Abstract: There is described herein use of a compound of formula (I) below to make cyclic peptides.

Abstract: A light source includes first and second semiconductor diode structures adapted to generate light, a light output section at least partially overlapping both of the first and the second semiconductor diode structures and being adapted to output light from the first and the second semiconductor diode structures, and a light reflecting structure at least partially enclosing side surfaces of the first and the second semiconductor diode structures and the light output section and being adapted to reflect light from the first and the second semiconductor diode structures towards the light output section. The area of the light output section is less than the combined area of the first and the second semiconductor diode structures.

Abstract: A communication network comprises an access network, a subsystem and a gateway computer that bridges the access network and the subsystem. A plurality of client applications of a single user may connect to services provided by the subsystem. The gateway registers the user in the subsystem and associates all communication of the plurality of instances with a unique identifier that identifies the combination of the user and the gateway thus reducing the number of user registrations in the subsystem.

Abstract: A method of producing a picornavirus-like particle (PVLP) in a plant is provided. The method comprises introducing a first nucleic acid and a second nucleic acid into the plant, portion of the plant, or a plant cell. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding a polyprotein. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more protease. The plant, portion of the plant, or plant cell is incubated under conditions that permit the expression of the nucleic acids, thereby producing the PVLP. A PVLP comprising the polyprotein is also provided.

Abstract: A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plant lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.

Abstract: Methods, systems and computer-readable media for optimizing SerDes system parameters based on a bit error rate detected by a forward error correction unit (FEC). A SerDes receiver receives a data stream over a link and uses a FEC to detect error information in the received data stream. The system tunes and optimizes one or more SerDes system parameters using the detected error information. The system minimizes power consumption by decreasing power supply voltage until a maximum acceptable input error rate threshold is reached. The FEC allows the system to tolerate errors in the input data stream up to the threshold while preventing propagation of these errors in the FEC output data stream.

Abstract: An earpiece (100) and acoustic management module (300) for in-ear canal echo suppression control suitable is provided. The earpiece can include an Ambient Sound Microphone (111) to capture ambient sound, an Ear Canal Receiver (125) to deliver audio content to an ear canal, an Ear Canal Microphone (123) configured to capture internal sound, and a processor (121) to generate a voice activity level (622) and suppress an echo of spoken voice in the electronic internal signal, and mix an electronic ambient signal with an electronic internal signal in a ratio dependent on the voice activity level and a background noise level to produce a mixed signal (323) that is delivered to the ear canal (131).

Abstract: Methods and systems for imaging tissue of a subject are disclosed, and involve illuminating the tissue with a coherent light having a coherent wavelength, acquiring image data of the tissue using a color image sensor, and processing the image data using laser speckle contrast analysis while correcting for differences in sensitivity of color pixels at the coherent wavelength to generate a perfusion image of the tissue. The perfusion image is then displayed to the user. Also disclosed are methods and systems for correcting for ambient light and for acquiring white light images along with laser speckle images.

Abstract: The invention provides a lighting unit, comprising a light source and a light sensor arrangement. An optical feedback path is provided from the light source (or another light source in the same overall system) to the light sensor arrangement. The light source is turned on in response to an external input and is maintained on as a result of the optical feedback path. This lighting unit can be turned on using an signal such as an optical signal which is received from an external source, and then maintained on using optical feedback from the light source itself. This makes it possible to control a lighting unit area such as a wall using an external device such as a torch or laser pointer, without the need for complex electronic protocols.

Abstract: A light emitting arrangement is suggested for generating directional projections of light with sharply defined beam profile. Light from a top-emitting solid state light source (12), having reflective side-coating (34), is pre-collimated via a beam-shaping optic (16), before being propagated through a secondary collimating funnel (18), capturing any light rays with still too great an escape angle. Chip-scale package dimensions may be achieved through the use of a thin-film side-coating and undersized phosphor layers. Substrate level process flow further allows for parallel processing of a plurality of devices.

Abstract: Method for operation of a strap-down ship's gyro compass for optimal calculation of position and course angle on a ship, with three rotational rate sensors each mutually aligned to each other at a right angle, and two nominally horizontally aligned orthogonal acceleration sensors, without required specification of the geographic latitude and/or of the speed of the ship, characterized by the steps: a. Preparation of a set of dynamic equations based on the angular velocity components detected by the rotational rate sensor, b. Preparation of a measured data equation based on the force components detected by the acceleration sensors, c. Determination of the properties of the lever arm between the strap-down ship's gyro compass and the point of rotation of the ship, and d.

