Abstract: A method of producing a virus like particle (VLP) in a plant comprising modified hemagglutinin is provided. The method comprises introducing a nucleic acid comprising a regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a modified influenza hemagglutinin (HA) protein into the plant, or portion of the plant, the modified HA protein comprises a modified proteolytic loop. Followed by incubating the plant or portion of the plant under conditions that permit the expression of the nucleic acids, thereby producing the VLP. The modified proteolytic loop may comprise one or more protease cleavage sites exhibiting reduced or abolished cleavage by a protease. The nucleotide sequence encoding the HA may be selected from the group consisting of B HA, C, H1, H2, H3, H4, H5, H6, H7, H8, H9, H10, H11, H12, H13, H14, H15, and H16. Also described is a virus like particle (VLP) produced by the method, and plants expressing the VLP.

Abstract: A refrigeration system operable in cooling mode and defrosting mode is provided. The refrigeration system includes a defrost line connecting a first reservoir to an evaporation stage for conveying at least part of the flash gas from the first reservoir to the evaporation stage when the refrigeration system is operating in defrosting mode. The flash gas thereby releases heat in the evaporation stage for defrosting the evaporation stage. The refrigeration system can also include a discharge line connecting the evaporation stage to a second reservoir.

Abstract: The present invention relates to an adapter (100) for coupling with a medical coupling unit (1) and a medical sensor (2) that are configured for being coupled for electrical signal transmission between them. The adapter comprises an adapter coupling unit (101) configured to fit with a coupling-side connector (10) of the medical coupling unit (1) and including a plurality of coupling-side electrical contacts (111, 113) for contacting a plurality of electrical contacts (11, 13) of the coupling-side connector (10) and a sensor-side connector (120) configured to fit with a sensor-side connector (20) of the medical sensor (2) and including a plurality of sensor-side electrical contacts (121, 123) for contacting a plurality of electrical contacts (21, 23) of the sensor-side connector (20), allowing the adapter coupling unit (101) to be mechanically coupled between the medical coupling unit (1) and the medical sensor (2).

Abstract: A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plant lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.

Abstract: A computer-implemented method, a system or a non-transitory computer-readable medium of doing the same, for monitoring movement of anatomical features throughout a radiation treatment session. The method may include monitoring the movement of the anatomical features with a first modality. The method may further include obtaining positional information of the anatomical features with a second modality over a finite acquisition time. The method may also include providing an indication of a clinically relevant movement associated with the anatomical features during the finite acquisition time based on the monitored movement from the first modality.

Abstract: Cloud-assisted computing systems, devices, and associated methods of global discovery services are disclosed herein. In one embodiment, a computing device of a processing plant in an operational technology (“OT”) infrastructure is configured to upon detecting a data server is connected to the OT network in a processing plant, collect, from the detected data server, data representing a configuration of the data server and transmit a registration request containing the collected data to a cloud computing system via a secure connection to register the detected data server as a data source in the OT infrastructure. The computing device can then receive a registration confirmation indicating that the configuration of the data server is stored in the cloud computing system and is discoverable by client devices at other processing plants in the OT infrastructure.

Abstract: Systems and techniques for estimating illumination from a single image are provided. An example system may include a neural network. The neural network may include an encoder that is configured to encode an input image into an intermediate representation. The neural network may also include an intensity decoder that is configured to decode the intermediate representation into an output light intensity map. An example intensity decoder is generated by a multi-phase training process that includes a first phase to train a light mask decoder using a set of low dynamic range images and a second phase to adjust parameters of the light mask decoder using a set of high dynamic range image to generate the intensity decoder.

Abstract: The present invention relates to an apparatus for assessing medical device quality. It is described to provide (210) at least one report associated with at least one medical image acquired by a medical device, wherein a report is associated with a corresponding medical image. The at least one report is analyzed and at least one image quality parameter is generated (220), wherein an image quality parameter is associated with a 5 corresponding report. The at least one image quality parameter is assessed and generating alert information relating to the medical device is generated (230).

Abstract: Earpieces and methods for acute sound detection and reproduction are provided. A method can include measuring an external ambient sound level (xASL), monitoring a change in the xASL for detecting an acute sound, estimating a proximity of the acute sound, and upon detecting the acute sound and its proximity, reproducing the acute sound within an ear canal, where the ear canal is at least partially occluded by an earpiece. Other embodiments are disclosed.

Abstract: An earpiece (100) and acoustic management module (300) for in-ear canal echo suppression control suitable is provided. The earpiece can include an Ambient Sound Microphone (111) to capture ambient sound, an Ear Canal Receiver (125) to deliver audio content to an ear canal, an Ear Canal Microphone (123) configured to capture internal sound, and a processor (121) to generate a voice activity level (622) and suppress an echo of spoken voice in the electronic internal signal, and mix an electronic ambient signal with an electronic internal signal in a ratio dependent on the voice activity level and a background noise level to produce a mixed signal (323) that is delivered to the ear canal (131).

