Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: Techniques and solutions are provided for facilitating the definition and use of virtual environments. Typically, virtual environments require manual linking of virtual environment components, such as locations, avatars to be displayed, avatar interactions, and actions to be taken upon a selected interaction. This is in addition to actions to define, for example, a visual representation of a virtual location or an avatar. Disclosed techniques provide standardized data objects that can represent components of a virtual environment and relationships between such components. For example, aspects of a virtual environment can be predefined, and a user can configure the virtual environment with particular avatars and particular avatar content (such as media to be rendered for that avatar). In particular aspects, components of a virtual environment, such as avatars, can be determined at runtime, included based on attributes associated with a particular user for whom the virtual environment is to be rendered.

Abstract: The present disclosure provides a class of polymeric material comprising units with crown- ether- and cyclodextrin-based structure and preparation method thereof. Advantageously, the present polymeric material may be useful in lithium ion recovery with desirable reusability and/or metal ion selectivity.

Abstract: A medical device including an elongated shaft having a proximal end, a distal end, and a lumen therethrough. An expandable element is disposed proximate the distal end about the elongated shaft and in fluid communication with the lumen. An inner shaft is disposed within the lumen and within a portion of the expandable element, the inner shaft defining an exhaust port, an infusion port, and a pressure monitoring port. The pressure monitoring port is spaced from both the infusion port and the exhaust port and/or fluidly isolated from the both the infusion port and the exhaust port within the inner shaft. A pressure monitoring tube is disposed within the inner shaft and configured to measure a fluid pressure within the expandable element, with a distal end of the pressure monitoring tube terminating within the expandable element adjacent the pressure monitoring port.

Abstract: A bone plate includes a bone-contacting surface, an upper surface opposite the bone-contacting surface, and a hole having a circumference and extending from the upper surface to the bone-contacting surface. The hole includes a first portion having a plurality of substantially parallel lips, each lip extends around the circumference of the hole and defines a diameter of the hole. The diameters of the hole, as defined by the lips, decrease in a direction from the upper surface to a center of the hole and increase in a direction from the center of the hole toward the bone-contacting surface.

Abstract: A method, apparatus, and system for network monitoring are provided. The method retrieves and processes performance data files from each technology type in the network. These performance data files are then loaded into a time series database. At least one key performance indicator is derived from the data. The performance data is organized by region and pool level and then displayed by region and pool level. The method provides configurable thresholds for key performance indicators and alerts users to those thresholds. The apparatus provides a display allowing both monitoring and test functions to be selected. The display is automatically updated based on a predetermined, selectable time interval.

Abstract: A multilayer integral geogrid, including one or more cellular layers, has a plurality of oriented multilayer strands interconnected by partially oriented multilayer junctions with an array of openings therein. The multilayer integral geogrid having one or more cellular layers is produced from a coextruded or laminated multilayer polymer starting sheet. The integral geogrid has a multilayer construction, with at least one outer layer thereof having the cellular structure. By virtue of the cellular layer structure, the multilayer integral geogrid provides for increased layer vertical compressibility under load, resulting in enhanced material properties that provide performance benefits to use of the multilayer integral geogrid to stabilize and strengthen soil, aggregates, or other particulate materials.

Abstract: A level shifter having current boosting stages is provided. The level shifter includes a level shifting stage including a plurality of transistors and first and second nodes. The level shifting stage is configured to transfer a first signal of a first voltage domain to a second signal of a second voltage domain. A plurality of current boosting stages are associated with the transistors, respectively. A first current boosting stage provides a first boosting stage current path to support a first level shifter current path of a first transistor of the plurality of transistors in response to: a first supply voltage of the first voltage domain being greater than a second supply voltage of the second voltage domain, the first signal having a first logical state and the first node having a logical state reflecting that the first signal has a second logical state different from the first logical state.

Abstract: The present invention relates to the development of antibacterial biocellulosic patches/membranes for transdermal drug delivery. Novel high cellulose producing bacterial strain Komagatacibacter hansenii (MBS-8) has been isolated. The production and purification process of biocellulosic membranes is developed in such a way that the membranes produced are of desired thickness and length, suitable for drug impregnation in a cost-effective manner for the development of transdermal patches. Further, a process for efficient drug impregnation of Mupirocin in BC membranes has been developed. Weight and drug content of mupirocin impregnated BCM were found to be uniform.

Abstract: An illustrative cloud-based air-gapped data storage management (destination) system obtains authorized access to other (source) systems' backup copies, replicates those copies within the destination system, parses supplemental metadata included in the source backup copies, and integrates the replica copies into the destination system as though natively created there. Replica copies are integrated as backup copies without first restoring the source backup copies to a native data format. The source system lacks knowledge of or connectivity with the destination system, thus maintaining an “air gap” between the systems. The destination system preferably operates in a cloud computing environment. The destination system uses supplemental metadata from the replica copies to re-create or mimic the source's computing environment and to restore backed up data from the replica copies.