Abstract: A camera for a vehicle vision system includes a front housing portion, a circuit board, and a rear housing portion having a connector portion for connection of a vehicle coaxial cable. The circuit board includes a first solder pad for soldering a core pin connecting element, and a second solder pad that partially circumscribes the first solder pad for soldering a shielding connecting element. The second solder pad only partially circumscribes the first solder pad so as to have a gap between opposing ends of the second solder pad. The gap is configured to allow for escape of gases that evaporate out of the solder during the soldering process. The core pin connecting element electrically connects between a core pin of the connected coaxial cable and circuitry of the circuit board and the shielding connecting element electrically connects between shielding of the coaxial cable and circuitry of the circuit board.

Abstract: The present disclosure provides, inter alia, RAF-Degrading Conjugate Compounds that are useful in the treatment of cancer and other RAF related diseases. Also provided are, pharmaceutical compositions, methods of treatment, and kits comprising a RAF-Degrading Conjugate Compound.

Abstract: A camera for a vehicular vision system includes a camera housing, a PCB having circuitry disposed thereat, and a lens assembly. The circuitry includes an imager disposed at one side of the PCB, and the circuitry includes connecting terminals that protrude from the circuit board. The PCB is disposed in the camera housing and retained thereat via a fastener. The camera housing is open at a rear portion, and a sealing material is dispensed in the camera housing to seal the PCB and the connecting terminals in the camera housing. An electrical connector receives the connecting terminals and is disposed at an outer portion of the sealing material at the rear of the camera housing. The sealing material includes a thermally conductive resin and is dispensed in the camera housing in an uncured state. The sealing material, when cured, attaches the electrical connector at the rear portion of the camera.

Abstract: Earpieces and methods for acute sound detection and reproduction are provided. A method can include measuring an external ambient sound level (xASL), monitoring a change in the xASL for detecting an acute sound, estimating a proximity of the acute sound, and upon detecting the acute sound and it's proximity, reproducing the acute sound within an ear canal, where the ear canal is at least partially occluded by an earpiece. Other embodiments are disclosed.

Abstract: A system for selecting a loudspeaker based on its low frequency rendering. The system comprises a plurality of synthesizers for generating a corresponding plurality of signals. The system comprises a plurality of filters for band-pass filtering the plurality of generated signals. Each filter filters the signal generated by one of the plurality of synthesizers. Each filter is configured for performing the band-pass filtering in a dedicated frequency band. The system comprises a plurality of loudspeakers for playing the plurality of filtered signals. Each loudspeaker plays the signal filtered by one of the plurality of filters. The system comprises a channel configurator for selecting one among the plurality of loudspeakers based on a reference amplitude spectrum of a model signal and a low frequency response of each one of the plurality of loudspeakers.

Abstract: The invention concerns an oscillator for a timepiece movement, comprising a staff rigidly connected to a balance carrying first and second bipolar magnets spaced apart from the staff and capable, depending on the angular position of the balance, of being positioned alternately within range of a magnetic field produced by a fixed bipolar magnet, the latter being located on the trajectory of the first and second bipolar magnets and being arranged in such a way that, when one of the bipolar magnets approaches the fixed bipolar magnet, identical polarities are located opposite each other in order to produce a repulsive force. The oscillator further comprises a pallet assembly and an escape wheel for establishing a kinematic connection between a source of energy of the timepiece movement and the balance staff, and arranged in such a way that the balance is capable of having a sustained periodic oscillating movement of an amplitude greater than 90 degrees.

Abstract: A system for generating a query includes a term unit (1) for extracting a term from at least one input document (51), to obtain an extracted term. A category unit (2) is arranged for associating the extracted term with a category that is semantically related with the extracted term. A query unit (3) is arranged for generating a query in dependence on the extracted term and the category. The query unit (3) includes an additional term unit (4) for generating at least one additional search term based on the category, and the query unit (3) is arranged for including the additional search term in the query. A submit unit (5) is arranged for submitting the query to at least one search engine (50), to obtain a plurality of found documents.

Abstract: This application relates to substituted imidazopyridines, compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to substituted imidazopyridines and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.

Abstract: The invention provides a water-activatable luminescent particulate material (1) comprising particles (100), wherein each particle (100) comprises a solid state light source (10) functionally coupled with a water-activatable battery (20) and a water absorbing shell (120) enclosing at least part of the water-activatable battery (20). The invention also provides a luminescent particulate material spray device comprising a container configured to host the water-activatable luminescent particulate material.