Abstract: The present invention relates to an improved process of conjugation to obtain synthetic oligosaccharide-protein (OS-PR) conjugates. The process of synthetic OS-PR conjugation is a rapid process providing oligosaccharide-protein conjugates which are highly immunogenic and elicit specific and homogenous immune responses. The synthetic oligosaccharide comprising of four to eight repeating units of respective monomers and at least one in-built terminal amino linker, said synthetic polysaccharide mimics natural polysaccharide obtained from gram negative bacteria such as Neisseria meningitidis serogroups A, C, Y, W, X and Haemophilus influenzae and carrier protein is obtained from gram positive bacteria such as Clostridium tetani (tetanus toxoid) or Corynebacterium diphtheriae (CRM197) or their recombinant versions. The conjugation chemistry of the said oligosaccharide-protein conjugate of the present invention is thio-ether linkage. The present invention takes complete process time in the range of 14-22 hours.

Abstract: A semiconductor device includes a semiconductor substrate and a semiconductor layer formed thereon; a first well region disposed in a portion of the semiconductor layer; a second well region disposed in another portion of the semiconductor layer; a pair of third well regions disposed in a portion of the semiconductor layer at opposite sides of the second well region; a plurality of isolation elements disposed over the semiconductor layer, respectively between the third well regions and the first and second well region; a deep well region disposed in a portion of the semiconductor substrate adjacent to the semiconductor layer between the first and second well region; a first doping region disposed in the first well region; and second doping regions disposed in the third well regions.

Abstract: Multiple data paths may be available to a data management system for transferring data between a primary storage device and a secondary storage device. The data management system may be able to gain operational advantages by performing load balancing across the multiple data paths. The system may use application layer characteristics of the data for transferring from a primary storage to a backup storage during data backup operation, and correspondingly from a secondary or backup storage system to a primary storage system during restoration.

Abstract: A system and method are provided to model a network path with performance characterization for individual path segments of the network path and correlate the faults and performance issues to identify the factors that are causing network path performance degradation. The system described herein provides for codebook correlation technology to identify the root cause of network path performance degradation. In an embodiment, an algorithm is provided to model the network path with performance characterization and analysis. The performance of a network path is determined by performance characteristics of individual hops along the network path. The path performance is then characterized with weighted attributes indicative of performance over individual hops along the network path. The individual hops along the network path are modeled with weighted attributes indicative of performance. The performance symptoms may be aggregated to determine path performance using codebook correlation to perform a causal analysis.

Abstract: An external fixation frame for correcting a bone deformity includes a first fixation ring and a second fixation ring. A posterior adjustable length strut couples a posterior portion of the first fixation ring to a posterior portion of the second fixation ring and has universal joint. Medial and lateral adjustable length struts couples medial and lateral portions of the first fixation ring to medial and lateral portions of the second fixation ring respectively, each of the medial and lateral adjustable length struts including a constrained hinge joint. The fixation frame also includes a half ring hingedly coupled to the second fixation ring, and an anterior adjustable length strut coupling an anterior portion of the first fixation ring to the half ring.

Abstract: A system provides placement of components for an integrated circuit having a plurality of flip-flops. The system clusters the plurality of flip-flops into a plurality of clusters and relocates one or more of the flip-flops in response to overlapping placement locations. The clustering includes using a K-means algorithm to assign a flip-flop to a cluster while adding weight to each cluster based on its current size.

Abstract: An external fixation frame for correcting a bone deformity includes a first fixation ring and a second fixation ring. A posterior adjustable length strut couples a posterior portion of the first fixation ring to a posterior portion of the second fixation ring and has universal joint. Medial and lateral adjustable length struts couples medial and lateral portions of the first fixation ring to medial and lateral portions of the second fixation ring respectively, each of the medial and lateral adjustable length struts including a constrained hinge joint. The fixation frame also includes a half ring hingedly coupled to the second fixation ring, and an anterior adjustable length strut coupling an anterior portion of the first fixation ring to the half ring.

Abstract: An electronic device includes a communication interface configured to receive a call from another electronic device, a sensor to sense a motion speed of the electronic device, and a processor configured to provide, to a server, a status of the electronic device based on the motion speed for notifying the another electronic device of the status, determine a type of the call according to an input received from the another electronic device after providing the status, and control to provide a notification related to the call in the electronic device based on the type of the call.

Abstract: One or more techniques and/or computing devices are provided for resilient replication of storage operations. For example, a first storage controller may host first storage having a replication relationship with second storage hosted by a second storage controller. To improve resiliency against transient network issues of a network between the storage controllers, the first storage controller may implement a queue and retry mechanism to retry replication operations not acknowledge back by the second storage controller within a threshold time. The second storage controller may maintain a cumulative sequence number of a latest replication operation performed in order, an operation response map of replication operations performed out of order, and an operation finder map identifying currently implemented replication operations, which may be used to process incoming replication operations. Single write semantics, write order consistency, and reduction of write amplification may be provided.

Abstract: An external fixation system includes top and bottom fixation plates that may be connected to fragments of a bone. At least one y-shaped strut attaches the two fixation plates. Each y-shaped strut has first, second and third telescopic struts coupled at a connector joint. The first strut member is coupled to the top fixation plate and the second and third strut members are coupled to the bottom fixation plate. Each strut member may include a joint and may also include an actuation unit connecting the particular strut member to the top or bottom fixation plate. Rotation of a head portion of the actuation unit causes rotation of a threaded rod, causing adjustment in the length of the respective strut member. As the lengths of the strut members change, the joints may reposition, leading to the top fixation plate becoming repositioned with respect to the bottom fixation plate.

