in enhanced material properties that provide performance benefits to use of the integral geogrid in soil geosyuthetic reinforcement.

Abstract: A method for managing memory for applications in a computing system includes receiving a selection of a preferred application. During user-controlled operation over the application, the transitions of selected application between foreground and background are monitored. A retention of the application in memory is triggered upon a transition of the application to background during the user operation. Retention of the application includes compressing memory portions of the application. Accordingly, the application is retained within the memory based on said compressed memory portions. A requirement to restore the retained application is sensed based on either a user selection or an automatically generated prediction and the application is restored from the retained state back to the foreground.

Abstract: A method for use in planning of tasks to be performed by one or more vehicles within an evolving site includes obtaining a request relating to at least one task to be performed by the one or more vehicles, wherein the at least one task involves at least travelling from a starting location to a target location, obtaining geographic location data comprising at least the starting location and the target location, obtaining site data from at least a dynamic BIM of the site, planning of the at least one task by using at least the request, the geographic location data, and the site data as input data to a prediction model, wherein the planning of the at least one task comprises at least planning of a travel path within the site, providing information relating to the planned at least one task to be presented via at least one user interface, and generating site update data for updating the dynamic BIM based on user input.

Abstract: The present invention discloses a method for preventing retraction of aqueous drops on a hydrophobic surface. The present invention also discloses a medical device coated with a hydrophilic coating comprising a substrate and a coating composition.

Abstract: The present invention relates to a computer implemented method for determining a weld integrity test result performed by a system configured to aseptically transferring cells to a container (BR), the method comprising welding (710) a vial to a connector to obtain a fluid-tight seal between the vial (V) and a connector (C), the connector being provided with a pair of conduits each having one end protruding through the connector and into the vial, sealing (720) an opposite end of one of the conduits, generating (730) a fluid pressure different to an ambient fluid pressure at an opposite end of the other conduit, measuring (740) a fluid pressure within at least one of the conduits, determining (750) a fluid pressure change based on the ambient pressure and the measured fluid pressure, determining (760) the weld integrity test result as pass or as fail based on the fluid pressure change.

Abstract: Systems and methods are provided for provided for automatic evaluation of sperm morphology. An image of a semen sample is obtained, and at least a portion of the image is provided to a convolutional neural network classifier. The convolutional neural network classifier evaluates the portion of the image to assign to the portion of the image a set of likelihoods that the portion of the image belongs to a plurality of output classes representing the morphology of sperm within the portion of the image. A metric is assigned to the semen sample based on the likelihoods assigned by the convolutional neural network.

Abstract: A sensor for a flexible sensor assembly includes a drive coil, a first set of sensing coils, a second set of sensing coils, and a configuration for sensing for discontinuities in a structure desired to be sensed. A method of operating the sensor can include positioning the sensor proximate to the structure, energizing the drive coil, and sensing eddy currents with the sensing coils.

Abstract: Systems and methods are provided for provided for automatic evaluation of a human embryo. An image of the embryo is obtained and provided to a neural network to generate a plurality of values representing the morphology of the embryo. The plurality of values representing the morphology of the embryo are evaluated at an expert system to provide an output class representing one of a current quality of the embryo, a future quality of the embryo, a likelihood that implantation of the embryo will be successful, and a likelihood that implantation of the embryo will result in a live birth.

Abstract: Recommending commute options to a user based on a relevance of physical advertisements on the commute options to user's requirements includes capturing, by a computer, physical advertisements on possible commute options within a region, determining an item requirement of a user and correlating the captured physical advertisements on each possible commute option with the determined item requirement of the user, and determining a user's availability to look at the physical advertisements on each possible commute option between a starting point of a trip and a final point of the trip. A relevance score is then assigned to each of the captured physical advertisements on each possible commute option and the determined item requirement of the user, and based on the relevance score and the determined user's availability to look at the physical advertisements for each possible commute option, all possible commute options are sorted and communicated to a user device.

Abstract: The present disclosure proposes a semiconductor device including a silicon substrate; a channel positioned on the top surface of the substrate; a drift region positioned on the top of the channel; a trench; a first polysilicon layer positioned within the channel and the drift region on the bottom of the trench; a second polysilicon layer positioned on the top of the first polysilicon layer, and positioned within the drift region inside of the trench; a third polysilicon layer positioned on the top of the second polysilicon layer, and positioned within the drift region inside of the trench. The first polysilicon layer and the second polysilicon layer and the third polysilicon layer are isolated by a gate oxide and a RESURF oxide respectively, from the channel and from the drift and from each other forming at least partially three separated structures.

Abstract: An integrated circuit includes an input pad and a Schmitt trigger coupled to the input pad. The Schmitt trigger includes a first inverter and a second inverter. The Schmitt trigger includes a pull-up transistor coupled to an input of the second inverter and configure to supply a high reference voltage to the input of the second inverter.

Abstract: The present invention relates to a process for refinery wastewater treatment. More particularly, the present invention relates to an automated process for treatment of refinery wastewater. The process of the present invention provides complete automation for controlling different critical parameters that enhance biological activity of activated sludge process (ASP) and helps in significant reduction in sludge recycling that increases the treatment efficiency.

Abstract: Methods are presented herein for a reduced state machine that describes nodes and relationship dynamics representing real network elements (networking devices and software processes) in a computer/data network, and abstracted logical items. Logical states of networking features of the network elements are reflected in the graph, while configuration data is stored for completeness. A method called a “Versioner Algorithm” is provided to record the temporal history of a node and its state over time within the node's metadata itself, while recorded relationships represent logical relations between observed nodes. A method is also provided to time-travel back to observe a historical view of the network. Further still, a method is provided to a difference of two historical topologies and return that data in human-readable or machine consumable form.