Abstract: A robotic surgical system includes a surgical console with a tracking device for determining whether a user is engaged with the surgical console and controls a mode of operation of at least one component of the robotic surgical system based on whether or not the user is engaged with the surgical console.

Abstract: A system and a method of preventing generation of duplicate network routes in a Software Defined Wide Area Network (SD-WAN) are described. A network route management service receives network route information from a network device connected to a subnetwork present in the SD-WAN. The network route information is compared with a master network route information for identifying presence of one or more duplicate network routes in the network route information. Upon identification, the duplicate network routes are removed from the network route information, and the network route information excluding the one or more duplicate network routes is transmitted to the network device.

Abstract: An embodiment semiconductor structure includes a metal layer. The semiconductor structure also includes a redistribution layer (RDL) structure including an RDL platform and a plurality of RDL pillars disposed between the RDL platform and the metal layer. Additionally, the semiconductor structure includes an under-bump metal (UBM) layer disposed on the RDL platform and a solder bump disposed on the UBM layer, where the UBM layer, the RDL platform, and the RDL pillars form an electrical connection between the solder bump and the metal layer.

Abstract: A system for processing patient data associated with a joint of a patient. The system comprising a computing device executing instructions to generate a 3D patient bone model of the joint in a non-weighted pose. The instructions rearrange 3D first and second bone models in order to mimic a weighted pose of the joint of the patient from a 2D image of the joint of the patient in a weighted pose by performing the steps of: generating a plurality of 2D projections of poses of the 3D patient bone model; comparing the plurality of 2D projections to contour lines of the first bone and the second bone in the 2D image; identifying particular 2D projections that best-fit a shape and size of the contour lines; and arranging the 3D first and second bone models relative to each other according to orientations represented by the particular 2D projections that were identified.

Abstract: Disclosed herein are methods and systems for analyzing a cross-sectional feature of a structural element on a semiconductor wafer to determine whether an isolated or a systemic failure to reach preselected parameters occurred.

Abstract: Provided are telomerase inhibitor compounds. Some compounds include a lactone or lactam group that is covalently bonded to a phenyl ring, which is itself bonded to a pyrazole group. In other cases, a sulfonamide-containing moiety is covalently bonded to a phenyl ring, which is itself bonded to a pyrazole group. In some embodiments, the telomerase inhibitor compound has a vinyl sulfonamide group bonded to an amide moiety and an aromatic group. In other cases, the inhibitor compound has an isothiazolidine 1,1-dioxide core that is bonded to a phenyl group. Aspects of the invention also include pharmaceutical compositions comprising the subject telomerase inhibitor compounds, as well as methods of treating telomerase-related diseases or conditions.

Abstract: An electronic device includes a UDC and a UDC controller configured to determine an optimal number of frames required to be captured for a scene to compensate at least one parameter to optimize an output media using the UDC, obtain a multi-frame fusion media by performing at least one multi-frame fusion on the determined optimal number of frames, perform a light source spread correction on the multi-frame fusion media, and optimize the output media based on the light source spread correction on the multi-frame fusion media.

Abstract: A disclosed framework enables virtually any aggressive Recovery Point Objective (RPO) to be enforced for a production database, without limitation on type of database management system (DBMS) or size of the production database. The framework overcomes technological barriers of the prior art, such as bottlenecks presented by a storage manager computer that traditionally managed database backups. To avoid the bottlenecks, an illustrative data storage management system does not engage the storage manager computer in storage operations that could impact the database RPO. Certain components are added and enhanced to autonomously capture database transaction logs, which are stored securely and persistently away from the DBMS. In a separate and less frequent operation, and with involvement of the storage manager computer, the illustrative system generates secondary copies in their final form. Meanwhile, temporary backup files can be used in restore operations without first being converted into secondary copies.

Abstract: A medical device including a proximal end portion and a distal end portion opposite the proximal end portion. An elongate shaft is disposed between the proximal and distal end portions and defines a lumen therebetween. The distal end portion includes a plurality of tubes extending from a distal end of the elongate shaft, the plurality of tubes defining a fluid pathway therein in communication with the lumen for circulation of cryogenic fluid, the plurality of tubes having a common exhaust lumen in fluid communication with the lumen.

Abstract: There is provided a method and memory controller for managing memory operations in storage device. The memory controller receives plurality of requests from a user. The memory controller switches operating mode of storage device dynamically based on time interval between each of the plurality of requests and predefined threshold. The switching comprises notifying first cores to switch second cores from active state to power down state while switching to scaled down mode and restarting second cores while switching to striping FTL mode. Thereby, managing memory operations of storage device. Thus, the present disclosure manages the memory operations and optimises power consumption of the storage device.