Abstract: An external fixator system comprising at least two fixation plates which are arranged at a distance to each another, at least one adjustable length strut having a first end region and a second end region which are in connection with the fixation plates and at least one actuation unit to adjust the length of the strut in order to adjust the distance and/or orientation between the fixation plates. The actuation unit is in a fixed connection with at least one of the fixation plates as well as with at least one of the end regions of the respective strut in order to connect the strut with the fixation plate. The actuation unit comprises a feedback unit which provides the user with a feedback concerning the degree of the actuation.

Abstract: An illustrative approach to managing snapshots streamlines how and when snapshots are generated in a storage management system, such that fewer snapshots may be generated without diminishing the scope of data protection. A novel unified-snapshot storage policy may govern snapshots for any number of subclients. A unified-snapshot job based on the unified-snapshot storage policy enables the illustrative storage management system to automatically discover relevant components and generate at most one snapshot per target logical unit number (“LUN”) in a storage array. Each snapshot may comprise the data of any number of subclients and/or clients in the storage management system. Accordingly, one unified-snapshot job may yield a minimum but sufficient number of snapshots comprising data of all subclients associated with the governing unified-snapshot storage policy. An enhanced storage manager may manage the unified-snapshot jobs.

Abstract: A high availability distributed, deduplicated storage system according to certain embodiments is arranged to include multiple deduplication database media agents. The deduplication database media agents store signatures of data blocks stored in secondary storage. In addition, the deduplication database media agents are configured as failover deduplication database media agents in the event that one of the deduplication database media agents becomes unavailable.

Abstract: A system may read an input file having an input file size and including a first record and a second record. The first and second record may each have a record length. The system may parse the input file into a first split file and a second split file, with the first split file including the first record and the second split file including the second record. The system may distribute the first split file to a first node to generate a first output file and the second split file to a second node to generate a second output file. Any number of additional split files may be distributed to generate any number output files. The system may combine the output files to generate a converted data file.

Abstract: A system according to certain embodiments associates a signature value corresponding to a data block with one or more data blocks and a reference to the data block to form a signature/data word corresponding to the data block. The system further logically organizes the signature/data words into a plurality of files each comprising at least one signature/data word such that the signature values are embedded in the respective file. The system according to certain embodiments reads a previously stored signature value corresponding to a respective data block for sending from a backup storage system having at least one memory device to a secondary storage system.

Abstract: Techniques for providing shared access to, e.g., a small computer system interface (SCSI) storage device in a computer network include providing an operational mode on SCSI interfaces with a first media agent and a second media agent such that, in response to inquiry messages on the SCSI interfaces, the SCSI storage device appears as a SCSI target device to the first media agent and the second media agent and mapping data operations between the first media agent and the SCSI storage device and the second media agent and the SCSI storage device to logically unique channel numbers for the first media agent and the second media agent to perform data storage operations over their respective SCSI interfaces by concurrently sharing the SCSI storage device.

Abstract: Systems and methods are provided herein for automatically configuring newly installed secondary storage computing devices and managing secondary storage computing devices when one or more become unavailable. For example, a storage manager can then detect the computing resources available to the newly installed secondary storage computing device, assign a role to the newly installed secondary storage computing device based on the detected computing resources, configure the newly installed secondary storage computing device with deduplication and storage policies used by the other secondary storage computing devices, re-partition secondary storage devices to allocate memory for the newly installed secondary storage computing device, and instruct other secondary storage computing devices to replicate their managed data such that the newly installed secondary storage computing device has access to the replicated data.

Abstract: Systems and methods are provided herein for automatically configuring newly installed secondary storage computing devices and managing secondary storage computing devices when one or more become unavailable. For example, a storage manager can then detect the computing resources available to the newly installed secondary storage computing device, assign a role to the newly installed secondary storage computing device based on the detected computing resources, configure the newly installed secondary storage computing device with deduplication and storage policies used by the other secondary storage computing devices, re-partition secondary storage devices to allocate memory for the newly installed secondary storage computing device, and instruct other secondary storage computing devices to replicate their managed data such that the newly installed secondary storage computing device has access to the replicated data.

Abstract: Systems and methods are provided herein for automatically configuring newly installed secondary storage computing devices and managing secondary storage computing devices when one or more become unavailable. For example, a storage manager can then detect the computing resources available to the newly installed secondary storage computing device, assign a role to the newly installed secondary storage computing device based on the detected computing resources, configure the newly installed secondary storage computing device with deduplication and storage policies used by the other secondary storage computing devices, re-partition secondary storage devices to allocate memory for the newly installed secondary storage computing device, and instruct other secondary storage computing devices to replicate their managed data such that the newly installed secondary storage computing device has access to the replicated data.

Abstract: Systems and methods are provided herein for automatically configuring newly installed secondary storage computing devices and managing secondary storage computing devices when one or more become unavailable. For example, a storage manager can then detect the computing resources available to the newly installed secondary storage computing device, assign a role to the newly installed secondary storage computing device based on the detected computing resources, configure the newly installed secondary storage computing device with deduplication and storage policies used by the other secondary storage computing devices, re-partition secondary storage devices to allocate memory for the newly installed secondary storage computing device, and instruct other secondary storage computing devices to replicate their managed data such that the newly installed secondary storage computing device has access to the replicated data.