Abstract: The invention provides an LED module having a concentrated light output window. Light output from a first output window of an LED assembly (e.g. from a plurality of LEDs) is passed to an input window of a light directing element and redirected to be emitted from a second, smaller output window of a light directing element. This difference in size thereby concentrates the light output by the light directing element. The second output window (of the light directing element) is substantially perpendicular to the first output window, allowing for the size of the LED assembly in a particular dimension to not be necessarily constrained by the size of the second output window.

Abstract: A method of producing a rotavirus-like particle (RLP) in a plant is provided. The method comprises expressing within a host or host cell for example a plant, portion of a plant or plant cell one or more nucleic acid comprising one or more regulatory region operatively linked to a first, second and third nucleotide sequence, the regulatory region active in the host or host cell. The first nucleotide sequence encoding a first rotavirus protein, the second nucleotide sequence encoding a second rotavirus protein and the third nucleotide sequence encoding a third rotavirus protein. The first, second and third encode rotavirus protein NSP4 and VP2 or VP6 and VP4 or VP7. The host or host cell is incubated under conditions that permit the expression of the nucleic acids, so that NSP4 and either VP2 of VP6 and VP4 or VP7 are expressed, thereby producing the RLP. Hosts comprising the RLP, compositions comprising the RLP and method for using the composition are also provided.

Abstract: The invention relates to an androgynous coupling device (10) for connecting modules, in particular for constructing a spacecraft of modular design, wherein, in order to connect the modules, the coupling device (10) can be coupled to an identically constructed further androgynous coupling device and has a plurality of coupling elements (30, 32). It is provided that the androgynous coupling device (10) has a covering element (18) which covers the coupling elements (30, 32) in a passive state of the coupling device (10), wherein a first of the coupling elements (30) can be moved outwardly through the covering element (18) for active coupling to the identically constructed further coupling device. The invention furthermore relates to a module, in particular a module for constructing a spacecraft of modular design, having at least one such coupling device (10).

Abstract: The present invention relates to a lighting device (100, 200, 300) comprising a split lighting engine with at least two thermally separated sub-engines (104, 106, 202, 204, 206, 302). Each sub-engine comprises at least one solid state light source (114, 212, 306) and a component (118, 210, 304) adapted to regulate electric current or power to the at least one solid state light source (114, 212, 306), so that the sub-engines (104, 106, 202, 204, 206, 302) are individually drivable based on a thermal environment of each sub-engine.

Abstract: Disclosed is an economical and effective way of producing a modular retaining wall for a material to be retained, using only blocks which in and of themselves are of insufficient thickness to function as retaining wall blocks. The modular wall includes backer blocks and facing blocks which are connected by separate connectors in a back to back, spaced apart arrangement, thereby forming a hollow retaining wall. The hollow wall is filled with loose filler material to increase the mass and retaining capacity of the wall. None of the wall components is embedded in the material to be retained. Further disclosed are wall components and a wall kit for a modular retaining wall. A double sided decorative wall is also disclosed. The modular wall system allows for the construction of retaining walls and freestanding, double sided, decorative walls forming both straight and curved walls.

Abstract: A method for synthesizing chimeric influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of chimeric influenza HA in a plant or a portion of a plant. The invention is also directed towards a VLP comprising chimeric influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding chimeric influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.

Abstract: A method of producing a picornavirus-like particle (PVLP) in a plant is provided. The method comprises introducing a first nucleic acid and a second nucleic acid into the plant, portion of the plant, or a plant cell. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding a polyprotein. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more protease. The plant, portion of the plant, or plant cell is incubated under conditions that permit the expression of the nucleic acids, thereby producing the PVLP. A PVLP comprising the polyprotein is also provided.

Abstract: Precatalysts of formula I and IV, and processes for the functionalization of SP2-carbons using the same are described herein. The precatalysts comprise a fluoroborate salt protected intramolecular frustrated lewis pair (FLP). The precatalysts are bench stable with improved stability towards moisture and/or air. The precatalysts can be used to generate in situ the corresponding FLP catalyst.

Abstract: In an example embodiment, a technique is provided for model review using augmented reality. An augmented reality device obtains tiles from a remote computing device for an overview resolution, and augments the model at the overview resolution and an overview view size into a physical environment at a data location. The augmented reality device displays the model augmented into the physical environment to a user disposed at a view location. In response to input requesting a change to the new resolution, the augmented reality device obtains additional tiles from the remote computing device for the new resolution, augments the model at the new resolution and a new view size into the physical environment, and displays the model augmented into the physical environment to the user disposed at the view location. In response to input that requests navigation of the model, the augmented reality device changes at least one of the data location or the view location.

Abstract: A method according to embodiments of the invention includes providing a light emitting semiconductor structure grown on a substrate. The substrate has a front side and a back side opposite the front side. Notches are formed in the substrate. The notches extend from the front side of the substrate into the substrate. After forming notches in the substrate, the back side of the substrate is thinned to expose the notches.